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Article: SPECIFICITIES OF THE COURSE OF SUBCLINICAL HEPATITIS AMONG YOUNG ADULTS WITH ACUIE GLOMERULONEPHRITIS.

Sargsyan, M

2023 , Issue 334, Page(s) 52–56

Abstract: In spite of the progress in medical science in our country during recent years, the investigation of some problems of development and course of acute glomerulonephritis (AG) particularly in young adults remains topical. In this paper we discuss classical ...

Abstract	In spite of the progress in medical science in our country during recent years, the investigation of some problems of development and course of acute glomerulonephritis (AG) particularly in young adults remains topical. In this paper we discuss classical types of AG in young adults, when the intake of paracetamol and diclofenac led to a dysfunctional and organic liver injury, at the same time it negatively affected the course of AG. Goal - assessment of cause-and-effect relations of renal and liver injuries in young adults with acute glomerulonephritis. To achieve the goals of the research we examined 150 male patients with AG, aged 18-25. According to clinical presentations all the patients were divided into two groups. In the first group (102 patients) the disease manifested with acute nephritic syndrome; in the second group of patients (48 patients) - with isolated urinary syndrome. Out of 150 patients examined for AG 66 had subclinical liver injury, which resulted from the effect of antipyretic hepatotoxic drugs taken in the initial stage of the disease. Due to the toxic and immunological liver injury, levels of transaminases increase, and albumin levels decrease. These changes occur along with the development of AG and are correlated with some laboratory values (ASLO, CRP, ESR, hematuria), the injury is more evident when etiological factor is the streptococcal infection. In AG liver injury has a toxic allergic character and is more expressed in post streptococcal glomerulonephritis. Frequency of liver injury depends on specific features of a particular organism; it does not depend on the dose of the taken drug. In case of any type of AG it is necessary to assess the functional state of liver and after the treatment of the main disease hepatologist follow-up of patients is recommended.
MeSH term(s)	Humans ; Male ; Young Adult ; Adolescent ; Adult ; Hepatitis/complications ; Glomerulonephritis/complications ; Kidney ; Nephritis ; Antipyretics
Chemical Substances	Antipyretics
Language	English
Publishing date	2023-03-03
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COMPARATIVE ASSESSMENT OF ATHLETES' AUTONOMIC REACTIVITY BY HRV INDICATORS IN FUNCTIONAL TESTS OF VARIOUS DIRECTIONS.

Aghajanyan, M / Sargsyan, M

Georgian medical news

2023 , Issue 334, Page(s) 23–28

Abstract: The purpose of the research is to study and comparatively evaluate the changes in HRV indicators in functional tests of various directions. HRV was studied in 50 elite athletes (athletics, wrestling, judo, football) , at age 20-26 years old. The research ...

Abstract	The purpose of the research is to study and comparatively evaluate the changes in HRV indicators in functional tests of various directions. HRV was studied in 50 elite athletes (athletics, wrestling, judo, football) , at age 20-26 years old. The research was held in the scientific research laboratory of the Armenian State Institute of Physical Culture and Sport using the hardware - software complex "Varikard 2.5.1, Iskim - 6.2. The studies were carried out in the morning, in the preparatory phase of the training process, at rest and during functional testing. In orthotest HRV was recorded at rest 5 min supine followed by 5 min standing. 20 minutes later, a treadmill test was carried out on Treadmill Proteus LTD_7560 with a gradually increasing load (1 km/h per minute) until exhaustion. The duration of test was 13-15 minutes, HRV recorded after test 5 min supine. HRV time indicators - HR(b/m), MxDMn(ms), SI (un) and frequency (spectral) indicators - TP (ms2), HF (ms2), LF (ms2), VLF(ms2) are analyzed. The degree and direction of changes in HRV indicators are connected with the different type of stress factors, their intensity and duration. The HRV time indicators in both tests change unidirectionally: sympathetic activation causes an increase in heart rate, a decrease in the variation range MxDMn and an increase in the stress index SI, with the greatest degree of shifts in the treadmill test. The spectral indicators of HRV in both tests vary in different directions. In orthotest, the vasomotor center is activated, expressed by an increase in LF wave amplitude against the background of a decrease in the HF wave, but without a significant reaction from the total power of the TP spectrum and the humoral-metabolic component VLF. With the treadmill test, there is an energy-deficient state, expressed by a sharp decrease in TP wave amplitude and all spectral indicators reflecting the activity of individual management levels of heart rhythm control. The picture of correlation links emphasizes the balanced functioning of the autonomic nervous system at rest, increased sympathetic activity and regulation centralization in orthotest, as well as an imbalance of autonomic regulation in treadmill test.
MeSH term(s)	Humans ; Young Adult ; Adult ; Heart Rate ; Athletes ; Sports ; Armenia ; Autonomic Nervous System
Language	English
Publishing date	2023-03-03
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
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Article: ASSESSMENT OF REACTIVITY TO THE BODY UNDER CONDITIONS OF PHYSICAL ACTIVITY IN STUDENTS AGED 17-20 YEARS.

