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Article: HEPCIDIN AND FERRITIN MODULATED IN OBESE MALE.

Mahmmod, M / Sarhat, E

2024 , Issue 344, Page(s) 114–118

Abstract: Obesity has reached truly epidemic proportions worldwide and has become one of the most prevalent health problems that our world currently faces. The goal of the study is to identify the relationship between body mass index (BMI), insulin, hepcidin, and ... ...

Abstract	Obesity has reached truly epidemic proportions worldwide and has become one of the most prevalent health problems that our world currently faces. The goal of the study is to identify the relationship between body mass index (BMI), insulin, hepcidin, and ferritin in obese males. Ninety males were recruited into the study; forty participants were assigned to the obese group were have BMI>30 kg/m2, twenty to overweight group were have BMI between 25-30 kg/m2, and another thirty to the control group were have slow BMI<25 kg/m2. The serum hepcidin, serum fasting insulin, serum ferritin and fasting glucose were evaluated in each of the studied groups. The Obese group showed a significant increase of the serum hepcidin concentration compared with the control group (4.65±1.92 vs. 3.43±1.52, p=0.015). No prominent differences were detected in the three groups in ferritin and glucose concentration. Investigation of iron regulated cytokine hepcidin can be participated in future as iron deficiency marker in obese subject in conjugation with serum iron and serum ferritin.
MeSH term(s)	Humans ; Male ; Ferritins ; Hepcidins ; Obesity/complications ; Iron ; Glucose ; Insulin
Chemical Substances	Ferritins (9007-73-2) ; Hepcidins ; Iron (E1UOL152H7) ; Glucose (IY9XDZ35W2) ; Insulin
Language	English
Publishing date	2024-01-18
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS.

Al-Barwani, R / Sarhat, E

Georgian medical news

2024 , Issue 347, Page(s) 66–69

Abstract: Omentin and vaspin levels have been shown to change in many inflammatory diseases, the present study aimed to evaluate the omentin and vaspin levels in breast cancer patients. To do so serum samples were collected and analysed for omentin, vaspin, renal ... ...

Abstract	Omentin and vaspin levels have been shown to change in many inflammatory diseases, the present study aimed to evaluate the omentin and vaspin levels in breast cancer patients. To do so serum samples were collected and analysed for omentin, vaspin, renal and liver function tests. The levels of creatinine (p<0.01) and urea (p<0.05) showed substantial increases, while omentin and Vaspin levels notably decreased (p<0.05). Additionally, breast cancer patients exhibited significantly higher levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine transaminase (ALT) compared to the control group (p<0.05). In comparison to the control group, individuals with breast cancer demonstrated reduced blood concentrations of omentin and vaspin and elevated levels of creatinine and urea. Additionally, liver function testing indicated lower levels of Alanine transaminase (ALT), Alkaline phosphatase (ALP), and Aspartate aminotransferase (AST) in breast cancer patients. Breast cancer patients had lower levels of omentin and vaspin, and higher levels of creatinine and urea compared to the control group. Liver function tests also indicated lower levels of AST, ALP, and ALT in breast cancer patients compared to the control group.
MeSH term(s)	Female ; Humans ; Alanine Transaminase ; Alkaline Phosphatase ; Aspartate Aminotransferases ; Breast Neoplasms ; Creatinine ; Urea
Chemical Substances	Alanine Transaminase (EC 2.6.1.2) ; Alkaline Phosphatase (EC 3.1.3.1) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Creatinine (AYI8EX34EU) ; Urea (8W8T17847W) ; ITLN1 protein, human ; SERPINA12 protein, human
Language	English
Publishing date	2024-03-20
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: ASSESSMENT OF OSTEOPONTIN, SCLEROSTIN, AND OSTEOCALCIN LEVELS IN PATIENTS WITH HYPOTHYROIDISM ON MEDICAL THERAPY.

Jarjees, Z / Sarhat, E

Georgian medical news

2024 , Issue 347, Page(s) 131–135

Abstract: Thyroid hormones are critical regulators of bone maintenance in adulthood and play an important part in the development of bones. They also play a function in the formation of bones. Childhood hypothyroidism leads to delayed skeletal development, limited ...

