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Article ; Online: Asphyxiation caused by giant fibrovascular polyp of the esophagus.

Sargent, Rachel L / Hood, Ian C

Archives of pathology & laboratory medicine

2006 Volume 130, Issue 5, Page(s) 725–727

Abstract: Giant fibrovascular polyps of the esophagus are rare, benign, "tumorlike" lesions that typically present as large pedunculated growths arising in the cervical esophagus. The predominant histologic component of these lesions is variable, often resulting ... ...

Abstract	Giant fibrovascular polyps of the esophagus are rare, benign, "tumorlike" lesions that typically present as large pedunculated growths arising in the cervical esophagus. The predominant histologic component of these lesions is variable, often resulting in misdiagnosis. Clinically, these polyps present with nonspecific symptoms and are often undiagnosed or misdiagnosed until they are significant in size. Diagnosis is best made by upper endoscopic evaluation; surgical excision is the definitive treatment. Although rare, asphyxia resulting from obstruction of the glottis is the most serious complication. We describe a case of asphyxiation caused by laryngeal occlusion by a giant esophageal polyp and we provide a review of the literature.
MeSH term(s)	Airway Obstruction/etiology ; Asphyxia/etiology ; Biomarkers, Tumor/analysis ; Esophageal Neoplasms/chemistry ; Esophageal Neoplasms/complications ; Fatal Outcome ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Polyps/chemistry ; Polyps/complications
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2006-01-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/2006-130-725-ACBGFP
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Article: Comparison of Bcl-2, CD38 and ZAP-70 Expression in Chronic Lymphocytic Leukemia.

Sargent, Rachel L / Craig, Fiona E / Swerdlow, Steven H

International journal of clinical and experimental pathology

2009 Volume 2, Issue 6, Page(s) 574–582

Abstract: Chronic lymphocytic leukemia (CLL) was previously considered a uniform disease characterized by autonomous over-expression of bcl-2. Recently the pathogenic role of bcl-2 has been questioned and attention has turned to prognostic subtypes of CLL ... ...

Abstract	Chronic lymphocytic leukemia (CLL) was previously considered a uniform disease characterized by autonomous over-expression of bcl-2. Recently the pathogenic role of bcl-2 has been questioned and attention has turned to prognostic subtypes of CLL differing in CD38 and ZAP-70 expression. However, the relationship between bcl-2 and CD38 or ZAP-70 expression remains uncertain and was investigated using flow cytometric immunophenotyping of 50 CLL specimens. CLL cells were consistently bcl-2 positive but varied in expression level: mean fluorescence intensity (MFI) 45-152. Although there was no significant difference in bcl-2 expression between CD38 or ZAP-70 positive and negative specimens, an inverse correlation was identified between percentage of CD38 positive B-cells and bcl-2 MFI when all (p<0.03, r(2)=0.10) and peripheral blood (p<0.004, r(2)=0.27) samples were analyzed. While bcl-2 levels do not appear to be a major discriminator between indolent and more aggressive subtypes of CLL, CD38 and bcl-2 expression appear to be interrelated.
Language	English
Publishing date	2009-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2418306-4
ISSN	1936-2625
ISSN	1936-2625
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Article ; Online: Gilteritinib induces differentiation in relapsed and refractory

McMahon, Christine M / Canaani, Jonathan / Rea, Bryan / Sargent, Rachel L / Qualtieri, Julianne N / Watt, Christopher D / Morrissette, Jennifer J D / Carroll, Martin / Perl, Alexander E

Blood advances

2019 Volume 3, Issue 10, Page(s) 1581–1585

MeSH term(s)	Aniline Compounds/pharmacology ; Aniline Compounds/therapeutic use ; Cell Differentiation ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Pyrazines/pharmacology ; Pyrazines/therapeutic use ; Recurrence ; fms-Like Tyrosine Kinase 3/metabolism
Chemical Substances	Aniline Compounds ; Pyrazines ; gilteritinib ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
Language	English
Publishing date	2019-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2018029496
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Article ; Online: Molecular and clinicopathologic characterization of AML with isolated trisomy 4.

Bains, Ashish / Lu, Gary / Yao, Hui / Luthra, Rajalakshmi / Medeiros, L Jeffrey / Sargent, Rachel L

American journal of clinical pathology

2012 Volume 137, Issue 3, Page(s) 387–394

Abstract: Acute myeloid leukemia (AML) with isolated trisomy 4 is rare. Associations with KIT mutations on chromosome 4q12 have been documented. The clinicopathologic features and mutational status of KIT, FLT3, NPM1, CEBPA, and RAS were assessed in 13 AML cases ... ...

