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Book ; Online: Cuentas y cuentos... Cuida de las cuentas públicas

Suárez Pineda, Jesús Alberto / Cárdenas Chaves, María Luz / Méndez Parada, Vernon Weis / Rojas Ávila, Luisa Katherine / Castillo Caicedo, Iván Jesús / Wilches Cuervo, Claudia Patricia / Contento Sanz, Laura / Varela Urrego, Jorge de Jesús

custodia de la probidad

2020

Keywords	Public finance accounting
Language	Spanish
Size	1 electronic resource (181 pages)
Publisher	Editorial Fundación Universitaria San Mateo
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030376186
ISBN	9789585263338 ; 9585263335
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Bi- and trispecific immune cell engagers for immunotherapy of hematological malignancies.

Tapia-Galisteo, Antonio / Álvarez-Vallina, Luis / Sanz, Laura

Journal of hematology & oncology

2023 Volume 16, Issue 1, Page(s) 83

Abstract: Immune cell engagers are engineered antibodies with at least one arm binding a tumor-associated antigen and at least another one directed against an activating receptor in immune effector cells: CD3 for recruitment of T cells and CD16a for NK cells. The ... ...

Abstract	Immune cell engagers are engineered antibodies with at least one arm binding a tumor-associated antigen and at least another one directed against an activating receptor in immune effector cells: CD3 for recruitment of T cells and CD16a for NK cells. The first T cell engager (the anti-CD19 blinatumomab) was approved by the FDA in 2014, but no other one hit the market until 2022. Now the field is gaining momentum, with three approvals in 2022 and 2023 (as of May): the anti-CD20 × anti-CD3 mosunetuzumab and epcoritamab and the anti-B cell maturation antigen (BCMA) × anti-CD3 teclistamab, and another three molecules in regulatory review. T cell engagers will likely revolutionize the treatment of hematological malignancies in the short term, as they are considerably more potent than conventional monoclonal antibodies recognizing the same tumor antigens. The field is thriving, with a plethora of different formats and targets, and around 100 bispecific T cell engagers more are already in clinical trials. Bispecific NK cell engagers are also in early-stage clinical studies and may offer similar efficacy with milder side effects. Trispecific antibodies (engaging either T cell or NK cell receptors) raise the game even further with a third binding moiety, which allows either the targeting of an additional tumor-associated antigen to increase specificity and avoid immune escape or the targeting of additional costimulatory receptors on the immune cell to improve its effector functions. Altogether, these engineered molecules may change the paradigm of treatment for relapsed or refractory hematological malignancies.
MeSH term(s)	Humans ; T-Lymphocytes ; Antibodies, Bispecific/pharmacology ; Immunotherapy ; Hematologic Neoplasms/drug therapy ; Killer Cells, Natural ; Antigens, CD19 ; Antineoplastic Agents/therapeutic use ; Antigens, Neoplasm
Chemical Substances	Antibodies, Bispecific ; Antigens, CD19 ; Antineoplastic Agents ; Antigens, Neoplasm
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2429631-4
ISSN	1756-8722 ; 1756-8722
ISSN (online)	1756-8722
ISSN	1756-8722
DOI	10.1186/s13045-023-01482-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Persistent Genital Ulcer.

Clemente Tomás, Claudia Pilar / Moreno Sanz, Laura

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

2023 Volume 45, Issue 12, Page(s) 102082

MeSH term(s)	Humans ; Female ; Ulcer/etiology ; Genital Diseases, Female ; Genitalia
Language	English
Publishing date	2023-03-02
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	2171082-X
ISSN	1701-2163
ISSN	1701-2163
DOI	10.1016/j.jogc.2022.11.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Engineered mRNA and the Rise of Next-Generation Antibodies.