Abstract	Thyroid hormones are critical regulators of bone maintenance in adulthood and play an important part in the development of bones. They also play a function in the formation of bones. Childhood hypothyroidism leads to delayed skeletal development, limited linear growth, and impaired bone mineral accumulation. This research aims to assess the serum concentration of sclerostin, osteocalcin, and osteopontin in women diagnosed with hypothyroidism. Additionally, it seeks to examine the impact of medical treatment on the levels of sclerostin, osteocalcin, and osteopontin in individuals with hypothyroidism. This research examined a total of 180 women, divided into three groups: 70 women before treatment, 70 women after treatment, and 40 control subjects. The age range of the participants was between 15 and 54 years. The participants in this research are categorized into three distinct groups: The first cohort consisted of 70 women diagnosed with hypothyroidism, as confirmed by medical professionals. The second group consisted of 70 women who had undergone treatment for hypothyroidism. The research included a control group consisting of healthy women with no family history of thyroid illness. These women were in good health and their ages were similar to those of the women with hypothyroidism. According to the presented data show a decrease in the mean of the serum level of sclerostin, and osteocalcin in hypothyroidism women before and after treatment compared with the control group (13.4±4.9 versus 19.8±5.1 and 21.5±5.0), (9.8±4.7 versus 14.35±12.63 and 15.20±14.73), respectively. The result was significant (p<0.01), with no differences in osteopontin levels between study groups. It was concluded that the sclerostin, and osteocalcin decreased in women with hypothyroidism before treatment in comparison with women after treatment and healthy women, while Furthermore no differences in Osteopontin levels between the three groups.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Middle Aged ; Young Adult ; Hypothyroidism/drug therapy ; Osteocalcin ; Osteopontin ; Patients
Chemical Substances	Osteocalcin (104982-03-8) ; Osteopontin (106441-73-0) ; BGLAP protein, human ; SOST protein, human ; SPP1 protein, human
Language	English
Publishing date	2024-03-20
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: METFORMIN EFFECTS ON BLOOD LEVELS OF GREMLIN-1 IN POLYCYSTIC OVARIAN WOMEN.

Allow, Sh / Sarhat, E

Georgian medical news

2023 , Issue 337, Page(s) 51–55

Abstract: Polycystic ovary syndrome (PCOS), a hormonal disorder affecting millions of women worldwide, characterized by symptoms such as irregular menstrual cycles, weight gain, acne, and excess hair growth. PCOS is linked to higher levels of gremlin-1, a protein ... ...

Abstract	Polycystic ovary syndrome (PCOS), a hormonal disorder affecting millions of women worldwide, characterized by symptoms such as irregular menstrual cycles, weight gain, acne, and excess hair growth. PCOS is linked to higher levels of gremlin-1, a protein involved in ovarian follicle development, which may cause insulin resistance and metabolic abnormalities. The objective is to evaluate the effects of metformin treatment on gremlin-1 levels in patients with PCOS. Sixty patients diagnosed with PCOs based on the Rotterdam criteria were selected as the PCOS group, while 30 healthy women matched for age were selected as the control group. The patients took metformin 850 mg twice daily and provided fasting blood samples before and after treatment. Data was collected through a questionnaire, direct interviewing, ultrasound examination, and laboratory examination, and analyzed using SPSS for Windows 7. The study found that PCOS patients had increased levels of gremlin compared to the control group. Additionally, PCOS patients had increased levels of blood glucose, insulin, and HOMA-IR. After taking metformin, patients showed a significant decrease in gremlin concentration. Treatment with metformin also resulted in a decrease in body mass index, blood glucose, insulin, and HOMA-IR. Metformin decrease gremlin and insulin resistance in patients with polycystic ovary syndrome.
MeSH term(s)	Female ; Humans ; Blood Glucose/metabolism ; Body Mass Index ; Hypoglycemic Agents/therapeutic use ; Insulin ; Insulin Resistance ; Metformin/therapeutic use ; Polycystic Ovary Syndrome/drug therapy ; Intercellular Signaling Peptides and Proteins/blood
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Insulin ; Metformin (9100L32L2N) ; GREM1 protein, human ; Intercellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-06-22
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: METFORMIN EFFECTS ON NEUREGULIN-1 IN POLYCYSTIC OVARIAN WOMEN.

Tawfeq, M / Sarhat, E

Georgian medical news

2023 , Issue 337, Page(s) 56–62

Abstract: The study aims to assess the levels of Neuregulin 1 (NRG1) in patients with Polycystic Ovary Syndrome (PCOS) and to determine the impact of metformin treatment on their serum NRG1 levels. PCOS is a common endocrine disorder in women of reproductive age, ... ...

