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  1. Article ; Online: Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients

    Aaron Bodansky / Chung-Yu Wang / Aditi Saxena / Anthea Mitchell / Andrew F. Kung / Saki Takahashi / Khamal Anglin / Beatrice Huang / Rebecca Hoh / Scott Lu / Sarah A. Goldberg / Justin Romero / Brandon Tran / Raushun Kirtikar / Halle Grebe / Matthew So / Bryan Greenhouse / Matthew S. Durstenfeld / Priscilla Y. Hsue /
    Joanna Hellmuth / J. Daniel Kelly / Jeffrey N. Martin / Mark S. Anderson / Steven G. Deeks / Timothy J. Henrich / Joseph L. DeRisi / Michael J. Peluso

    JCI Insight, Vol 8, Iss

    2023  Volume 11

    Abstract: Some individuals do not return to baseline health following SARS-CoV-2 infection, leading to a condition known as long COVID. The underlying pathophysiology of long COVID remains unknown. Given that autoantibodies have been found to play a role in ... ...

    Abstract Some individuals do not return to baseline health following SARS-CoV-2 infection, leading to a condition known as long COVID. The underlying pathophysiology of long COVID remains unknown. Given that autoantibodies have been found to play a role in severity of SARS-CoV-2 infection and certain other post-COVID sequelae, their potential role in long COVID is important to investigate. Here, we apply a well-established, unbiased, proteome-wide autoantibody detection technology (T7 phage-display assay with immunoprecipitation and next-generation sequencing, PhIP-Seq) to a robustly phenotyped cohort of 121 individuals with long COVID, 64 individuals with prior COVID-19 who reported full recovery, and 57 pre-COVID controls. While a distinct autoreactive signature was detected that separated individuals with prior SARS-CoV-2 infection from those never exposed to SARS-CoV-2, we did not detect patterns of autoreactivity that separated individuals with long COVID from individuals fully recovered from COVID-19. These data suggest that there are robust alterations in autoreactive antibody profiles due to infection; however, no association of autoreactive antibodies and long COVID was apparent by this assay.
    Keywords COVID-19 ; Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: SARS-CoV-2 antibody prevalence in Sierra Leone, March 2021

    Tushar Singh / Eugene T Richardson / Raphael Frankfurter / Rashid Ansumana / Sulaiman Lakoh / Curtis Blanton / Osman Sankoh / Mohamed Vandi / Mohamed Samai / Mohamed Bailor Barrie / J Daniel Kelly / Joseph Sam Kanu / James Sylvester Squire / Zikan Koroma / Silleh Bah / Abdulai Brima / Sarah A Goldberg / Smit Chitre / Chidinma Osuagwu /
    Justin Maeda / Bernard Barekye / Tamuno-Wari Numbere / Mohammed Abdulaziz / Anthony Mounts

    BMJ Global Health, Vol 6, Iss

    a cross-sectional, nationally representative, age-stratified serosurvey

    2021  Volume 11

    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Chronic viral coinfections differentially affect the likelihood of developing long COVID

    Michael J. Peluso / Tyler-Marie Deveau / Sadie E. Munter / Dylan Ryder / Amanda Buck / Gabriele Beck-Engeser / Fay Chan / Scott Lu / Sarah A. Goldberg / Rebecca Hoh / Viva Tai / Leonel Torres / Nikita S. Iyer / Monika Deswal / Lynn H. Ngo / Melissa Buitrago / Antonio Rodriguez / Jessica Y. Chen / Brandon C. Yee /
    Ahmed Chenna / John W. Winslow / Christos J. Petropoulos / Amelia N. Deitchman / Joanna Hellmuth / Matthew A. Spinelli / Matthew S. Durstenfeld / Priscilla Y. Hsue / J. Daniel Kelly / Jeffrey N. Martin / Steven G. Deeks / Peter W. Hunt / Timothy J. Henrich

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 3

    Abstract: BACKGROUND The presence and reactivation of chronic viral infections, such as EBV, CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts of individuals with COVID-19 over a ... ...

    Abstract BACKGROUND The presence and reactivation of chronic viral infections, such as EBV, CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts of individuals with COVID-19 over a longer time course consistent with current case definitions of LC are limited.METHODS In a cohort of 280 adults with prior SARS-CoV-2 infection, we assessed the presence and types of LC symptoms and prior medical history (including COVID-19 history and HIV status) and performed serological testing for EBV and CMV using a commercial laboratory. We used covariate-adjusted binary logistic regression models to identify independent associations between variables and LC symptoms.RESULTS We observed that LC symptoms, such as fatigue and neurocognitive dysfunction, at a median of 4 months following initial diagnosis were independently associated with serological evidence suggesting recent EBV reactivation (early antigen–diffuse IgG positivity) or high nuclear antigen (EBNA) IgG levels but not with ongoing EBV viremia. Serological evidence suggesting recent EBV reactivation (early antigen–diffuse IgG positivity) was most strongly associated with fatigue (OR = 2.12). Underlying HIV infection was also independently associated with neurocognitive LC (OR = 2.5). Interestingly, participants who had serologic evidence of prior CMV infection were less likely to develop neurocognitive LC (OR = 0.52).CONCLUSION Overall, these findings suggest differential effects of chronic viral coinfections on the likelihood of developing LC and association with distinct syndromic patterns. Further assessment during the acute phase of COVID-19 is warranted.TRIAL REGISTRATION Long-term Impact of Infection with Novel Coronavirus; ClinicalTrials.gov NCT04362150.FUNDING This work was supported by NIH/National Institute of Allergy and Infectious Diseases grants (3R01AI141003-03S1, R01AI158013, and K24AI145806); the Zuckerberg San Francisco General Hospital Department of Medicine and Division of HIV, ...
    Keywords COVID-19 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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