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  1. Article ; Online: Impact of the COVID 19 pandemic on new diagnoses of HIV infection.

    Galicia, Pilar / Sanz Moreno, José / Ramos-Rincón, José-Manuel

    Medicina clinica (English ed.)

    2023  Volume 160, Issue 3, Page(s) 133–134

    Language English
    Publishing date 2023-02-04
    Publishing country Spain
    Document type Case Reports
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2022.09.014
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  2. Article ; Online: Impact of the COVID 19 pandemic on new diagnoses of HIV infection.

    Galicia, Pilar / Sanz Moreno, José / Ramos-Rincón, José-Manuel

    Medicina clinica

    2022  Volume 160, Issue 3, Page(s) 133–134

    MeSH term(s) Humans ; COVID-19 ; HIV Infections/diagnosis ; HIV Infections/epidemiology
    Language Spanish
    Publishing date 2022-10-24
    Publishing country Spain
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.09.019
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  3. Article ; Online: Reply to "How to limit bias in quasiexperimental studies".

    Barbero-Allende, José María / Montero-Ruiz, Eduardo / Vallés-Purroy, Alfonso / Sanz-Moreno, José

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2019  Volume 38, Issue 1, Page(s) 46–47

    Title translation Respuesta a «Cómo limitar los sesgos en estudios cuasiexperimentales».
    MeSH term(s) Arthritis, Infectious ; Bias ; Cefazolin ; Humans ; Teicoplanin
    Chemical Substances Teicoplanin (61036-62-2) ; Cefazolin (IHS69L0Y4T)
    Language Spanish
    Publishing date 2019-06-22
    Document type Letter ; Comment
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2019.05.007
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  4. Article: Very-Low-Level Viremia, Inflammatory Biomarkers, and Associated Baseline Variables: Three-Year Results of the Randomized TANGO Study.

    Wang, Ruolan / Underwood, Mark / Llibre, Josep M / Bernal Morell, Enrique / Brinson, Cynthia / Sanz Moreno, José / Scholten, Stefan / Moore, Richard / Saggu, Parminder / Oyee, James / Moodley, Riya / Wynne, Brian / Kisare, Michelle / Jones, Bryn / Ait-Khaled, Mounir

    Open forum infectious diseases

    2023  Volume 11, Issue 1, Page(s) ofad626

    Abstract: Background: We compared proportions of participants with target detected, target not detected (TND), and elevated viral load (VL) and assessed baseline variables associated with week 144 inflammatory biomarker levels between dolutegravir-lamivudine (DTG/ ...

    Abstract Background: We compared proportions of participants with target detected, target not detected (TND), and elevated viral load (VL) and assessed baseline variables associated with week 144 inflammatory biomarker levels between dolutegravir-lamivudine (DTG/3TC) and tenofovir alafenamide-based regimens (TBRs) in the TANGO study (post hoc).
    Methods: TANGO is an open-label, multicenter, phase 3 study that randomized adults with VL <50 copies/mL to switch to once-daily fixed-dose DTG/3TC or continue TBR. At baseline and each study visit, the VL was measured. Elevated VL event frequencies were assessed, including "blips." Interleukin 6, D-dimer, high-sensitivity C-reactive protein, soluble CD14, and soluble CD163 were measured at baseline and at week 144. Log
    Results: High, comparable proportions of participants had VL <40 copies/mL and TND at week 144 (DTG/3TC, 279 of 369 [76%]; TBR, 267 of 372 [72%], intention-to-treat exposed Snapshot analysis; adjusted difference, 3.9% [95% confidence interval, -2.5% to 10.2%]), with similar TND proportions at all postbaseline visits (123 of 369 [33%] vs 101 of 372 [27%], respectively). Similar proportions of DTG/3TC participants had ≥1 postbaseline VL ≥50 copies/mL (28 of 369 [8%] vs 42 of 372 [11%] for TBR), primarily blips (18 of 369 [5%] and 26 of 372 [7%], respectively). Week 144 inflammatory biomarker levels were low and comparable between groups and associated with multiple demographic and baseline characteristics, including baseline biomarker levels, indicating a multifactorial inflammatory response.
    Conclusions: Week 144 biomarker levels were low and generally comparable between treatment groups, reflecting similar, robust, and durable viral suppression observed using the stringent TND end point.
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad626
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  5. Article ; Online: Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D.