Ksajikyan, N / Aghababyan, H / Sargsyan, M

Georgian medical news

2024 , Issue 347, Page(s) 54–58

Abstract: Physical activity is such an essential socio-biological element, which provides a balance between the body and the external environment and contributes to the improvement of metabolic process regulation mechanisms. However, the abuse of physical activity ...

Abstract	Physical activity is such an essential socio-biological element, which provides a balance between the body and the external environment and contributes to the improvement of metabolic process regulation mechanisms. However, the abuse of physical activity often leads to unwanted changes in the basic physiological processes in the athletes' organism, due to the impact of a variety of reasons. The state of the organism's regulatory systems and the provision of the necessary adaptation of the organism to physical activity are crucial in assessing the athlete's physical fitness. It is known that during physical exertion, the functional state of the organism is determined by a reaction limiting the efficiency of the cardiovascular and respiratory systems. It was revealed that with long-term physical activity restriction, blood circulation regulatory mechanisms, as well as synocardial reflexes, are disrupted. This research is devoted to the study of students' organism adaptive capabilities depending on the central or autonomous type of vegetative regulation. Registration and analysis of ECG of students by the method of variational heart rate monitoring were carried out. With the help of a special program, the students' heart rate integral indicators were analyzed. All studies were carried out twice: before physical exertion and immediately after physical exertion. In this study, we aimed to explore the adaptive capabilities of students bodies depending on the central or autonomous type of autonomic regulation. Three types of response to physical activity have been identified: optimal, paradoxical, and atypical. In all types of reactions, a certain level and direction of intensity of the processes of regulation of the athletes' organism is expressed. The study of the distinctive features of vegetative regulation makes it possible to assess athletes' organism functional state better and determine violations of their adaptive capabilities. According to the research results, based on the primary signs of the athletes' organism adaptive capabilities and the corresponding reaction, it is possible to determine the optimal dose of physical exertion for athletes.
MeSH term(s)	Humans ; Exercise ; Physical Exertion ; Athletes ; Autonomic Nervous System ; Students
Language	English
Publishing date	2024-04-12
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
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Article: [CORRELATION ANALYSIS BETWEEN CLINICO-LABORATORY AND INSTRUMENTAL INDICATORS OF CARDIAC INVOVLVEMENT IN YOUNG ADULTS SUFFERING FROM ACUTE POST-STREPTOCOCCAL GLOMERULONEPHRITIS WITH ACUTE RENO-CARDIAL SYNDROME].

Sargsyan, M / Minasyan, A / Alaverdyan, T / Melkonyan, A

Georgian medical news

2020 , Issue 301, Page(s) 112–120

Abstract: Study goal - to study the characteristics of the development of acute reno-cardial syndrome (ARCS) and correlation analysis between clinic-laboratory and instrumental indicators of cardiac involvement in young adults in acute post-streptococcal ... ...

