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  1. Article ; Online: A survey of knowledge and attitudes relating to cervical and breast cancer among women in Ethiopia

    Bekele Chaka / Abdul-Rauf Sayed / Bridgette Goeieman / Sarah Rayne

    BMC Public Health, Vol 18, Iss 1, Pp 1-

    2018  Volume 8

    Abstract: Abstract Background Breast cancer and cervical cancer are the two leading cancers among women in Ethiopia. This study investigated knowledge and attitudes related to these two types of cancer among women in 4 zones of Ethiopia. This is the first study ... ...

    Abstract Abstract Background Breast cancer and cervical cancer are the two leading cancers among women in Ethiopia. This study investigated knowledge and attitudes related to these two types of cancer among women in 4 zones of Ethiopia. This is the first study employing a validated questionnaire to investigate knowledge and attitudes relating to breast and cervical cancer in Ethiopia. Methods A community based cross-sectional study was conducted from September to November 2015 in the North Shewa zone (Amhara region), Gamo Gofa zone (Southern Nations, Nationalities and Peoples’ region) and zones 1 and 3 (Afar region) of Ethiopia. A total of 799 women aged 18 years and older participated in the survey. Multiple logistic regression analysis was used to investigate the association of possible predictors with breast and cervical cancer knowledge. Results A total of 799 women aged 18 years and older participated in the survey. Of the women interviewed, 63.0% had heard of breast cancer and 42.2% had heard of cervical cancer. Among those who had heard of breast cancer, 21.3% (107/503) had heard of breast cancer screening and 1.4% of women aged 40 years and older had undergone at least one breast screening examination. Fewer than half of the participants provided the correct response to questions related to risk factors for breast and cervical cancer. Among those who had heard of cervical cancer, 41.5% (140/337) had heard of cervical cancer screening and 3.3% had undergone at least one cervical cancer screening examination. Women with primary and higher levels of education were more likely to have heard of breast cancers (OR = 3.0; 95% CI: 2.1–4.2; p < 0.001) and cervical cancer (OR = 1.9; 95% CI: 1.4–2.6; p < 0.001). From the overall attitude score, the majority of the women were found to have negative attitudes towards breast cancer (67.4%) and cervical cancer (70.6%). Conclusions This study found that the overall knowledge of risk factors for breast cancer and cervical cancer among women was low. Lack of cancer ...
    Keywords Breast cancer ; Cervical cancer ; Knowledge attitudes and beliefs ; Ethiopia ; Oncology ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2018-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A geospatial analysis of two-hour surgical access to district hospitals in South Africa

    Kathryn M. Chu / Angela J. Dell / Harry Moultrie / Candy Day / Megan Naidoo / Stephanie van Straten / Sarah Rayne

    BMC Health Services Research, Vol 20, Iss 1, Pp 1-

    2020  Volume 5

    Abstract: Abstract Background In a robust health care system, at least 80% of a country’s population should be able to access a district hospital that provides surgical care within 2 hours. The objective was to identify the proportion of the population living ... ...

    Abstract Abstract Background In a robust health care system, at least 80% of a country’s population should be able to access a district hospital that provides surgical care within 2 hours. The objective was to identify the proportion of the population living within 2 hours of a district hospital with surgical capacity in South Africa. Methods All government hospitals in the country were identified. Surgical district hospitals were defined as district hospitals with a surgical provider, a functional operating theatre, and the provision of at least one caesarean section annually. The proportion of the population within two-hour access was estimated using service area methods. Results Ninety-eight percent of the population had two-hour access to any government hospital in South Africa. One hundred and thirty-eight of 240 (58%) district hospitals had surgical capacity and 86% of the population had two-hour access to these facilities. Conclusion Improving equitable surgical access is urgently needed in sub-Saharan Africa. This study demonstrated that in South Africa, just over half of district hospitals had surgical capacity but more than 80% of the population had two-hour access to these facilities. Strengthening district hospital surgical capacity is an international mandate and needed to improve access.
    Keywords Global surgery ; Surgical access ; Geographic information systems ; Surgical capacity ; District hospital ; South Africa ; Public aspects of medicine ; RA1-1270
    Subject code 900
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Breast abnormalities in adolescents receiving antiretroviral therapy

    Jackie L. Dunlop / Wiedaad Slemming / Kathryn Schnippel / Caroline Makura / Leon J. Levin / Sarah Rayne / Marnie Vujovic / Cynthia Firnhaber

    Southern African Journal of HIV Medicine, Vol 20, Iss 1, Pp e1-e

    2019  Volume 7

    Abstract: Background: Antiretrovirals, particularly efavirenz (EFV), have been shown to cause breast abnormalities in adults. Little is known about the prevalence of these adverse effects among adolescents receiving antiretroviral therapy (ART). Objectives: The ... ...

