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  1. Article ; Online: Radiolabeled gemcitabine hydrochloride as an imaging agent for lung cancer: Radiolabeling, quality control and cell incorporation studies.

    Ekinci, Meliha / Santos-Oliveira, Ralph / İlem-Özdemir, Derya

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2023  Volume 198, Page(s) 110856

    Abstract: The development of new drugs that can specifically screen tumors is a global need. When it comes to lung cancer, which is the second main cause of cancer-related deaths, early detection of lung tumors using appropriate imaging is very important. In this ... ...

    Abstract The development of new drugs that can specifically screen tumors is a global need. When it comes to lung cancer, which is the second main cause of cancer-related deaths, early detection of lung tumors using appropriate imaging is very important. In this study, gemcitabine hydrochloride (GCH) was radiolabeled with [
    MeSH term(s) Humans ; Technetium/chemistry ; Gemcitabine ; Antioxidants ; Reducing Agents ; Radiopharmaceuticals/chemistry ; Lung Neoplasms/diagnostic imaging ; Quality Control
    Chemical Substances Technetium (7440-26-8) ; Gemcitabine ; Antioxidants ; Reducing Agents ; Radiopharmaceuticals
    Language English
    Publishing date 2023-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2023.110856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: The Comparative Toxic Impact Assessment of Carbon Nanotubes, Fullerene, Graphene, and Graphene Oxide on Marine Microalgae

    Pikula, Konstantin / Johari, Seyed Ali / Santos-Oliveira, Ralph / Golokhvast, Kirill

    Toxics

    2023  Volume 11, Issue 6

    Abstract: The growing production and application of carbon-based nanomaterials (CNMs) represent possible risks for aquatic systems. However, the variety of CNMs with different physical and chemical properties and different morphology complicate the understanding ... ...

    Abstract The growing production and application of carbon-based nanomaterials (CNMs) represent possible risks for aquatic systems. However, the variety of CNMs with different physical and chemical properties and different morphology complicate the understanding of their potential toxicity. This paper aims to evaluate and compare the toxic impact of the four most common CNMs, namely multiwalled carbon nanotubes (CNTs), fullerene (C60), graphene (Gr), and graphene oxide (GrO) on the marine microalgae
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11060491
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  3. Article ; Online: Toxicity and Biotransformation of Carbon-Based Nanomaterials in Marine Microalgae

    Pikula, Konstantin / Johari, Seyed Ali / Santos-Oliveira, Ralph / Golokhvast, Kirill

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: This work is related to the environmental toxicology risk assessment and evaluation of the possible transformation of carbon-based nanomaterials (CNMs) after contact with marine microalgae. The materials used in the study represent common and widely ... ...

    Abstract This work is related to the environmental toxicology risk assessment and evaluation of the possible transformation of carbon-based nanomaterials (CNMs) after contact with marine microalgae. The materials used in the study represent common and widely applied multi-walled carbon nanotubes (CNTs), fullerene (C
    MeSH term(s) Nanotubes, Carbon/toxicity ; Microalgae ; Fullerenes/toxicity ; Nanostructures/toxicity ; Biotransformation
    Chemical Substances Nanotubes, Carbon ; Fullerenes
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210020
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  4. Article ; Online: Biodistribution of

    Ekinci, Meliha / Santos-Oliveira, Ralph / Ilem-Ozdemir, Derya

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2022  Volume 176, Page(s) 21–31

    Abstract: Lung cancer (LC) is a common type of cancer, which is a leading cause of death around the world. There is an urgency for the development of new drugs that could diagnose the LC in the early stages and in a precise manner. In this direction, the ... ...

    Abstract Lung cancer (LC) is a common type of cancer, which is a leading cause of death around the world. There is an urgency for the development of new drugs that could diagnose the LC in the early stages and in a precise manner. In this direction, the development of nanoparticles radiolabeled with the diagnostic radioisotopes represent an important advance in the field of cancer imaging. In this study were developed PLA/PVA/Atezolizumab nanoparticles which were radiolabeled with
    MeSH term(s) Animals ; Antibodies, Monoclonal, Humanized ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/drug therapy ; Mice ; Nanoparticles ; Polyesters ; Radiopharmaceuticals ; Technetium/pharmacology ; Tissue Distribution
    Chemical Substances Antibodies, Monoclonal, Humanized ; Polyesters ; Radiopharmaceuticals ; atezolizumab (52CMI0WC3Y) ; Technetium (7440-26-8)
    Language English
    Publishing date 2022-05-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2022.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1651: Show issues Location:
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  5. Article ; Online: Individual and Binary Mixture Toxicity of Five Nanoparticles in Marine Microalga

    Pikula, Konstantin / Johari, Seyed Ali / Santos-Oliveira, Ralph / Golokhvast, Kirill

    International journal of molecular sciences

    2022  Volume 23, Issue 2

    Abstract: The investigation of the combined toxic action of different types of nanoparticles (NPs) and their interaction between each other and with aquatic organisms is an important problem of modern ecotoxicology. In this study, we assessed the individual and ... ...

    Abstract The investigation of the combined toxic action of different types of nanoparticles (NPs) and their interaction between each other and with aquatic organisms is an important problem of modern ecotoxicology. In this study, we assessed the individual and mixture toxicities of cadmium and zinc sulfides (CdS and ZnS), titanium dioxide (TiO
    MeSH term(s) Cadmium Compounds/toxicity ; Drug Interactions ; Microalgae/drug effects ; Microalgae/growth & development ; Nanoparticles ; Oxides/toxicity ; Silicon Dioxide/toxicity ; Sulfides/toxicity ; Titanium/toxicity ; Water Pollutants, Chemical/toxicity ; Zinc Compounds/toxicity
    Chemical Substances Cadmium Compounds ; Oxides ; Sulfides ; Water Pollutants, Chemical ; Zinc Compounds ; cadmium sulfide (057EZR4Z7Q) ; titanium dioxide (15FIX9V2JP) ; Silicon Dioxide (7631-86-9) ; Titanium (D1JT611TNE) ; zinc sulfide (KPS085631O)
    Language English
    Publishing date 2022-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23020990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Radiolabeled Human Serum Albumin Nanoparticles Co-Loaded with Methotrexate and Decorated with Trastuzumab for Breast Cancer Diagnosis.