Abstract	Study goal - to study the characteristics of the development of acute reno-cardial syndrome (ARCS) and correlation analysis between clinic-laboratory and instrumental indicators of cardiac involvement in young adults in acute post-streptococcal glomerulonephritis (APSG) with acute nephritic syndrome (ANS) complicated by acute kidney injury (AKI) and without it, to identify the role of the etiological factor on the course of APSG. 220 male patients with APSG with ANS aged 18-20 were examined. The patients were divided into 2 groups based on the functional state of kidneys. The first group included 140 patients with APSG without ANS, the second group included 80 patients with AKI. Impairment of cardiovascular function was observed in all 220 patients. In 71.4% of group I patients bradycardia occurred, in 83.7% of group II patients, in addition to bradycardia, extrasystolic arrhythmia was observed. Lung congestion occurred in 17.8% of patients of group I and in all patients of group II. ECG and Echocardiography studies conducted during the cardiac asthma attacks occurred as a decrease of voltage, broadening of the P wave, lengthening of the PQ interval, broadening of the QRS complex, dilatations of the right and left atrium. Thus in the development of acute reno-cardial syndrome (ARCS) the degree of manifestation of hypervolemia with hypertension, as a result of active immune inflammation of the glomerular apparatus with the development of AKI, plays the main role in the development of ARCS with APSG. ARCS is clinically manifested by cardiac asthma attacks, bradycardia, and rhythm disorders. The severity of clinical manifestations of AKI and ARCS correlates with the degree of macrohematuria, GFR decrease, complement C3 fraction, monocyte level and increased levels of CEC (ЦИК), ASLO. As a rule ARCS in case of APSG with ANS in young adults has a successful outcome. There is a direct correlation between the indicators of the etiological factor and clinical manifestation of the disease. The course was severe in case of previously occurred streptodermа.
MeSH term(s)	Acute Disease ; Acute Kidney Injury ; Adolescent ; Adult ; Glomerulonephritis ; Humans ; Hypertension ; Kidney ; Male ; Young Adult
Language	Russian
Publishing date	2020-05-30
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A False-Negative Pregnancy Test in an Adolescent.

Sargsyan, Mane / Amin, Mody / Hassanein, Mahmoud M / Basak, Ratna B

Pediatrics in review

2022 Volume 43, Issue 9, Page(s) 529–531

MeSH term(s)	Adolescent ; False Positive Reactions ; Female ; Humans ; Pregnancy ; Pregnancy Tests
Language	English
Publishing date	2022-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	774515-1
ISSN	1526-3347 ; 0191-9601
ISSN (online)	1526-3347
ISSN	0191-9601
DOI	10.1542/pir.2020-004896
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Article ; Online: Alginate coated biogenic silver nanoparticles for the treatment of Pseudomonas infections in rainbow trout.

Kulikouskaya, Viktoryia / Nikalaichuk, Viktoryia / Hileuskaya, Kseniya / Ladutska, Alena / Grigoryan, Karine / Kozerozhets, Irina / Hovsepyan, Varduhi / Sargsyan, Mariam / Sidarenka, Anastasiya

International journal of biological macromolecules

2023 Volume 251, Page(s) 126302

Abstract: Pseudomonas species are among the main pathogens causing rainbow trout infections. The present study provides a simple, green, sustainable, and rapid technique to synthesize of biogenic alginate-capped silver nanoparticles (Alg-Ag NPs) suitable for the ... ...

Abstract	Pseudomonas species are among the main pathogens causing rainbow trout infections. The present study provides a simple, green, sustainable, and rapid technique to synthesize of biogenic alginate-capped silver nanoparticles (Alg-Ag NPs) suitable for the treatment of Pseudomonas infections. It has been shown that the mechanism (aggregative or autocatalytic) of Alg-Ag NPs formation depended on Alg concentration and the heating approach used. The rate constants and activation energy were calculated. Alg-Ag NPs were characterized by UV-Vis, FTIR, XRD, TEM, AFM, XPS, and DLS. The optimal conditions for the fabrication of spherically-shaped (17-19 nm) and negatively-charged (zeta-potential <-50 mV) Alg-Ag NPs, which are stable during 9 months, included hot-plate assisted synthesis at 100 °C in diluted (1 mg/mL) Alg solutions. In vitro studies showed that Alg-Ag NPs exhibited prominent antimicrobial activity against collection Pseudomonas strains (inhibition zones ranged from 9.0 ± 1.0 to 19.0 ± 1.0 mm), with no significant loss of antibacterial efficacy after 9 months of storage. AFM analysis confirmed that the antibacterial effect of Alg-Ag NPs dealt with the direct nanomechanical disrupting of bacterial cells. The ability of Alg-Ag NPs to inhibit the growth of virulent P.aeruginosa, P.fluorescens and P. putida strains isolated from infected rainbow trout was evaluated. All tested strains were susceptible to Alg(10)-Ag NPs, while Alg(1)-Ag NPs demonstrated a limited strain-specific antibacterial effect. The obtained data displayed the prospects for the application of biogenic Alg-Ag NPs to create novel delivery systems for combating Pseudomonas infections in rainbow trout.
Language	English
Publishing date	2023-08-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.126302
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Book ; Online: Preventing Clean Label Poisoning using Gaussian Mixture Loss

