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  1. Article ; Online: Exact fluctuation and long-range correlations in a single-file model under resetting.

    Santra, Saikat / Singh, Prashant

    Physical review. E

    2024  Volume 109, Issue 3-1, Page(s) 34123

    Abstract: Resetting is a renewal mechanism in which a process is intermittently repeated after a random or fixed time. This simple act of stop and repeat profoundly influences the behavior of a system as exemplified by the emergence of nonequilibrium properties ... ...

    Abstract Resetting is a renewal mechanism in which a process is intermittently repeated after a random or fixed time. This simple act of stop and repeat profoundly influences the behavior of a system as exemplified by the emergence of nonequilibrium properties and expedition of search processes. Herein we explore the ramifications of stochastic resetting in the context of a single-file system called random average process (RAP) in one dimension. In particular, we focus on the dynamics of tracer particles and analytically compute the variance, equal time correlation, autocorrelation, and unequal time correlation between the positions of different tracer particles. Our study unveils that resetting gives rise to rather different behaviors depending on whether the particles move symmetrically or asymmetrically. For the asymmetric case, the system for instance exhibits a long-range correlation which is not seen in absence of the resetting. Similarly, in contrast to the reset-free RAP, the variance shows distinct scalings for symmetric and asymmetric cases. While for the symmetric case, it decays (towards its steady value) as ∼e^{-rt}/sqrt[t], we find ∼te^{-rt} decay for the asymmetric case (r being the resetting rate). Finally, we examine the autocorrelation and unequal time correlation in the steady state and demonstrate that they obey interesting scaling forms at late times. All our analytical results are substantiated by extensive numerical simulations.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.109.034123
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  2. Article ; Online: Clinical landscape of citrin deficiency: A global perspective on a multifaceted condition.

    Kido, Jun / Makris, Georgios / Santra, Saikat / Häberle, Johannes

    Journal of inherited metabolic disease

    2024  

    Abstract: Citrin deficiency is an autosomal recessive disorder caused by a defect of citrin resulting from mutations in SLC25A13. The clinical manifestation is very variable and comprises three types: neonatal intrahepatic cholestasis caused by citrin deficiency ( ... ...

    Abstract Citrin deficiency is an autosomal recessive disorder caused by a defect of citrin resulting from mutations in SLC25A13. The clinical manifestation is very variable and comprises three types: neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD: OMIM 605814), post-NICCD including failure to thrive and dyslipidemia caused by citrin deficiency, and adult-onset type II citrullinemia (CTLN2: OMIM 603471). Frequently, NICCD can run with a mild clinical course and manifestations may resolve in the post-NICCD. However, a subset of patients may develop CTLN2 when they become more than 18 years old, and this condition is potentially life-threatening. Since a combination of diet with low-carbohydrate and high-fat content supplemented with medium-chain triglycerides is expected to ameliorate most manifestations and to prevent the progression to CTLN2, early detection and intervention are important and may improve long-term outcome in patients. Moreover, infusion of high sugar solution and/or glycerol may be life-threatening in patients with citrin deficiency, particularly CTLN2. The disease is highly prevalent in East Asian countries but is more and more recognized as a global entity. Since newborn screening for citrin deficiency has only been introduced in a few countries, the diagnosis still mainly relies on clinical suspicion followed by genetic testing or selective metabolic screening. This paper aims at describing (1) the different stages of the disease focusing on clinical aspects; (2) the current published clinical situation in East Asia, Europe, and North America; (3) current efforts in increasing awareness by establishing management guidelines and patient registries, hereby illustrating the ongoing development of a global network for this rare disease.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438341-2
    ISSN 1573-2665 ; 0141-8955
    ISSN (online) 1573-2665
    ISSN 0141-8955
    DOI 10.1002/jimd.12722
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  3. Book ; Online: Exact fluctuation and long-range correlations in a single-file model under resetting

    Santra, Saikat / Singh, Prashant

    2023  

    Abstract: Resetting is a renewal mechanism in which a process is intermittently repeated after a random or fixed time. This simple act of stop and repeat profoundly influences the behaviour of a system as exemplified by the emergence of non-equilibrium properties ... ...

    Abstract Resetting is a renewal mechanism in which a process is intermittently repeated after a random or fixed time. This simple act of stop and repeat profoundly influences the behaviour of a system as exemplified by the emergence of non-equilibrium properties and expedition of search processes. Herein, we explore the ramifications of stochastic resetting in the context of a single-file system called random average process (RAP) in one dimension. In particular, we focus on the dynamics of tracer particles and analytically compute the variance, equal time correlation, autocorrelation and unequal time correlation between the positions of different tracer particles. Our study unveils that resetting gives rise to rather different behaviours depending on whether the particles move symmetrically or asymmetrically. For the asymmetric case, the system for instance exhibits a long-range correlation which is not seen in absence of the resetting. Similarly, in contrast to the reset-free RAP, the variance shows distinct scalings for symmetric and asymmetric cases. While for the symmetric case, it decays (towards its steady value) as $\sim e^{-r t} / \sqrt{t}$, we find $\sim t e^{-r t}$ decay for the asymmetric case ($r$ being the resetting rate). Finally, we examine the autocorrelation and unequal time correlation in the steady state and demonstrate that they obey interesting scaling forms at late times. All our analytical results are substantiated by extensive numerical simulations.

