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  1. Article ; Online: Adaptation of the professionalism mini-evaluation exercise instrument into Turkish: a validity and reliability study.

    Taşçı, Ali İhsan / Akdeniz, Esra / Gülpınar, Mehmet Ali / Danacıoğlu, Yavuz Onur / Sarı, Emine Ergül / Yaşar, Levent / Karandere, Faruk / Ferahman, Sina

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 698

    Abstract: Background: There is an ongoing search for standardized scales appropriate for each culture to evaluate professionalism, which is one of the basic competencies of a physician. The Professionalism Mini-evaluation Exercise (P-MEX) instrument was ... ...

    Abstract Background: There is an ongoing search for standardized scales appropriate for each culture to evaluate professionalism, which is one of the basic competencies of a physician. The Professionalism Mini-evaluation Exercise (P-MEX) instrument was originally developed in Canada to meet this need. In this study, it was aimed to adapt the P-MEX to Turkish and to evaluate the validity and reliability of the Turkish version.
    Methods: A total of 58 residents at Bakirkoy Dr. Sadi Konuk Training and Research Hospital were assessed with the Turkish version of P-MEX by 24 raters consisting of faculty members, attending physicians, peer residents, and nurses during patient room visits, outpatient clinic and group practices. For construct validity, the confirmatory factor analysis was performed. For reliability, Cronbach's alpha scores were calculated. Generalizibility and decision studies were undertaken to predict the reliability of the validated tool under different conditions. After the administration of P-MEX was completed, the participants were asked to provide feedback on the acceptability, feasibility, and educational impact of the instrument.
    Results: A total of 696 forms were obtained from the administration of P-MEX. The content validity of P-MEX was found to be appropriate by the faculty members. In the confirmatory factor analysis of the original structure of the 24-item Turkish scale, the goodness-of-fit parameters were calculated as follows: CFI = 0.675, TLI = 0.604, and RMSEA = 0.089. In the second stage, the factors on which the items loaded were changed without removing any item, and the model was modified. For the modified model, the CFI, TLI, and RMSEA values were calculated as 0.857, 0.834, and 0.057, respectively. The decision study on the results obtained from the use of P-MEX in a Turkish population revealed the necessity to perform this evaluation 18 times to correctly evaluate professionalism with this instrument. Cronbach's alpha score was 0.844. All the faculty members provided positive feedback on the acceptability, feasibility, and educational impact of the adapted P-MEX.
    Conclusion: The findings of this study showed that the Turkish version of P-MEX had sufficient validity and reliability in assessing professionalism among residents. Similarly, the acceptability and feasibility of the instrument were found to be high, and it had a positive impact on education.
    Trial registration: 2020/249, Bakirkoy Dr. Sadi Konuk Training and Research Hospital.
    MeSH term(s) Humans ; Professionalism ; Reproducibility of Results ; Educational Status ; Ambulatory Care Facilities ; Canada
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04675-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevalence of congenital sucrase-isomaltase deficiency in Turkey may be much higher than the estimates.

    Taskin, Didem Gulcu / Civan, Hasret Ayyildiz / Sari, Emine ErgüL / Altuntaş, Cansu / Ersoy, Melike / Tuncel, Tolga / Onay, Hüseyin / Selimoğlu, Ayşe

    Journal of genetics

    2023  Volume 102

    Abstract: Congenital sucrase-isomaltase deficiency (CSID) is a rare autosomal carbohydrate malabsorption disorder caused by mutations in the sucrase-isomaltase gene. While the prevalence of CSID is high in the indigenous populations of Alaska and Greenland, it is ... ...

