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  1. Article: A Review Study on the Trends of Psychological Challenges, Coping Ways, and Public Support During the COVID-19 Pandemic in the Vulnerable Populations in the United States.

    Kumar, Rakesh / Singh, Anand / Mishra, Rahul / Saraswati, Ushasi / Bhalla, Jaideep / Pagali, Sandeep

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 920581

    Abstract: Background: The COVID-19 pandemic resulted in significant mortality and morbidity in the United States. The mental health impact during the pandemic was huge and affected all age groups and population types. We reviewed the existing literature to ... ...

    Abstract Background: The COVID-19 pandemic resulted in significant mortality and morbidity in the United States. The mental health impact during the pandemic was huge and affected all age groups and population types. We reviewed the existing literature to understand the present trends of psychological challenges and different coping strategies documented across different vulnerable sections of the United States population. This rapid review was carried out to investigate the trends in psychological impacts, coping ways, and public support during the COVID-19 pandemic crisis in the United States.
    Materials and methods: We undertook a rapid review of the literature following the COVID-19 pandemic in the United States. We searched PubMed as it is a widely available database for observational and experimental studies that reported the psychological effects, coping ways, and public support on different age groups and healthcare workers (HCWs) during the COVID-19 pandemic.
    Results: We included thirty-five studies in our review and reported data predominantly from the vulnerable United States population. Our review findings indicate that COVID-19 has a considerable impact on the psychological wellbeing of various age groups differently, especially in the elderly population and HCWs. Review findings suggest that factors like children, elderly population, female gender, overconcern about family, fear of getting an infection, personality, low spirituality, and lower resilience levels were at a higher risk of adverse mental health outcomes during this pandemic. Systemic support, higher resilience levels, and adequate knowledge were identified as protecting and preventing factors. There is a paucity of similar studies among the general population, and we restricted our review specifically to vulnerable subgroups of the population. All the included studies in our review investigated and surveyed the psychological impacts, coping skills, and public support system during the COVID-19 pandemic.
    Conclusion: The evidence to date suggests that female gender, child and elderly population, and racial factors have been affected by a lack of support for psychological wellbeing. Further, research using our hypothesized framework might help any population group to deal with a pandemic-associated mental health crisis, and in that regard, analysis of wider societal structural factors is recommended.
    Language English
    Publishing date 2022-07-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.920581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Household secondary attack rate in mild COVID-19.

    Narayan, Ananthu / Saraswati, Ushasi / Kaur, Ishmeet / Kumari, Aakansha / Kumar, Arvind / Vishwakarma, Vishal Kumar / Kumar, Upendra / Sahoo, Vishwajeet / Wig, Naveet

    Journal of family medicine and primary care

    2023  Volume 12, Issue 4, Page(s) 743–747

    Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has reached a staggering number of almost 280 million cases worldwide, with over 5.4 million deaths as of 29 December 2021. A further understanding of the factors related to the household ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has reached a staggering number of almost 280 million cases worldwide, with over 5.4 million deaths as of 29 December 2021. A further understanding of the factors related to the household spread of the infection might help to bring about specific protocols to curb such transmission.
    Objective: This study aims to find the secondary attack rate (SAR) and factors affecting SAR among the households of mild COVID-19 cases.
    Methods: An observational study was designed where data of patients admitted at All India Institute of Medical Sciences, New Delhi due to mild COVID-19 were collected, and outcome was noted after the discharge of the patient. Index cases who were the first in the household to have a positive infection only were included. Based on these data, the overall household SAR, factors related to the index case and contacts that affected transmissibility were noted.
    Results: A total of 60 index cases having contacts with 184 household members were included in the present study. The household SAR was measured to be 41.85%. At least one positive case was present in 51.67% households. Children below 18 years old had lower odds of getting a secondary infection compared to adults and elderly [odds ratio (OR) = 0.46, 95%CI = 0.22-0.94, p = 0.0383). An exposure period of more than a week was significantly associated with a higher risk of infection (p = 0.029). The rate of transmissibility drastically declined with effective quarantine measures adopted by the index case (OR = 0.13, 95%CI = 0.06-0.26, p < 0.00001). Symptomatic index cases contributed more to the SAR than asymptomatic primaries (OR = 4.74, 95%CI = 1.03-21.82,
    Conclusion: The high SAR shows the household is a potential high-risk unit for transmissibility of COVID-19. Proper quarantine measures of all those exposed to the index case can mitigate such spread and lead to reduction of risk of COVID-19 within a household.
    Language English
    Publishing date 2023-04-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_156_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Prevalence, sex differences, and implications of pulmonary hypertension in patients with apical hypertrophic cardiomyopathy.