Yaseen, Muhammad / Aadil, Muneeb / Sargsyan, Maria

2020

Abstract: Since 2014 when Szegedy et al. showed that carefully designed perturbations of the input can lead Deep Neural Networks (DNNs) to wrongly classify its label, there has been an ongoing research to make DNNs more robust to such malicious perturbations. In ... ...

Abstract	Since 2014 when Szegedy et al. showed that carefully designed perturbations of the input can lead Deep Neural Networks (DNNs) to wrongly classify its label, there has been an ongoing research to make DNNs more robust to such malicious perturbations. In this work, we consider a poisoning attack called Clean Labeling poisoning attack (CLPA). The goal of CLPA is to inject seemingly benign instances which can drastically change decision boundary of the DNNs due to which subsequent queries at test time can be mis-classified. We argue that a strong defense against CLPA can be embedded into the model during the training by imposing features of the network to follow a Large Margin Gaussian Mixture distribution in the penultimate layer. By having such a prior knowledge, we can systematically evaluate how unusual the example is, given the label it is claiming to be. We demonstrate our builtin defense via experiments on MNIST and CIFAR datasets. We train two models on each dataset: one trained via softmax, another via LGM. We show that using LGM can substantially reduce the effectiveness of CLPA while having no additional overhead of data sanitization. The code to reproduce our results is available online. Comment: Preliminary v1
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2020-02-10
Publishing country	us
Document type	Book ; Online
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Article: Pathology and Clinics of Naturally Occurring Low-Virulence Variants of African Swine Fever Emerged in Domestic Pigs in the South Caucasus.

Avagyan, Hranush / Hakobyan, Sona / Baghdasaryan, Bagrat / Arzumanyan, Hranush / Poghosyan, Arpine / Bayramyan, Nane / Semerjyan, Anna / Sargsyan, Mariam / Voskanyan, Henry / Vardanyan, Tigranuhi / Karalyan, Naira / Hakobyan, Lina / Abroyan, Liana / Avetisyan, Aida / Karalova, Elena / Semerjyan, Zara / Karalyan, Zaven

Pathogens (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: Shortly after the establishment of African swine fever virus (ASFV) genotype II in 2007, cases of acute fatal infection were observed. However, after several years of circulation in the Eurasian region, the clinical signs of the disease changed. ... ...

Abstract	Shortly after the establishment of African swine fever virus (ASFV) genotype II in 2007, cases of acute fatal infection were observed. However, after several years of circulation in the Eurasian region, the clinical signs of the disease changed. Currently, this disease can occur acutely, subclinically, chronically, or asymptomatically. Cases of the complete recovery of infected pigs, and the disappearance of ASFV from their tissues and secretions have been described. This form of the disease first appeared in Armenia at the end of 2011. This virus was described and identified as the Dilijan2011IMB strain. The goal of our research was to study the main features of clinical, pathological, immunological, virological, and genetic parameters involved in the development of new forms of African swine fever (ASF). Chronic ASF was characterized with low titers of the virus and a decrease in the intensity of hemadsorption. Additionally, a reduced intensity in clinical symptoms and pathoanatomical results was noted. The absolute, but not the relative number of immune cells changes; the neutropenia (in bone marrow and spleen), lymphopenia (in bone marrow), lymphocytosis (only in spleen), lymphoid cell depletion (in bone marrow), and pancytopenia (in bone marrow) observed in the chronic form of ASF were less pronounced compared to in the acute form. When comparing the late stage of chronic ASF to the acute form, the key cytological indicators in the spleen, lymph nodes, and blood were less severe in the chronic stage. Bone marrow failure in the chronic form, expressed in a pronounced decrease in all cell types, generally coincided with the data in the acute form of ASF. The same data were obtained after assessing serum TNF-alpha levels. Thus, we can conclude that the chronic form of ASF occurs due to a less pronounced immune response, as well as a decrease in virus titers in the blood and tissues of infected pigs.
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens13020130
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Article ; Online: A Survival Analysis of Patients with Recurrent Epithelial Ovarian Cancer Based on Relapse Type: A Multi-Institutional Retrospective Study in Armenia.