    Torres, Montserrat / Casado, Guiomar / Vigón, Lorena / Rodríguez-Mora, Sara / Mateos, Elena / Ramos-Martín, Fernando / López-Wolf, Daniel / Sanz-Moreno, José / Ryan-Murua, Pablo / Taboada-Martínez, María Luisa / López-Huertas, María Rosa / Cervero, Miguel / Coiras, Mayte

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 150, Page(s) 112965

    Abstract: Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment ... ...

    Abstract Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment and improve cytotoxic response against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved in patients with COVID-19 pneumonia and levels of 25-hydroxyvitamin D (25(OH)D) of 14.8 ng/ml (SD: 6.18) to test antiviral efficacy, tolerance and safety of 10,000 IU/day of cholecalciferol (vitamin D
    MeSH term(s) Cholecalciferol/adverse effects ; Dietary Supplements ; Humans ; Immunity ; Prospective Studies ; Respiratory Distress Syndrome/drug therapy ; SARS-CoV-2 ; Single-Blind Method ; Vitamin D ; Vitamins/therapeutic use ; COVID-19 Drug Treatment
    Chemical Substances Vitamins ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2022-04-14
    Publishing country France
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.112965
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
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  6. Article ; Online: Medical Prognosis of Infectious Diseases in Nursing Homes by Applying Machine Learning on Clinical Data Collected in Cloud Microservices.

    Garcés-Jiménez, Alberto / Calderón-Gómez, Huriviades / Gómez-Pulido, José M / Gómez-Pulido, Juan A / Vargas-Lombardo, Miguel / Castillo-Sequera, José L / Aguirre, Miguel Pablo / Sanz-Moreno, José / Polo-Luque, María-Luz / Rodríguez-Puyol, Diego

    International journal of environmental research and public health

    2021  Volume 18, Issue 24

    Abstract: Background: treating infectious diseases in elderly individuals is difficult; patient referral to emergency services often occurs, since the elderly tend to arrive at consultations with advanced, serious symptoms.: Aim: it was hypothesized that ... ...

    Abstract Background: treating infectious diseases in elderly individuals is difficult; patient referral to emergency services often occurs, since the elderly tend to arrive at consultations with advanced, serious symptoms.
    Aim: it was hypothesized that anticipating an infectious disease diagnosis by a few days could significantly improve a patient's well-being and reduce the burden on emergency health system services.
    Methods: vital signs from residents were taken daily and transferred to a database in the cloud. Classifiers were used to recognize patterns in the spatial domain process of the collected data. Doctors reported their diagnoses when any disease presented. A flexible microservice architecture provided access and functionality to the system.
    Results: combining two different domains, health and technology, is not easy, but the results are encouraging. The classifiers reported good results; the system has been well accepted by medical personnel and is proving to be cost-effective and a good solution to service disadvantaged areas. In this context, this research found the importance of certain clinical variables in the identification of infectious diseases.
    Conclusions: this work explores how to apply mobile communications, cloud services, and machine learning technology, in order to provide efficient tools for medical staff in nursing homes. The scalable architecture can be extended to big data applications that may extract valuable knowledge patterns for medical research.
    MeSH term(s) Aged ; Biomedical Research ; Cloud Computing ; Communicable Diseases/diagnosis ; Communicable Diseases/epidemiology ; Humans ; Machine Learning ; Nursing Homes
    Language English
    Publishing date 2021-12-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182413278
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  7. Article ; Online: Impact of Remdesivir on the Treatment of COVID-19 During the First Wave in Spain.

    Soriano, Alejandro / Montejano, Rocío / Sanz-Moreno, José / Figueira, Juan Carlos / Grau, Santiago / Güerri-Fernández, Robert / Castro-Gómez, Antonio / Pérez-Román, Inés / Hidalgo-Vega, Álvaro / González-Domínguez, Almudena

    Advances in therapy

    2021  Volume 38, Issue 7, Page(s) 4057–4069

    Abstract: Introduction: Spain was one of the most affected countries during the first wave of COVID-19, having the highest mortality rate in Europe. The aim of this retrospective study is to estimate the impact that remdesivir-the first drug for COVID-19 approved ...

