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  1. AU="Sarah Lyon-Caen"
  2. AU="Endharti, Agustina Tri"
  3. AU="Baez-Noyer, Nelson"
  4. AU="Kucherlapati, Raju S."
  5. AU="Loyaux, Romain"
  6. AU="Yaxin Long"
  7. AU="Vlasenkova, Ramilia"
  8. AU="Taheri, Fateme"
  9. AU="Berman, Robert F"
  10. AU="Resnick, Cory M"
  11. AU=Freeman Gordon J AU=Freeman Gordon J
  12. AU="Fangru Zhou"

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  1. Artikel ; Online: Exposure to a mixture of non-persistent environmental chemicals and neonatal thyroid function in a cohort with improved exposure assessment

    Ophélie Coiffier / Dorothy Nakiwala / Matthieu Rolland / Andres Malatesta / Sarah Lyon-Caen / Benoît Chovelon / Patrice Faure / Anne Sophie Gauchez / Dorra Guergour / Amrit K. Sakhi / Azemira Sabaredzovic / Cathrine Thomsen / Isabelle Pin / Rémy Slama / Christelle Corne / Claire Philippat

    Environment International, Vol 173, Iss , Pp 107840- (2023)

    2023  

    Abstract: Background: In vitro and toxicological studies have shown that non-persistent environmental chemicals can perturb thyroid hormone homeostasis. Epidemiological studies with improved exposure assessment (i.e., repeated urine samples) are needed to evaluate ...

    Abstract Background: In vitro and toxicological studies have shown that non-persistent environmental chemicals can perturb thyroid hormone homeostasis. Epidemiological studies with improved exposure assessment (i.e., repeated urine samples) are needed to evaluate effects of these compounds, individually or as a mixture, in humans. We studied the associations between prenatal exposure to non-persistent environmental chemicals and neonatal thyroid hormones. Methods: The study population consisted of 442 mother–child pairs from the French SEPAGES mother–child cohort recruited between July 2014 and July 2017. For each participant, four parabens, five bisphenols, triclosan, triclocarban, benzophenone-3 as well as metabolites of phthalates and of di(isononyl)cyclohexane-1,2-dicarboxylate were assessed in two pools of repeated urine samples (median: 21 spot urines per pool), collected in the 2nd and 3rd trimesters of pregnancy, respectively. Thyroid stimulating hormone (TSH) and total thyroxine (T4) levels were determined in newborns from a heel-prick blood spot. Maternal iodine and selenium were assessed in urine and serum, respectively. Adjusted linear regression (uni-pollutant model) and Bayesian Kernel Machine Regression (BKMR, mixture model) were applied to study overall and sex-stratified associations between chemicals and hormone concentrations. Results: Interaction with child sex was detected for several compounds. Triclosan, three parabens, and one phthalate metabolite (OH-MPHP) were negatively associated with T4 among girls in the uni-pollutant model. BKMR also suggested a negative association between the mixture and T4 in girls, whereas in boys the association was positive. The mixture was not linked to TSH levels, and for this hormone the uni-pollutant model revealed associations with only a few compounds. Conclusion: Our study, based on repeated urine samples to assess exposure, showed that prenatal exposure to some phenols and phthalates disturb thyroid hormone homeostasis at birth. Furthermore, both uni-pollutant ...
    Schlagwörter Thyroid hormones ; Heel-prick blood spot ; Bisphenols ; Parabens ; Phthalates ; DINCH ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Exposure to phenols during pregnancy and the first year of life in a new type of couple-child cohort relying on repeated urine biospecimens

    Matthieu Rolland / Sarah Lyon-Caen / Amrit K. Sakhi / Isabelle Pin / Azemira Sabaredzovic / Cathrine Thomsen / Rémy Slama / Claire Philippat

    Environment International, Vol 139, Iss , Pp - (2020)

    2020  

    Abstract: Background: Parabens, bisphenol A and triclosan have been forbidden or restricted in specific types of consumer goods in Europe and France. Limited biomonitoring data are available in France since the implementation of these regulations, and exposure ... ...

