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  1. AU="Sanz-Magro, Adrián"
  2. AU="Fan, Shanhui"
  3. AU="Ellonen, Pekka"
  4. AU="Lambert, T"
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  1. Article ; Online: Restricting feeding to dark phase fails to entrain circadian activity and energy expenditure oscillations in Pitx3-mutant Aphakia mice.

    Fernández-Pérez, Antonio / Sanz-Magro, Adrián / Moratalla, Rosario / Vallejo, Mario

    Cell reports

    2022  Volume 38, Issue 2, Page(s) 110241

    Abstract: Metabolic homeostasis is under circadian regulation to adapt energy requirements to light-dark cycles. Feeding cycles are regulated by photic stimuli reaching the suprachiasmatic nucleus via retinohypothalamic axons and by nutritional information ... ...

    Abstract Metabolic homeostasis is under circadian regulation to adapt energy requirements to light-dark cycles. Feeding cycles are regulated by photic stimuli reaching the suprachiasmatic nucleus via retinohypothalamic axons and by nutritional information involving dopaminergic neurotransmission. Previously, we reported that Pitx3-mutant Aphakia mice with altered development of the retinohypothalamic tract and the dopaminergic neurons projecting to the striatum, are resistant to locomotor and metabolic entrainment by time-restricted feeding. In their Matters Arising article, Scarpa et al. (2022) challenge this conclusion using mice from the same strain but following a different experimental paradigm involving calorie restriction. Here, we address their concerns by extending the analyses of our previous data, by identifying important differences in the experimental design between both studies and by presenting additional results on the dopaminergic deficit in the brain of Aphakia mice. This Matters Arising Response article addresses the Matters Arising article by Scarpa et al. (2022), published concurrently in Cell Reports.
    MeSH term(s) Animals ; Aphakia ; Dopamine ; Energy Metabolism ; Mice ; Photoperiod ; Suprachiasmatic Nucleus
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.110241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dopamine D1 Receptors Regulate Spines in Striatal Direct-Pathway and Indirect-Pathway Neurons.

    Suarez, Luz M / Solis, Oscar / Sanz-Magro, Adrian / Alberquilla, Samuel / Moratalla, Rosario

    Movement disorders : official journal of the Movement Disorder Society

    2020  Volume 35, Issue 10, Page(s) 1810–1821

    Abstract: Background: Dopamine transmission is involved in the maintenance of the structural plasticity of direct-pathway and indirect-pathway striatal projection neurons (d-SPNs and i-SPNs, respectively). The lack of dopamine in Parkinson's disease produces ... ...

    Abstract Background: Dopamine transmission is involved in the maintenance of the structural plasticity of direct-pathway and indirect-pathway striatal projection neurons (d-SPNs and i-SPNs, respectively). The lack of dopamine in Parkinson's disease produces synaptic remodeling in both types of SPNs, reducing the length of the dendritic arbor and spine density and increasing the intrinsic excitability. Meanwhile, the elevation of dopamine levels by levodopa recovers these alterations selectively in i-SPNs. However, little is known about the specific role of the D1 receptor (D1R) in these alterations.
    Methods: To explore the specific role of D1R in the synaptic remodeling of SPNs, we used knockout D1R mice (D1R
    Results: The genetic inactivation of D1R reduces the length of the dendritic tree and the spine density in all SPNs, although more so in d-SPNs, which also increases their spiking. In parkinsonian D1R
    Conclusions: D1R is essential for the maintenance of spine plasticity in d-SPNs but also affects i-SPNs, indicating an important crosstalk between these 2 types of neurons. © 2020 International Parkinson and Movement Disorder Society.
    MeSH term(s) Animals ; Corpus Striatum/metabolism ; Dendritic Spines ; Levodopa/pharmacology ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Receptors, Dopamine D1/genetics ; Receptors, Dopamine D1/metabolism
    Chemical Substances Receptors, Dopamine D1 ; Levodopa (46627O600J)
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

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  3. Article ; Online: Dopamine D2R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse.