    Comment: 16 pages, 7 figures
    Keywords Condensed Matter - Statistical Mechanics
    Subject code 612
    Publishing date 2023-11-07
    Publishing country us
    Document type Book ; Online
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  4. Article ; Online: Tunable, reversible resistive switching behavior of PVA-zirconia nanocomposite films and validation of the trap-assisted switching mechanism by the selective application of external bias voltages.

    Karmakar, Riju / Das, Amit Kumar / Dutta, Bilwadal / Sinha, Subhojyoti / Santra, Saikat / Pramanik, Subhamay / Kuiri, Probodh Kumar / Meikap, Ajit Kumar

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 23, Page(s) 15953–15969

    Abstract: Flexible, free-standing polyvinyl alcohol (PVA)-zirconia (mean particle size ∼24 nm) nanocomposite films have been synthesized and their performance as a potential next-generation resistive switching device material has been assessed in this report. The ... ...

    Abstract Flexible, free-standing polyvinyl alcohol (PVA)-zirconia (mean particle size ∼24 nm) nanocomposite films have been synthesized and their performance as a potential next-generation resistive switching device material has been assessed in this report. The nanocomposite films switch from a high resistive state (HRS) to a low resistive state (LRS) at the SET potential and from LRS to HRS at the RESET potential within the voltage window of 5 V. The origination of trap-assisted SET/RESET potentials has been experimentally validated by analyzing the experimental data and invoking various theoretical models. The impregnation of zirconium dioxide (ZrO
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp02012f
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  5. Article: Efficacy of early haematopoietic stem cell transplantation versus enzyme replacement therapy on neurological progression in severe Hunter syndrome: Case report of siblings and literature review.

    Sreekantam, Srividya / Smith, Laura / Stewart, Catherine / Kearney, Shauna / Lawson, Sarah / Raiman, Julian / Vijay, Suresh / Santra, Saikat

    Molecular genetics and metabolism reports

    2022  Volume 32, Page(s) 100881

    Abstract: Hunter syndrome is a neurodegenerative lysosomal storage disorder with limited treatment options to halt the progressive neurocognitive decline. Whilst Intravenous enzyme replacement therapy (ERT) does not cross the blood brain barrier; Intrathecal ERT, ... ...

    Abstract Hunter syndrome is a neurodegenerative lysosomal storage disorder with limited treatment options to halt the progressive neurocognitive decline. Whilst Intravenous enzyme replacement therapy (ERT) does not cross the blood brain barrier; Intrathecal ERT, in clinical studies, did not demonstrate significant effect on cognition, despite having better CNS delivery. Hematopoietic stem cell transplantation (HSCT) has the potential to treat CNS disease. We reviewed the literature and outline our experience of treating two siblings with severe Hunter syndrome: 'Sibling A' with intravenous and intrathecal ERT and 'Sibling B' with Early HSCT. A literature review identified 8 articles reporting on the comparative efficacy of both treatments. Our clinical outcomes indicate that Sibling B performed better than Sibling A in relation to early developmental milestones as well as neurocognition, activities of daily living, quality of life and neurophysiological outcomes in mid childhood. Sibling A's developmental trajectory fell within the extremely low range and Sibling B's development trajectory fell within the low-average to average range. This suggests HSCT had a disease modifying effect and highlights the efficacy of early HSCT in moderating the CNS progression in Hunter syndrome. Long term follow up is needed to elucidate the efficacy of HSCT on neurological progression.
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2821908-9
    ISSN 2214-4269
    ISSN 2214-4269
    DOI 10.1016/j.ymgmr.2022.100881
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  6. Article ; Online: Threading of various 'U' shaped bidentate axles into a heteroditopic macrocyclic wheel via Ni

    Nandi, Mandira / Santra, Saikat / Akhuli, Bidyut / Ghosh, Pradyut

    Dalton transactions (Cambridge, England : 2003)

    2017  Volume 46, Issue 23, Page(s) 7421–7433

    Abstract: The threading of 'U' shaped bent axles having diverse functionalities (Axle1-Axle10) is investigated by using a heteroditopic amido-amine macrocyclic (MC) wheel via ... ...

    Abstract The threading of 'U' shaped bent axles having diverse functionalities (Axle1-Axle10) is investigated by using a heteroditopic amido-amine macrocyclic (MC) wheel via Ni
    Language English
    Publishing date 2017-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c7dt00699c
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  7. Article: Wilson's Disease and Hyperornithinemia-hyperammonemia-homocitrullinuria Syndrome in a Child: A Case Report with Lessons Learned!

    Fernando, Meranthi / Vijay, Suresh / Santra, Saikat / Preece, Mary A / Brown, Rachel / Rodrigues, Astor / Gupte, Girish L

    Euroasian journal of hepato-gastroenterology

    2021  Volume 11, Issue 2, Page(s) 100–102

    Abstract: Background: Wilson's disease (WD) is a rare disorder of copper toxicosis. Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is even rarer. The coexistence of these two disorders and their clinical implications are not yet reported. We ... ...