    Abstract Background: Parabens, bisphenol A and triclosan have been forbidden or restricted in specific types of consumer goods in Europe and France. Limited biomonitoring data are available in France since the implementation of these regulations, and exposure data on infants is scarce worldwide. Understanding the predictors of phenol urinary concentrations will help identify potential targets for prevention. Aim: We described levels, variability and predictors of exposure to 12 phenols in pregnant women and infants recruited between 2014 and 2017 in a French couple-child cohort. Methods: Among 479 pregnant women and 150 of their infants, we studied phenol urinary concentrations in within-subject, within-period pools of repeated urine samples collected during the second and third trimesters of pregnancy (up to 42 samples per woman), at 2 months and 12 months (up to 14 samples per infant). Time trends and associations with demographic, protocol, occupational and behavioral factors were studied using interval censored models to accommodate for undetected and unquantified urine concentrations. Results: Detection rates were above 90% for bisphenol A, ethylparaben, methylparaben, benzophenone-3 and triclosan and below 5% for bisphenol AF, B, F and triclocarban. Median levels of bisphenol A, bisphenol S, methylparaben, ethylparaben and propylparaben at 12 months were similar or higher than during pregnancy. For pregnant women all phenols but benzophenone-3 and bisphenol S showed a linear decrease between 2014 and 2017 (p-values < 0.02). Women with the shortest education (primary and secondary school) had higher urinary concentrations of triclosan (β = 0.58 (95% confidence interval (CI), −0.04; 1.20)), ethyl (β = 0.43 (95%CI, 0.03; 0.84)) and propyl paraben (β = 1.39 (95%CI, 0.55; 2.24)) than those with the longest education. Cashiers had higher conccentrations of bisphenol S (β = 0.99 (95%CI, −0.11; 2.09)) but not of bisphenol A (β = −0.04 (95%CI, −0.26; 0.19)) than unemployed women. Conclusions: Despite recent regulations, ...
    Schlagwörter Bisphenols ; Infants ; Parabens ; Pooled biospecimens ; Pregnancy ; Triclosan ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms

    Pierre Lemire / Sofia Temam / Sarah Lyon-Caen / Catherine Quinot / Etienne Sévin / Sophie Remacle / Karine Supernant / Rémy Slama / Orianne Dumas / Valérie Siroux / Nicole Le Moual / the SEPAGES study group

    International Journal of Environmental Research and Public Health, Vol 18, Iss 3366, p

    2021  Band 3366

    Abstract: Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to ... ...

    Abstract Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects estimates. The women of the SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ingredients database. Agreements between the two methods were assessed by Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 with asthma symptom score ≥1) scanned 617 different products (580 with available ingredients list). Slight to fair agreements for sprays, bleach and scented HDCP were observed (Kappa: 0.35, 0.25, 0.11, respectively). Strength of the associations between HDCP and asthma symptom score varied between both methods but all odds ratios (OR) were greater than one. The number of scanned products used weekly was significantly associated with the asthma symptom score (adjusted-OR [CI 95%]: 1.15 [1.00–1.32]). This study shows the importance of using novel tools in epidemiological research to objectively assess HDCP and therefore reduce exposure measurement errors.
    Schlagwörter household cleaning products ; asthma ; smartphone application ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Estimation of exposure to atmospheric pollutants during pregnancy integrating space–time activity and indoor air levels: Does it make a difference?

    Ouidir, Marion / Claire Cracowski / Isabelle Pin / Johanna Lepeule / Lise Giorgis-Allemand / Rémy Slama / Sabrina Pontet / Sarah Lyon-Caen / Valérie Siroux / Xavier Morelli

    Environment international. 2015 Nov., v. 84

    2015  

    Abstract: Studies of air pollution effects during pregnancy generally only consider exposure in the outdoor air at the home address. We aimed to compare exposure models differing in their ability to account for the spatial resolution of pollutants, space–time ... ...

