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Article ; Online: Revisiting the disease specificity and nomenclature of ficolin-1-positive monocyte-derived dendritic cells in diffuse cutaneous systemic sclerosis: comment on the article by Xue et al.

Sarfati, Marika / Chapuy, Laurence / Mehta, Heena

Arthritis & rheumatology (Hoboken, N.J.)

2022 Volume 74, Issue 10, Page(s) 1721–1722

MeSH term(s)	Dendritic Cells ; Humans ; Lectins ; Monocytes ; Scleroderma, Diffuse ; Scleroderma, Systemic ; Ficolins
Chemical Substances	Lectins
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42247
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Article ; Online: Single-Cell Protein and RNA Expression Analysis of Mononuclear Phagocytes in Intestinal Mucosa and Mesenteric Lymph Nodes of Ulcerative Colitis and Crohn's Disease Patients.

Chapuy, Laurence / Sarfati, Marika

Cells

2020 Volume 9, Issue 4

Abstract: Inflammatory bowel diseases (IBDs), which include Crohn's disease (CD) and ulcerative colitis (UC), are driven by an abnormal immune response to commensal microbiota in genetically susceptible hosts. In addition to epithelial and stromal cells, innate ... ...

Abstract	Inflammatory bowel diseases (IBDs), which include Crohn's disease (CD) and ulcerative colitis (UC), are driven by an abnormal immune response to commensal microbiota in genetically susceptible hosts. In addition to epithelial and stromal cells, innate and adaptive immune systems are both involved in IBD immunopathogenesis. Given the advances driven by single-cell technologies, we here reviewed the immune landscape and function of mononuclear phagocytes in inflamed non-lymphoid and lymphoid tissues of CD and UC patients. Immune cell profiling of IBD tissues using scRNA sequencing combined with multi-color cytometry analysis identifies unique clusters of monocyte-like cells, macrophages, and dendritic cells. These clusters reflect either distinct cell lineages (nature), or distinct or intermediate cell types with identical ontogeny, adapting their phenotype and function to the surrounding milieu (nurture and tissue imprinting). These advanced technologies will provide an unprecedented view of immune cell networks in health and disease, and thus may offer a personalized medicine approach to patients with IBD.
MeSH term(s)	Colitis, Ulcerative/genetics ; Crohn Disease/genetics ; Humans ; Intestinal Mucosa/pathology ; Lymph Nodes/pathology ; Phagocytes/metabolism ; Proteins/genetics ; Proteins/metabolism ; RNA/metabolism ; Single-Cell Analysis
Chemical Substances	Proteins ; RNA (63231-63-0)
Language	English
Publishing date	2020-03-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9040813
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Article ; Online: The Conversion of Human Tissue-Like Inflammatory Monocytes Into Macrophages.

Bsat, Marwa / Mehta, Heena / Rubio, Manuel / Sarfati, Marika

Current protocols

2021 Volume 1, Issue 3, Page(s) e74

Abstract: Classical circulating ... ...

Abstract	Classical circulating LyC6
MeSH term(s)	Animals ; Cell Differentiation ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Humans ; Interferon-gamma ; Macrophages ; Mice ; Monocytes
Chemical Substances	Interferon-gamma (82115-62-6) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article
ISSN	2691-1299
ISSN (online)	2691-1299
DOI	10.1002/cpz1.74
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Article ; Online: Oral prednisone regulates human skin T cells in delayed‐type hypersensitivity reaction elicited by diphencyprone

Mehta, Heena / Jack, Carolyn / Maari, Catherine / Proulx, Étienne Saint‐Cyr / Bissonnette, Robert / Ramirez‐Valle, Francisco / Sarfati, Marika

Allergy. 2023 Aug., v. 78, no. 8, p. 2255-2265

2023 , Page(s) 2255–2265

Abstract: BACKGROUND: The potential benefit of inducing delayed‐type hypersensitivity (DTH) reaction in healthy volunteers (HVs) as experimental models to study skin inflammatory disorders was recently reported using bulk molecular technologies. Immunophenotype of ...