Sanz, Laura / Álvarez-Vallina, Luis

Antibodies (Basel, Switzerland)

2021 Volume 10, Issue 4

Abstract: Monoclonal antibodies are widely used as therapeutic agents in medicine. However, clinical-grade proteins require sophisticated technologies and are extremely expensive to produce, resulting in long lead times and high costs. The use of gene transfer ... ...

Abstract	Monoclonal antibodies are widely used as therapeutic agents in medicine. However, clinical-grade proteins require sophisticated technologies and are extremely expensive to produce, resulting in long lead times and high costs. The use of gene transfer methods for in vivo secretion of therapeutic antibodies could circumvent problems related to large-scale production and purification and offer additional benefits by achieving sustained concentrations of therapeutic antibodies, which is particularly relevant to short-lived antibody fragments and next-generation, Fc-free, multispecific antibodies. In recent years, the use of engineered mRNA-based gene delivery has significantly increased in different therapeutic areas because of the advantages it possesses over traditional gene delivery platforms. The application of synthetic mRNA will allow for the avoidance of manufacturing problems associated with recombinant proteins and could be instrumental in consolidating regulatory approvals for next-generation therapeutic antibodies.
Language	English
Publishing date	2021-09-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2073-4468
ISSN (online)	2073-4468
DOI	10.3390/antib10040037
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Chapter Mobile Systems as a Challenge for Neurological Diseases Management - The Case of Parkinson's Disease

Pastorino, Matteo / Teresa Arredondo Waldmeyer, Maria / Pansera, Mario / Cancela, Jorge / Pastor-Sanz, Laura

2011

Keywords	Physiological & neuro-psychology, biopsychology ; Society & social sciences
Size	1 Online-Ressource
Publisher	InTechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021047230
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Lived experiences of mental health nurses who care for clients who are parents: An approximation of Tronto's definition of care.

Vives-Espelta, Judit / Ortega-Sanz, Laura / Ferré-Grau, Carme / Burjalés-Martí, Maria-Dolors

Journal of psychiatric and mental health nursing

2024

Abstract: What is known on the subject: Adult psychiatric services typically focus on the mental health needs of the client but they do not support his or her parenting role. Many authors highlight the importance of a non-judgmental approach when providing ... ...

Abstract	What is known on the subject: Adult psychiatric services typically focus on the mental health needs of the client but they do not support his or her parenting role. Many authors highlight the importance of a non-judgmental approach when providing support and care to clients with mental illness who are parents. Assessments frequently focus on the negative aspects while the strengths of these families were often overlooked. There is a lack of scientific literature exploring nurses' experiences when caring for parents with mental illness and their families. What this paper adds to existing knowledge: Trust is the basis that helps clients to be open to receiving care and answering parenting-related questions. Therefore, without adequate professional-client trust, some care and interventions addressed to parents with mental illness could be poorly received by the client. Tronto's phases of care facilitated the collection of data and exploration of mental health nurses' experiences of care. What are the implications for practice: Mental health nurses should be aware of the potential needs of these families, as described in the scientific literature, so they can include them in their assessments. They also should consider the need to individualize each care since each situation of a family with parental mental illness is unique. Mental health nurses must take the person's environment into account (family, social and political aspects and different forms of stigma) since all these factors may influence how parents with mental illness receive and provide care. Abstract: Introduction Many authors highlight the importance of a non-judgmental approach when providing care to parents with mental illness. However, assessments frequently focus on the negative aspects while the strengths of such families were often overlooked. Aim To explore the lived experiences of mental health nurses who care for clients who are parents. Method We conducted a qualitative phenomenological study. The main data collection technique was in-depth interviews. Data were analysed according to Colaizzi model, subsequently, the main categories that arised were compared and related to the five phases of Tronto's care. Results The main categories identified from the analysis of the interviews were: (1) individualized care, (2) continuity of care, (3) psychoeducation and counselling, (4) trust and (5) context of the client. Discussion Trust is the basis that helps parents with mental illness to be open to receiving care and answering parenting-related questions. Without trust, some interventions could be poorly received by the client. Implications for Practice Mental health nurses should be aware of the potential needs of these families, so they can include them in their assessments. They also should consider the need to individualize each care since each situation of a family with parental mental illness is unique.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1328479-4
ISSN	1365-2850 ; 1351-0126
ISSN (online)	1365-2850
ISSN	1351-0126
DOI	10.1111/jpm.13041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mycorrhization of Moringa oleifera improves growth and nutrient accumulation in leaves

