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Article ; Online: COVID-19 and non-Hodgkin's lymphoma: A common susceptibility pattern?

Sara, De Matteis / Minelli, Cosetta / Broccia, Giorgio / Vineis, Paolo / Cocco, Pierluigi

2023 Volume 18, Issue 3, Page(s) e0277588

Abstract: Objective: To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence.: Design: Ecological study design.: Setting: Sardinia, Italy.: Participants: We used official reports on the total cases of COVID-19 in 2020, ...

Abstract	Objective: To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence. Design: Ecological study design. Setting: Sardinia, Italy. Participants: We used official reports on the total cases of COVID-19 in 2020, published data on NHL incidence, and socio-economic indicators by administrative unit, covering the whole regional population. Main outcomes and measures: We used multivariable regression analysis to explore the association between the natural logarithm (ln) of the 2020 cumulative incidence of COVID-19 and the ln-transformed NHL incidence in 1974-2003, weighing by population size and adjusting by socioeconomic deprivation and other covariates. Results: The cumulative incidence of COVID-19 increased in relation to past incidence of NHL (p < 0.001), socioeconomic deprivation (p = 0.006), and proportion of elderly residents (p < 0.001) and decreased with urban residency (p = 0.001). Several sensitivity analyses confirmed the finding of an association between COVID-19 and NHL. Conclusion: This ecological study found an ecological association between NHL and COVID-19. If further investigation would confirm our findings, shared susceptibility factors should be investigated among the plausible underlying mechanisms.
MeSH term(s)	Humans ; Aged ; COVID-19/epidemiology ; Lymphoma, Non-Hodgkin/epidemiology ; Incidence ; Italy/epidemiology
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0277588
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Incidence of non-Hodgkin's lymphoma among adults in Sardinia, Italy.

Giorgio Broccia / Jonathan Carter / Cansu Ozsin-Ozler / Federico Meloni / Sara De Matteis / Pierluigi Cocco

PLoS ONE, Vol 17, Iss 2, p e

2022 Volume 0260078

Abstract: The causes of the peculiar time trend in the incidence of non-Hodgkin's lymphoma (NHL) in most parts of the world and of its geographic distribution are still unknown. We used the data base of 1974-2003 incident cases of hematological malignancies to ... ...

Abstract	The causes of the peculiar time trend in the incidence of non-Hodgkin's lymphoma (NHL) in most parts of the world and of its geographic distribution are still unknown. We used the data base of 1974-2003 incident cases of hematological malignancies to explore the time trend of NHL incidence in the region of Sardinia, Italy, and we used Bayesian methods to plot the probability of NHL incidence by residential unit on the regional map. In 1974-2003, 4109 NHL cases were diagnosed among resident adults in Sardinia, with an incidence rate of 13.38 x 10-5 (95% CI 12.97-13.80). NHL incidence showed an upward trend along the study period with an average annual percent change (APC) of 4.94 (95% CI -5.39-16.4), which did not vary by gender or by age-group. Cancer registry data, covering part of the region starting from 1993, suggest that the increasing trend did not persist in the subsequent years. Areas with the highest probability of an excess incidence tended to cluster in the north-eastern part of the region and in two major urban centers, with the low incidence areas located in the south, confirming previous observations. Prevalence of viral infections, environmental and occupational exposures, or socio-economic deprivation would not explain the peculiar geographic distribution we observed. These findings provide convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants of NHL in the risk areas.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction

Giorgio Broccia / Jonathan Carter / Cansu Ozsin-Ozler / Federico Meloni / Ilaria Pilia / Sara De Matteis / Pierluigi Cocco

Scientific Reports, Vol 12, Iss 1, Pp 1-

Time trend and Bayesian mapping of multiple myeloma incidence in Sardinia, Italy

2022 Volume 1

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 and non-Hodgkin’s lymphoma: a common susceptibility pattern?

Sara, De Matteis / Minelli, Cosetta / Broccia, Giorgio / Vineis, Paolo / Cocco, Pierluigi

medRxiv

Abstract: Objective To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence. Design Ecological study design. Setting Sardinia, Italy. Participants We used official reports on the total cases of COVID-19 in 2020, published data ... ...

