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Article ; Online: Recurrent major umbilical bleeding caused by omental varices in two patients with umbilical hernia and portal hypertension.

Sarantitis, Ioannis / Satherley, Hywel / Varia, Haren / Pettit, Stephen

BMJ case reports

2015 Volume 2015

MeSH term(s)	Hemorrhage/etiology ; Hemorrhage/surgery ; Hernia, Umbilical/complications ; Humans ; Hypertension, Portal/complications ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Omentum/blood supply ; Tomography, X-Ray Computed ; Varicose Veins/etiology
Language	English
Publishing date	2015-08-05
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2015-209647
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Article ; Online: An unusual pelvic cyst found at laparoscopic hernia repair.

Sarantitis, Ioannis / Weerasinghe, Chamindri / Varia, Haren / Pettit, Stephen

BMJ case reports

2015 Volume 2015

MeSH term(s)	Aged ; Cysts/diagnostic imaging ; Cysts/pathology ; Diagnosis, Differential ; Hernia, Inguinal/surgery ; Humans ; Laparoscopy/methods ; Male ; Pelvis/diagnostic imaging ; Pelvis/pathology ; Radiography
Language	English
Publishing date	2015-04-09
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2015-210175
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Article ; Online: Small bowel diaphragm disease mimicking malignancy.

Sarantitis, Ioannis / Gerrard, Adam Daniel / Teasdale, Rebecca / Pettit, Stephen

BMJ case reports

2015 Volume 2015

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) can produce diaphragm disease where multiple strictures develop in the small bowel. This typically presents with anaemia and symptoms of small bowel obstruction. The strictures develop as a result of ... ...

Abstract	Non-steroidal anti-inflammatory drugs (NSAIDs) can produce diaphragm disease where multiple strictures develop in the small bowel. This typically presents with anaemia and symptoms of small bowel obstruction. The strictures develop as a result of circumferential mucosal ulceration with subsequent contraction of rings of scar tissue. We report a case of a 47-year-old woman with a 6-month history of NSAIDs abuse who presented with subacute small bowel obstruction 1 year after stopping NSAIDs. CT and MRI showed multiple ileal strictures with florid locoregional lymphadenopathy. A malignant diagnosis such as lymphoma was considered likely as florid mesenteric lymphadenopathy has not been previously reported in diaphragm disease. Laparotomy with small bowel resection was therefore performed. Histology showed diaphragm disease with the enlarged mesenteric nodes having reactive features. Gross locoregional lymphadenopathy should not deter a diagnosis of diaphragm disease in cases of multiple small bowel strictures where there is a strong history of NSAIDs use.
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Constriction, Pathologic/diagnosis ; Diaphragm/pathology ; Female ; Humans ; Ileal Diseases/diagnosis ; Intestinal Obstruction/diagnosis ; Intestinal Obstruction/surgery ; Intestine, Small/pathology ; Intestine, Small/surgery ; Laparotomy ; Middle Aged ; Substance-Related Disorders/complications
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2015-07-14
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2015-210174
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Article ; Online: Transperitoneal Enucleation of a Kidney Transplant Allograft Renal Cell Carcinoma.

Sarantitis, Ioannis / Pararajasingam, Ravi / Forgacs, Bence / Denley, Helen / Wood, Grahame / Augustine, Titus

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2016 Volume 16, Issue 5, Page(s) 614–616

Abstract: Development of malignancy after solid-organ trans?lant is a well-known long-term complication of immunosuppressive therapy. Thus far, there are no specific oncologic recommendations regarding management of de novo tumors in transplanted kidneys. Here, we ...

Abstract	Development of malignancy after solid-organ trans?lant is a well-known long-term complication of immunosuppressive therapy. Thus far, there are no specific oncologic recommendations regarding management of de novo tumors in transplanted kidneys. Here, we present the case of a 63-year-old male patient who developed a de novo renal cell carcinoma 6 years after the transplant procedure. The patient underwent nephron-sparing surgery with transperitoneal enucleation of the tumor. We discuss the decision-making process and the operative challenges that we faced. We conclude that this technique should be considered as a therapeutic strategy for selected patients so that transplant nephrectomy can be avoided.
MeSH term(s)	Allografts ; Carcinoma, Renal Cell/chemically induced ; Carcinoma, Renal Cell/immunology ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/surgery ; Clinical Decision-Making ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/surgery ; Kidney Neoplasms/chemically induced ; Kidney Neoplasms/immunology ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Organ Sparing Treatments ; Risk Factors ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2016-11-18
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2016.0037
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Zs.A 6632: Show issues

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Article ; Online: Natural history of SPINK1 germline mutation related-pancreatitis.

