Article ; Online: Effects of the essential oil of Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm. on healing and tissue repair after partial Achilles tenotomy in rats.
2017 Volume 32, Issue 6, Page(s) 449–458
Abstract: Purpose:: To investigate the cellular response to injury, analyzing histopathologic changes associated with increased cellularity, degeneration and disorganization of collagen fibers.: Methods:: Thirty wistar rats were divided in two groups after ... ...
| Abstract | Purpose:: To investigate the cellular response to injury, analyzing histopathologic changes associated with increased cellularity, degeneration and disorganization of collagen fibers. Methods:: Thirty wistar rats were divided in two groups after partial Achilles tenotomy: the right hind paw were treated with the essential oil of Alpinia zerumbet (EOAz), diluted to 33% (0.3 mL kg-1), and the left hind paw received sunflower oil for 3, 14, 30 and 90 days. Statistical significance was determined using a Chi-square and Pearson Correlation qualitative variables test. Moreover, Mann-Whitney U-test test for comparison between different groups of the same cell, one-way ANOVA, and Tukey's test of quantitative measurement. Results:: A decrease hyperemia (p < 0.001) was observed in the acute phase of inflammatory cell number (p < 0.001), whereas sub-acute phase was marked by significant correlation with macrophages in fibroblasts (r = 0.17, p = 0.03), with probable induction a dense and modeled tissue. At chronic phase, it was found an increase in the number of fibroblasts and a higher percentage of type I collagen fibers (78%) compared with control collagen fibers (55%). Conclusion:: Oil of Alpinia zerumbet stimulated the process of maturation, organization and tissue repair which gave it greater resistance. |
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| MeSH term(s) | Achilles Tendon/pathology ; Achilles Tendon/surgery ; Alpinia/chemistry ; Animals ; Collagen/drug effects ; Male ; Oils, Volatile/therapeutic use ; Rats ; Rats, Wistar ; Tenotomy ; Wound Healing/drug effects |
| Chemical Substances | Oils, Volatile ; Collagen (9007-34-5) |
| Language | English |
| Publishing date | 2017-03-27 |
| Publishing country | Brazil |
| Document type | Journal Article |
| ZDB-ID | 2012156-8 |
| ISSN | 1678-2674 ; 1678-2674 |
| ISSN (online) | 1678-2674 |
| ISSN | 1678-2674 |
| DOI | 10.1590/s0102-865020170060000005 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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