Abstract	Objective To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence. Design Ecological study design. Setting Sardinia, Italy. Participants We used official reports on the total cases of COVID-19 in 2020, published data on NHL incidence, and socio-economic indicators by administrative unit, covering the whole regional population. Main outcomes and measures We used multivariable regression analysis to explore the association between the natural logarithm (ln) of the 2020 cumulative incidence of COVID-19 and the ln-transformed NHL incidence in 1974-2003, weighing by population size and adjusting by socioeconomic deprivation and other covariates. Results The cumulative incidence of COVID-19 increased in relation to past incidence of NHL (p < 0.001), socioeconomic deprivation (p = 0.006), and proportion of elderly residents (p < 0.001) and decreased with urban residency (p = 0.001). Several sensitivity analyses confirmed the finding of an association between COVID-19 and NHL. Conclusion This ecological study found an ecological association between NHL and COVID-19. If further investigation would confirm our findings, shared susceptibility factors should be investigated among the plausible underlying mechanisms.
Keywords	covid19
Language	English
Publishing date	2022-11-03
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.11.01.22281794
Database	COVID19

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Article ; Online: Systematic Violence Monitoring to Reduce Underreporting and to Better Inform Workplace Violence Prevention Among Health Care Workers

Giovanni Veronesi / Marco Mario Ferrario / Emanuele Maria Giusti / Rossana Borchini / Lisa Cimmino / Monica Ghelli / Alberto Banfi / Alessandro Luoni / Benedetta Persechino / Cristina Di Tecco / Matteo Ronchetti / Francesco Gianfagna / Sara De Matteis / Gianluca Castelnuovo / Licia Iacoviello

JMIR Public Health and Surveillance, Vol 9, p e

Before-and-After Prospective Study

2023 Volume 47377

Abstract: BackgroundMonitoring workplace violence (WPV) against health care workers (HCWs) through incident reporting is crucial to drive prevention, but the actual implementation is spotty and experiences underreporting. ObjectiveThis study aims to introduce a ... ...

Abstract	BackgroundMonitoring workplace violence (WPV) against health care workers (HCWs) through incident reporting is crucial to drive prevention, but the actual implementation is spotty and experiences underreporting. ObjectiveThis study aims to introduce a systematic WPV surveillance in 2 public referral hospitals in Italy and assess underreporting, WPV annual rates, and attributes “before” (2016-2020) and “after” its implementation (November 2021 to 2022). MethodsDuring 2016-2020, incident reporting was based on procedures and data collection forms that were neither standardized between hospitals nor specific for aggressions. We planned and implemented a standardized WPV surveillance based on (1) an incident report form for immediate and systematic event notification, adopting international standards for violence definitions; (2) second-level root cause analysis with a dedicated psychologist, assessing violence determinants and impacts and offering psychological counseling; (3) a web-based platform for centralized data collection; and (4) periodic training for workforce coordinators and newly hired workers. We used data from incident reports to estimate underreporting, defined as an observed-to-expected (from literature and the “before” period) WPV ratio less than 1, and the 12-month WPV rates (per 100 HCWs) in the “before” and “after” periods. During the latter period, we separately estimated WPV rates for first and recurrent events. ResultsIn the “before” period, the yearly observed-to-expected ratios were consistently below 1 and as low as 0.27, suggesting substantial violence underreporting of up to 73%. WPV annual rates declined in 1 hospital (from 1.92 in 2016 to 0.57 in 2020) and rose in the other (from 0.52 to 1.0), with the divergence being attributable to trends in underreporting. Available data were poorly informative to identify at-risk HCW subgroups. In the “after” period, the observed-to-expected ratio rose to 1.14 compared to literature and 1.91 compared to the “before” period, consistently in both ...
Keywords	Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MultiTex RCT – a multifaceted intervention package for protection against cotton dust exposure among textile workers – a cluster randomized controlled trial in Pakistan

Asaad Ahmed Nafees / Sara De Matteis / Muhammad Masood Kadir / Peter Burney / David Coggon / Sean Semple / Paul Cullinan

Trials, Vol 20, Iss 1, Pp 1-

study protocol

2019 Volume 10

Abstract: Abstract Background In the Pakistani textile industry the prevalence of workplace respiratory illnesses, including byssinosis, is high. The MultiTex RCT study aims to determine the effectiveness of a multifaceted intervention package in reducing dust ... ...