Muller, Nelly / Sarantitis, Ioannis / Rouanet, Marie / de Mestier, Louis / Halloran, Christopher / Greenhalf, William / Férec, Claude / Masson, Emmanuelle / Ruszniewski, Philippe / Lévy, Philippe / Neoptolemos, John / Buscail, Louis / Rebours, Vinciane

EBioMedicine

2019 Volume 48, Page(s) 581–591

Abstract: Background: The aim was to describe genetic, clinical and morphological features in a large, multicentre European cohort of patients with SPINK1 related pancreatitis, in comparison with patients with idiopathic pancreatitis (IP).: Methods: All SPINK1 ...

Abstract	Background: The aim was to describe genetic, clinical and morphological features in a large, multicentre European cohort of patients with SPINK1 related pancreatitis, in comparison with patients with idiopathic pancreatitis (IP). Methods: All SPINK1 mutation carriers with pancreatic symptoms from two French and one English centers were included. Patients with IP were included in a control group. Genetic, clinical, radiological and biochemical data were collected. Findings: 209 and 302 patients were included in the SPINK1 and control groups (median follow-up: 8.3 years (3.7-17.4) vs 5.3 (2.5-8.8)). The median age at onset of symptoms was 20.1 years (17.5-22.8) in the SPINK1 group versus 41.2 (35.2-45.2). The age of exocrine pancreatic insufficiency (EPI) onset in the SPINK1 group was 49.5 (44.5-54.6) years vs. 65.2 (62.1-68.3), p < 0.001. SPINK1 patients with EPI were 5.3%, 14.7%, 28.3% and 52.4% at 20, 30, 40 and 50 years. Diabetes occurred 37.7 (33.3-42.1) years following the onset of symptoms in the SPINK1 group vs. 30.6 (17.3-43.8) (p = 0.002). SPINK1 patients with diabetes were 7.8%, 13.4%, 26.3% and 43.4% at 30, 40, 50 and 60 years. Seven patients (3.3%) developed pancreatic cancer in the SPINK1 group (versus 3 (0.99%), p = 0.1), at a median age of 60 vs 66 years. The cancer risk was 0.8% before 50 years, 11.9%, 27.7%, 51.8% at 60, 70 and 80 years and was 12 times higher than in controls (Cox HR 12.0 (3.0-47.8), p < 0.001). Interpretation: SPINK1 related pancreatitis is associated with earlier onset and pancreatic insufficiencies. p.N34S SPINK1 may well be associated with cancer.
MeSH term(s)	Adolescent ; Adult ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Genotype ; Germ-Line Mutation ; Humans ; Incidence ; Male ; Middle Aged ; Mutation ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/etiology ; Pancreatitis/epidemiology ; Pancreatitis/genetics ; Trypsin Inhibitor, Kazal Pancreatic/genetics ; Young Adult
Chemical Substances	SPINK1 protein, human ; Trypsin Inhibitor, Kazal Pancreatic (50936-63-5)
Language	English
Publishing date	2019-10-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2019.09.032
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Zs.A 7090: Show issues

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Article ; Online: Variation in training requirements within general surgery: comparison of 23 countries.

Whewell, H / Brown, C / Gokani, V J / Harries, R L / Aguilera, M L / Ahrend, H / Al Qallaf, A / Ansell, J / Beamish, A / Borraez-Segura, B / Di Candido, F / Chan, D / Govender, T / Grass, F / Gupta, A K / Dae Han, Y / Jensen, K K / Kusters, M / Wing Lam, K /

Machila, M / Marquardt, C / Moore, I / Ovaere, S / Park, H / Premaratne, C / Sarantitis, I / Sethi, H / Singh, R / Yonkus, J

BJS open

2020 Volume 4, Issue 4, Page(s) 714–723

Abstract: Background: Many differences exist in postgraduate surgical training programmes worldwide. The aim of this study was to provide an overview of the training requirements in general surgery across 23 different countries.: Methods: A collaborator ... ...

