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  1. Article ; Online: The in situ Structural Approach to Reveal the Filovirus Budding Mechanism.

    Watanabe, Reika / Saphire, Erica Ollmann

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 29 Suppl 1, Page(s) 900–901

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Development and Structural Analysis of Antibody Therapeutics for Filoviruses.

    Yu, Xiaoying / Saphire, Erica Ollmann

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 3

    Abstract: The filoviruses, including ebolaviruses and marburgviruses, are among the world's deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts. ...

    Abstract The filoviruses, including ebolaviruses and marburgviruses, are among the world's deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts. With recent technological developments, potent antibodies have been identified from immunized animals and human survivors of virus infections and have been characterized functionally and structurally. Structural insight into how the most successful antibodies target GP further guides vaccine development. Here we review the recent developments in the identification and characterization of neutralizing antibodies and cocktail immunotherapies.
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11030374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Manhattan Project against COVID.

    Scolnick, Edward M / Saphire, Erica Ollmann

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2022  Volume 36, Issue 2, Page(s) e22117

    MeSH term(s) COVID-19/immunology ; COVID-19 Vaccines/immunology ; Humans ; Immune System/immunology ; SARS-CoV-2/immunology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202101891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2266: Show issues Location:
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  4. Article ; Online: Inducing broad-based immunity against viruses with pandemic potential.

    Sette, Alessandro / Saphire, Erica Ollmann

    Immunity

    2022  Volume 55, Issue 5, Page(s) 738–748

    Abstract: The brutal toll of another viral pandemic can be blunted by investing now in research that uncovers mechanisms of broad-based immunity so we may have vaccines and therapeutics at the ready. We do not know exactly what pathogen may trigger the next wave ... ...

    Abstract The brutal toll of another viral pandemic can be blunted by investing now in research that uncovers mechanisms of broad-based immunity so we may have vaccines and therapeutics at the ready. We do not know exactly what pathogen may trigger the next wave or next pandemic. We do know, however, that the human immune system must respond and must be bolstered with effective vaccines and other therapeutics to preserve lives and livelihoods. These countermeasures must focus on features conserved among families of pathogens in order to be responsive against something yet to emerge. Here, we focus on immunological approaches to mitigate the impact of the next emerging virus pandemic by developing vaccines that elicit both broadly protective antibodies and T cells. Identifying human immune mechanisms of broad protection against virus families with pandemic potential will be our best defense for humanity in the future.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; T-Lymphocytes ; Vaccines
    Chemical Substances Antibodies, Viral ; Vaccines
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Novel attempts launched toward universal Sarbecovirus vaccine.

    Li, Haoyang / Saphire, Erica Ollmann

    Cell research

    2022  Volume 31, Issue 12, Page(s) 1226–1227

    MeSH term(s) Spike Glycoprotein, Coronavirus ; Vaccines
    Chemical Substances Spike Glycoprotein, Coronavirus ; Vaccines
    Language English
    Publishing date 2022-10-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-021-00556-z
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  6. Article ; Online: A glimpse into immune responses evolving against Ebola virus.

    Saphire, Erica Ollmann

    Nature medicine

    2019  Volume 25, Issue 10, Page(s) 1470–1471

    MeSH term(s) Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; Ebola Vaccines/chemistry ; Ebola Vaccines/immunology ; Ebola Vaccines/therapeutic use ; Ebolavirus/immunology ; Ebolavirus/pathogenicity ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunity, Innate/drug effects
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Ebola Vaccines
    Language English
    Publishing date 2019-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-019-0607-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4212: Show issues Location:
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  7. Article: Development and Structural Analysis of Antibody Therapeutics for Filoviruses

    Yu, Xiaoying / Saphire, Erica Ollmann

    Pathogens. 2022 Mar. 18, v. 11, no. 3

    2022  

    Abstract: The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts. ...