Abstract	Abstract Background In the Pakistani textile industry the prevalence of workplace respiratory illnesses, including byssinosis, is high. The MultiTex RCT study aims to determine the effectiveness of a multifaceted intervention package in reducing dust levels in cotton mills, decreasing the frequency of respiratory symptoms among cotton textile workers, and improving their lung function. Methods/design We will conduct a cluster-randomized controlled trial at 28 textile mills in Karachi. The intervention will comprise: training in occupational health for all workers and managers reinforced by regular refresher sessions; the formation of workplace committees to draw up, agree and promote a health and safety plan that includes wet mopping, safe disposal of cotton dust, and the use of simple face-masks, as well as further publicity about the risks from cotton dust; and provision of adequate supplies of face-masks to support the health and safety plan. Participating mills will be randomized to intervention and control arms following a baseline survey. The impact of the intervention will be determined through follow-up surveys conducted at 3, 12 and 18 months. Data collection in the surveys will include spirometry, questionnaire-based interviews and cotton-dust measurements. Discussion If successful, the study may pave the way for simple, low-cost interventions that can help reduce cotton-dust levels in textile mills, and improve the respiratory health of textile workers in developing countries such as Pakistan. Trial registration ClinicalTrials.gov, ID: NCT03738202. Registered on 12 November 2018.
Keywords	Randomized controlled trial ; Textile industry ; Cotton fiber ; Byssinosis ; Medicine (General) ; R5-920
Subject code	941
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Re-irradiation in lung disease by SBRT

Donatella Caivano / Maurizio Valeriani / Sara De Matteis / Paolo Bonome / Ivana Russo / Vitaliana De Sanctis / Giuseppe Minniti / Mattia Falchetto Osti

Radiation Oncology, Vol 13, Iss 1, Pp 1-

a retrospective, single institutional study

2018 Volume 8

Abstract: Abstract Background The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities. Methods From April 2011 to December 2016, twenty- ... ...

Abstract	Abstract Background The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities. Methods From April 2011 to December 2016, twenty-two patients received a re-irradiation by SBRT. Twenty- seven lesions were treated. The medium BED(10) of re-irradiation was 100.6 Gy (range: 48–151.2 Gy) and the medium EQD2(10) was 93.8 Gy (range: 40–126 Gy). In the previous treatment the medium BED(10) was 97.2 Gy (range: 40–120 Gy), the medium EQD2(10) was 81 Gy (range: 32.5–100 Gy). The median time between the first and the second treatment was 18 months. Results Local Control was reached in 18 out of 27 (66%) re-irradiated lesions, with rates of 67 and 54% at 1- year and 2- years respectively. The treatment was well tolerated; the maximum recorded toxicity was Grade 3. Conclusions Re- irradiation by SBRT may represent an option for the treatment of lung disease with good results in terms of LC and toxicity.
Keywords	Re-irradiation ; SBRT ; Lung ; Primary or metastatic disease ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study

Federico Meloni / Giannina Satta / Marina Padoan / Andrea Montagna / Ilaria Pilia / Alessandra Argiolas / Sara Piro / Corrado Magnani / Angela Gambelunghe / Giacomo Muzi / Giovanni Maria Ferri / Luigi Vimercati / Roberta Zanotti / Aldo Scarpa / Mariagrazia Zucca / Sara De Matteis / Marcello Campagna / Lucia Miligi / Pierluigi Cocco

Environmental Health, Vol 20, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Background The International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and ...

Abstract	Abstract Background The International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and risk of lymphoma subtypes in a multicenter case-control study conducted in Italy. Methods The Italian Gene-Environment Interactions in Lymphoma Etiology (ItGxE) study took place in 2011–17 in six Italian centres. Overall, 867 incident lymphoma cases and 774 controls participated in the study. Based on detailed questionnaire information, occupational experts classified duration, confidence, frequency, and intensity of exposure to glyphosate for each study subject. Using unconditional regression analysis, we modelled risk of major lymphoma subtypes associated with exposure to glyphosate adjusted by age, gender, education, and study centre. Results Very few study subjects (2.2%) were classified as ever exposed to glyphosate. Risk of follicular lymphoma (FL) was elevated 7-fold in subjects classified as ever exposed to glyphosate with medium-high confidence, 4.5-fold in association with medium-high cumulative exposure level, 12-fold with medium-high exposure intensity, and 6-fold with exposure for 10 days or more per year. Significant upward trends were detected with all the exposure metrics, but duration. The overall p-value for an upward trend with four independent metrics was 1.88 × 10− 4. There was no association with risk of lymphoma (any subtype), Non Hodgkin Lymphoma, B-cell lymphoma, or the major lymphoma subtypes other than FL. Conclusions Our findings provide limited support to the IARC decision to classify glyphosate as Group 2A human carcinogen.
Keywords	Glyphosate ; Follicular lymphoma ; Occupational exposure ; Pesticides ; Occupational cancer ; Industrial medicine. Industrial hygiene ; RC963-969 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of an asbestos cement factory on mesothelioma incidence

Carolina Mensi / Luciano Riboldi / Sara De Matteis / Pier Alberto Bertazzi / Dario Consonni

Environment International, Vol 74, Iss , Pp 191-

Global assessment of effects of occupational, familial, and environmental exposure

2015 Volume 199

Abstract: Few studies have examined the incidence of malignant mesothelioma (MM) associated with distinct sources of asbestos exposure (occupational, familial, or environmental). We assessed the impact of asbestos exposure—global and by source—on the incidence of ... ...

