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Book ; Thesis: Multi-frequency electrical impedance tomography for monitoring lung diseases

Aguiar Santos, Susana

(Aachener Beiträge zur Medizintechnik ; 51)

2018

Author's details	Susana Aguiar Santos
Series title	Aachener Beiträge zur Medizintechnik ; 51
Collection
Keywords	Electrical Impedance Tomography ; lung diseases ; lung monitoring ; multi-frequency
Subject code	670
Language	English
Size	xix, 179 Seiten, Illustrationen, Diagramme, 21 cm x 14.8 cm, 299 g
Publisher	Shaker Verlag
Publishing place	Aachen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, RWTH Aachen University, 2018
HBZ-ID	HT019932761
ISBN	978-3-8440-6378-3 ; 3-8440-6378-1
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2019 A 325	available for loan (reading room)	Lesesaal EG

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Article: How digitalization reinvented entrepreneurial resilience during COVID-19.

Santos, Susana C / Liguori, Eric W / Garvey, Erin

Technological forecasting and social change

2023 Volume 189, Page(s) 122398

Abstract: The emergence of new digital technologies has transformed entrepreneurship and, very likely, enabled many new and established ventures to avoid bankruptcy throughout the COVID-19 pandemic. Digital technologies are key to identifying, evaluating and ... ...

Abstract	The emergence of new digital technologies has transformed entrepreneurship and, very likely, enabled many new and established ventures to avoid bankruptcy throughout the COVID-19 pandemic. Digital technologies are key to identifying, evaluating and exploiting opportunities, scaling a venture's competitiveness, improving efficiency and innovating, especially during uncertain times. We explore how digital technologies reinvented entrepreneurial resilience during the COVID-19 pandemic and distill the digital artifacts, platforms and infrastructures used by entrepreneurs to demonstrate entrepreneurial resilience. We analyzed 42 reflective interviews featuring successful entrepreneurs from How I Built This "Resilience Series" podcast that explore how entrepreneurs responded to the COVID-19 crisis. We adopted a systematic approach to identify and describe the behaviors, actions and strategies related to digitalization to reinvent the business in the uncertain and resource-constrained context of COVID-19. The data analysis yielded thirteen first-order codes categorized into five second-order themes: creative digital pivoting, digital infrastructures, social impact through digital technology, burdens to digital adoption, and growth through digitalization. These second-order themes reveal to function as both enablers and barriers to entrepreneurial resilience in this adverse context. Our exploratory analysis suggests how digitalization influences entrepreneurial resilience.
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article
ISSN	0040-1625
ISSN	0040-1625
DOI	10.1016/j.techfore.2023.122398
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Modified Vertical Parasagittal Sub-Insular Hemispherotomy-Case Series and Technical Note.

Del Gaudio, Nicole / Ferrao Santos, Susana / Raftopoulos, Christian

Brain sciences

2023 Volume 13, Issue 10

Abstract: 1) Background: Hemispherotomy is the generally accepted treatment for hemispheric drug-resistant epilepsy (DRE). Lateral or vertical approaches are performed according to the surgeon's preference. Multiple technical variations have been proposed since ... ...

Abstract	(1) Background: Hemispherotomy is the generally accepted treatment for hemispheric drug-resistant epilepsy (DRE). Lateral or vertical approaches are performed according to the surgeon's preference. Multiple technical variations have been proposed since Delalande first described his vertical technique. We propose a sub-insular variation of the vertical parasagittal hemispherotomy (VPH) and describe our case series of patients operated on using this procedure. (2) Methods: Data from a continuous series of patients with hemispheric DRE who were operated on by the senior author (CR) using the modified sub-insular VPH technique were analyzed retrospectively. Pre-operative demographic and epilepsy characteristics, functional outcome, and surgical complications were extracted from medical charts. (3) Results: Twenty-five patients were operated on between August 2008 and August 2023; 23 have at least 3 months of follow-up. Of this group, 20 (86.9%) patients are seizure-free. Only two patients developed postoperative hydrocephalus (8.7%). All patients who were able to walk autonomously preoperatively and 20 (86.9%) of those with follow-up were able to walk without assistance. A total of 17 (74%) patients were able to perform adapted social activities at the latest follow-up. (4) Conclusions: Modified sub-insular VPH is a successful surgical technique for hemispheric DRE with seizure freedom rates similar to the largest series reported in the literature. Compared to other series, patients who were operated on with our modified technique had a lower rate of postoperative hydrocephalus and excellent long-term motor and cognitive outcomes.
Language	English
Publishing date	2023-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13101395
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Article ; Online: Paediatric Palliative Care in a Reference Centre of Inherited Metabolic Diseases.

