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  1. Article ; Online: Long noncoding RNAs

    Emily Dangelmaier / Sarah B Lazar / Ashish Lal

    PLoS Biology, Vol 17, Iss 2, p e

    p53's secret weapon in the fight against cancer?

    2019  Volume 3000143

    Abstract: p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53. This raises the possibility that a subset of these genes, regulated by a p53- ... ...

    Abstract p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53. This raises the possibility that a subset of these genes, regulated by a p53-induced long noncoding RNA (lncRNA), could control p53's tumor suppressor function. We propose molecular mechanisms through which lncRNAs could regulate this subset of genes and hypothesize an exciting, direct role of lncRNAs in p53's genome stability maintenance function. Exploring these mechanisms could reveal lncRNAs as indispensable mediators of p53 and lay the foundation for understanding how other transcription factors could act via lncRNAs.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Dynamics of replication origin over-activation

    Haiqing Fu / Christophe E. Redon / Bhushan L. Thakur / Koichi Utani / Robin Sebastian / Sang-Min Jang / Jacob M. Gross / Sara Mosavarpour / Anna B. Marks / Sophie Z. Zhuang / Sarah B. Lazar / Mishal Rao / Shira T. Mencer / Adrian M. Baris / Lorinc S. Pongor / Mirit I. Aladjem

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 15

    Abstract: DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed ... ...

    Abstract DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed distribution of replication initiation that over-duplicates early-replicating genomic regions.
    Keywords Science ; Q
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

    Xiao Ling Li / Lőrinc Pongor / Wei Tang / Sudipto Das / Bruna R Muys / Matthew F Jones / Sarah B Lazar / Emily A Dangelmaier / Corrine CR Hartford / Ioannis Grammatikakis / Qinyu Hao / Qinyu Sun / Aaron Schetter / Jennifer L Martindale / BinWu Tang / Lisa M Jenkins / Ana I Robles / Robert L Walker / Stefan Ambs /
    Raj Chari / Svetlana A Shabalina / Myriam Gorospe / S Perwez Hussain / Curtis C Harris / Paul S Meltzer / Kannanganattu V Prasanth / Mirit I Aladjem / Thorkell Andresson / Ashish Lal

    eLife, Vol

    2020  Volume 9

    Abstract: Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding potential. However, only a handful of endogenous proteins encoded by putative lncRNAs have been identified and assigned a function. Here, we report the discovery of a ... ...

    Abstract Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding potential. However, only a handful of endogenous proteins encoded by putative lncRNAs have been identified and assigned a function. Here, we report the discovery of a putative gastrointestinal-tract-specific lncRNA (LINC00675) that is regulated by the pioneer transcription factor FOXA1 and encodes a conserved small protein of 79 amino acids which we termed FORCP (FOXA1-Regulated Conserved Small Protein). FORCP transcript is undetectable in most cell types but is abundant in well-differentiated colorectal cancer (CRC) cells where it functions to inhibit proliferation, clonogenicity, and tumorigenesis. The epitope-tagged and endogenous FORCP protein predominantly localizes to the endoplasmic reticulum (ER). In response to ER stress, FORCP depletion results in decreased apoptosis. Our findings on the initial characterization of FORCP demonstrate that FORCP is a novel, conserved small protein encoded by a mis-annotated lncRNA that regulates apoptosis and tumorigenicity in well-differentiated CRC cells.
    Keywords lncRNA ; ORF ; FOXA1 ; LINC00675 ; CRC ; micropeptide ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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