Abstract	The study aims to assess the levels of Neuregulin 1 (NRG1) in patients with Polycystic Ovary Syndrome (PCOS) and to determine the impact of metformin treatment on their serum NRG1 levels. PCOS is a common endocrine disorder in women of reproductive age, while NRG1 is linked to regulating inflammation and ovulation. The study was conducted on sixty women with PCOS and thirty healthy women as the control group. Thirty patients completed the follow-up study and continued on metformin treatment for three months. The study was a cross-sectional study done in Salah Al-Deen general hospital/gynaecology and obstetrics department in Tikrit City from November 2022 to January 2023. The participants were diagnosed with PCOs based on the Rotterdam criteria, and their BMI and insulin resistance were measured before and after therapy. Fasting serum NRG1 was also measured. The study found that women with PCOS had increased levels of fasting blood glucose, insulin, and insulin resistance, as well as increased levels of NRG1. However, treatment with metformin for three months resulted in a significant decrease in body mass index, blood glucose, insulin, and insulin resistance. NRG1 level decreased significantly after 3 months of treatment with 850 mg per day with metformin in women with PCOS.
MeSH term(s)	Female ; Humans ; Blood Glucose ; Cross-Sectional Studies ; Follow-Up Studies ; Hypoglycemic Agents/therapeutic use ; Insulin ; Insulin Resistance/physiology ; Metformin/therapeutic use ; Neuregulin-1/blood ; Polycystic Ovary Syndrome/drug therapy
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Insulin ; Metformin (9100L32L2N) ; Neuregulin-1
Language	English
Publishing date	2023-06-02
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: ALTERED LEVELS OF ANTI-MULLERIAN HORMONE AND HEPCIDIN AS POTENTIAL BIOMARKERS FOR POLYCYSTIC OVARY SYNDROME.

Jihad, A / Sarhat, E

Georgian medical news

2023 , Issue 339, Page(s) 47–51

Abstract: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrinopathies in women of reproductive age group. Aim - to determine the relationship of Anti-Mullerian hormone (AMH) with hepcidin, ferritin, serum iron and interleukin-6 among PCOS women. A ... ...

Abstract	Polycystic Ovary Syndrome (PCOS) is one of the most common endocrinopathies in women of reproductive age group. Aim - to determine the relationship of Anti-Mullerian hormone (AMH) with hepcidin, ferritin, serum iron and interleukin-6 among PCOS women. A total of 60 PCOS women enrolled in the study, whose ages ranges were between 15-45 years old versus control group (30 healthy volunteer females with regular menstrual cycles aged between 15 to 45 years). All PCOS patients and healthy control underwent full physical examination and anthropometric measurements. Blood samples were collected from each woman for measurement of AMH, and hepcidin. The study showed that the Lowest mean of hepcidin was observed among PCOS women (13.27±1.46 ng/ml) as compared to the control group of non-PCOS women (98.76±2.88 ng/ml). The mean SD of AMH in PCOS women was (7.63±3.66 ng/ml), which was significantly higher than the control group with a mean SD of (2.09±1.11 ng/ml). Based on the study findings, women with PCOS had significantly higher average serum iron levels compared to the control group (223.5±57.3 and 129.1±44.9 g/dl), serum ferritin levels were significantly elevated in women with PCOS (279.9±44.9 and 129.1±44.9 ng/ml). The mean level of hepcidin was (14.77±1.31 ng/ml) in overweight PCOS women, which was elevated significantly than in PCOS women with normal BMI (12.18±1.58 /ml). The study found a negative correlation of serum hepcidin with each iron, ferritin and AMH among PCOS women.
MeSH term(s)	Humans ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Polycystic Ovary Syndrome/diagnosis ; Anti-Mullerian Hormone ; Hepcidins ; Biomarkers ; Ferritins ; Iron
Chemical Substances	Anti-Mullerian Hormone (80497-65-0) ; Hepcidins ; Biomarkers ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-07-28
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: HEPCIDIN AND IRON BIOMARKERS MODULATED IN HEMODIALYSIS PATIENTS.

Mohammed, M / Sarhat, E / Marbut, M

Georgian medical news

2024 , Issue 344, Page(s) 101–105

Abstract: Chronic kidney disease (CKD) describes abnormal kidney function and/or structure. It is common, frequently unrecognized, and often exists together with other conditions.Aim - to investigate the role of serum hepcidin in inflammation among hemodialysis ... ...