Abstract	Few studies have examined the incidence of malignant mesothelioma (MM) associated with distinct sources of asbestos exposure (occupational, familial, or environmental). We assessed the impact of asbestos exposure—global and by source—on the incidence of MM in Broni, an Italian town in which an asbestos cement factory once operated (1932–1993). Based on data collected by the Lombardy Mesothelioma Registry, we calculated the number of observed and expected MM cases among workers, their cohabitants, and people living in the area in 2000–2011. We identified 147 MM cases (17.45 expected), 138 pleural and nine peritoneal, attributable to exposure to asbestos from the factory. Thirty-eight cases had past occupational exposure at the factory (2.33 expected), numbering 32 men (26 pleural, six peritoneal) and six women (four pleural, two peritoneal). In the families of the workers, there were 37 MM cases (4.23 expected), numbering five men (all pleural) and 32 women (31 pleural, one peritoneal). Among residents in Broni or in the adjacent/surrounding towns, there were 72 cases of pleural MM (10.89 expected), numbering 23 men and 49 women. The largest MM excess was found in the towns of Broni (48 observed, 3.68 expected) and Stradella (16 observed, 1.85 expected). This study documents the large impact of the asbestos cement factory, with about 130 excess MM cases in a 12-year period. The largest MM burden was among women, from non-occupational exposure. Almost half of the MM cases were attributable to environmental exposure. Keywords: Asbestos, Mesothelioma, Cancer incidence, Occupational exposure, Familial exposure, Environmental exposure
Keywords	Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Occupational self-coding and automatic recording (OSCAR)

Sara De Matteis / Deborah Jarvis / Heather Young / Alan Young / Naomi Allen / James Potts / Andrew Darnton / Lesley Rushton / Paul Cullinan

Scandinavian Journal of Work, Environment & Health, Vol 43, Iss 2, Pp 181-

a novel web-based tool to collect and code lifetime job histories in large population-based studies

2017 Volume 186

Abstract: OBJECTIVES: The standard approach to the assessment of occupational exposures is through the manual collection and coding of job histories. This method is time-consuming and costly and makes it potentially unfeasible to perform high quality analyses on ... ...

Abstract	OBJECTIVES: The standard approach to the assessment of occupational exposures is through the manual collection and coding of job histories. This method is time-consuming and costly and makes it potentially unfeasible to perform high quality analyses on occupational exposures in large population-based studies. Our aim was to develop a novel, efficient web-based tool to collect and code lifetime job histories in the UK Biobank, a population-based cohort of over 500 000 participants. METHODS: We developed OSCAR (occupations self-coding automatic recording) based on the hierarchical structure of the UK Standard Occupational Classification (SOC) 2000, which allows individuals to collect and automatically code their lifetime job histories via a simple decision-tree model. Participants were asked to find each of their jobs by selecting appropriate job categories until they identified their job title, which was linked to a hidden 4-digit SOC code. For each occupation a job title in free text was also collected to estimate Cohen’s kappa (κ) inter-rater agreement between SOC codes assigned by OSCAR and an expert manual coder. RESULTS: OSCAR was administered to 324 653 UK Biobank participants with an existing email address between June and September 2015. Complete 4-digit SOC-coded lifetime job histories were collected for 108 784 participants (response rate: 34%). Agreement between the 4-digit SOC codes assigned by OSCAR and the manual coder for a random sample of 400 job titles was moderately good [κ=0.45, 95% confidence interval (95% CI) 0.42–0.49], and improved when broader job categories were considered (κ=0.64, 95% CI 0.61–0.69 at a 1-digit SOC-code level). CONCLUSIONS: OSCAR is a novel, efficient, and reasonably reliable web-based tool for collecting and automatically coding lifetime job histories in large population-based studies. Further application in other research projects for external validation purposes is warranted.
Keywords	population-based study ; occupational self-coding ; oscar ; automatic recording ; web-based tool ; lifetime job history ; exposure assessment method ; standard occupational classification ; data coding ; occupation ; data collection ; Public aspects of medicine ; RA1-1270
Subject code	331
Language	English
Publishing date	2017-03-01T00:00:00Z
Publisher	Nordic Association of Occupational Safety and Health (NOROSH)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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