    Anand, Vidhu / Covington, Megan K / Saraswati, Ushasi / Scott, Christopher G / Lee, Alexander T / Frantz, Robert P / Anavekar, Nandan S / Geske, Jeffrey B / Arruda-Olson, Adelaide M / Klarich, Kyle W

    Frontiers in cardiovascular medicine

    2024  Volume 10, Page(s) 1288747

    Abstract: Introduction: Apical hypertrophic cardiomyopathy (ApHCM) is a subtype of hypertrophic cardiomyopathy (HCM) that affects up to 25% of Asian patients and is not as well understood in non-Asian patients. Although ApHCM has been considered a more "benign" ... ...

    Abstract Introduction: Apical hypertrophic cardiomyopathy (ApHCM) is a subtype of hypertrophic cardiomyopathy (HCM) that affects up to 25% of Asian patients and is not as well understood in non-Asian patients. Although ApHCM has been considered a more "benign" variant, it is associated with increased risk of atrial and ventricular arrhythmias, apical thrombi, stroke, and progressive heart failure. The occurrence of pulmonary hypertension (PH) in ApHCM, due to elevated pressures on the left side of the heart, has been documented. However, the exact prevalence of PH in ApHCM and sex differences remain uncertain.
    Methods: We sought to evaluate the prevalence, risk associations, and sex differences in elevated pulmonary pressures in the largest cohort of patients with ApHCM at a single tertiary center. A total of 542 patients diagnosed with ApHCM were identified using ICD codes and clinical notes searches, confirmed by cross-referencing with cardiac MRI reports extracted through Natural Language Processing and through manual evaluation of patient charts and imaging records.
    Results: In 414 patients, echocardiogram measurements of pulmonary artery systolic pressure (PASP) were obtained at the time of diagnosis. The mean age was 59.4 ± 16.6 years, with 181 (44%) being females. The mean PASP was 38 ± 12 mmHg in females vs. 33 ± 9 mmHg in males (
    Conclusion: PH was present in 34% of patients with ApHCM at diagnosis, with female sex predominance. PH in ApHCM was associated with symptoms and increased mortality.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1288747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Invasive Cardiac Hemodynamics in Apical Hypertrophic Cardiomyopathy.

    Malik, Awais A / Saraswati, Ushasi / Miranda, William R / Covington, Megan / Scott, Christopher G / Lee, Alex T / Arruda-Olson, Adelaide / Geske, Jeffrey B / Klarich, Kyle W / Anand, Vidhu

    Journal of the American Heart Association

    2024  , Page(s) e032520

    Abstract: Background: Symptomatic limitations in apical hypertrophic cardiomyopathy may occur because of diastolic dysfunction with resultant elevated left ventricular filling pressures, cardiac output limitation to exercise, pulmonary hypertension (PH), valvular ...

    Abstract Background: Symptomatic limitations in apical hypertrophic cardiomyopathy may occur because of diastolic dysfunction with resultant elevated left ventricular filling pressures, cardiac output limitation to exercise, pulmonary hypertension (PH), valvular abnormalities, and/or arrhythmias. In this study, the authors aimed to describe invasive cardiac hemodynamics in a cohort of patients with apical hypertrophic cardiomyopathy.
    Methods and results: Patients presenting to a comprehensive hypertrophic cardiomyopathy center with apical hypertrophic cardiomyopathy were identified (n=542) and those who underwent invasive hemodynamic catheterization (n=47) were included in the study. Of these, 10 were excluded due to postmyectomy status or incomplete hemodynamic data. The mean age was 56±18 years, 16 (43%) were women, and ejection fraction was preserved (≥50%) in 32 (91%) patients. The most common indication for catheterization was dyspnea (48%) followed by suspected PH (13%), and preheart transplant evaluation (10%). Elevated left ventricular filling pressures at rest or exercise were present in 32 (86%) patients. PH was present in 30 (81%) patients, with 6 (20%) also having right-sided heart failure. Cardiac index was available in 25 (86%) patients with elevated resting filling pressures. Of these, 19 (76%) had reduced cardiac index and all 6 with right-sided heart failure had reduced cardiac index. Resting hemodynamics were normal in 8 of 37 (22%) patients, with 5 during exercise; 3 of 5 (60%) patients had exercise-induced elevation in left ventricular filling pressures.
    Conclusions: In patients with apical hypertrophic cardiomyopathy undergoing invasive hemodynamic cardiac catheterization, 86% had elevated left ventricular filling pressures at rest or with exercise, 81% had PH, and 20% of those with PH had concomitant right-sided heart failure.
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.032520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Gastrointestinal treatment-related adverse events of combined immune checkpoint inhibitors: a meta-analysis.

    Karna, Rahul / S Deliwala, Smit / Ramgopal, Balasubramanian / Asawa, Palash / Mishra, Rahul / P Mohan, Babu / Jayakrishnan, Thejus / Grover, Dheera / Kalra, Tanisha / Bhalla, Jaideep / Saraswati, Ushasi / K Gangwani, Manesh / Dhawan, Manish / G Adler, Douglas

    Immunotherapy

    2023  Volume 15, Issue 10, Page(s) 773–786

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Neoplasms/drug therapy ; Diarrhea ; Colon
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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