Saraiva, Bárbara Martins / Santos, Susana / Ferreira, Ana Cristina / Paiva, Mafalda

Endocrine, metabolic & immune disorders drug targets

2023

Abstract: Introduction: Paediatric palliative care (PPC) has a significant role in improving the quality of life of children with life-limiting or life-threatening illnesses, diminishing symptom burden, and providing holistic support to patients and families. ... ...

Abstract	Introduction: Paediatric palliative care (PPC) has a significant role in improving the quality of life of children with life-limiting or life-threatening illnesses, diminishing symptom burden, and providing holistic support to patients and families. Inherited metabolic diseases (IMD) are a group of heterogeneous diseases that often present with severe neurologic impairment, needing lifelong care and challenging symptom management. Objective: Our aim was to characterize the cohort of patients with IMD followed by the paediatric palliative care team (PPCT) and to describe the provision of care provided. Methods: The descriptive analysis of demographic, clinical, and care delivery data of a cohort of paediatric patients was carried out with a confirmed diagnosis of IMD, followed in a Reference Centre, in the care of PPCT between 2018 and 2023. Results: Thirteen (10%) of a total of 134 patients in the care of PPCT had a confirmed diagnosis of an IMD: 6 mitochondrial, 3 peroxisomal, 3 lysosomal, and 1 pterin metabolism disorder. The median age at referral was 9 years (0-18), the median duration of care was 2 years [2-4], median number of home visits in the last year was 2 [1-4], and median number of outpatient consults was 4 [2 -8]. Twelve patients (92%) had no autonomy in their activities of daily living. Neurologic (100%), gastrointestinal (92%), and respiratory (69%) symptoms were the main focus of care. All patients were polymedicated (5 or more different drugs). Nine (69%) had percutaneous gastrostomy and 2 (15%) had noninvasive ventilation. Median hospital admissions before and after starting care by PPCT were 4 and 1. Moreover, three patients died and one was at home. Conclusion: Mitochondrial, lysosomal, and peroxisomal disorders are complex multisystemic diseases that very often have no treatment intended to cure. These patients have a heavy symptom burden and frequent intercurrences. Addressing these symptoms is challenging, but PPC has proven to reduce hospital admissions with consequent improvement in quality of life. In the future, PPC should be available for all children and families with life-threatening conditions.
Language	English
Publishing date	2023-09-14
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530323666230914114425
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Zs.A 5824: Show issues

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Article ; Online: Circular RNAs: Promising Targets in Osteoporosis.

Moura, Sara Reis / Fernandes, Maria João / Santos, Susana G / Almeida, Maria Inês

Current osteoporosis reports

2023 Volume 21, Issue 3, Page(s) 289–302

Abstract: Purpose of review: Circular RNAs (circRNAs) are RNA transcripts derived from fragments of pre-messenger RNAs through a back-splicing process. An advantage that rises from their circular covalently closed conformation is their high stability, when ... ...

Abstract	Purpose of review: Circular RNAs (circRNAs) are RNA transcripts derived from fragments of pre-messenger RNAs through a back-splicing process. An advantage that rises from their circular covalently closed conformation is their high stability, when compared with their linear counterparts. The current review focuses on the emerging roles of circRNAs in osteoporosis, including in osteogenic differentiation and osteoclastogenesis. Their potential as osteoporosis biomarkers will also be discussed. Recent findings: Although firstly described as non-coding, some of these single-stranded RNAs were recently reported to possess protein-coding capacity. On the other hand, the circRNAs exhibit cell and tissue-specific patterns at the transcriptome level in eukaryotes and are regulated throughout the development or disease progression. Even though thousands of these circular transcripts are listed and annotated, only a limited number of studies describe their biological role in bone processes. Recent evidence indicates inhibitory activator roles in both osteoblasts and osteoclasts differentiation and function. Latest screenings in the blood, plasma, or serum of osteoporosis patients support the potential for circRNA signature to be used as biomarkers in osteoporosis, but further validation is required. While intense research into circRNAs has been detailing their biological roles, there remains a need for standardization and further research to fulfil the future potential of this emerging and highly promising class of regulatory molecules.
MeSH term(s)	Humans ; RNA, Circular/genetics ; Osteogenesis/genetics ; RNA/genetics ; Biomarkers ; Osteoporosis/genetics
Chemical Substances	RNA, Circular ; RNA (63231-63-0) ; Biomarkers
Language	English
Publishing date	2023-04-29
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-023-00786-7
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Article ; Online: É só mais um e-mail! - O tempo de trabalho do teletrabalhador domiciliário

Santos, Susana Ferreira dos

2020

Abstract: Algumas das considerações centram-se no desvio à regra da voluntariedade no contexto da pandemia da COVID-19; a possibilidade de, no futuro, ser consagrado um direito ao teletrabalho; o facto de a confiança ser o substantivo certo para o teletrabalho ... ...