    Abstract Introduction: Spain was one of the most affected countries during the first wave of COVID-19, having the highest mortality rate in Europe. The aim of this retrospective study is to estimate the impact that remdesivir-the first drug for COVID-19 approved in the EU-would have had in the first wave.
    Methods: This study simulated the impact that remdesivir could have had on the Spanish National Health System (SNHS) capacity (bed occupancy) and the number of deaths that could have been prevented, based on two scenarios: a real-life scenario (without remdesivir) and an alternative scenario (with remdesivir). It considered the clinical results of the ACTT-1 trial in hospitalized patients with COVID-19 and pneumonia who required supplemental oxygen. The occupancy rates in general wards and ICUs were estimated in both scenarios.
    Results: Remdesivir use could have prevented the admission of 2587 patients (43.75%) in the ICUs. It could have also increased the SNHS capacity in 5656 general wards beds and 1700 ICU beds, showing an increase in the number of beds available of 17.53% (95% CI 3.98%-24.42%) and 23.98% (95% CI 21.33%-28.22%), respectively, at the peak of the occupancy rates. Furthermore, remdesivir use could have prevented 7639 deaths due to COVID-19, which implies a 27.51% reduction (95% CI 14.25%-34.07%).
    Conclusions: Remdesivir could have relieved the pressure on the SNHS and could have reduced the death toll, providing a better strategy for the management of COVID-19 during the first wave.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Europe ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Spain/epidemiology
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-021-01804-9
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  8. Article ; Online: Dual prophylaxis with teicoplanin and cefazolin in the prevention of prosthetic joint infection.

    Barbero-Allende, José María / García-Sánchez, Marta / Montero-Ruiz, Eduardo / Vallés-Purroy, Alfonso / Plasencia-Arriba, Miguel Ángel / Sanz-Moreno, José

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2019  Volume 37, Issue 9, Page(s) 588–591

    Abstract: Introduction: There is a growing increase in prosthetic joint infection (PJI) incidence due to cephalosporin-resistant bacteria, used in surgical prophylaxis. The replacement of these with glycopeptides has not been shown to improve the results, but ... ...

    Title translation Profilaxis dual con teicoplanina añadida a cefazolina en la prevención de la infección de prótesis articular.
    Abstract Introduction: There is a growing increase in prosthetic joint infection (PJI) incidence due to cephalosporin-resistant bacteria, used in surgical prophylaxis. The replacement of these with glycopeptides has not been shown to improve the results, but they have been shown to improve with their combination.
    Methods: Comparative study of combination of teicoplanin and cefazolin before arthroplasty surgery against cefazolin alone from a previous control group.
    Results: During the control period, there were 16 PJIs from 585 surgeries, while in the intervention group there were 6 from 579 (incidence 2.7% vs. 1.03%, RR 0.4, P=.04). In control group, 11 of the infections were caused by Gram-positive bacteria versus 4 in the intervention group (1.8% vs. 0.7%, P=.08).
    Conclusions: The addition of teicoplanin to cefazolin in the prophylaxis of arthroplasty surgery was associated with a reduction in the incidence of PJI, thanks to a decrease in infections caused by Gram-positive bacteria.
    MeSH term(s) Aged ; Antibiotic Prophylaxis ; Arthritis, Infectious/epidemiology ; Arthritis, Infectious/etiology ; Arthritis, Infectious/microbiology ; Arthritis, Infectious/prevention & control ; Arthroplasty ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; Bacterial Infections/prevention & control ; Cefazolin/administration & dosage ; Cefazolin/adverse effects ; Cefazolin/therapeutic use ; Cephalosporin Resistance ; Drug Resistance, Multiple, Bacterial ; Drug Substitution ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/microbiology ; Prosthesis-Related Infections/prevention & control ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/microbiology ; Surgical Wound Infection/prevention & control ; Teicoplanin/administration & dosage ; Teicoplanin/adverse effects ; Teicoplanin/therapeutic use
    Chemical Substances Teicoplanin (61036-62-2) ; Cefazolin (IHS69L0Y4T)
    Language Spanish
    Publishing date 2019-03-12
    Document type Comparative Study ; Journal Article
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2018.12.013
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  9. Article ; Online: Efficacy and safety of nevirapine + Kivexa (abacavir/lamivudine) as a simplification strategy for HIV patients with undetectable viral load.