    Abstract Congenital sucrase-isomaltase deficiency (CSID) is a rare autosomal carbohydrate malabsorption disorder caused by mutations in the sucrase-isomaltase gene. While the prevalence of CSID is high in the indigenous populations of Alaska and Greenland, it is imprecise and ambiguous in the Turkish pediatric population. In this cross-sectional case-control study, which is retrospective in nature, next-generation sequencing (NGS) results obtained from records of 94 pediatric patients with chronic nonspecific diarrhea were reviewed. Demographic characteristics, clinical symptoms and treatment responses of those diagnosed with CSID were evaluated. We identified one new, homozygous frame-shift mutation and 10 other heterozygous mutations. Two cases were from the same family and nine were from different families. While the median age at onset of symptoms was 6 months (0-12), median age at diagnosis was 60 months (18-192) with a median delay of 5 years and 5 months (10 months -15 years and 5 months) in diagnosis. Clinical symptoms included diarrhea (100%), abdominal pain (54.5%), vomiting after consuming sucrose (27.2%), diaper dermatitis (36.3%) and growth retardation (81%). Our clinical study revealed that sucrase-isomaltase deficiency may have been underdiagnosed in patients with chronic diarrhea in Turkey. In addition, the frequency of heterozygous mutation carriers was significantly higher than that of homozygous mutation carriers and those with a heterozygous mutations responded well to the treatment.
    MeSH term(s) Child ; Humans ; Infant ; Infant, Newborn ; Case-Control Studies ; Cross-Sectional Studies ; Diarrhea/epidemiology ; Diarrhea/genetics ; Prevalence ; Retrospective Studies ; Turkey/epidemiology ; Sucrase-Isomaltase Complex/metabolism
    Chemical Substances Sucrase-Isomaltase Complex (EC 3.2.1.-)
    Language English
    Publishing date 2023-06-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 3039-9
    ISSN 0973-7731 ; 0958-8361 ; 0022-1333
    ISSN (online) 0973-7731
    ISSN 0958-8361 ; 0022-1333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Imaging of Multisystem Inflammatory Disease in Children (MIS-C) Associated With COVID-19.

    Palabiyik, Figen / Akcay, Nihal / Sevketoglu, Esra / Hatipoglu, Nevin / Sari, Emine Ergul / Inci, Ercan

    Academic radiology

    2021  Volume 28, Issue 9, Page(s) 1200–1208

    Abstract: Rationale and objectives: To retrospectively evaluate imaging findings in multisystem inflammatory disease in children associated with COVID-19 (MIS-C).: Materials and methods: The radiological imaging findings of 45 pediatric patients aged between ... ...

    Abstract Rationale and objectives: To retrospectively evaluate imaging findings in multisystem inflammatory disease in children associated with COVID-19 (MIS-C).
    Materials and methods: The radiological imaging findings of 45 pediatric patients aged between 52 days and 16 years, who were diagnosed with MIS-C according to the World Health Organization (WHO) criteria, were evaluated. All the patients underwent chest X-ray and echocardiography. The findings obtained from 25 abdominal radiographs, 24 abdominal US, 7 abdominal CT, 16 thorax CT, 21 cranial MRI and one spinal MRI, MR cholangiography (MRCP) and cardiac MRI examinations were categorized and evaluated according to the affected systems.
    Results: While the most common findings in chest X-ray were perihilar opacity and peribronchial thickening, pleural effusion was the most finding in thorax CT. Echocardiography findings of myocarditis were observed in 31% of the cases. The most common findings in abdominal radiological evaluation were hepatomegaly and splenomegaly, edema in the gallbladder wall and periportal area, mesenteric lymph nodes in the right lower quadrant, thickening of the intestinal walls, and free fluid. Reversible splenial lesion syndrome (RESLES) was the most common neurological finding. Acute disseminated encephalomyelitis (ADEM)-like lesions, acute hemorrhagic necrotizing encephalomyelitis, and radiological findings consistent with Guillain-Barré syndrome were found in one case each.
    Conclusion: Radiological findings seen in MIS-C in pediatric cases are correlated with the affected system. According to the system involved, there is no specific finding for this disease. Radiological findings are not the primary diagnostic tool but can assist in the evaluation of the affected systems and to guide treatment.
    MeSH term(s) COVID-19 ; Child ; Echocardiography ; Humans ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2021-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2021.05.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of 601 children with multisystem inflammatory syndrome (Turk MISC study).