Rubio-Sanz, Laura / Jaizme-Vega, María C

Journal of plant nutrition. 2022 July 21, v. 45, no. 12

2022

Abstract: Moringa (Moringa oleifera Lam.) is a fast-growing tree originating from the Himalayan foothills that grows in tropical and subtropical countries. Known as the “tree of life,” moringa has several beneficial properties, for example, their leaves have ... ...

Abstract	Moringa (Moringa oleifera Lam.) is a fast-growing tree originating from the Himalayan foothills that grows in tropical and subtropical countries. Known as the “tree of life,” moringa has several beneficial properties, for example, their leaves have nutritious proteins with essential amino acids, vitamins and nutrients like calcium, potassium and iron in high concentrations. These properties allow the powder of moringa leaves to be used as a functional food product and as a food nutritional supplement. Funneliformis mosseae (Glomus mosseae) is an Arbuscular Mycorrhizal Fungi (AMF) with the ability to associate with several plant species developing a mutualistic symbiosis association between roots of the plant and fungi. In the present study, the benefits of mycorrhization of M. oleifera plants with F. mosseae on plant growth and leaf nutrient content under complete nutrient supply and in the presence of different nutrient deficiencies (N, P) were evaluated. Benefits on plant growth and leaf nutrient content were shown at early mycorrhization stages. In addition, we demonstrated the benefits of mycorrhizated moringa plants in relation to nutritional fertilization, since it allows a reduction in fertilizer doses by facilitating the assimilation of the nutrients available in the soil.
Keywords	Glomus mosseae ; Moringa oleifera ; calcium ; fertilizers ; functional foods ; iron ; mutualism ; nutrient content ; plant growth ; plant nutrition ; potassium ; soil ; vesicular arbuscular mycorrhizae
Language	English
Dates of publication	2022-0721
Size	p. 1765-1773.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	446190-3
ISSN	1532-4087 ; 0190-4167
ISSN (online)	1532-4087
ISSN	0190-4167
DOI	10.1080/01904167.2022.2027969
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: When three is not a crowd: trispecific antibodies for enhanced cancer immunotherapy.

Tapia-Galisteo, Antonio / Compte, Marta / Álvarez-Vallina, Luis / Sanz, Laura

Theranostics

2023 Volume 13, Issue 3, Page(s) 1028–1041

Abstract: Despite the clinical success of the first bispecific antibody approved by the FDA against B cell malignancies (blinatumomab), many obstacles remain such as dosing, treatment resistance, and modest efficacy in solid tumors. To overcome these limitations, ... ...

Abstract	Despite the clinical success of the first bispecific antibody approved by the FDA against B cell malignancies (blinatumomab), many obstacles remain such as dosing, treatment resistance, and modest efficacy in solid tumors. To overcome these limitations, considerable efforts have been dedicated to the development of multispecific antibodies, opening up new avenues to address both the complex biology of cancer and the onset of anti-tumoral immune responses. Simultaneous targeting of two tumor-associated antigens is presumed to enhance cancer cell selectivity and reduce immune escape. Co-engagement of CD3, along with agonists of co-stimulatory molecules or antagonists of co-inhibitory immune checkpoint receptors in a single molecule, may revert T cell exhaustion. Similarly, targeting of two activating receptors in NK cells may improve their cytotoxic potency. And these are only examples of the potential of antibody-based molecular entities engaging three (or more) relevant targets. From the perspective of health care costs, multispecific antibodies are appealing, since a similar (or superior) therapeutic effect could be obtained with a single therapeutic agent as with a combination of different monoclonal antibodies. Despite challenges in production, multispecific antibodies are endowed with unprecedented properties, which may render them more potent biologics for cancer therapy.
MeSH term(s)	Humans ; Antibodies, Bispecific/pharmacology ; Immunotherapy ; Neoplasms/drug therapy ; Killer Cells, Natural ; Antineoplastic Agents/pharmacology ; Antibodies, Monoclonal/therapeutic use
Chemical Substances	Antibodies, Bispecific ; Antineoplastic Agents ; Antibodies, Monoclonal
Language	English
Publishing date	2023-01-22
Publishing country	Australia
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.81494
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Applications of trimerbodies in cancer immunotherapy.

