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Article ; Online: Factors associated with delayed diagnosis of leprosy in an endemic area in Northeastern Brazil: a cross-sectional study.

Santos, Glicya Monaly Claudino Dos / Byrne, Rachel L / Cubas-Atienzar, Ana Isabel / Santos, Victor Santana

2024 Volume 40, Issue 1, Page(s) e00113123

Abstract: This study aimed to investigate the factors related to the individual and the health system that contribute to delayed diagnosis of leprosy in an endemic area in the Northeastern Brazil. This is a cross-sectional study of 120 individuals with leprosy. ... ...

Abstract	This study aimed to investigate the factors related to the individual and the health system that contribute to delayed diagnosis of leprosy in an endemic area in the Northeastern Brazil. This is a cross-sectional study of 120 individuals with leprosy. Demographic and clinical data and information on the factors related to the individual and the health system that contribute to delayed diagnosis of leprosy were obtained. Delayed diagnosis in months was estimated for each participant by interviews. A multivariate Poisson's regression analysis was performed between the outcome and the independent variables. The median delay in the diagnosis of leprosy was 10.5 (4.0-24.0) months. Approximately 12.6% of participants had grade 2 disability (G2D) at the time of diagnosis. In the multivariate Poisson regression analysis, males, older age, low schooling level, residing in urban areas, multibacellar or tuberculoid leprosy, not seeking healthcare immediately after symptom onset, suspected leprosy, excessive referrals, and the need for three or more consultations to confirm the diagnosis were associated with longer diagnostic delay. This study found a significant delay in the diagnosis of leprosy in Arapiraca, Northeastern Brazil, which may explain the continuously high rate of G2D among new cases. Factors related to the individual and the health system were associated with longer diagnostic delay. Interventions to raise awareness of the disease among the general population and strengthen primary health care are urgently needed.
MeSH term(s)	Male ; Humans ; Cross-Sectional Studies ; Delayed Diagnosis ; Brazil/epidemiology ; Leprosy/diagnosis ; Leprosy/epidemiology ; Educational Status
Language	English
Publishing date	2024-01-08
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311XEN113123
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Article ; Online: Relationship between living conditions in neighborhoods in the Northeast Brazil and COVID-19 estimates during the third wave associated with the Omicron variant.

Martins-Filho, Paulo Ricardo / Santos, Victor Santana

Biodemography and social biology

2022 , Page(s) 1–5

Abstract: Brazil experienced a critical increase in COVID-19 cases during the first weeks of 2022 due to community transmission of the SARS-CoV-2 Omicron variant. Furthermore, there has been a significant increase in the country's demand for hospital beds, ... ...

Abstract	Brazil experienced a critical increase in COVID-19 cases during the first weeks of 2022 due to community transmission of the SARS-CoV-2 Omicron variant. Furthermore, there has been a significant increase in the country's demand for hospital beds, especially among those unvaccinated or partially vaccinated. Despite this scenario, the number of deaths was considerably lower than in previous COVID-19 waves. However, evidence is limited regarding the disease burden at this stage of the pandemic in more vulnerable regions. In this ecological study, we investigated the impacts of the third wave of COVID-19 caused by the Omicron on cases and deaths in a region of Northeast Brazil, and their relationship with the living conditions of the population in a neighborhood-level analysis. We found that neighborhoods with worse living conditions had a lower COVID-19 incidence (median 193.4 cases per 10 000) than those with better living conditions (median 335.1 cases per 10 000) (p < .001), but no differences were found regarding mortality. Despite advances in vaccination coverage against the disease in Brazil and the significant reduction in the number of deaths during the third wave, our findings may suggest differences in access to diagnostic resources for COVID-19 in the poorest communities.
Language	English
Publishing date	2022-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2482287-5
ISSN	1948-5573 ; 0037-766X ; 1948-5565
ISSN (online)	1948-5573
ISSN	0037-766X ; 1948-5565
DOI	10.1080/19485565.2022.2149464
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Article ; Online: Scorpion envenomation in Brazil and its relationship with the social determinants of health: A population-based ecological study.