    Espadas, Isabel / Ortiz, Oscar / García-Sanz, Patricia / Sanz-Magro, Adrián / Alberquilla, Samuel / Solis, Oscar / Delgado-García, José María / Gruart, Agnès / Moratalla, Rosario

    Cerebral cortex (New York, N.Y. : 1991)

    2020  Volume 31, Issue 4, Page(s) 2187–2204

    Abstract: Dopamine receptors play an important role in motivational, emotional, and motor responses. In addition, growing evidence suggests a key role of hippocampal dopamine receptors in learning and memory. It is well known that associative learning and synaptic ...

    Abstract Dopamine receptors play an important role in motivational, emotional, and motor responses. In addition, growing evidence suggests a key role of hippocampal dopamine receptors in learning and memory. It is well known that associative learning and synaptic plasticity of CA3-CA1 requires the dopamine D1 receptor (D1R). However, the specific role of the dopamine D2 receptor (D2R) on memory-related neuroplasticity processes is still undefined. Here, by using two models of D2R loss, D2R knockout mice (Drd2-/-) and mice with intrahippocampal injections of Drd2-small interfering RNA (Drd2-siRNA), we aimed to investigate how D2R is involved in learning and memory as well as in long-term potentiation of the hippocampus. Our studies revealed that the genetic inactivation of D2R impaired the spatial memory, associative learning, and the classical conditioning of eyelid responses. Similarly, deletion of D2R reduced the activity-dependent synaptic plasticity in the hippocampal CA1-CA3 synapse. Our results demonstrate the first direct evidence that D2R is essential in behaving mice for trace eye blink conditioning and associated changes in hippocampal synaptic strength. Taken together, these results indicate a key role of D2R in regulating hippocampal plasticity changes and, in consequence, acquisition and consolidation of spatial and associative forms of memory.
    MeSH term(s) Animals ; Avoidance Learning/physiology ; CA1 Region, Hippocampal/metabolism ; CA3 Region, Hippocampal/metabolism ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neuronal Plasticity/physiology ; RNA, Small Interfering/administration & dosage ; Receptors, Dopamine D2/deficiency ; Receptors, Dopamine D2/genetics ; Spatial Memory/physiology ; Synapses/genetics ; Synapses/metabolism
    Chemical Substances RNA, Small Interfering ; Receptors, Dopamine D2
    Language English
    Publishing date 2020-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhaa354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice.

    Solís, Oscar / García-Sanz, Patricia / Martín, Ana B / Granado, Noelia / Sanz-Magro, Adrián / Podlesniy, Petar / Trullas, Ramón / Murer, M Gustavo / Maldonado, Rafael / Moratalla, Rosario

    Addiction biology

    2019  Volume 26, Issue 1, Page(s) e12840

    Abstract: Repeated cocaine exposure causes long-lasting neuroadaptations that involve alterations in cellular signaling and gene expression mediated by dopamine in different brain regions, such as the striatum. Previous studies have pointed out to the dopamine D1 ... ...

    Abstract Repeated cocaine exposure causes long-lasting neuroadaptations that involve alterations in cellular signaling and gene expression mediated by dopamine in different brain regions, such as the striatum. Previous studies have pointed out to the dopamine D1 receptor as one major player in psychostimulants-induced behavioral, cellular, and molecular changes. However, the role of other dopamine receptors has not been fully characterized. Here we used dopamine D2 receptor knockout (D2
    MeSH term(s) Amphetamines/pharmacology ; Animals ; Benzazepines ; Central Nervous System Stimulants/pharmacology ; Cocaine/pharmacology ; Corpus Striatum/metabolism ; Dopamine Uptake Inhibitors/pharmacology ; Mice ; Mice, Knockout ; Neurons/metabolism ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism
    Chemical Substances Amphetamines ; Benzazepines ; Central Nervous System Stimulants ; Dopamine Uptake Inhibitors ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; SK&F 81297 (71636-61-8) ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1324314-7
    ISSN 1369-1600 ; 1355-6215
    ISSN (online) 1369-1600
    ISSN 1355-6215
    DOI 10.1111/adb.12840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4586: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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