    Ekinci, Meliha / Alencar, Luciana Magalhães Rebelo / Lopes, André Moreni / Santos-Oliveira, Ralph / İlem-Özdemir, Derya

    Journal of functional biomaterials

    2023  Volume 14, Issue 9

    Abstract: Breast cancer is a leading cause of cancer-related mortality among women worldwide, with millions of new cases diagnosed yearly. Addressing the burden of breast cancer mortality requires a comprehensive approach involving early detection, accurate ... ...

    Abstract Breast cancer is a leading cause of cancer-related mortality among women worldwide, with millions of new cases diagnosed yearly. Addressing the burden of breast cancer mortality requires a comprehensive approach involving early detection, accurate diagnosis, effective treatment, and equitable access to healthcare services. In this direction, nano-radiopharmaceuticals have shown potential for enhancing breast cancer diagnosis by combining the benefits of nanoparticles and radiopharmaceutical agents. These nanoscale formulations can provide improved imaging capabilities, increased targeting specificity, and enhanced sensitivity for detecting breast cancer lesions. In this study, we developed and evaluated a novel nano-radio radiopharmaceutical, technetium-99m ([
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14090477
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  7. Article ; Online: Inside Brazilian nuclear medicine: numbers, projections and behaviors.

    da Silva Brandão Rodrigues, Marlon / Magne, Tais Monteiro / Santos-Oliveira, Ralph

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 13, Page(s) 3809–3816

    MeSH term(s) Humans ; Nuclear Medicine ; Brazil ; Neural Pathways ; Radionuclide Imaging
    Language English
    Publishing date 2023-08-08
    Publishing country Germany
    Document type Editorial
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06386-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
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  8. Article ; Online: EDITORIAL: Radiopharmaceuticals for Cancer Therapy and Diagnosis.

    Santos-Oliveira, Ralph

    Anti-cancer agents in medicinal chemistry

    2017  Volume 17, Issue 3, Page(s) 310

    Language English
    Publishing date 2017-08-16
    Publishing country Netherlands
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/187152061703170222190946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5583: Show issues Location:
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  9. Article: Molecular Imaging for Lung Cancer: Exploring Small Molecules, Peptides, and Beyond in Radiolabeled Diagnostics.

    Ekinci, Meliha / Magne, Tais Monteiro / Alencar, Luciana Magalhães Rebelo / Fechine, Pierre Basilio Almeida / Santos-Oliveira, Ralph / Ilem-Özdemir, Derya

    Pharmaceutics

    2024  Volume 16, Issue 3

    Abstract: It is evident that radiolabeled drug delivery systems hold great promise in the field of lung cancer management. The combination of therapeutic agents with radiotracers not only allows for precise localization within lung tumors but also enables real- ... ...

    Abstract It is evident that radiolabeled drug delivery systems hold great promise in the field of lung cancer management. The combination of therapeutic agents with radiotracers not only allows for precise localization within lung tumors but also enables real-time monitoring of drug distribution. This approach has the potential to enhance targeted therapy and improve patient outcomes. The integration of advanced imaging modalities, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), has played a crucial role in the non-invasive tracking of radiolabeled drugs. These techniques provide valuable insights into drug pharmacokinetics, biodistribution, and tumor-targeting efficiency, offering clinicians the ability to personalize treatment regimens. The comprehensive analysis of preclinical and clinical studies presented in this review underscores the progress made in the field. The evidence suggests that radiolabeled drug delivery systems have the potential to revolutionize oncology by offering precise, targeted, and image-guided therapeutic interventions for lung cancer. This innovative approach not only enhances the effectiveness of treatment but also contributes to the development of personalized medicine strategies, tailoring interventions to the specific characteristics of each patient's cancer. The ongoing research in this area holds promise for further advancements in lung cancer management, potentially leading to improved outcomes and quality of life for patients.
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16030404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cellulose-based hydrogels towards an antibacterial wound dressing.

    Guamba, Esteban / Vispo, Nelson Santiago / Whitehead, Daniel C / Singh, Ajaya Kumar / Santos-Oliveira, Ralph / Niebieskikwiat, Dario / Zamora-Ledezma, Camilo / Alexis, Frank

    Biomaterials science

    2023  Volume 11, Issue 10, Page(s) 3461–3468

    Abstract: Hydrogels are promising candidates for wound healing bandages because they can mimic the native skin microenvironment. Additionally, there is increasing growth in the use of naturally derived materials and plant-based biomaterials to produce healthcare ... ...

    Abstract Hydrogels are promising candidates for wound healing bandages because they can mimic the native skin microenvironment. Additionally, there is increasing growth in the use of naturally derived materials and plant-based biomaterials to produce healthcare products with healing purposes because of their biocompatibility and biodegradation properties. In this study, cellulose extracted from biodiverse sources in Ecuador was used as the raw material for the fabrication of hydrogels with enhanced antifouling properties. Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM) were used to characterize the cellulose and hydrogels.
    MeSH term(s) Cellulose/pharmacology ; Cellulose/chemistry ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Anti-Bacterial Agents/chemistry ; Bandages ; Skin
    Chemical Substances Cellulose (9004-34-6) ; Hydrogels ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm01369j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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