    Abstract The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts. With recent technological developments, potent antibodies have been identified from immunized animals and human survivors of virus infections and have been characterized functionally and structurally. Structural insight into how the most successful antibodies target GP further guides vaccine development. Here we review the recent developments in the identification and characterization of neutralizing antibodies and cocktail immunotherapies.
    Keywords glycoproteins ; humans ; monoclonal antibodies ; vaccine development ; viruses
    Language English
    Dates of publication 2022-0318
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11030374
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Lifted Up from Lockdown.

    Arturo, Emilia C / Saphire, Erica Ollmann

    Cell

    2020  Volume 183, Issue 1, Page(s) 1–3

    Abstract: The pandemic has impacted every scientist differently. Many negative impacts are frequently discussed. Here we highlight unexpected positives that we have found and hope will persist: improved access to experts; deeper and broader human engagement among ... ...

    Abstract The pandemic has impacted every scientist differently. Many negative impacts are frequently discussed. Here we highlight unexpected positives that we have found and hope will persist: improved access to experts; deeper and broader human engagement among colleagues, collaborators, and competitors; and significant democratization of research.
    MeSH term(s) COVID-19/psychology ; Humans ; Optimism/psychology ; Pandemics/ethics ; SARS-CoV-2/pathogenicity
    Keywords covid19
    Language English
    Publishing date 2020-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.09.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1167: Show issues Location:
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    Zs.MG 58: Show issues

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  9. Article ; Online: New Advances in the Effort against Ebola.

    Saphire, Erica Ollmann

    Cell host & microbe

    2015  Volume 17, Issue 5, Page(s) 545–547

    Abstract: The unprecedented scale of the recent Ebola virus outbreak caused many to wonder whether this virus is different, and raised concerns about how to contain the outbreak. Two recent studies published in Science (Hoenen et al., 2015; Marzi et al., 2015) ... ...

    Abstract The unprecedented scale of the recent Ebola virus outbreak caused many to wonder whether this virus is different, and raised concerns about how to contain the outbreak. Two recent studies published in Science (Hoenen et al., 2015; Marzi et al., 2015) shed light on the subject and offer a new solution.
    MeSH term(s) Animals ; Ebola Vaccines/immunology ; Ebolavirus/genetics ; Ebolavirus/immunology ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/virology ; Humans ; Mutation Rate
    Chemical Substances Ebola Vaccines
    Language English
    Publishing date 2015-03-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2015.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Stopping pandemics before they start: Lessons learned from SARS-CoV-2.

    Edwards, Aled M / Baric, Ralph S / Saphire, Erica Ollmann / Ulmer, Jeffrey B

    Science (New York, N.Y.)

    2022  Volume 375, Issue 6585, Page(s) 1133–1139

    Abstract: The vaccine and drug discovery responses to COVID-19 have worked far better than could have been imagined. Yet by the end of 2021, more than 5 million people had died, and the pandemic continues to evolve and rage globally. This Review will describe how ... ...

    Abstract The vaccine and drug discovery responses to COVID-19 have worked far better than could have been imagined. Yet by the end of 2021, more than 5 million people had died, and the pandemic continues to evolve and rage globally. This Review will describe how each of the vaccines, antibody therapies, and antiviral drugs that have been approved to date were built on decades of investment in technology and basic science. We will caution that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has so far proven a straightforward test of our pandemic preparedness, and we will recommend steps we should undertake now to prepare for, to minimize the effects of, and ideally to prevent future pandemics. Other Reviews in this series describe the interactions of SARS-CoV-2 with the immune system and those therapies that target the host response to infection.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Disease Progression ; Drug Development ; Drug Discovery ; Humans ; Pandemics/prevention & control ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; Vaccine Development ; Vaccinology ; Viral Vaccines/immunology ; Virus Diseases/drug therapy ; Virus Diseases/prevention & control
    Chemical Substances Antibodies, Monoclonal ; Antiviral Agents ; COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abn1900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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