    Cabello Úbeda, Alfonso / Sanz Moreno, José / Williams, Frances / Górgolas, Miguel

    Journal of acquired immune deficiency syndromes (1999)

    2011  Volume 58, Issue 3, Page(s) e95–6

    MeSH term(s) Adult ; Aged ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Antiretroviral Therapy, Highly Active/adverse effects ; Antiretroviral Therapy, Highly Active/methods ; CD4 Lymphocyte Count ; Dideoxynucleosides/administration & dosage ; Dideoxynucleosides/adverse effects ; Drug Combinations ; Female ; HIV Infections/drug therapy ; HIV Infections/virology ; Humans ; Lamivudine/administration & dosage ; Lamivudine/adverse effects ; Male ; Middle Aged ; Nevirapine/administration & dosage ; Nevirapine/adverse effects ; Treatment Outcome ; Viral Load
    Chemical Substances Anti-HIV Agents ; Dideoxynucleosides ; Drug Combinations ; Kivexa ; Lamivudine (2T8Q726O95) ; Nevirapine (99DK7FVK1H)
    Language English
    Publishing date 2011-10-17
    Publishing country United States
    Document type Letter
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0b013e31822ccfe3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2442: Show issues Location:
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  10. Article ; Online: Efficacy and tolerability of telaprevir (TVR)-based triple therapy in HIV/HCV-coinfected patients.

    De Los Santos, Ignacio / Montes, Marisa / Sanz-Moreno, Jose / De Miguel, Julio / Sanz-Sanz, Jesus / Gaspar, Gabriel / Perez-Caballero, Laura

    Journal of the International AIDS Society

    2014  Volume 17, Issue 4 Suppl 3, Page(s) 19633

    Abstract: Introduction: Clinical trials (CT) on triple therapy against HCV infection in HIV-infected patients including TVR plus pegylated interferon and ribavirin (PR) have reported considerably higher response rates than with PR alone. This study was aimed to ... ...

    Abstract Introduction: Clinical trials (CT) on triple therapy against HCV infection in HIV-infected patients including TVR plus pegylated interferon and ribavirin (PR) have reported considerably higher response rates than with PR alone. This study was aimed to evaluate the efficacy and safety of triple therapy including TVR in HIV/HCV-coinfected patients in real-life conditions.
    Materials and methods: HIV/HCV genotype 1 patients seen at four Hospitals in Madrid who received therapy including TVR plus PR for at least two weeks were included. The response was evaluated during treatment, and sustained viral response (SVR) was evaluated 12 and 24 weeks after the end of the treatment.
    Results: Fifty-eight patients have been included; 79% male, median age 48 y.o.; 38% were IL28B rs12979860 genotype CT or TT, 58.6% of patients presented cirrhosis and 24.1% presented fibrosis F3. Infection with genotype 1a was observed in 53.4% of patients. Median baseline HCV-RNA was 3,282,263 IU/mL (77.5% had >800,000 IU/mL). The most commonly used antiretroviral (ARV) drugs were tenofovir/emtricitabine [36 (62%) patients], etravirine [21 (36%) patients], abacavir/lamivudine [18 (31%) patients], boosted protease inhibitors [16 (27.5%) patients] and raltegravir [12 (20.6%) patients]. Of the 42 (72.4%) patients who had received previous HCV treatment, 13.7% were null responders, 25.8% were partial responders and 31% had relapsed. In an ITT approach, proportions of patients with undetectable HCV RNA were 67.8% (38/56) at TW4, 83.3% (40/48) at TW12, 80% (36/45) at TW24, 79.4% at TW36 (31/39) and 72% (26/36) at TW48. Fifteen (25.8%) patients discontinued HCV therapy [8 (13.8%) because they fulfilled stopping rules, 5 (8.6%) individuals due to adverse events and 2 (3.4%) were lost to follow-up]. Rash associated with TVR (grade 1) was observed in two cases (3.4%) and all the patients showed anaemia at some point of treatment. In an analysis by ITT in the 31 patients who had a 60 week follow-up after starting therapy, SVR-12 was observed in 21 (67.7%) patients. And in the analysis by ITT in 28 patients who had a 72 week follow-up after starting therapy, SVR-24 was observed in 17 (60.7%) patients.
    Conclusions: Response to triple therapy with TVR plus PR in HIV/HCV-patients under real-life conditions, and therefore, including a high proportion of difficult to treat patients, is similar to that found in CT. The safety profile of TVR-based therapy is also comparable to that shown in CT, with only a rate of discontinuation of 8.6% of individuals related to toxicity.
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.7448/IAS.17.4.19633
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