Abstract	Algumas das considerações centram-se no desvio à regra da voluntariedade no contexto da pandemia da COVID-19; a possibilidade de, no futuro, ser consagrado um direito ao teletrabalho; o facto de a confiança ser o substantivo certo para o teletrabalho vingar; entre outras questões. Em seguida, as nossas reflexões versam sobre o tempo de trabalho. Na discussão desta questão é irrelevante tratar-se de um teletrabalhador voluntário (antes da COVID-19) ou de um teletrabalhador forçado (depois da COVID-19). Na atual revolução organizacional, podemos assistir à preocupante inexequibilidade das regras relacionadas com os limites máximos do período normal de trabalho diário e semanal. info:eu-repo/semantics/publishedVersion
Keywords	Teletrabalho ; Teletrabalhador ; Tempo de trabalho ; covid19
Language	Portuguese
Publisher	Ordem dos Advogados
Publishing country	pt
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New graphene-containing pharmaceutical formulations for infrared lamps-based phototherapy of skin cancer: In vitro validation and ex-vivo human skin permeation.

Silva, Filipa A L S / Pinto, Soraia / Santos, Susana G / Magalhães, Fernão D / Sarmento, Bruno / Pinto, Artur M

Nanomedicine : nanotechnology, biology, and medicine

2024 Volume 57, Page(s) 102734

Abstract: Basal cell carcinoma (BCC) is the most common form of human cancer, and treatment usually involves surgery, with alternative strategies being needed. We propose the use of carbopol hydrogels (HG) for topical administration of nanographene oxide (GOn) and ...

Abstract	Basal cell carcinoma (BCC) is the most common form of human cancer, and treatment usually involves surgery, with alternative strategies being needed. We propose the use of carbopol hydrogels (HG) for topical administration of nanographene oxide (GOn) and partially-reduced nanographene oxide (p-rGOn) for photothermal therapy (PTT) of BCC. GOn and p-rGOn incorporated into the HG present lateral sizes ∼200 nm, being stable for 8 months. After 20 min irradiation with an infrared (IR) photothermal therapy lamp (15.70 mW cm
MeSH term(s)	Humans ; Graphite/pharmacology ; Drug Compounding ; Phototherapy ; Skin Neoplasms/drug therapy ; Hydrogels ; Oxides ; Cell Line, Tumor
Chemical Substances	Graphite (7782-42-5) ; Hydrogels ; Oxides
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2024.102734
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Self-reported oral health and normative indices of dental caries among adolescents: a cohort study.

Santos, Susana Aguiar / Ortiz, Fernanda Ruffo / Agostini, Bernardo Antonio / Ardenghi, Thiago Machado

Brazilian oral research

2022 Volume 36, Page(s) e021

Abstract: This study assessed the association between self-reported oral health and the normative indices of dental caries in an adolescent population. This study is based on a 6-year data from a cohort, beginning in 2012, with 1,134 twelve-year-old adolescents. ... ...

Abstract	This study assessed the association between self-reported oral health and the normative indices of dental caries in an adolescent population. This study is based on a 6-year data from a cohort, beginning in 2012, with 1,134 twelve-year-old adolescents. After three phases of data collection, 68% of the samples were followed up. Self-reported oral health was evaluated through the question: "Would you say that the health of your teeth, lips, jaws, and mouth is …?", and answers were categorized as "good" or "poor." Calibrated dentists examined clinical conditions using the decayed, missing, and filled teeth (DMFT) index. Statistical analysis was performed using multilevel logistic regression models, considering the dependence of those observed thrice and adjusted for demographic, socioeconomic, and dental visit variables. Adolescents who evaluated their oral health as poor had higher mean DMFT (OR: 1.35; CI95% 1.22-1.50). When evaluated separately, decayed (OR: 2.43; CI95% 1.83-3.23) and missing (OR: 3.94; CI95% 1.26-12.26) teeth also presented significant results, showing poor self-reported oral health associated with a higher mean. Adolescents' self-perceived oral health was associated with normative dental caries indices, and this association was maintained throughout adolescence.
MeSH term(s)	Adolescent ; Cohort Studies ; Cross-Sectional Studies ; DMF Index ; Dental Caries/epidemiology ; Humans ; Oral Health ; Prevalence ; Self Report
Language	English
Publishing date	2022-02-09
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2179332-3
ISSN	1807-3107 ; 1806-8324 ; 1517-7491
ISSN (online)	1807-3107
ISSN	1806-8324 ; 1517-7491
DOI	10.1590/1807-3107bor-2022.vol36.0021
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Zs.A 3037: Show issues