    Yilmaz, Dilek / Ekemen Keles, Yildiz / Emiroglu, Melike / Duramaz, Burcu Bursal / Ugur, Cuneyt / Aldemir Kocabas, Bilge / Celik, Talyan / Ozdemir, Halil / Bayturan, Semra / Turel, Ozden / Erdeniz, Emine Hafize / Cakici, Ozlem / Cakmak Taskin, Esra / Erbas, İrem Ceren / Genceli, Mustafa / Sari, Emine Ergul / Caymaz, Canan / Kizil, Mahmut Can / Sutcu, Murat /
    Demirbuga, Asuman / Alkan, Gulsum / Bagcı, Zafer / Timurtas Dayar, Gulperi / Ozkan, Esra Akyuz / Tekin Yilmaz, Ayse / Akca, Mehtap / Yesil, Edanur / Kara, Soner Sertan / Akturk, Hacer / Yasar, Belma / Umit, Zuhal / Uygun, Hatice / Erdem, Nurettin / Buyukcam, Ayse / Karadag Oncel, Eda / Tuter Oz, Sadiye Kubra / Cetin, Hafize Selma / Anil, Ayse Berna / Yilmaz, Resul / Zengin, Neslihan / Uzuner, Selcuk / Albayrak, Hatice / Borakay, Ozgur / Topal, Sevgi / Arslan, Gazi / Yazar, Abdullah / Ozer, Arife / Kendirli, Tanil / Kara, Emine Manolya / Demirkol, Demet / Battal, Fatih / Kosker, Muhammet / Metin Akcan, Ozge / Kihtir, Hasan Serdar / Gul, Doruk / Zararci, Kazim / Alakaya, Mehmet / Kula, Nilgun / Celik, Elif / Petmezci, Ercument / Evren, Gultac / Kara Aksay, Ahu / Konca, Capan / Sert, Ahmet / Arslan, Derya / Bornaun, Helen / Tekeli, Onur / Bal, Alkan / Sahin, Irfan Oguz / Demir, Selcan / Sap, Fatih / Akyol, Mehmet Bedir / Tanidir, Ibrahim Cansaran / Donmez, Yasemin Nuran / Ucar, Tayfun / Coban, Senay / Arga, Gul / Hancerli Torun, Selda / Karpuz, Derya / Celik, Serkan Fazli / Varan, Celal / Elmali, Ferhan / Oncel, Selim / Belet, Nursen / Hatipoglu, Nevin / Dalgic Karabulut, Nazan / Turgut, Mehmet / Somer, Ayper / Kuyucu, Necdet / Dinleyici, Ener Cagri / Ciftci, Ergin / Kara, Ates

    European journal of pediatrics

    2023  Volume 182, Issue 12, Page(s) 5531–5542

    Abstract: Purpose: Due to its link with the 2019 coronavirus, the multisystem inflammatory syndrome in children (MISC) has garnered considerable international interest. The aim of this study, in which MISC patients were evaluated multicenter, and the data of the ... ...

    Abstract Purpose: Due to its link with the 2019 coronavirus, the multisystem inflammatory syndrome in children (MISC) has garnered considerable international interest. The aim of this study, in which MISC patients were evaluated multicenter, and the data of the third period of the Turk-MISC study group, to compare the clinical and laboratory characteristics and outcomes of MISC patients who did and did not require admission to an intensive care unit (ICU).
    Methods: This retrospective multicenter observational study was carried out between June 11, 2021, and January 01, 2022. The demographics, complaints, laboratory results, system involvements, and outcomes of the patients were documented.
    Results: A total of 601 patients were enrolled; 157 patients (26.1%) required hospitalization in the intensive care unit (ICU). Median age was 8 years (interquartile range (IQR) 4.5-11.3 years. The proportion of Kawasaki disease-like features in the ICU group was significantly higher than in the non-ICU group (56.1% vs. 43.2% p = 0.006). The ICU group had considerably lower counts of both lymphocytes and platelets (lymphocyte count 900 vs. 1280 cells × μL, platelet count 153 vs. 212 cells × 10
    What is known: • Lymphopenia and thrombocytopenia were an independent predictor factors in patients with MISC who needed to stay in intensive care unit. • The possibility of the need to stay in the intensive care unit in patients with MISC who had Kawasaki disease-like findings was controversial compared with those who did not.
    What is new: • A one-unit increase log D dimer and log troponin was demonstrated to require for intensive care unit by 1.8 and 1.4 times, respectively. • Serum procalcitonin levels had the best performance to predict stay in the intensive care unit stay.
    MeSH term(s) Child ; Humans ; Infant, Newborn ; Infant ; Child, Preschool ; Mucocutaneous Lymph Node Syndrome ; Procalcitonin ; Intensive Care Units ; Ferritins ; Troponin ; Retrospective Studies
    Chemical Substances Procalcitonin ; Ferritins (9007-73-2) ; Troponin
    Language English
    Publishing date 2023-10-02
    Publishing country Germany
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-05207-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluation of vaccination status of health care workers for recommended vaccines and their acceptance of SARS-CoV-2 vaccines.