    Abstract Studies of air pollution effects during pregnancy generally only consider exposure in the outdoor air at the home address. We aimed to compare exposure models differing in their ability to account for the spatial resolution of pollutants, space–time activity and indoor air pollution levels. We recruited 40 pregnant women in the Grenoble urban area, France, who carried a Global Positioning System (GPS) during up to 3weeks; in a subgroup, indoor measurements of fine particles (PM2.5) were conducted at home (n=9) and personal exposure to nitrogen dioxide (NO2) was assessed using passive air samplers (n=10). Outdoor concentrations of NO2, and PM2.5 were estimated from a dispersion model with a fine spatial resolution. Women spent on average 16h per day at home. Considering only outdoor levels, for estimates at the home address, the correlation between the estimate using the nearest background air monitoring station and the estimate from the dispersion model was high (r=0.93) for PM2.5 and moderate (r=0.67) for NO2. The model incorporating clean GPS data was less correlated with the estimate relying on raw GPS data (r=0.77) than the model ignoring space–time activity (r=0.93). PM2.5 outdoor levels were not to moderately correlated with estimates from the model incorporating indoor measurements and space–time activity (r=−0.10 to 0.47), while NO2 personal levels were not correlated with outdoor levels (r=−0.42 to 0.03). In this urban area, accounting for space–time activity little influenced exposure estimates; in a subgroup of subjects (n=9), incorporating indoor pollution levels seemed to strongly modify them.
    Schlagwörter air ; air pollution ; exposure models ; global positioning systems ; monitoring ; nitrogen dioxide ; particulates ; pollutants ; pregnancy ; pregnant women ; samplers ; urban areas ; France
    Sprache Englisch
    Erscheinungsverlauf 2015-11
    Umfang p. 161-173.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2015.07.021
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  5. Artikel ; Online: Deciphering the Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal and Child Health

    Sarah Lyon-Caen / Valérie Siroux / Johanna Lepeule / Philippe Lorimier / Pierre Hainaut / Pascal Mossuz / Joane Quentin / Karine Supernant / David Meary / Laurence Chaperot / Sam Bayat / Flemming Cassee / Sarah Valentino / Anne Couturier-Tarrade / Delphine Rousseau-Ralliard / Pascale Chavatte-Palmer / Claire Philippat / Isabelle Pin / Rémy Slama /
    The SEPAGES Study Group

    International Journal of Environmental Research and Public Health, Vol 16, Iss 20, p

    Design of SEPAGES Couple-Child Cohort

    2019  Band 3888

    Abstract: In humans, studies based on Developmental Origins of Health and Disease (DOHaD) concept and targeting short half-lived chemicals, including many endocrine disruptors, generally assessed exposures from spot biospecimens. Effects of early-life exposure to ... ...

    Abstract In humans, studies based on Developmental Origins of Health and Disease (DOHaD) concept and targeting short half-lived chemicals, including many endocrine disruptors, generally assessed exposures from spot biospecimens. Effects of early-life exposure to atmospheric pollutants were reported, based on outdoor air pollution levels. For both exposure families, exposure misclassification is expected from these designs: for non-persistent chemicals, because a spot biospecimen is unlikely to capture exposure over windows longer than a few days; for air pollutants, because indoor levels are ignored. We developed a couple-child cohort relying on deep phenotyping and extended personal exposure assessment aiming to better characterize the effects of components of the exposome, including air pollutants and non-persistent endocrine disruptors, on child health and development. Pregnant women were included in SEPAGES couple-child cohort (Grenoble area) from 2014 to 2017. Maternal and children exposure to air pollutants was repeatedly assessed by personal monitors. DNA, RNA, serum, plasma, placenta, cord blood, meconium, child and mother stools, living cells, milk, hair and repeated urine samples were collected. A total of 484 pregnant women were recruited, with excellent compliance to the repeated urine sampling protocol (median, 43 urine samples per woman during pregnancy). The main health outcomes are child respiratory health using early objective measures, growth and neurodevelopment. Compared to former studies, the accuracy of assessment of non-persistent exposures is expected to be strongly improved in this new type of birth cohort tailored for the exposome concept, with deep phenotyping and extended exposure characterization. By targeting weaknesses in exposure assessment of the current approaches of cohorts on effects of early life environmental exposures with strong temporal variations, and relying on a rich biobank to provide insight on the underlying biological pathways whereby exposures affect health, this design is expected to provide deeper understanding of the interplay between the Exposome and child development and health.
    Schlagwörter dohad ; environmental epidemiology ; birth cohort ; endocrine disruptors ; atmospheric pollutants ; exposome ; child health ; Medicine ; R
    Thema/Rubrik (Code) 333 ; 360
    Sprache Englisch
    Erscheinungsdatum 2019-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Estimation of exposure to atmospheric pollutants during pregnancy integrating space–time activity and indoor air levels