Abstract	Acute myeloid leukemia (AML) with isolated trisomy 4 is rare. Associations with KIT mutations on chromosome 4q12 have been documented. The clinicopathologic features and mutational status of KIT, FLT3, NPM1, CEBPA, and RAS were assessed in 13 AML cases with isolated trisomy 4. There were 9 men and 4 women with a median age of 54 years. Median blast count was 84% (range, 24%-93%). Morphologic features varied across five 2008 World Health Organization categories. FLT3 (5/10) and NPM1 (4/10) mutations were observed at a frequency similar to normal-karyotype AML cases. KIT D816V (1/10), RAS (1/11; NRAS), and CEBPA (0/9) mutations were rare or absent. In 11 of 13 cases, complete remission was achieved. In 8 cases, relapse occurred, with median relapse-free survival of 11 months. Median overall survival was 28 months. AML with isolated trisomy 4 is rare and associated with high bone marrow blast counts and an intermediate to poor prognosis. KIT mutations are uncommon.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chromosomes, Human, Pair 4 ; Female ; Humans ; Kaplan-Meier Estimate ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/pathology ; Leukocyte Count ; Male ; Middle Aged ; Mutation ; Nuclear Proteins/genetics ; Proto-Oncogene Proteins c-kit/genetics ; Remission Induction ; Survival Rate ; Texas/epidemiology ; Trisomy ; Young Adult ; fms-Like Tyrosine Kinase 3/genetics
Chemical Substances	Nuclear Proteins ; nucleophosmin (117896-08-9) ; FLT3 protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
Language	English
Publishing date	2012-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1309/AJCP7ZC9YQERSKGX
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Article ; Online: Chronic lymphocytic leukemia with t(14;18)(q32;q21).

Tang, Guilin / Banks, Haley E / Sargent, Rachel L / Medeiros, L Jeffrey / Abruzzo, Lynne V

Human pathology

2012 Volume 44, Issue 4, Page(s) 598–605

Abstract: The t(14;18)(q32;q21) is a cytogenetic hallmark of follicular lymphoma and also occurs in approximately 20% of diffuse large B-cell lymphomas of follicle center cell origin. Relatively few cases of chronic lymphocytic leukemia/small lymphocytic lymphoma ... ...

Abstract	The t(14;18)(q32;q21) is a cytogenetic hallmark of follicular lymphoma and also occurs in approximately 20% of diffuse large B-cell lymphomas of follicle center cell origin. Relatively few cases of chronic lymphocytic leukemia/small lymphocytic lymphoma with t(14;18) have been reported previously. We report the clinicopathologic, cytogenetic, and molecular genetic features of 12 patients with chronic lymphocytic leukemia associated with t(14;18). There were 9 men and 3 women, with a median age of 51 years at diagnosis. To date, 11 patients have required chemotherapy, 6 before coming to our institution. At last follow-up, 5 patients have died of disease. Karyotypic analysis showed that 10 cases had t(14;18) in the stemline and 2 cases in the sideline; t(14;18) was the sole abnormality in the stemline in 2 cases. In 11 cases, other abnormalities were identified in the stemline or sidelines, most commonly trisomy 12 in 6 cases. Trisomy 12 was associated with atypical morphology and immunophenotype. Of 8 cases tested, 7 showed somatically mutated immunoglobulin heavy chain variable region genes. We conclude that the t(14;18) in chronic lymphocytic leukemia is associated with relatively young age at diagnosis, mutated immunoglobulin heavy chain variable region genes, and a clinical course that usually requires chemotherapy. The cytogenetic findings, in particular, t(14;18) in the stemline in 10 cases and as the sole karyotypic abnormality in 2 cases, suggest that t(14;18) is an early pathogenetic event in this small subset of chronic lymphocytic leukemia cases.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Chromosomes, Human, Pair 12 ; Chromosomes, Human, Pair 14/genetics ; Chromosomes, Human, Pair 18/genetics ; DNA Mutational Analysis ; DNA, Neoplasm/analysis ; Female ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/genetics ; Immunophenotyping ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/mortality ; Male ; Middle Aged ; Mutation ; Neoplastic Stem Cells/pathology ; Prognosis ; Survival Rate ; Translocation, Genetic ; Trisomy
Chemical Substances	Antineoplastic Agents ; DNA, Neoplasm ; Immunoglobulin Heavy Chains ; Immunoglobulin Variable Region
Language	English
Publishing date	2012-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2012.07.005
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Article ; Online: Molecular and Cytogenetic Education in Hematopathology Fellowship.