Abstract	BACKGROUND: The potential benefit of inducing delayed‐type hypersensitivity (DTH) reaction in healthy volunteers (HVs) as experimental models to study skin inflammatory disorders was recently reported using bulk molecular technologies. Immunophenotype of skin T cells, including cellular source of Type 1, 2, and 3 cytokines, in a local DTH reaction and their modulation by oral drugs remain to be investigated. METHOD: Purified protein derivative (PPD), nickel, diphencyprone (DPCP), or house dust mite (HDM) was administered as sensitizer to 40 HVs. In addition, 20 HVs were randomized to receive oral prednisone or placebo before DPCP challenge. We characterized the immunophenotype and cytokine profile of CD3⁺ T cell infiltrate, and examined the modulation by oral prednisone at single‐cell level using multiparameter flow cytometry and unsupervised analysis. RESULTS: PPD was biased toward a Th1 and Tc1 response, and HDM a Th2/Th17 and Tc2. Nickel and DPCP displayed a mixed Th1/Th2/Th17 and Tc1 response. CD4⁺CD25⁺FoxP3⁺ regulatory T cells (Tregs), the minor CD4⁺CD25⁺FoxP3⁻ICOS⁺PD‐1⁺ (activated PD‐1⁺ Th), and CD103⁺ tissue resident memory (TRM) cells were detected in all groups. DPCP uniquely elicited rare CD8⁺CD103⁺CD25⁺RoRγt⁺PD‐1⁺ICOS⁺IFNγ⁺ T cells (activated CD8⁺IFNγ⁺PD‐1⁺ TRM). Oral prednisone decreased frequencies of activated PD‐1⁺ Th and CD8⁺IFNγ⁺PD‐1⁺ TRM subsets relative to placebo in DPCP reaction. The latter was positively correlated with improvement of clinical parameters with prednisone. CONCLUSION: DTH and skin CD3⁺ T cell profiles elicited by common sensitizers can be modulated by oral drugs. Corticosteroids reduce the frequencies of activated PD‐1⁺ Th and CD8⁺IFNγ⁺PD‐1⁺ TRM cells after DPCP exposure.
Keywords	T-lymphocytes ; adrenal cortex hormones ; cytokines ; delayed hypersensitivity ; dust mites ; flow cytometry ; immunophenotype ; memory ; nickel ; placebos ; prednisone ; skin (animal)
Language	English
Dates of publication	2023-08
Size	p. 2255-2265
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15764
Database	NAL-Catalogue (AGRICOLA)

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Uh III Zs.150: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 125: Show issues

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Article ; Online: A two-step human culture system replicates intestinal monocyte maturation cascade: Conversion of tissue-like inflammatory monocytes into macrophages.

Bsat, Marwa / Chapuy, Laurence / Rubio, Manuel / Sarfati, Marika

European journal of immunology

2020 Volume 50, Issue 11, Page(s) 1676–1690

Abstract: Monocyte maturation program into macrophages (MΦ) is well defined in murine gut under homeostatic or inflammatory conditions. Obviously, in vivo tracking of monocytes in inflamed tissues remains difficult in humans. Furthermore, in vitro models fall ... ...

Abstract	Monocyte maturation program into macrophages (MΦ) is well defined in murine gut under homeostatic or inflammatory conditions. Obviously, in vivo tracking of monocytes in inflamed tissues remains difficult in humans. Furthermore, in vitro models fall short in generating the surrogates of transient extravasated tissue inflammatory monocytes. Here, we aimed to unravel environmental cues that replicated the human monocyte "waterfall" process in vitro by first, generating tissue-like inflammatory monocytes, which were then shifted toward MΦ. Purified CD14
MeSH term(s)	Animals ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Cell Differentiation/physiology ; Cells, Cultured ; Coculture Techniques/methods ; Colon/cytology ; Colon/metabolism ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-10/metabolism ; Lipopolysaccharide Receptors/metabolism ; Macrophages/cytology ; Macrophages/metabolism ; Mice ; Monocytes/cytology ; Monocytes/metabolism ; Receptors, Cell Surface/metabolism ; Th1 Cells/cytology ; Th1 Cells/metabolism ; Th17 Cells/cytology ; Th17 Cells/metabolism ; Transforming Growth Factor beta/metabolism
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD163 antigen ; Lipopolysaccharide Receptors ; Receptors, Cell Surface ; Transforming Growth Factor beta ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2020-06-29
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202048555
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

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Article ; Online: Oral prednisone regulates human skin T cells in delayed-type hypersensitivity reaction elicited by diphencyprone.

Mehta, Heena / Jack, Carolyn / Maari, Catherine / Proulx, Étienne Saint-Cyr / Bissonnette, Robert / Ramirez-Valle, Francisco / Sarfati, Marika

Allergy

2023 Volume 78, Issue 8, Page(s) 2255–2265

Abstract: Background: The potential benefit of inducing delayed-type hypersensitivity (DTH) reaction in healthy volunteers (HVs) as experimental models to study skin inflammatory disorders was recently reported using bulk molecular technologies. Immunophenotype ... ...