    Marion Ouidir / Lise Giorgis-Allemand / Sarah Lyon-Caen / Xavier Morelli / Claire Cracowski / Sabrina Pontet / Isabelle Pin / Johanna Lepeule / Valérie Siroux / Rémy Slama

    Environment International, Vol 84, Iss , Pp 161-

    Does it make a difference?

    2015  Band 173

    Abstract: Studies of air pollution effects during pregnancy generally only consider exposure in the outdoor air at the home address. We aimed to compare exposure models differing in their ability to account for the spatial resolution of pollutants, space–time ... ...

    Abstract Studies of air pollution effects during pregnancy generally only consider exposure in the outdoor air at the home address. We aimed to compare exposure models differing in their ability to account for the spatial resolution of pollutants, space–time activity and indoor air pollution levels. We recruited 40 pregnant women in the Grenoble urban area, France, who carried a Global Positioning System (GPS) during up to 3 weeks; in a subgroup, indoor measurements of fine particles (PM2.5) were conducted at home (n = 9) and personal exposure to nitrogen dioxide (NO2) was assessed using passive air samplers (n = 10). Outdoor concentrations of NO2, and PM2.5 were estimated from a dispersion model with a fine spatial resolution. Women spent on average 16 h per day at home. Considering only outdoor levels, for estimates at the home address, the correlation between the estimate using the nearest background air monitoring station and the estimate from the dispersion model was high (r = 0.93) for PM2.5 and moderate (r = 0.67) for NO2. The model incorporating clean GPS data was less correlated with the estimate relying on raw GPS data (r = 0.77) than the model ignoring space–time activity (r = 0.93). PM2.5 outdoor levels were not to moderately correlated with estimates from the model incorporating indoor measurements and space–time activity (r = −0.10 to 0.47), while NO2 personal levels were not correlated with outdoor levels (r = −0.42 to 0.03). In this urban area, accounting for space–time activity little influenced exposure estimates; in a subgroup of subjects (n = 9), incorporating indoor pollution levels seemed to strongly modify them. Keywords: Exposure assessment, Air pollutants, Space–time activity, Global Positioning System, Indoor environment, Pregnancy
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2015-11-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children

    Maribel Casas / Xavier Basagaña / Amrit K. Sakhi / Line S. Haug / Claire Philippat / Berit Granum / Cyntia B. Manzano-Salgado / Céline Brochot / Florence Zeman / Jeroen de Bont / Sandra Andrusaityte / Leda Chatzi / David Donaire-Gonzalez / Lise Giorgis-Allemand / Juan R. Gonzalez / Esther Gracia-Lavedan / Regina Grazuleviciene / Mariza Kampouri / Sarah Lyon-Caen /
    Pau Pañella / Inga Petraviciene / Oliver Robinson / Jose Urquiza / Marina Vafeiadi / Céline Vernet / Dagmar Waiblinger / John Wright / Cathrine Thomsen / Rémy Slama / Martine Vrijheid

    Environment International, Vol 121, Iss , Pp 561-

    2018  Band 573

    Abstract: Background: Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. Objectives: We evaluated the variability of urinary concentrations of 24 ... ...