    Abstract Background: Antiretrovirals, particularly efavirenz (EFV), have been shown to cause breast abnormalities in adults. Little is known about the prevalence of these adverse effects among adolescents receiving antiretroviral therapy (ART). Objectives: The aim of this article was to examine the extent of breast abnormalities in adolescents receiving ART and determine any clinical associations. Methods: A retrospective record review describing breast conditions in adolescents receiving ART at three facilities in Johannesburg was conducted. Patients aged 10–19 years, who presented from January to December 2014, were included in the study. Analyses were conducted to determine whether EFV was associated with increased breast conditions. Results: Of the 631 patient records reviewed, 37 (6%) had an abnormal breast event documented; with 24/37 (65%) being male patients. Patients with abnormal breast conditions were 1.5 years older than patients with normal breast development (p 0.0005). Forty-one abnormal breast events were observed in 37 patients, with 20 described as gynaecomastia or lipomastia (49%). Of the 37 patients, 44% (n = 19) had concurrent generalised lipodystrophy. Of those with an abnormal breast event, 71% of patients had CD4 counts 500 cells/µL and were virologically suppressed (n = 29). Those on EFV had a significantly higher prevalence of breast abnormalities compared to other regimens (p = 0.016). Conclusion: Of the studied patients, 6% had an abnormal breast condition. The use of EFV and increased age were associated with breast abnormalities in this population. Further research is needed to better understand the implications of this potential side effect.
    Keywords adolescent ; hiv ; antiretroviral ; gynaecomastia ; breast ; Public aspects of medicine ; RA1-1270 ; Infectious and parasitic diseases ; RC109-216
    Subject code 616 ; 610
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher AOSIS
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Male Breast Cancer Has Limited Effect on Survivor’s Perceptions of Their Own Masculinity

    Sarah Rayne MBChB, MMed, FCS (SA) / Kathryn Schnippel MPA / John Thomson MBChB, MMed / Joanna Reid MBChB / Carol Benn MBChB, FCS(SA)

    American Journal of Men's Health, Vol

    2017  Volume 11

    Abstract: The purpose of the current study was to describe male breast cancer in Johannesburg, South Africa, and assess whether male breast cancer patients’ perception of their own masculinity was affected by having a cancer commonly seen in women. A retrospective ...

    Abstract The purpose of the current study was to describe male breast cancer in Johannesburg, South Africa, and assess whether male breast cancer patients’ perception of their own masculinity was affected by having a cancer commonly seen in women. A retrospective file review was carried out at two hospitals, one private and one government, of male breast cancer patients from 2007 to 2012 followed by a telephone survey of patients identified during review. Of approximately 3,000 breast cancer patients seen in the 5 years reviewed, 23 cases of male breast cancer were identified. Most were diagnosed with invasive ductal carcinoma ( n = 19, 83%). Stage at presentation was from stages 0 to 3 (Stage 0 [ n = 2, 9%], Stage 1 [ n = 3, 13%], Stage 2 [ n = 12, 52%], Stage 3 [ n = 6, 26%]) and no patients were metastatic at presentation. The telephonic survey was completed by 18 patients (78%). Nearly all ( n = 17/18) shared their diagnosis with family and close friends. Two thirds of patients delayed presentation and government hospital patients were more likely to present later than private sector hospital patients. Although most male breast cancer patients sampled did not perceive the breast cancer diagnosis as affecting their masculinity, Black men and those treated in government hospitals were less likely to be aware of male breast cancer, and were more likely to have their perception of their own masculinity affected.
    Keywords Medicine ; R
    Language English
    Publishing date 2017-03-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Surgical site infection after gastrointestinal surgery in children

    Sèbastien Gaujoux / Nebyou Seyoum / Ville Sallinen / Ari Leppäniemi / Andrea Belli / Clare Skerritt / Naomi Wright / Savva Pronin / Azmina Verjee / Thomas Pinkney / Neil Smart / Oliver Warren / Michele Sacco / Arnav Agarwal / Simon Paterson-Brown / David Evans / Philip Choi / Ashish Gupta / Jonathan Myers /
    Victor Kong / Michael Wilson / Ewen M Harrison / Mircea Beuran / Zahra Jaffry / Leonardo Solaini / Thomas M Drake / Dmitri Nepogodiev / Adesoji O Ademuyiwa / Philip Alexander / Sara W Al-Saqqa / Sule Burger / Kathryn Chu / Dhruv Ghosh / Hosni Khairy Salem / Marie Carmela Lapitan / Ismail Lawani / Maria Lorena Aguilera / Mayaba Maimbo / Alex Makupe / Rachel Moore / Vanessa Msosa / Alphonse Zeta Mutabazi / Riinu Ots / Ahmad Uzair Qureshi / Sarah Rayne / Marie Dione Parreno-Sacdalan / Richard Spence / Stephen Tabiri / Richard Lilford / Dion Morton

    BMJ Global Health, Vol 5, Iss

    an international, multicentre, prospective cohort study

    2020  Volume 12

    Abstract: Introduction Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study ... ...

    Abstract Introduction Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.Methods A multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).Results Of 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.Conclusion The odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
    Subject code 360
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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