Compte, Marta / Sanz, Laura / Álvarez-Vallina, Luis

International review of cell and molecular biology

2022 Volume 369, Page(s) 71–87

Abstract: Trimerbodies, with their unique structural and functional properties, are the basis of a new generation of therapeutic antibodies, which due to their small size and plasticity are ideal for the generation of novel biological protein drugs with multiple ... ...

Abstract	Trimerbodies, with their unique structural and functional properties, are the basis of a new generation of therapeutic antibodies, which due to their small size and plasticity are ideal for the generation of novel biological protein drugs with multiple competitive advantages over conventional full-length monoclonal antibodies. Since their emergence, trimerbodies have been used in preclinical cancer diagnosis and therapy. Trimerbodies are highly adaptable molecules, as they allow target-specific modulation of T cell-mediated anti-tumor immunity to enhance preexisting responses or to generate de novo immune responses. In fact, a tumor-specific humanized 4-1BB-agonistic trimerbody has shown a rather impressive safety and efficacy profile in preclinical studies making it a realistic option for clinical development. Moreover, thanks to the avidity effect they are endowed with considerable therapeutic potential as carriers to deliver cytotoxic payloads to tumors. In addition, molecular imaging studies could benefit from some intermediate-sized trivalent trimerbodies as promising candidates for targeted therapy and tumor imaging.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Humans ; Immunotherapy ; Neoplasms
Chemical Substances	Antibodies, Monoclonal ; Antineoplastic Agents, Immunological
Language	English
Publishing date	2022-05-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2427220-6
ISSN	1937-6448 ; 0074-7696
ISSN	1937-6448 ; 0074-7696
DOI	10.1016/bs.ircmb.2022.03.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nanobody-Based EGFR-Targeting Immunotoxins for Colorectal Cancer Treatment.

Narbona, Javier / Hernández-Baraza, Luisa / Gordo, Rubén G / Sanz, Laura / Lacadena, Javier

Biomolecules

2023 Volume 13, Issue 7

Abstract: Immunotoxins (ITXs) are chimeric molecules that combine the specificity of a targeting domain, usually derived from an antibody, and the cytotoxic potency of a toxin, leading to the selective death of tumor cells. However, several issues must be ... ...

Abstract	Immunotoxins (ITXs) are chimeric molecules that combine the specificity of a targeting domain, usually derived from an antibody, and the cytotoxic potency of a toxin, leading to the selective death of tumor cells. However, several issues must be addressed and optimized in order to use ITXs as therapeutic tools, such as the selection of a suitable tumor-associated antigen (TAA), high tumor penetration and retention, low kidney elimination, or low immunogenicity of foreign proteins. To this end, we produced and characterized several ITX designs, using a nanobody against EGFR (V
MeSH term(s)	Humans ; Immunotoxins/chemistry ; Single-Domain Antibodies/pharmacology ; Single-Domain Antibodies/therapeutic use ; Antigens, Neoplasm ; Colorectal Neoplasms/drug therapy ; ErbB Receptors
Chemical Substances	Immunotoxins ; Single-Domain Antibodies ; Antigens, Neoplasm ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13071042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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