Abstract	Background: Many differences exist in postgraduate surgical training programmes worldwide. The aim of this study was to provide an overview of the training requirements in general surgery across 23 different countries. Methods: A collaborator affiliated with each country collected data from the country's official training body website, where possible. The information collected included: management, teaching, academic and operative competencies, mandatory courses, years of postgraduate training (inclusive of intern years), working-hours regulations, selection process into training and formal examination. Results: Countries included were Australia, Belgium, Canada, Colombia, Denmark, Germany, Greece, Guatemala, India, Ireland, Italy, Kuwait, the Netherlands, New Zealand, Russia, Saudi Arabia, South Africa, South Korea, Sweden, Switzerland, UK, USA and Zambia. Frameworks for defining the outcomes of surgical training have been defined nationally in some countries, with some similarities to those in the UK and Ireland. However, some training programmes remain heterogeneous with regional variation, including those in many European countries. Some countries outline minimum operative case requirement (range 60-1600), mandatory courses, or operative, academic or management competencies. The length of postgraduate training ranges from 4 to 10 years. The maximum hours worked per week ranges from 38 to 88 h, but with no limit in some countries. Conclusion: Countries have specific and often differing requirements of their medical profession. Equivalence in training is granted on political agreements, not healthcare need or competencies acquired during training.
Language	English
Publishing date	2020-06-11
Publishing country	England
Document type	Journal Article
ISSN	2474-9842
ISSN (online)	2474-9842
DOI	10.1002/bjs5.50293
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Article ; Online: Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer.

Sheel, A R G / Harrison, S / Sarantitis, I / Nicholson, J A / Hanna, T / Grocock, C / Raraty, M / Ramesh, J / Farooq, A / Costello, E / Jackson, R / Chapman, M / Smith, A / Carter, R / Mckay, C / Hamady, Z / Aithal, G P / Mountford, R / Ghaneh, P /

Hammel, P / Lerch, M M / Halloran, C / Pereira, S P / Greenhalf, W

The American journal of gastroenterology

2018 Volume 114, Issue 1, Page(s) 155–164

Abstract: Objectives: Intraductal papillary mucinous neoplasms (IPMNs) are associated with risk of pancreatic ductal adenocarcinoma (PDAC). It is unclear if an IPMN in individuals at high risk of PDAC should be considered as a positive screening result or as an ... ...

Abstract	Objectives: Intraductal papillary mucinous neoplasms (IPMNs) are associated with risk of pancreatic ductal adenocarcinoma (PDAC). It is unclear if an IPMN in individuals at high risk of PDAC should be considered as a positive screening result or as an incidental finding. Stratified familial pancreatic cancer (FPC) populations were used to determine if IPMN risk is linked to familial risk of PDAC. Methods: This is a cohort study of 321 individuals from 258 kindreds suspected of being FPC and undergoing secondary screening for PDAC through the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC). Computerised tomography, endoscopic ultrasound of the pancreas and magnetic resonance imaging were used. The risk of being a carrier of a dominant mutation predisposing to pancreatic cancer was stratified into three even categories (low, medium and high) based on: Mendelian probability, the number of PDAC cases and the number of people at risk in a kindred. Results: There was a median (interquartile range (IQR)) follow-up of 2 (0-5) years and a median (IQR) number of investigations per participant of 4 (2-6). One PDAC, two low-grade neuroendocrine tumours and 41 cystic lesions were identified, including 23 IPMN (22 branch-duct (BD)). The PDAC case occurred in the top 10% of risk, and the BD-IPMN cases were evenly distributed amongst risk categories: low (6/107), medium (10/107) and high (6/107) (P = 0.63). Conclusions: The risk of finding BD-IPMN was independent of genetic predisposition and so they should be managed according to guidelines for incidental finding of IPMN.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma/epidemiology ; Carcinoma/genetics ; Carcinoma/pathology ; Cohort Studies ; Early Detection of Cancer ; Europe/epidemiology ; Family ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Pedigree ; Registries ; Risk Factors ; Young Adult
Language	English
Publishing date	2018-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.1038/s41395-018-0395-y
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Article ; Online: The cytoskeleton of the cardiac muscle cell.

Sarantitis, Ioannis / Papanastasopoulos, Panagiotis / Manousi, Maria / Baikoussis, Nikolaos G / Apostolakis, Efstratios

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2012 Volume 53, Issue 5, Page(s) 367–379

MeSH term(s)	Cytoskeleton/physiology ; Cytoskeleton/ultrastructure ; Humans ; Intermediate Filament Proteins/physiology ; Mechanotransduction, Cellular/physiology ; Microscopy, Electron ; Myocytes, Cardiac/physiology ; Myocytes, Cardiac/ultrastructure ; Organelles/physiology ; Sarcolemma/physiology ; Signal Transduction/physiology
Chemical Substances	Intermediate Filament Proteins
Language	English
Publishing date	2012-09-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
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Article ; Online: Safety of magnetic resonance imaging in patients with implanted cardiac prostheses and metallic cardiovascular electronic devices.