Abstract	Background: The potential benefit of inducing delayed-type hypersensitivity (DTH) reaction in healthy volunteers (HVs) as experimental models to study skin inflammatory disorders was recently reported using bulk molecular technologies. Immunophenotype of skin T cells, including cellular source of Type 1, 2, and 3 cytokines, in a local DTH reaction and their modulation by oral drugs remain to be investigated. Method: Purified protein derivative (PPD), nickel, diphencyprone (DPCP), or house dust mite (HDM) was administered as sensitizer to 40 HVs. In addition, 20 HVs were randomized to receive oral prednisone or placebo before DPCP challenge. We characterized the immunophenotype and cytokine profile of CD3 Results: PPD was biased toward a Th1 and Tc1 response, and HDM a Th2/Th17 and Tc2. Nickel and DPCP displayed a mixed Th1/Th2/Th17 and Tc1 response. CD4 Conclusion: DTH and skin CD3
MeSH term(s)	Humans ; Prednisone/therapeutic use ; Programmed Cell Death 1 Receptor ; Nickel ; Forkhead Transcription Factors/metabolism
Chemical Substances	Prednisone (VB0R961HZT) ; diphenylcyclopropenone (I7G14NW5EC) ; Programmed Cell Death 1 Receptor ; Nickel (7OV03QG267) ; Forkhead Transcription Factors
Language	English
Publishing date	2023-05-19
Publishing country	Denmark
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15764
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Uh III Zs.150: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 125: Show issues

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Article ; Online: Inflammatory Skin Disorders: Monocyte-Derived Cells Take Center Stage.

Mehta, Heena / Angsana, Julianty / Bissonnette, Robert / Muñoz-Elías, Ernesto J / Sarfati, Marika

Frontiers in immunology

2021 Volume 12, Page(s) 691806

MeSH term(s)	Humans ; Inflammation/immunology ; Mononuclear Phagocyte System/immunology ; Skin Diseases/immunology
Language	English
Publishing date	2021-07-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.691806
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Article ; Online: Increased frequencies of basophils, type 2 innate lymphoid cells and Th2 cells in skin of patients with atopic dermatitis but not psoriasis.

Mashiko, Shunya / Mehta, Heena / Bissonnette, Robert / Sarfati, Marika

Journal of dermatological science

2017 Volume 88, Issue 2, Page(s) 167–174

Abstract: Background: Pathogenesis of atopic dermatitis (AD) involves interaction between type 2 cells that include basophils, mast cells, innate lymphoid type 2 cells (ILC2), and Th2 cells. Levels of IL-4 and IL-13 are elevated in AD patients.: Objective: ... ...

Abstract	Background: Pathogenesis of atopic dermatitis (AD) involves interaction between type 2 cells that include basophils, mast cells, innate lymphoid type 2 cells (ILC2), and Th2 cells. Levels of IL-4 and IL-13 are elevated in AD patients. Objective: Here, we investigated the distribution of type 2 cells and the source of IL-4 and IL-13 in skin and blood of AD relative to psoriasis. Methods: Lesional skin biopsies and blood were collected from patients. Skin cell suspensions were prepared by mild enzymatic digestion and mechanical dissociation. IL-4 and IL-13 expression was analyzed at single-cell level before or after stimulation using flow cytometry. Results: Frequencies of basophils, ILC2 and Th2 but not mast cells were significantly elevated in skin, and not blood, of AD relative to psoriasis. IL-4 production by circulating basophils and Th2 cells, and IL-13 by ILCs and Th2 cells was similar in both diseases. In contrast, skin T cells expressed IL-4 and IL-13 prior to stimulation in AD when compared to psoriasis. Moreover, skin basophils, which were detected in AD only, expressed IL-4 following stimulation. Interestingly, basophils and ILC2 were positively correlated in skin, whereas skin basophils were inversely correlated with blood ILC2. Conclusions: Lesional AD skin harbors a distinctive innate and adaptive type 2 profile, which is characterized by basophils producing IL-4, Th2 cells expressing IL-4 or IL-13, and ILC2. This underlies the therapeutic efficacy of targeting IL-4 and IL-13 signaling pathways in AD.
MeSH term(s)	Adult ; Basophils/immunology ; Basophils/metabolism ; Biopsy ; Dermatitis, Atopic/blood ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/pathology ; Female ; Flow Cytometry ; Humans ; Immunity, Innate ; Interleukin-13/metabolism ; Interleukin-13/secretion ; Interleukin-4/metabolism ; Interleukin-4/secretion ; Male ; Middle Aged ; Psoriasis/blood ; Psoriasis/immunology ; Psoriasis/pathology ; Signal Transduction ; Skin/cytology ; Skin/immunology ; Skin/pathology ; Th2 Cells/immunology ; Th2 Cells/metabolism ; Th2 Cells/secretion ; Young Adult
Chemical Substances	IL4 protein, human ; Interleukin-13 ; Interleukin-4 (207137-56-2)
Language	English
Publishing date	2017-11
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	1024446-3
ISSN	1873-569X ; 0923-1811
ISSN (online)	1873-569X
ISSN	0923-1811
DOI	10.1016/j.jdermsci.2017.07.003
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Zs.A 2870: Show issues