Siqueira, Thayane Santos / Dos Santos, Adriano José / Santos, João Lucas Cavalcante / da Silva, Rikelly Rhuana Nunes / Silva, José Rodrigo Santos / Santos, Victor Santana

Acta tropica

2024 Volume 253, Page(s) 107165

Abstract: This study comprehensively analyzed cases of scorpion envenomation in Brazil, exploring the temporal trends and geographic patterns of such incidents between January 1, 2012, and December 31, 2022. Simultaneously, we assessed the correlation between ... ...

Abstract	This study comprehensively analyzed cases of scorpion envenomation in Brazil, exploring the temporal trends and geographic patterns of such incidents between January 1, 2012, and December 31, 2022. Simultaneously, we assessed the correlation between scorpion envenomation and social determinants of health and social vulnerability. We conducted a population-based ecological study, gathering information on the number of scorpion envenomation cases in Brazil, as well as socioeconomic data and social vulnerability indicators across the 5,570 Brazilian municipalities. The season-trend model, based on the classical additive decomposition method, informed estimations of scorpion envenomation variations over time. The spatial correlation of scorpion envenomation with socioeconomic and vulnerability indicators was assessed using the Bivariate Moran's I. A total of 1,343,224 cases of scorpion envenomation were recorded in Brazil from Jan 2012 to Dec 2022. A single increasing time trend was observed for the entire country for this period (APC 8.94, P < 0.001). The seasonal analysis was significant for Brazil as a whole and all regions (p < 0.001), with peaks evident between October and November. The spatial distribution of cases was heterogeneous, with spatial clusters concentrated in the high-risk Southeast and Northeast regions. There was a high incidence of scorpion envenomation in municipalities facing social vulnerability, and, paradoxically, in those with better sanitation and waste collection. Our study revealed a heterogeneous geographical distribution of scorpion accidents in Brazil. Municipalities with higher social vulnerability exhibited a high incidence of scorpion envenomation.
MeSH term(s)	Humans ; Brazil/epidemiology ; Social Determinants of Health ; Scorpion Stings/epidemiology ; Cities ; Social Conditions
Language	English
Publishing date	2024-02-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2024.107165
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Article ; Online: No evidence supports the use of ether and chloroform inhalation for treating COVID-19.

Martins-Filho, Paulo Ricardo / Santos, Victor Santana

Revista panamericana de salud publica = Pan American journal of public health

2020 Volume 44, Page(s) e41

Keywords	covid19
Language	English
Publishing date	2020-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1376934-0
ISSN	1680-5348 ; 1020-4989
ISSN (online)	1680-5348
ISSN	1020-4989
DOI	10.26633/RPSP.2020.41
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Zs.A 4694: Show issues

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Article: Poorer and more densely populated regions have lower vaccination capability against COVID-19.

Martins-Filho, Paulo Ricardo / Rocha Santana, Ricardo Ruan / Santos, Victor Santana / Barberia, Lorena G

EXCLI journal

2022 Volume 21, Page(s) 621–622

Language	English
Publishing date	2022-03-21
Publishing country	Germany
Document type	Journal Article
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2022-4798
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Article ; Online: Prevalence of sleep disorders in children with Congenital Zika Syndrome.

Tavares, Carolina Santos Souza / Marques, Raquel Souza / Santos, Victor Santana / Santos, Hudson P / Reis, Monique Carla da Silva / Martins-Filho, Paulo Ricardo

Journal of tropical pediatrics

2023 Volume 69, Issue 6

Abstract: Studies have reported that children with Congenital Zika Syndrome (CZS) experience changes in their sleep patterns, which can result in mood disturbances, behavioral issues and delays in growth and development. This systematic review synthesized the ... ...

