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  1. Article ; Online: Molecular engineering of a spheroid-penetrating phage nanovector for photodynamic treatment of colon cancer cells.

    Turrini, Eleonora / Ulfo, Luca / Costantini, Paolo Emidio / Saporetti, Roberto / Di Giosia, Matteo / Nigro, Michela / Petrosino, Annapaola / Pappagallo, Lucia / Kaltenbrunner, Alena / Cantelli, Andrea / Pellicioni, Valentina / Catanzaro, Elena / Fimognari, Carmela / Calvaresi, Matteo / Danielli, Alberto

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 144

    Abstract: Photodynamic therapy (PDT) represents an emerging strategy to treat various malignancies, including colorectal cancer (CC), the third most common cancer type. This work presents an engineered M13 phage retargeted towards CC cells through pentavalent ... ...

    Abstract Photodynamic therapy (PDT) represents an emerging strategy to treat various malignancies, including colorectal cancer (CC), the third most common cancer type. This work presents an engineered M13 phage retargeted towards CC cells through pentavalent display of a disulfide-constrained peptide nonamer. The M13
    MeSH term(s) Humans ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Photochemotherapy/methods ; Bacteriophages ; Cell Death ; Rose Bengal/pharmacology ; Rose Bengal/chemistry ; Colonic Neoplasms/therapy
    Chemical Substances Photosensitizing Agents ; Rose Bengal (1ZPG1ELY14)
    Language English
    Publishing date 2024-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-024-05174-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A modular phage vector platform for targeted photodynamic therapy of Gram-negative bacterial pathogens.

    Petrosino, Annapaola / Saporetti, Roberto / Starinieri, Francesco / Sarti, Edoardo / Ulfo, Luca / Boselli, Luca / Cantelli, Andrea / Morini, Andrea / Zadran, Suleman Khan / Zuccheri, Giampaolo / Pasquini, Zeno / Di Giosia, Matteo / Prodi, Luca / Pompa, Pier Paolo / Costantini, Paolo Emidio / Calvaresi, Matteo / Danielli, Alberto

    iScience

    2023  Volume 26, Issue 10, Page(s) 108032

    Abstract: Growing antibiotic resistance has encouraged the revival of phage-inspired antimicrobial approaches. On the other hand, photodynamic therapy (PDT) is considered a very promising research domain for the protection against infectious diseases. Yet, very ... ...

    Abstract Growing antibiotic resistance has encouraged the revival of phage-inspired antimicrobial approaches. On the other hand, photodynamic therapy (PDT) is considered a very promising research domain for the protection against infectious diseases. Yet, very few efforts have been made to combine the advantages of both approaches in a modular, retargetable platform. Here, we foster the M13 bacteriophage as a multifunctional scaffold, enabling the selective photodynamic killing of bacteria. We took advantage of the well-defined molecular biology of M13 to functionalize its capsid with hundreds of photo-activable Rose Bengal sensitizers and contemporarily target this light-triggerable nanobot to specific bacterial species by phage display of peptide targeting moieties fused to the minor coat protein pIII of the phage. Upon light irradiation of the specimen, the targeted killing of diverse Gram(-) pathogens occurred at subnanomolar concentrations of the phage vector. Our findings contribute to the development of antimicrobials based on targeted and triggerable phage-based nanobiotherapeutics.
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Orthogonal nanoarchitectonics of M13 phage for receptor targeted anticancer photodynamic therapy.

    Ulfo, Luca / Cantelli, Andrea / Petrosino, Annapaola / Costantini, Paolo Emidio / Nigro, Michela / Starinieri, Francesco / Turrini, Eleonora / Zadran, Suleman Khan / Zuccheri, Giampaolo / Saporetti, Roberto / Di Giosia, Matteo / Danielli, Alberto / Calvaresi, Matteo

    Nanoscale

    2022  Volume 14, Issue 3, Page(s) 632–641

    Abstract: Photodynamic therapy (PDT) represents a promising therapeutic modality for cancer. Here we used an orthogonal nanoarchitectonics approach (genetic/chemical) to engineer M13 bacteriophages as targeted vectors for efficient photodynamic killing of cancer ... ...

