Article ; Online: Belzutifan-induced regression of retinal capillary hemangioblastoma: A case-series.
American journal of ophthalmology case reports
2024 Volume 33, Page(s) 102011
Abstract: Purpose: To report a series of three patients with von Hippel-Lindau (VHL) disease who demonstrated regression of their retinal hemangioblastomas (RH) using belzutifan in conjunction with photocoagulation therapy.: Observations: Patient 1, a 23-year- ... ...
Abstract | Purpose: To report a series of three patients with von Hippel-Lindau (VHL) disease who demonstrated regression of their retinal hemangioblastomas (RH) using belzutifan in conjunction with photocoagulation therapy. Observations: Patient 1, a 23-year-old female, presented with multiple RHs in her right eye (OD) that were lasered. Her left eye (OS) revealed a large inferotemporal RH that measured approximately 2.1 mm Conclusions: Belzutifan, a hypoxia-inducible factor inhibitor, is an FDA-approved medication for VHL disease associated with renal cell carcinoma, central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors that do not require immediate surgical resection. Because of the high incidence of VHL-associated RHs, adjuvant laser photocoagulation therapy when belzutifan is suspended or withheld can allow for the regression of large lesions. In this case series, we also propose a reproducible and technically simple method to measure RH lesions size, using Optos fundus imaging. |
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Language | English |
Publishing date | 2024-02-10 |
Publishing country | United States |
Document type | Case Reports |
ISSN | 2451-9936 |
ISSN (online) | 2451-9936 |
DOI | 10.1016/j.ajoc.2024.102011 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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