Soma, Lorinda A / Kovach, Alexandra E / Siddon, Alexa J / Beck, Rose / Gibson, Sarah E / Swerdlow, Steven H / Kim, Annette S / Wu, David / Jones, Dan / Cook, James R / Prakash, Sonam / Rosado, Flavia / Crane, Genevieve / Bradley, Kyle / Weinberg, Olga K / Sargent, Rachel L

American journal of clinical pathology

2019 Volume 152, Issue 4, Page(s) 438–445

Abstract: Objectives: Given the increased complexity of molecular and cytogenetic testing (MOL-CG), the Society for Hematopathology Education Committee (SH-EC) was interested in determining what the current expectations are for MOL-CG education in hematopathology ...

Abstract	Objectives: Given the increased complexity of molecular and cytogenetic testing (MOL-CG), the Society for Hematopathology Education Committee (SH-EC) was interested in determining what the current expectations are for MOL-CG education in hematopathology (HP) fellowship training. Methods: The SH-EC sent a questionnaire to HP fellowship program directors (HP-PDs) covering MOL-CG training curricula, test menus, faculty background, teaching, and sign-out roles. These findings were explored via a panel-based discussion at the 2018 SH-EC meeting for HP-PDs. Results: HP fellows are expected to understand basic principles, nomenclature, and indications for and limitations of testing. Interpretation of common assays is within that scope, but not necessarily proficiency in technical troubleshooting of testing or analysis of complex raw data. Conclusions: The consensus was that HP fellows should understand the components of MOL-CG testing necessary to incorporate those results into an accurate, clinically relevant, and integrated HP report.
MeSH term(s)	Cytogenetic Analysis ; Education, Medical, Graduate ; Fellowships and Scholarships ; Humans ; Molecular Biology/education ; Pathology, Clinical/education ; Surveys and Questionnaires
Language	English
Publishing date	2019-05-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqz048
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Article ; Online: Clinical implications of cytogenetic heterogeneity in multiple myeloma patients with TP53 deletion.

Hao, Suyang / Lin, Pei / Medeiros, L Jeffrey / Fang, Lianghua / Carballo-Zarate, Adrian A / Konoplev, Sergej N / Sargent, Rachel L / Weber, Donna M / Thomas, Sheeba K / Manasanch, Elisabet E / Orlowski, Robert Z / Lu, Xinyan

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2017 Volume 30, Issue 10, Page(s) 1378–1386

Abstract: TP53 deletion (ΔTP53) in myeloma is known to be a high-risk finding associated with poorer prognosis. The prognostic impact of underlying cytogenetic heterogeneity in patients with myeloma associated with ΔTP53 is unknown. We studied 90 patients with ... ...

Abstract	TP53 deletion (ΔTP53) in myeloma is known to be a high-risk finding associated with poorer prognosis. The prognostic impact of underlying cytogenetic heterogeneity in patients with myeloma associated with ΔTP53 is unknown. We studied 90 patients with myeloma associated with ΔTP53 identified by interphase fluorescence in situ hybridization and assessed the impact of karyotype and coexisting alterations of IGH, RB1, and CKS1B. There were 54 men and 36 women with a median age of 59 years (range 38-84); 14 patients had a normal karyotype (NK/ΔTP53), 73 had a complex karyotype (CK/ΔTP53), and 3 had a non-complex abnormal karyotype. Patients with CK/ΔTP53 showed a significantly poorer overall survival compared with patients with NK/ΔTP53 (P=0.0243). Furthermore, in the CK/ΔTP53 group, patients with IGH rearrangement other than t(11;14)(q13;q32)/CCND1-IGH, designated as adverse-IGH, had an even worse outcome (P=0.0045). In contrast, RB1 deletion, CKS1B gain, ploidy, additional chromosome 17 abnormalities, or ΔTP53 clone size did not impact prognosis. Stem cell transplant did not improve overall survival in either the NK/ΔTP53 or CK/ΔTP53 (P=0.8810 and P=0.1006) groups, but tandem stem cell transplant did improve the overall survival of patients with CK/ΔTP53 (P=0.0067). Multivariate analysis confirmed in this cohort that complex karyotype (hazard ratio 1.976, 95% CI 1.022-3.821, P=0.043), adverse-IGH (hazard ratio 3.126, 95% CI 1.192-8.196, P=0.020), and tandem stem cell transplant independently correlate with overall survival (hazard ratio 0.281, 95% CI 0.091-0.866, P=0.027). We conclude that comprehensive genetic assessment adds to TP53 status in the risk stratification of myeloma patients.
MeSH term(s)	Abnormal Karyotype ; Adult ; Aged ; Aged, 80 and over ; Female ; Gene Deletion ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multiple Myeloma/genetics ; Multiple Myeloma/mortality ; Prognosis ; Retrospective Studies ; Tumor Suppressor Protein p53/genetics
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2017-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/modpathol.2017.63
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Article ; Online: Identification of putative pathogenic microRNA and its downstream targets in anaplastic lymphoma kinase-negative anaplastic large cell lymphoma.

