Article ; Online: Influence of Inosine on Cerebral Hemodynamics in Space Motion Sickness in Experimental Animals.
Central nervous system agents in medicinal chemistry
2021 Volume 21, Issue 2, Page(s) 93–103
Abstract: Background: Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity, or gender. It is an acute disorder; it can also present as a chronic disorder in some individuals. Motion sickness not only includes vomiting and nausea, ... ...
| Abstract | Background: Motion sickness occurs worldwide in healthy individuals regardless of age, ethnicity, or gender. It is an acute disorder; it can also present as a chronic disorder in some individuals. Motion sickness not only includes vomiting and nausea, but also includes other features such as pallor of varying degrees, cold sweating, headache, drowsiness, increased salivation, and cranial pain, which are severe. Some of the other assessment scales can interpret sickness on exposure to virtual or visual stimulation and while travelling in different types of transport. Aim: The aim of our research is to study the effect of the drug on the level of blood flow and vascular reactivity of cerebral vessels when simulating changes in the cerebral circulation in terrestrial conditions characteristic of hypogravity. Methods: Chronic experiments were performed on non-anesthetized rabbits with large hemispheres, thalamus and hypothalamus were implanted with the needle-platinum electrodes 150 mm in diameter in the cortex, and local blood flow and vascular reactivity were recorded accordingly. Cerebrovascular disturbances were modeled using an MSAOP (motion sickness of animals in the anti-orthostatic position) with an inclined angle of 45° for 2 hours. Local blood flow (BF) was measured in ml/min/100g of tissue by the method of registration of hydrogen clearance. The vasodilator coefficient of reactivity (CrCO Results: Inosine has pronounced protective properties in cerebrovascular disorders on the background of space motion sickness (SMS) modeling, which is manifested by normalization of BF and restoration of compensatory reactions of cerebral vessels. In the mechanism of cerebroprotective action of inosine, it is able to correct the metabolic processes, which play an important role and help increase the compensatory capabilities and functional stability of the cerebrovascular system under gravitational influences. Conclusion: When using inosine orally, the effects are more pronounced than when administered intravenously, which should be taken into account when using it for the prevention of cerebrovascular disorders in extreme conditions. |
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| MeSH term(s) | Animals ; Cerebrovascular Circulation ; Hemodynamics ; Inosine ; Motion Sickness/drug therapy ; Rabbits ; Space Motion Sickness | |||||
| Chemical Substances | Inosine (5A614L51CT) | |||||
| Language | English | |||||
| Publishing date | 2021-04-29 | |||||
| Publishing country | United Arab Emirates | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2227560-5 | |||||
| ISSN | 1875-6166 ; 1871-5249 | |||||
| ISSN (online) | 1875-6166 | |||||
| ISSN | 1871-5249 | |||||
| DOI | 10.2174/1871524921666210428111827 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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