    Oygar, Pembe Derin / Büyükçam, Ayşe / Sahbudak Bal, Zumrut / Dalgıç, Nazan / Bozdemir, Şefika Elmas / Karbuz, Adem / Çetin, Benhur Şirvan / Kara, Yalçın / Çetin, Ceren / Hatipoğlu, Nevin / Uygun, Hatice / Aygün, Fatma Deniz / Hançerli Törün, Selda / Şener Okur, Dicle / Yılmaz Çiftdoğan, Dilek / Tural Kara, Tuğçe / Yahşi, Aysun / Özer, Arife / Öcal Demir, Sevliya /
    Akkoç, Gülşen / Turan, Cansu / Salı, Enes / Şen, Semra / Erdeniz, Emine Hafize / Kara, Soner Sertan / Emiroğlu, Melike / Erat, Tuğba / Aktürk, Hacer / Laçinel Gürlevik, Sibel / Sütçü, Murat / Gayretli Aydın, Zeynep Gökçe / Yıldız Atikan, Başak / Yeşil, Edanur / Güner Özenen, Gizem / Çelebi, Emel / Efe, Kadir / Kizmaz Isancli, Didem / Selver Durmuş, Habibe / Tekeli, Seher / Karaaslan, Ayşe / Bülbül, Lida / Almış, Habip / Kaba, Özge / Ekemen Keleş, Yıldız / Yazıcıoğlu, Bahadır / Bahtiyar Oğuz, Serife / Ovalı, Hüsnü Fahri / Doğan, Hazal Helin / Çelebi, Solmaz / Çakir, Deniz / Karasulu, Burcugül / Alkan, Gülsüm / Yenidoğan, İrem / Gül, Doruk / Parıltan Kücükalioğlu, Burcu / Avcu, Gülhadiye / Kukul, Musa Gürel / Bilen, Melis / Yaşar, Belma / Üstün, Tuğba / Kılıç, Ömer / Akın, Yasemin / Oral Cebeci, Sinem / Bucak, İbrahim Hakan / Sarı Yanartaş, Mehpare / Şahin, Aslıhan / Arslanoglu, Sertaç / Elevli, Murat / Çoban, Rabia / Tuter Öz, Sadiye Kübra / Hatipoğlu, Halil / Erkum, İlyas Tolga / Turgut, Mehmet / Demirbuğa, Asuman / Özçelik, Taha / Çiftçi, Diclehan / Sarı, Emine Ergül / Akkuş, Gökhan / Hatipoğlu, Sadık Sami / Dinleyici, Ener Cağrı / Hacimustafaoğlu, Mustafa / Özkınay, Ferda / Kurugöl, Zafer / Cengiz, Ali Bulent / Somer, Ayper / Tezer, Hasan / Kara, Ateş

    Human vaccines & immunotherapeutics

    2022  Volume 18, Issue 5, Page(s) 2044707

    Abstract: Introduction: Health care workers (HCWs) are disproportionately exposed to infectious diseases and play a role in nosocomial transmission, making them a key demographic for vaccination. HCW vaccination rates are not optimal in many countries; hence, ... ...

    Abstract Introduction: Health care workers (HCWs) are disproportionately exposed to infectious diseases and play a role in nosocomial transmission, making them a key demographic for vaccination. HCW vaccination rates are not optimal in many countries; hence, compulsory vaccination policies have been implemented in some countries. Although these policies are effective and necessary under certain conditions, resolving HCWs' hesitancies and misconceptions about vaccines is crucial. HCWs have the advantage of direct contact with patients; hence, they can respond to safety concerns, explain the benefits of vaccination, and counter antivaccine campaigns that escalate during pandemics, as has been observed with COVID-19.
    Method: A short survey was carried out in May-June 2020 on the vaccination status of HCWs working with pediatric patients with COVID-19. The survey inquired about their vaccination status (mumps/measles/rubella [MMR], varicella, influenza, and diphtheria/tetanus [dT]) and willingness to receive hypothetical future COVID-19 vaccines. The respondents were grouped according to gender, age, occupation, and region.
    Results: In total, 4927 HCWs responded to the survey. Most were young, healthy adults. The overall vaccination rates were 57.8% for dT in the past 10 years, 44.5% for MMR, 33.2% for varicella, and 13.5% for influenza. Vaccination rates were the highest among physicians. The majority of HCWs (81%) stated that they would be willing to receive COVID-19 vaccines.
    Conclusion: Although vaccination rates for well-established vaccines were low, a majority of HCWs were willing to receive COVID-19 vaccines when available. Education and administrative trust should be enhanced to increase vaccination rates among HCWs.
    MeSH term(s) Adult ; COVID-19/prevention & control ; COVID-19 Vaccines ; Chickenpox ; Child ; Health Personnel ; Humans ; Influenza Vaccines ; Influenza, Human/prevention & control ; Measles/prevention & control ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2022.2044707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS-CoV-2 seropositivity among pediatric health care personnel after the first peak of the pandemic: nationwide surveillance in Turkey.