Mehrotra, Meenakshi / Medeiros, L Jeffrey / Luthra, Rajyalakshmi / Sargent, Rachel L / Yao, Hui / Barkoh, Bedia A / Singh, Rajesh / Patel, Keyur P

Human pathology

2014 Volume 45, Issue 10, Page(s) 1995–2005

Abstract: Anaplastic large cell lymphomas (ALCL) are tumors of T/null-cell lineage characterized by uniform CD30 expression. The 2008 World Health Organization classification subdivided ALCLs into 2 groups: anaplastic lymphoma kinase (ALK)-positive (established ... ...

Abstract	Anaplastic large cell lymphomas (ALCL) are tumors of T/null-cell lineage characterized by uniform CD30 expression. The 2008 World Health Organization classification subdivided ALCLs into 2 groups: anaplastic lymphoma kinase (ALK)-positive (established entity) and ALK-negative (proposed new entity) ALCL. The genetic basis for the pathogenesis of newly categorized ALK- ALCL is poorly understood. In this study, we used microRNA microarray analysis to identify differentially expressed microRNAs in ALK+ and ALK- ALCL. ALK- ALCL showed significantly higher expression of miR-155 (0.888 ± 0.228) compared with ALK+ ALCL (0.0565 ± 0.009) on microarray and by quantitative real-time polymerase chain reaction in ALK- ALCL compared with ALK+ ALCL (P < .05) with a strong correlation between the 2 platforms (R = 0.9, P < .0003). A novel in situ hybridization method allows direct visualization of expression patterns and relative quantitation of miR-155 (mean score, 2.3 versus 1.3; P = .01) for the first time in tissue sections of ALCL. Among computationally predicted targets of miR-155, we identified ZNF652 (r = -0.57, P = .05), BACH1 (r = 0.88, P = .02), RBAK (r = 0.81, P = .05), TRIM32 (r = 0.92, P = .01), E2F2 (r = 0.81, P = .05), and TP53INP1 (r = -0.31, P = .03) as genes whose expression by quantitative real-time polymerase chain reaction correlated significantly with the level of miR-155 in ALCL tumor tissue.
MeSH term(s)	Adolescent ; Adult ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; In Situ Hybridization ; Lymphoma, Large-Cell, Anaplastic/enzymology ; Lymphoma, Large-Cell, Anaplastic/genetics ; Male ; MicroRNAs/genetics ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Real-Time Polymerase Chain Reaction ; Receptor Protein-Tyrosine Kinases/biosynthesis ; Reverse Transcriptase Polymerase Chain Reaction ; Young Adult
Chemical Substances	MIRN155 microRNA, human ; MicroRNAs ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; anaplastic lymphoma kinase (EC 2.7.10.1)
Language	English
Publishing date	2014-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2014.06.012
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Article ; Online: Bone marrow fibrosis in patients with primary myelodysplastic syndromes has prognostic value using current therapies and new risk stratification systems.

Fu, Bin / Jaso, Jesse M / Sargent, Rachel L / Goswami, Maitrayee / Verstovsek, Srdan / Medeiros, L Jeffrey / Wang, Sa A

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2013 Volume 27, Issue 5, Page(s) 681–689

Abstract: Bone marrow fibrosis has recently been recognized as an adverse histological feature in patients with primary myelodysplastic syndromes. In this study, we assessed the prognostic impact of bone marrow fibrosis in patients with primary myelodysplastic ... ...