    Abstract Background: Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. Objectives: We evaluated the variability of urinary concentrations of 24 non-persistent chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide metabolites, and cotinine, between weeks from different pregnancy trimesters in pregnant women, and between days and between seasons in children. Methods: 154 pregnant women and 152 children from six European countries were enrolled in 2014–2015. Pregnant women provided three urine samples over a day (morning, midday, and night), for one week in the 2nd and 3rd pregnancy trimesters. Children provided two urines a day (morning and night), over two one-week periods, six months apart. We pooled all samples for a given subject that were collected within a week. In children, we also made four daily pools (combining morning and night voids) during the last four days of the first follow-up week. Pools were analyzed for all 24 metabolites of interest. We calculated intraclass-correlation coefficients (ICC) and estimated the number of pools needed to obtain an ICC above 0.80. Results: All phthalate metabolites and phenols were detected in >90% of pools whereas certain OP pesticide metabolites and cotinine were detected in <43% of pools. We observed fair (ICC = 0.40–0.59) to good (0.60–0.74) between-day reliability of the pools of two samples in children for all chemicals. Reliability was poor (<0.40) to fair between trimesters in pregnant women and between seasons in children. For most chemicals, three daily pools of two urines each (for weekly exposure windows) and four weekly pools of 15–20 urines each would be necessary to obtain an ICC above 0.80. Conclusions: This quantification of the variability of biomarker measurements of many non-persistent chemicals during several time windows shows that for many of these compounds a few dozen samples are required to ...
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2018-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children

    Casas, Maribel / Xavier Basagaña / Amrit K. Sakhi / Line S. Haug / Claire Philippat / Berit Granum / Cyntia B. Manzano-Salgado / Céline Brochot / Florence Zeman / Jeroen de Bont / Sandra Andrusaityte / Leda Chatzi / David Donaire-Gonzalez / Lise Giorgis-Allemand / Juan R. Gonzalez / Esther Gracia-Lavedan / Regina Grazuleviciene / Mariza Kampouri / Sarah Lyon-Caen /
    Pau Pañella / Inga Petraviciene / Oliver Robinson / Jose Urquiza / Marina Vafeiadi / Céline Vernet / Dagmar Waiblinger / John Wright / Cathrine Thomsen / Rémy Slama / Martine Vrijheid

    Environment international. 2018 Dec., v. 121

    2018  

    Abstract: Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions.We evaluated the variability of urinary concentrations of 24 non-persistent chemicals: ... ...

    Abstract Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions.We evaluated the variability of urinary concentrations of 24 non-persistent chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide metabolites, and cotinine, between weeks from different pregnancy trimesters in pregnant women, and between days and between seasons in children.154 pregnant women and 152 children from six European countries were enrolled in 2014–2015. Pregnant women provided three urine samples over a day (morning, midday, and night), for one week in the 2nd and 3rd pregnancy trimesters. Children provided two urines a day (morning and night), over two one-week periods, six months apart. We pooled all samples for a given subject that were collected within a week. In children, we also made four daily pools (combining morning and night voids) during the last four days of the first follow-up week. Pools were analyzed for all 24 metabolites of interest. We calculated intraclass-correlation coefficients (ICC) and estimated the number of pools needed to obtain an ICC above 0.80.All phthalate metabolites and phenols were detected in >90% of pools whereas certain OP pesticide metabolites and cotinine were detected in <43% of pools. We observed fair (ICC = 0.40–0.59) to good (0.60–0.74) between-day reliability of the pools of two samples in children for all chemicals. Reliability was poor (<0.40) to fair between trimesters in pregnant women and between seasons in children. For most chemicals, three daily pools of two urines each (for weekly exposure windows) and four weekly pools of 15–20 urines each would be necessary to obtain an ICC above 0.80.This quantification of the variability of biomarker measurements of many non-persistent chemicals during several time windows shows that for many of these compounds a few dozen samples are required to accurately assess exposure over periods encompassing several trimesters or months.
    Schlagwörter biomarkers ; cotinine ; dose response ; organophosphorus compounds ; pesticide metabolites ; phenols ; phthalates ; pregnancy ; pregnant women ; school children ; temporal variation ; urine ; Europe
    Sprache Englisch
    Erscheinungsverlauf 2018-12
    Umfang p. 561-573.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2018.09.046
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