    Abstract Background: Wilson's disease (WD) is a rare disorder of copper toxicosis. Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is even rarer. The coexistence of these two disorders and their clinical implications are not yet reported. We report on a child who succumbed to death due to liver disease caused by both disorders, documenting their disease-causing mutations and highlighting the lessons learnt out of this case.
    Case description: A child who was diagnosed to have WD soon after birth due to known parental heterozygosity was later found to have developmental delay, seizures, and hyperammonemia. Subsequent evaluation confirmed hyperornithinemia-hyperammonamia-homocitrullinuria (HHH) syndrome as a comorbidity. Though this child was commenced on medical treatment for both the metabolic diseases since early life, his liver disease was rapidly progressive requiring a liver transplant (LTx) at 6-years. He died in the posttransplant period possibly due to sepsis and hidden metabolic consequences.
    Conclusion: This case highlights that co-occurrence of WD and HHH syndrome would cause progressive liver disease despite medical treatment. Hence, the close clinical follow-up and early LTx would be warranted.
    How to cite this article: Fernando M, Vijay S, Santra S,
    Language English
    Publishing date 2021-10-25
    Publishing country India
    Document type Case Reports
    ZDB-ID 2651614-7
    ISSN 2231-5128 ; 2231-5047
    ISSN (online) 2231-5128
    ISSN 2231-5047
    DOI 10.5005/jp-journals-10018-1351
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  8. Book ; Online: Gap Statistics for Confined Particles with Power-Law Interactions

    Santra, Saikat / Kethepalli, Jitendra / Agarwal, Sanaa / Dhar, Abhishek / Kulkarni, Manas / Kundu, Anupam

    2021  

    Abstract: We consider the $N$ particle classical Riesz gas confined in a one-dimensional external harmonic potential with power law interaction of the form $1/r^k$ where $r$ is the separation between particles. As special limits it contains several systems such as ...

    Abstract We consider the $N$ particle classical Riesz gas confined in a one-dimensional external harmonic potential with power law interaction of the form $1/r^k$ where $r$ is the separation between particles. As special limits it contains several systems such as Dyson's log-gas ($k\to 0^+$), Calogero-Moser model ($k=2$), 1d one component plasma ($k=-1$) and the hard-rod gas ($k\to \infty$). Despite its growing importance, only large-$N$ field theory and average density profile are known for general $k$. In this Letter, we study the fluctuations in the system by looking at the statistics of the gap between successive particles. This quantity is analogous to the well-known level spacing statistics which is ubiquitous in several branches of physics. We show that the variance goes as $N^{-b_k}$ and we find the $k$ dependence of $b_k$ via direct Monte Carlo simulations. We provide supporting arguments based on microscopic Hessian calculation and a quadratic field theory approach. We compute the gap distribution and study its system size scaling. Except in the range $-1<k<0$, we find scaling for all $k>-2$ with both Gaussian and non-Gaussian scaling forms.

    Comment: 13 pages, 11 figures
    Keywords Condensed Matter - Statistical Mechanics ; Condensed Matter - Quantum Gases ; Mathematical Physics
    Subject code 612
    Publishing date 2021-09-30
    Publishing country us
    Document type Book ; Online
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  9. Article ; Online: Syntheses of metallo-pseudorotaxanes, rotaxane and post-synthetically functionalized rotaxane: a comprehensive spectroscopic study and dynamic properties.

    Santra, Saikat / Bej, Somnath / Nandi, Mandira / Mondal, Partha / Ghosh, Pradyut

    Dalton transactions (Cambridge, England : 2003)

    2017  Volume 46, Issue 39, Page(s) 13300–13313

    Abstract: Herein, a bis-amido tris-amine macrocycle and five bipyridine-based bidentate chelating ligands were investigated towards various divalent transition metal ion ( ... ...

    Abstract Herein, a bis-amido tris-amine macrocycle and five bipyridine-based bidentate chelating ligands were investigated towards various divalent transition metal ion (Ni
    Language English
    Publishing date 2017-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c7dt01364g
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  10. Article ; Online: [2]Pseudorotaxane composed of heteroditopic macrobicycle and pyridine N-oxide based axle: recognition site dependent axle orientation.

    Saha, Subrata / Santra, Saikat / Ghosh, Pradyut

    Organic letters

    2015  Volume 17, Issue 8, Page(s) 1854–1857

    Abstract: A strategy for threading an axle having a hydrogen bond acceptor unit in the cavity of a C3v symmetric amido-amine macrobicycle is investigated. The macrobicycle acts as a wheel in its neutral as well as triprotonated states to form threaded ... ...

    Abstract A strategy for threading an axle having a hydrogen bond acceptor unit in the cavity of a C3v symmetric amido-amine macrobicycle is investigated. The macrobicycle acts as a wheel in its neutral as well as triprotonated states to form threaded architectures with a pyridine N-oxide derivative. The negative oxygen dipole of the axle is capable of [2]pseudorotaxane formation in two different orientations with the wheel in its neutral and triprotonated states.
    Language English
    Publishing date 2015-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.5b00470
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