    Abstract Photodynamic therapy (PDT) represents a promising therapeutic modality for cancer. Here we used an orthogonal nanoarchitectonics approach (genetic/chemical) to engineer M13 bacteriophages as targeted vectors for efficient photodynamic killing of cancer cells. M13 was genetically refactored to display on the phage tip a peptide (SYPIPDT) able to bind the epidermal growth factor receptor (EGFR). The refactored M13
    MeSH term(s) Bacteriophage M13/genetics ; Capsid Proteins/genetics ; Humans ; Neoplasms/drug therapy ; Peptides ; Photochemotherapy
    Chemical Substances Capsid Proteins ; Peptides
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d1nr06053h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Spiky Gold Nanoparticles for the Photothermal Eradication of Colon Cancer Cells.

    Costantini, Paolo Emidio / Di Giosia, Matteo / Ulfo, Luca / Petrosino, Annapaola / Saporetti, Roberto / Fimognari, Carmela / Pompa, Pier Paolo / Danielli, Alberto / Turrini, Eleonora / Boselli, Luca / Calvaresi, Matteo

    Nanomaterials (Basel, Switzerland)

    2021  Volume 11, Issue 6

    Abstract: Colorectal cancer (CRC) is a widespread and lethal disease. Relapses of the disease and metastasis are very common in instances of CRC, so adjuvant therapies have a crucial role in its treatment. Systemic toxic effects and the development of resistance ... ...

    Abstract Colorectal cancer (CRC) is a widespread and lethal disease. Relapses of the disease and metastasis are very common in instances of CRC, so adjuvant therapies have a crucial role in its treatment. Systemic toxic effects and the development of resistance during therapy limit the long-term efficacy of existing adjuvant therapeutic approaches. Consequently, the search for alternative strategies is necessary. Photothermal therapy (PTT) represents an innovative treatment for cancer with great potential. Here, we synthesize branched gold nanoparticles (BGNPs) as attractive agents for the photothermal eradication of colon cancer cells. By controlling the NP growth process, large absorption in the first NIR biological window was obtained. The FBS dispersed BGNPs are stable in physiological-like environments and show an extremely efficient light-to-heat conversion capability when irradiated with an 808-nm laser. Sequential cycles of heating and cooling do not affect the BGNP stability. The uptake of BGNPs in colon cancer cells was confirmed using flow cytometry and confocal microscopy, exploiting their intrinsic optical properties. In dark conditions, BGNPs are fully biocompatible and do not compromise cell viability, while an almost complete eradication of colon cancer cells was observed upon incubation with BGNPs and irradiation with an 808-nm laser source. The PTT treatment is characterized by an extremely rapid onset of action that leads to cell membrane rupture by induced hyperthermia, which is the trigger that promotes cancer cell death.
    Language English
    Publishing date 2021-06-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano11061608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Advanced photodynamic therapy with an engineered M13 phage targeting EGFR: Mitochondrial localization and autophagy induction in ovarian cancer cell lines.

    Bortot, Barbara / Apollonio, Maura / Baj, Gabriele / Andolfi, Laura / Zupin, Luisa / Crovella, Sergio / di Giosia, Matteo / Cantelli, Andrea / Saporetti, Roberto / Ulfo, Luca / Petrosino, Annapaola / Di Lorenzo, Giovanni / Romano, Federico / Ricci, Giuseppe / Mongiat, Maurizio / Danielli, Alberto / Calvaresi, Matteo / Biffi, Stefania

    Free radical biology & medicine

    2021  Volume 179, Page(s) 242–251

    Abstract: Photodynamic therapy (PDT) is a potential synergistic approach to chemotherapy for treating ovarian cancer, the most lethal gynecologic malignancy. Here we used M13 bacteriophage as a targeted vector for the efficient photodynamic killing of SKOV3 and ... ...

    Abstract Photodynamic therapy (PDT) is a potential synergistic approach to chemotherapy for treating ovarian cancer, the most lethal gynecologic malignancy. Here we used M13 bacteriophage as a targeted vector for the efficient photodynamic killing of SKOV3 and COV362 cells. The M13 phage was refactored (M13
    MeSH term(s) Autophagy ; Bacteriophage M13 ; Cell Line ; Cell Line, Tumor ; Chlorophyllides ; ErbB Receptors/genetics ; Female ; Humans ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Photochemotherapy ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Porphyrins/pharmacology
    Chemical Substances Chlorophyllides ; Photosensitizing Agents ; Porphyrins ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2021.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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