Abstract	Studies have reported that children with Congenital Zika Syndrome (CZS) experience changes in their sleep patterns, which can result in mood disturbances, behavioral issues and delays in growth and development. This systematic review synthesized the available evidence on the prevalence of sleep disorders in children with CZS. Eligible studies were those with an observational design that reported sleep disorders in children with CZS using validated questionnaires, polysomnography/electroencephalographic recording or parent/caregiver reports. Searches were conducted in PubMed, Web of Science, SCOPUS and Embase, as well as a gray literature search using Google Scholar. The Freeman-Tukey double-arcsine transformation with a random-effects model was used to estimate the pooled prevalence of sleep disorders with a 95% confidence interval (CI). Five studies were included and data from 340 Brazilian children with CZS were analyzed. The overall prevalence of sleep disorders was 27.4% (95% CI 16.7-39.4), without differences among studies using validated questionnaires (29.4%, 95% CI 21.4-37.8) or report from parents and caregivers (27.4%, 95% CI 11.5-47.0). Sleep disorders are prevalent in children with CZS, impacting their development and quality of life. It is critical to examine the quality of sleep in these children to develop appropriate interventions that can mitigate these issues.
MeSH term(s)	Child ; Humans ; Pregnancy ; Female ; Zika Virus Infection/complications ; Zika Virus Infection/epidemiology ; Zika Virus Infection/congenital ; Zika Virus ; Prevalence ; Quality of Life ; Brazil/epidemiology ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology ; Pregnancy Complications, Infectious/epidemiology
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	800065-7
ISSN	1465-3664 ; 0449-3281 ; 0142-6338
ISSN (online)	1465-3664
ISSN	0449-3281 ; 0142-6338
DOI	10.1093/tropej/fmad033
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Zs.A 932: Show issues

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Article ; Online: Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.

Martins-Filho, Paulo Ricardo / Barreto-Filho, José Augusto Soares / Santos, Victor Santana

Arquivos brasileiros de cardiologia

2020 Volume 115, Issue 2, Page(s) 273–277

Abstract: Background: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative ... ...

Title translation	Biomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.
Abstract	Background: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19. Methods: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results. Results: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection. Conclusions: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277).
MeSH term(s)	Betacoronavirus ; Biomarkers/blood ; COVID-19 ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/virology ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Humans ; Myocardium/pathology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	Biomarkers
Keywords	covid19
Language	English
Publishing date	2020-10-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20200372
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Zs.A 548: Show issues

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Article ; Online: Factors associated with mortality in patients with COVID-19. A quantitative evidence synthesis of clinical and laboratory data.

Martins-Filho, Paulo Ricardo / Tavares, Carolina Santos Souza / Santos, Victor Santana

European journal of internal medicine

2020 Volume 76, Page(s) 97–99

MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Hospital Mortality ; Host Microbial Interactions/immunology ; Humans ; Multiple Organ Failure/etiology ; Multiple Organ Failure/immunology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/physiopathology ; Prognosis ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Survival Analysis
Keywords	covid19
Language	English
Publishing date	2020-04-23
Publishing country	Netherlands
Document type	Letter ; Meta-Analysis
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2020.04.043
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Article ; Online: To breastfeed or not to breastfeed? Lack of evidence on the presence of SARS-CoV-2 in breastmilk of pregnant women with COVID-19.

Martins-Filho, Paulo Ricardo / Santos, Victor Santana / Santos, Hudson P

Revista panamericana de salud publica = Pan American journal of public health

2020 Volume 44, Page(s) e59

Abstract: A rapid systematic review was carried out to evaluate the current evidence related to the presence of SARS-CoV-2 in breast milk from pregnant women with COVID-19. Eight studies analyzing the presence of SARS-CoV-2 RNA in the breast milk of 24 pregnant ... ...