    Oygar, Pembe Derin / Büyükçam, Ayşe / Bal, Zümrüt Şahbudak / Dalgıç, Nazan / Bozdemir, Şefika Elmas / Karbuz, Adem / Çetin, Benhur Şirvan / Kara, Yalçın / Çetin, Ceren / Hatipoğlu, Nevin / Uygun, Hatice / Aygün, Fatma Deniz / Törün, Selda Hançerli / Okur, Dicle Şener / Çiftdoğan, Dilek Yılmaz / Kara, Tuğçe Tural / Yahşi, Aysun / Özer, Arife / Demir, Sevliya Öcal /
    Akkoç, Gülşen / Turan, Cansu / Salı, Enes / Şen, Semra / Erdeniz, Emine Hafize / Kara, Soner Sertan / Emiroğlu, Melike / Erat, Tuğba / Aktürk, Hacer / Gürlevik, Sibel Laçinel / Sütçü, Murat / Aydın, Zeynep Gökçe Gayretli / Atikan, Başak Yıldız / Yeşil, Edanur / Güner, Gizem / Çelebi, Emel / Efe, Kadir / İşançlı, Didem Kızmaz / Durmuş, Habibe Selver / Tekeli, Seher / Karaaslan, Ayşe / Bülbül, Lida / Almış, Habip / Kaba, Özge / Keleş, Yıldız Ekemen / Yazıcıoğlu, Bahadır / Oğuz, Şerife Bahtiyar / Ovalı, Hüsnü Fahri / Doğan, Hazal Helin / Çelebi, Solmaz / Çakır, Deniz / Karasulu, Burcugül / Alkan, Gülsüm / Yenidoğan, İrem / Gül, Doruk / Küçükalioğlu, Burcu Parıltan / Avcu, Gülhadiye / Kukul, Musa Gürel / Bilen, Melis / Yaşar, Belma / Üstün, Tuğba / Kılıç, Ömer / Akın, Yasemin / Cebeci, Sinem Oral / Bucak, Ibrahim Hakan / Yanartaş, Mehpare Sarı / Şahin, Aslıhan / Arslanoğlu, Sertaç / Elevli, Murat / Çoban, Rabia / Öz, Şadiye Kübra Tüter / Hatipoğlu, Halil / Erkum, İlyas Tolga / Turgut, Mehmet / Demirbuğa, Asuman / Özçelik, Taha / Çiftçi, Diclehan / Sarı, Emine Ergül / Akkuş, Gökhan / Hatipoğlu, Sadık Sami / Dinleyici, Ener Çağrı / Hacımustafaoğlu, Mustafa / Özkınay, Ferda / Kurugöl, Zafer / Cengiz, Ali Bülent / Somer, Ayper / Tezer, Hasan / Kara, Ateş

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 113, Page(s) 184–189

    Abstract: Background: Understanding SARS-CoV-2 seroprevalence among health care personnel is important to explore risk factors for transmission, develop elimination strategies and form a view on the necessity and frequency of surveillance in the future.: ... ...

    Abstract Background: Understanding SARS-CoV-2 seroprevalence among health care personnel is important to explore risk factors for transmission, develop elimination strategies and form a view on the necessity and frequency of surveillance in the future.
    Methods: We enrolled 4927 health care personnel working in pediatric units at 32 hospitals from 7 different regions of Turkey in a study to determine SARS Co-V-2 seroprevalence after the first peak of the COVID-19 pandemic. A point of care serologic lateral flow rapid test kit for immunoglobulin (Ig)M/IgG was used. Seroprevalence and its association with demographic characteristics and possible risk factors were analyzed.
    Results: SARS-CoV-2 seropositivity prevalence in health care personnel tested was 6.1%. Seropositivity was more common among those who did not universally wear protective masks (10.6% vs 6.1%). Having a COVID-19-positive co-worker increased the likelihood of infection. The least and the most experienced personnel were more likely to be infected. Most of the seropositive health care personnel (68.0%) did not suspect that they had previously had COVID-19.
    Conclusions: Health surveillance for health care personnel involving routine point-of-care nucleic acid testing and monitoring personal protective equipment adherence are suggested as important strategies to protect health care personnel from COVID-19 and reduce nosocomial SARS-CoV-2 transmission.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Child ; Delivery of Health Care ; Health Personnel ; Humans ; Pandemics ; SARS-CoV-2 ; Seroepidemiologic Studies ; Turkey/epidemiology
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-09-27
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.09.054
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