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Article: Mutual Interaction of Basophils and T Cells in Chronic Inflammatory Diseases.

Sarfati, Marika / Wakahara, Keiko / Chapuy, Laurence / Delespesse, Guy

Frontiers in immunology

2015 Volume 6, Page(s) 399

Abstract: Basophils are, together with mast cells, typical innate effector cells of allergen-induced IgE-dependent allergic diseases. Both cell types express the high-affinity receptor for IgE (FcεR1), release histamine, inflammatory mediators, and cytokines ... ...

Abstract	Basophils are, together with mast cells, typical innate effector cells of allergen-induced IgE-dependent allergic diseases. Both cell types express the high-affinity receptor for IgE (FcεR1), release histamine, inflammatory mediators, and cytokines following FcεR1 cross-linking. Basophils are rare granulocytes in blood, lymphoid, and non-lymphoid tissues, and the difficulties to detect and isolate these cells has hampered the study of their biology and the understanding of their possible role in pathology. Furthermore, the existence of other FcεR1-expressing cells, including professional Ag-presenting dendritic cells, generated some controversy regarding the ability of basophils to express MHC Class II molecules, present Ag and drive naïve T cell differentiation into Th2 cells. The focus of this review is to present the recent advances on the interactions between basophils and peripheral blood and tissue memory Th1, Th2, and Th17 cells, as well as their potential role in IgE-independent non-allergic chronic inflammatory disorders, including human inflammatory bowel diseases. Basophils interactions with the innate players of IgE-dependent allergic inflammation, particularly innate lymphoid cells, will also be considered. The previously unrecognized function for basophils in skewing adaptive immune responses opens novel perspectives for the understanding of their contribution to the pathogenesis of inflammatory diseases.
Language	English
Publishing date	2015
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2015.00399
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Article ; Online: Differential Pathogenic Th17 Profile in Mesenteric Lymph Nodes of Crohn's Disease and Ulcerative Colitis Patients.

Bsat, Marwa / Chapuy, Laurence / Rubio, Manuel / Wassef, Ramses / Richard, Carole / Schwenter, Frank / Loungnarath, Rasmy / Soucy, Geneviève / Mehta, Heena / Sarfati, Marika

Frontiers in immunology

2019 Volume 10, Page(s) 1177

Abstract: The drug targets IL23 and IL12 regulate pathogenicity and plasticity of intestinal Th17 cells in Crohn's disease (CD) and ulcerative colitis (UC), the two most common inflammatory bowel diseases (IBD). However, studies examining Th17 dysregulation in ... ...

Abstract	The drug targets IL23 and IL12 regulate pathogenicity and plasticity of intestinal Th17 cells in Crohn's disease (CD) and ulcerative colitis (UC), the two most common inflammatory bowel diseases (IBD). However, studies examining Th17 dysregulation in mesenteric lymph nodes (mLNs) of these patients are rare. We showed that in mLNs, CD could be distinguished from UC by increased frequencies of CCR6
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/immunology ; Crohn Disease/diagnosis ; Crohn Disease/genetics ; Crohn Disease/immunology ; Cytokines/genetics ; Cytokines/immunology ; Cytokines/metabolism ; Female ; Gene Expression Profiling/methods ; Humans ; Immunologic Memory/genetics ; Immunologic Memory/immunology ; Interleukin-17/genetics ; Interleukin-17/immunology ; Interleukin-17/metabolism ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Male ; Mesentery/immunology ; Middle Aged ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Young Adult
Chemical Substances	Cytokines ; Interleukin-17
Language	English
Publishing date	2019-05-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.01177
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