Abstract	A rapid systematic review was carried out to evaluate the current evidence related to the presence of SARS-CoV-2 in breast milk from pregnant women with COVID-19. Eight studies analyzing the presence of SARS-CoV-2 RNA in the breast milk of 24 pregnant women with COVID-19 during the third trimester of pregnancy were found. All patients had fever and/or symptoms of acute respiratory illness and chest computed tomography images indicative of COVID-19 pneumonia. Most pregnant women had cesarean delivery (91.7%) and two neonates had low birthweight (< 2 500 g). Biological samples collected immediately after birth from upper respiratory tract (throat or nasopharyngeal) of neonates and placental tissues showed negative results for the presence SARS-CoV-2 by RT-PCR test. No breast milk samples were positive for SARS-CoV-2 and, to date, there is no evidence on the presence of SARS-CoV-2 in breast milk of pregnant women with COVID-19. However, data are still limited and breastfeeding of women with COVID-19 remains a controversial issue. There are no restrictions on the use of milk from a human breast milk bank.
Keywords	covid19
Language	English
Publishing date	2020-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1376934-0
ISSN	1680-5348 ; 1020-4989
ISSN (online)	1680-5348
ISSN	1020-4989
DOI	10.26633/RPSP.2020.59
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Zs.A 4694: Show issues

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Book ; Online: Biomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19

Martins-Filho, Paulo Ricardo / Barreto-Filho, José Augusto Soares / Santos, Victor Santana

Arquivos Brasileiros de Cardiologia v.115 n.2 2020

2020

Abstract: Resumo Fundamento O SARS-CoV-2 é um vírus de RNA emergente associado à doença respiratória aguda grave conhecida como COVID-19. Embora a COVID-19 seja predominantemente uma doença pulmonar, alguns pacientes apresentam graves danos cardiovasculares. ... ...

Abstract	Resumo Fundamento O SARS-CoV-2 é um vírus de RNA emergente associado à doença respiratória aguda grave conhecida como COVID-19. Embora a COVID-19 seja predominantemente uma doença pulmonar, alguns pacientes apresentam graves danos cardiovasculares. Realizamos uma síntese de evidências quantitativas de dados clínicos, biomarcadores de lesão miocárdica e complicações cardíacas associadas ao óbito hospitalar em pacientes com COVID-19. Métodos Buscamos nas bases de dados PubMed, Embase e Google Scholar para identificar estudos que comparassem dados clínicos, biomarcadores de lesão miocárdica e complicações cardíacas entre pacientes sobreviventes e não sobreviventes da COVID-19. Os tamanhos dos efeitos foram apresentados como diferença média ou diferença média padronizada para variáveis contínuas e razão de risco para variáveis dicotômicas, com intervalos de confiança de 95%. Foi utilizado um modelo de efeitos aleatórios para agrupar os resultados. Resultados Foram incluídos seis estudos retrospectivos que relataram dados de 1.141 pacientes (832 sobreviventes e 309 não sobreviventes). Verificamos que condições cardiovasculares subjacentes; elevação de troponina cardíaca I de alta sensibilidade; N-terminal do pró-hormônio do peptídeo natriurético do tipo B e creatina quinase-MB; e complicações cardíacas foram associadas ao aumento do risco de óbito em pacientes com infecção por SARS-CoV-2. Conclusões A confirmação de que condições cardiovasculares subjacentes, elevação de biomarcadores de lesão miocárdica durante a infecção por COVID-19 e descompensação cardiovascular aguda são preditores de mortalidade na infecção por SARS-CoV-2 deve incentivar novas pesquisas para esclarecer possíveis mecanismos e testar tratamentos adequados. (Arq Bras Cardiol. 2020; 115(2):273-277)
Keywords	Coronavírus ; COVID-19 ; SARS-CoV-2 ; Mortalidade ; covid19
Language	Portuguese
Publishing date	2020-08-01
Publisher	Sociedade Brasileira de Cardiologia - SBC
Publishing country	br
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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