Abstract	Bone marrow fibrosis has recently been recognized as an adverse histological feature in patients with primary myelodysplastic syndromes. In this study, we assessed the prognostic impact of bone marrow fibrosis in patients with primary myelodysplastic syndromes under the recently revised new risk stratification systems: the New Comprehensive Cytogenetic Scoring System and the Revised International Prognostic Scoring System. From 2002 to 2012, a total of 79 (13%) patients with primary myelodysplastic syndromes and moderate/severe bone marrow fibrosis were identified; and these patients were compared with a control group of 166 patients with myelodysplastic syndromes but no significant fibrosis. Bone marrow fibrosis predicted an inferior overall survival and leukemia event-free survival for patients who received no hematopoietic stem cell transplant in univariate and multivariate analysis. Eleven patients with bone marrow fibrosis and 32 control group patients underwent hematopoietic stem cell transplant; and bone marrow fibrosis was an independent risk for an inferior overall survival but not leukemia-free survival. In addition, 17 (4%) patients developed bone marrow fibrosis during the course of myelodysplastic syndromes, which was accompanied by clinical and cytogenetic evidence of disease progression. JAK2 V617F mutations were detected in 6 of the 28 patients with bone marrow fibrosis presenting at the time of diagnosis and 2 of the 7 patients with bone marrow fibrosis developing in the course of disease, significantly higher than the control group patients. We conclude that bone marrow fibrosis is an adverse risk feature in primary myelodysplastic syndromes in the current therapeutic era, and this risk feature is not captured by newly revised risk stratification systems. Inclusion of bone marrow fibrosis in patient assessment may further aid in risk-adapted therapeutic decisions.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone Marrow/pathology ; Bone Marrow Examination ; Disease Progression ; Female ; Fibrosis ; Hematopoietic Stem Cell Transplantation ; Humans ; Janus Kinase 2/genetics ; Male ; Middle Aged ; Mutation ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/mortality ; Myelodysplastic Syndromes/pathology ; Myelodysplastic Syndromes/therapy ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Survival Rate ; Young Adult
Chemical Substances	Janus Kinase 2 (EC 2.7.10.2)
Language	English
Publishing date	2013-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/modpathol.2013.187
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Article ; Online: Does Taking the Fellowship In-Service Hematopathology Examination and Performance Relate to Success on the American Board of Pathology Hematology Examination?

Monaghan, Sara A / Felgar, Raymond E / Kelly, Melissa A / Ali, Asma M / Anastasi, John / Bellara, Aarti P / Rinder, Henry M / Sargent, Rachel L / Wagner, Jay / Swerdlow, Steven H / Johnson, Rebecca L

American journal of clinical pathology

2016 Volume 146, Issue 1, Page(s) 107–112

Abstract: Objectives: The biannual Fellow In-Service Hematopathology Examination (FISHE) assesses knowledge in five content areas. We examined the relationship between taking the FISHE and performance on it with outcomes on the first attempted American Board of ... ...

Abstract	Objectives: The biannual Fellow In-Service Hematopathology Examination (FISHE) assesses knowledge in five content areas. We examined the relationship between taking the FISHE and performance on it with outcomes on the first attempted American Board of Pathology Hematology subspecialty certifying examination (ABP-HE). Methods: The pass rate between the ABP-HE candidates who took the spring FISHE and those who did not were compared. The likelihood of fellows passing the ABP-HE based on their percentiles on the FISHE was also assessed. Results: ABP-HE candidates who took the spring FISHE had a higher pass rate (96.4%) than those who did not (76.1%, P < .001). Spring FISHE performance, including total percentile and percentiles in four of five FISHE content areas, was only a weak predictor of passing the ABP-HE. Conclusions: Candidates who take the spring FISHE do better on the ABP-HE than those who do not. Most fellows passed the first attempted ABP-HE regardless of FISHE performance. Whether this is due to fellows making use of the FISHE as a self-evaluation tool to help identify and then correct their knowledge deficiencies remains to be determined.
MeSH term(s)	Certification ; Clinical Competence ; Education, Medical, Graduate ; Educational Measurement ; Fellowships and Scholarships ; Humans ; United States
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqw085
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