Baikoussis, Nikolaos G / Apostolakis, Efstratios / Papakonstantinou, Nikolaos A / Sarantitis, Ioannis / Dougenis, Dimitrios

The Annals of thoracic surgery

2011 Volume 91, Issue 6, Page(s) 2006–2011

Abstract: Magnetic resonance imaging (MRI) in patients with implanted cardiac prostheses and metallic cardiovascular electronic devices is sometimes a risky procedure. Thus MRI in these patients should be performed when it is the only examination able to help with ...

Abstract	Magnetic resonance imaging (MRI) in patients with implanted cardiac prostheses and metallic cardiovascular electronic devices is sometimes a risky procedure. Thus MRI in these patients should be performed when it is the only examination able to help with the diagnosis. Moreover the diagnostic benefit must outweigh the risks. Coronary artery stents, prosthetic cardiac valves, metal sternal sutures, mediastinal vascular clips, and epicardial pacing wires are not contraindications for MRI, in contrast to pacemakers and implantable cardioverter-defibrillators. Appropriate patient selection and precautions ensure MRI safety. However it is commonly accepted that although hundreds of patients with pacemakers or implantable cardioverter-defibrillators have undergone safe MRI scanning, it is not a safe procedure. Currently, heating of the pacemaker lead is the major problem undermining MRI safety. According to the US Food and Drug Administration (FDA), there are currently neither "MRI-safe" nor "MRI-compatible" pacemakers and implantable cardioverter-defibrillators. In this article we review the international literature in regard to safety during MRI of patients with implanted cardiac prostheses and metallic cardiovascular electronic devices.
MeSH term(s)	Angioplasty, Balloon, Coronary ; Defibrillators, Implantable ; Heart Valve Prosthesis ; Humans ; Magnetic Resonance Imaging/adverse effects ; Pacemaker, Artificial ; Stents
Language	English
Publishing date	2011-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2011.02.068
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Article ; Online: The diagnostic value of Rosemont and Japanese diagnostic criteria for 'indeterminate', 'suggestive', 'possible' and 'early' chronic pancreatitis.

Sheel, Andrea R G / Baron, Ryan D / Sarantitis, Ioannis / Ramesh, Jayapal / Ghaneh, Paula / Raraty, Michael G T / Yip, Vincent / Sutton, Robert / Goulden, Michael R / Campbell, Fiona / Farooq, Ammad / Healey, Priya / Jackson, Richard / Halloran, Christopher M / Neoptolemos, John P

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

2018 Volume 18, Issue 7, Page(s) 774–784

Abstract: Background: Longitudinal data are lacking to support consensus criteria for diagnosing early chronic pancreatitis.: Methods: Retrospective single centre study of the initial evidence for chronic pancreatitis (CP), with reassessment after follow-up ( ... ...

Abstract	Background: Longitudinal data are lacking to support consensus criteria for diagnosing early chronic pancreatitis. Methods: Retrospective single centre study of the initial evidence for chronic pancreatitis (CP), with reassessment after follow-up (January 2003-November 2016). Results: 807 patients were previously diagnosed with chronic pancreatitis. This diagnosis was rejected in 118 patients: 52 had another pathology altogether, the remaining 66 patients formed the study population. 38 patients with 'normal' imaging were reclassified as chronic abdominal pain syndrome (CAPS), and 28 patients had minimal change features of CP on EUS (MCEUS) but never progressed. Strict application of the Japanese diagnostic criteria would diagnose only two patients with early CP and eleven as possible CP. Patients were more likely to have MCEUS if the EUS was performed within 12 months of an attack of acute pancreatitis. 40 patients with MCEUS were identified, including an additional 12 who progressed to definite CP after a median of 30 (18.75-36.5) months. Those continuing to consume excess alcohol and/or continued smoking were significantly more likely to progress. Those who progressed were more likely to develop pancreatic exocrine insufficiency, require pancreatic surgery and had higher mortality. Conclusion: There needs to be more stringent application of the systems used for diagnosing chronic pancreatitis with revision of the current terminology 'indeterminate', 'suggestive', 'possible', and 'early' chronic pancreatitis. All patients with MCEUS features of CP require ongoing clinical follow up of at least 30 months and all patients with these features should be strongly counselled regarding smoking cessation and abstinence from alcohol.
MeSH term(s)	Adult ; Endosonography ; Female ; Humans ; Male ; Middle Aged ; Pancreas/pathology ; Pancreatitis, Chronic/diagnosis ; Pancreatitis, Chronic/diagnostic imaging ; Risk Factors ; Severity of Illness Index
Language	English
Publishing date	2018-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2056680-3
ISSN	1424-3911 ; 1424-3903
ISSN (online)	1424-3911
ISSN	1424-3903
DOI	10.1016/j.pan.2018.08.002
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