Abstract	Chronic kidney disease (CKD) describes abnormal kidney function and/or structure. It is common, frequently unrecognized, and often exists together with other conditions.Aim - to investigate the role of serum hepcidin in inflammation among hemodialysis patients with chronic kidney disease (CKD).This prospective hospital-based study conducted in Kirkuk city included 30 CKD patients undergoing regular hemodialysis at Kirkuk General Hospital, along with 30 healthy individuals as controls. Blood samples were collected before and after hemodialysis, as well as from the control group, and analyzed for various parameters. The blood samples were collected for determination of hepcidin levels were determined using Enzyme-Linked Immunosorbent Assay, while S. iron, total iron-binding capacity (TIBC).The study found that HD patients had significantly higher levels of serum hepcidin compared to the control group. The mean serum hepcidin level in HD patients was 246.1±72.4 ng/ml, while in the control group, it was 105.7±20.2 ng/ml. Serum ferritin levels were also found to be significantly higher in HD patients compared to the control group (430.5±148.3 ng/ml vs. 153.8±60.6 ng/ml). HD patients had lower serum iron and total iron-binding capacity (TIBC) levels compared to the control group (63.10±15.62 µg/dl vs. 92.98±26.68 µg/dl and 265.4±61.1 µg/dl vs. 273.3±65.9 µg/dl, respectively). After dialysis, both serum hepcidin levels decreased, with the mean serum hepcidin decreasing from 246.1±72.4 ng/ml to 206.3±61.8 ng/ml The study also demonstrated a positive correlation between hepcidin levels serum ferritin, urea, and creatinine, and a negative correlation with serum iron and hemoglobin levels in patients before hemodialysis.HD patients have higher levels of serum hepcidin, ferritin, iron and TIBC, suggesting potential involvement in inflammation and iron metabolism dysregulation.
MeSH term(s)	Humans ; Hepcidins ; Prospective Studies ; Renal Dialysis ; Biomarkers ; Ferritins ; Inflammation ; Renal Insufficiency, Chronic/therapy
Chemical Substances	Hepcidins ; Biomarkers ; Ferritins (9007-73-2)
Language	English
Publishing date	2024-01-18
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: IMPACT OF METFORMIN ON OSTEOPROTEGERIN LEVELS IN POLYCYSTIC OVARIAN WOMEN.

Khalaf, S / Al Anzy, M / Sarhat, E

Georgian medical news

2024 , Issue 346, Page(s) 144–146

Abstract: Metformin is an important agent in the treatment of polycystic ovary syndrome (PCOS) treatment. Osteoblast express osteoprotegerin (OPG) which has integral effects on bone metabolism nexus. This cross-sectional research sought to identify the impact of ... ...

Abstract	Metformin is an important agent in the treatment of polycystic ovary syndrome (PCOS) treatment. Osteoblast express osteoprotegerin (OPG) which has integral effects on bone metabolism nexus. This cross-sectional research sought to identify the impact of metformin therapy on serum level osteoblast express osteoprotegerin and prolactin in women with polycystic ovary syndrome. Methods: 30 patients with PCOS and 30 controls. The current study revealed that prolactin levels were increased in PCOS group compared to control group which is highly significant. While after treatment with metformin prolactin level was reduced significantly in than before treatment. Osteoprotegerin concentrations were considerably dropped in the PCOS group contrasted with the control group. Conversely, serum osteoprotegerin in metformin-treated group were higher compared to PCOS group. Osteoblast express osteoprotegerin level increased after 3 months of treatment with metformin in women with polycystic ovary syndrome.
MeSH term(s)	Humans ; Female ; Polycystic Ovary Syndrome/drug therapy ; Metformin/pharmacology ; Metformin/therapeutic use ; Prolactin ; Osteoprotegerin ; Cross-Sectional Studies ; Hypoglycemic Agents
Chemical Substances	Metformin (9100L32L2N) ; Prolactin (9002-62-4) ; Osteoprotegerin ; Hypoglycemic Agents
Language	English
Publishing date	2024-03-19
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: HISTOLOGICAL AND BIOCHEMICAL STUDY OF THE EFFECT OF FEXOFENADINE ON SALIVARY GLAND IN RATS.

Mahmood, E / Sarhat, E / Tawfeq, M / Wadee, S

Georgian medical news

2024 , Issue 347, Page(s) 38–40

Abstract: Fexofenadine is a newly introduced oral non-sedating agent used for allergic diseases. We sought to investigate the effects of the use of fexofenadine on the salivary gland of adult male albino rats. 30 adult male albino rats were classified randomly ... ...