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Article ; Online: Improved mRNA affinity chromatography binding capacity and throughput using an oligo-dT immobilized electrospun polymer nanofiber adsorbent.

Dewar, Emily A / Guterstam, Peter / Holland, David / Lindman, Susanna / Lundbäck, Peter / Brito Dos Santos, Susana / Wang, Sheng-Ching / Swartz, Andrew R

Journal of chromatography. A

2024 Volume 1717, Page(s) 464670

Abstract: Increased demand for mRNA-based therapeutics and improved in vitro transcription (IVT) yields have challenged the mRNA purification platform. Hybridization-affinity chromatography with an immobilized oligo-deoxythymidilic acid (oligodT) ligand is often ... ...

Abstract	Increased demand for mRNA-based therapeutics and improved in vitro transcription (IVT) yields have challenged the mRNA purification platform. Hybridization-affinity chromatography with an immobilized oligo-deoxythymidilic acid (oligodT) ligand is often used to capture mRNA through base pairing with the polyadenylated tail. Commercially available oligodT matrices include perfusive cross-linked poly(styrene-divinylbenzene) 50 µm POROS™ chromatography resin beads and convective polymethacrylate CIMmultus® monolithic columns consisting of 2 µm interconnected channels. POROS™ columns may be limited by poor mass transfer for larger mRNAs and slow flowrates, while monoliths can operate at higher flowrates but are limited by modest binding capacity. To enable both high flowrates and binding capacity for mRNA of all lengths, prototype chromatography media was developed by Cytiva using oligodT immobilized electrospun cellulose nanofibers (Fibro™) with a 0.3-0.4 µm pore size. In this work, four polyadenylated mRNAs ranging from ∼1900-4300 nucleotides were used to compare the dynamic binding capacity (DBC) of Fibro™, POROS® and CIMmultus® columns as a function of residence time and binding buffer compositions. Fibro™ improved the DBC ∼2-4-fold higher than CIMmultus® and ∼2-13-fold higher than POROS™ across all residence times, mRNA length, and binding matrix compositions tested. CIMmultus® DBC was least dependent on residence time and mRNA size, while both Fibro™ and POROS™ DBC increased at slower flowrates and with shorter mRNA. Surprisingly, inverse size exclusion (ISE) experiments showed that POROS™ was not limited by diffusion and POROS™ along with CIMmultus® demonstrate higher mRNA permeation however the Fibro™ prototype is not in the final configuration. Lastly, IVT reaction products were subjected to purification and oligodT elution product yield, quality, and purity were consistent across the three matrices investigated. These results highlight the benefits of high DBC and equivalent product profiles offered by the oligodT Fibro™ prototype compared to commercially available oligodT media.
MeSH term(s)	Polymers/chemistry ; Nanofibers ; RNA, Messenger ; Chromatography, Affinity/methods ; Cellulose
Chemical Substances	Polymers ; RNA, Messenger ; Cellulose (9004-34-6)
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2024.464670
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Article: New MoS

Campos, Miguel T / Silva, Filipa A L S / Fernandes, José Ramiro / Santos, Susana G / Magalhães, Fernão D / Oliveira, Maria J / Pinto, Artur M

Pharmaceutics

2024 Volume 16, Issue 3

Abstract: Non-melanoma skin cancer (NMSC) is one of the most common types of cancer worldwide. Despite the low mortality rate, rising incidence and recurrence rates are a burden on healthcare systems. Standard treatments such as chemotherapy, radiotherapy, and ... ...

Abstract	Non-melanoma skin cancer (NMSC) is one of the most common types of cancer worldwide. Despite the low mortality rate, rising incidence and recurrence rates are a burden on healthcare systems. Standard treatments such as chemotherapy, radiotherapy, and surgery are either invasive or toxic to healthy tissues; therefore, new, alternative, selective treatments are needed. In this work, a combined photothermal and chemotherapeutic approach is proposed. MoS
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics16030360
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