Current oncology (Toronto, Ont.)

2024 Volume 31, Issue 3, Page(s) 1323–1334

Abstract: Background: Annually, approximately 200 new ovarian cancer cases are diagnosed in Armenia, which is considered an upper-middle-income country. This study aimed to summarize the survival outcomes of patients with relapsed ovarian cancer in Armenia based ... ...

Abstract	Background: Annually, approximately 200 new ovarian cancer cases are diagnosed in Armenia, which is considered an upper-middle-income country. This study aimed to summarize the survival outcomes of patients with relapsed ovarian cancer in Armenia based on the type of recurrence, risk factors, and choice of systemic treatment. Methods: This retrospective case-control study included 228 patients with relapsed ovarian cancer from three different institutions. Results: The median age of the patients was 55. The median follow-up times from relapse and primary diagnosis were 21 and 48 months, respectively. The incidence of platinum-sensitive relapse was 81.6% (186), while platinum-resistant relapse was observed in only 18.4% (42) of patients. The median post-progression survival of the platinum-sensitive group compared to the platinum-resistant group was 54 vs. 25 months ( Conclusions: Overall, despite new therapeutic approaches, ovarian cancer continues to be one of the deadly malignant diseases affecting women, especially in developing countries with a lack of resources, where chemotherapy remains the primary available systemic treatment for the majority of patients. Low survival rates demonstrate the urgent need for more research focused on this group of patients with poor outcomes.
MeSH term(s)	Humans ; Female ; Carcinoma, Ovarian Epithelial ; Retrospective Studies ; Case-Control Studies ; Armenia ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Survival Analysis ; Recurrence
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Multicenter Study ; Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol31030100
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Article ; Online: ON BOUNDARY LAYER THE 3D PROBLEM ABOUT FORCED VIBRATIONS OF ORTHOTROPIC PLATE, FREELY-LYING ON THE RIGID FOUNDATION

Sargsyan M. Z.

Proceedings of NAS RA : Mechanics , Vol 62, Iss 4, Pp 73-

2009 Volume 79

Abstract: The problem of boundary layer of the orthotropic plate simply supported on the rigid foundation is considered, when on the upper plane of plate the normal load affects. The stressedly-deformed state boundary layer of plate is determined by using the ... ...

Abstract	The problem of boundary layer of the orthotropic plate simply supported on the rigid foundation is considered, when on the upper plane of plate the normal load affects. The stressedly-deformed state boundary layer of plate is determined by using the asymptotic method. The damping of values for boundary layer are researched. The method of conjugation of the solutions of inner problem and of boundary layer is showed.
Keywords	boundary layer ; plate ; damping ; frequency ; Coulomb friction ; singularly perturbed system ; 3D problem ; forced vibration ; conjugation of solutions ; пограничный слой ; пластина ; затухание ; частота ; кулоново трение ; сингулярно-возмущенная система ; трехмерная задача ; вынужденные колебания ; сопряжение решений ; Descriptive and experimental mechanics ; QC120-168.85 ; Physics ; QC1-999 ; Science ; Q
Language	Armenian
Publishing date	2009-12-01T00:00:00Z
Publisher	National Academy of Sciences of the Republic of Armenia
Document type	Article ; Online
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