Abstract	Fexofenadine is a newly introduced oral non-sedating agent used for allergic diseases. We sought to investigate the effects of the use of fexofenadine on the salivary gland of adult male albino rats. 30 adult male albino rats were classified randomly into 3 groups, as follows: Group A (control group) which consisted of 10 healthy rats. Group B (treated group) which consisted of 10 rats received FEX 5mg/kg/day, and Group C (treated group) which consisted of 10 rats received FEX 10mg/kg/day. Blood samples were obtained to assess serum levels of Thioredoxin reductase (TRX) and malondialdehyde (MDA). Salivary glands were removed and prepared for histological examination. This study showed that significantly (p<0.05) higher TRX and MDA levels were observed in group B and group C, compared to group A. The histological examination for salivary tissues revealed degenerative changes in serous cells of acini were present with deep pyknotic nuclei. Vacuolar cytoplasmic degeneration is also seen in other certain cells. Blood congestion was present in the intralobular blood vessels, particularly around the striated ducts. The glandular secretion duct contained mucus and serous secretion and the wall of the duct was surrounded by many WBCs with macrophage. Fexofenadine hydrochloride use induces remarkable histopathological changes with dose-dependent response and remarkably linked to elevation of oxidative stress markers.
MeSH term(s)	Rats ; Animals ; Male ; Salivary Glands ; Terfenadine/pharmacology ; Terfenadine/analogs & derivatives ; Cell Nucleus ; Epithelial Cells
Chemical Substances	fexofenadine (E6582LOH6V) ; Terfenadine (7BA5G9Y06Q)
Language	English
Publishing date	2024-04-12
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: EVALUATION OF FETUIN-A LEVEL IN POLYCYSTIC OVARY SYNDROME AND ITS ASSOCIATION WITH ASPROSIN AND SOME BIOCHEMICAL PARAMETERS.

Mahmmoed, B / Hilal, N / Sarhat, E

Georgian medical news

2023 , Issue 343, Page(s) 63–66

Abstract: An ovarian cyst is a common hormonal disorder that affects the ovaries in females of reproductive age. Environmental and genetic factors may contribute to the beginning of the disease, although the lack of a clear aetiology. Menstrual irregularities, ... ...

Abstract	An ovarian cyst is a common hormonal disorder that affects the ovaries in females of reproductive age. Environmental and genetic factors may contribute to the beginning of the disease, although the lack of a clear aetiology. Menstrual irregularities, increased hair growth, and acne are some of the most important signs. In order to control symptoms and prevent the development of chronic medical disorders, early identification is essential. The goal of this study was to assess fetuin-A levels and relationships in polycystic ovary syndrome (PCOS) patients. The connection between fetuin-A and asprosin and several biochemical parameters, including fasting blood sugar, insulin, cholesterol, and triglycerides in women patients with polycystic ovarian syndrome. Ninety females were included in the trial; 60 individuals (females) were selected who were diagnosed with PCOS by a gynaecological specialist and ranged in age from 15 to 45. The result was a change in the ovulation-inducing hormones LH and FSH as well as an increase in the proteins fetuin-A and Asprosin. On the other hand, 30 individuals (all female) were used as a control group. Their ages were recorded as well as the fact that they did not have PCOS. For all groups, laboratory tests were done to determine the levels of fetuin-A, Asprosin, fasting blood sugar, Insulin, total cholesterol, and triglyceride. For parents and a control group, investigators performed an asprosin analysis, The findings of the comparison were statistically not significant (P value=0.115). performed a Fetuin-A analysis as well, the results were statistically highly significant with a P value of 0.0002 when compared to the outcomes of the two sick groups and the healthy controls.
MeSH term(s)	Female ; Humans ; alpha-2-HS-Glycoprotein ; Blood Glucose/metabolism ; Cholesterol ; Insulin ; Polycystic Ovary Syndrome
Chemical Substances	alpha-2-HS-Glycoprotein ; Blood Glucose ; Cholesterol (97C5T2UQ7J) ; Insulin ; FBN1 protein, human ; AHSG protein, human
Language	English
Publishing date	2023-12-12
Publishing country	Georgia (Republic)
Document type	Journal Article
ZDB-ID	2443648-3
ISSN	1512-0112
ISSN	1512-0112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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