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Article: Advancing liposome technology for innovative strategies against malaria.

Miatmoko, Andang / Octavia, Rifda Tarimi / Araki, Tamasa / Annoura, Takeshi / Sari, Retno

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2024 Volume 32, Issue 6, Page(s) 102085

Abstract: This review discusses the potential of liposomes as drug delivery systems for antimalarial therapies. Malaria continues to be a significant cause of mortality and morbidity, particularly among children and pregnant women. Drug resistance due to patient ... ...

Abstract	This review discusses the potential of liposomes as drug delivery systems for antimalarial therapies. Malaria continues to be a significant cause of mortality and morbidity, particularly among children and pregnant women. Drug resistance due to patient non-compliance and troublesome side effects remains a significant challenge in antimalarial treatment. Liposomes, as targeted and efficient drug carriers, have garnered attention owing to their ability to address these issues. Liposomes encapsulate hydrophilic and/or hydrophobic drugs, thus providing comprehensive and suitable therapeutic drug delivery. Moreover, the potential of passive and active drug delivery enables drug concentration in specific target tissues while reducing adverse effects. However, successful liposome formulation is influenced by various factors, including drug physicochemical characteristics and physiological barriers encountered during drug delivery. To overcome these challenges, researchers have explored modifications in liposome nanocarriers to achieve efficient drug loading, controlled release, and system stability. Computational approaches have also been adopted to predict liposome system stability, membrane integrity, and drug-liposome interactions, improving formulation development efficiency. By leveraging computational methods, optimizing liposomal drug delivery systems holds promise for enhancing treatment efficacy and minimizing side effects in malaria therapy. This review consolidates the current understanding and highlights the potential of liposome strategies against malaria.
Language	English
Publishing date	2024-04-24
Publishing country	Saudi Arabia
Document type	Journal Article ; Review
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2024.102085
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Article ; Online: Training on the Utilization of Lime to Empower the Lime Farmers in Bolo Village, Gresik

Idha Kusumawati / Sari Retno / Handayani Rosita / Harjono Suko / Yuwono Mochamad / Munandar Tristiana Erawati

Community Development Journal, Vol 7, Iss

2023 Volume 1

Abstract: Lime (Citrus aurantifolia (Christm.) Swingle) is one of the important agricultural commodities for residents in the Bolo village, Gresik. The resident of Bolo Village owns an average of 1/4 hectare of lime plantations. However, the price of lime is not ... ...

Abstract	Lime (Citrus aurantifolia (Christm.) Swingle) is one of the important agricultural commodities for residents in the Bolo village, Gresik. The resident of Bolo Village owns an average of 1/4 hectare of lime plantations. However, the price of lime is not stable. In the harvest season, when conditions become surplus in the market, lime prices often drop, causing losses for the farmers. Lack of knowledge about lime product processing is also an obstacle in the utilization and processing of crops. This community service activity aims to improve the knowledge and skills of citrus farmers in Bolo Village to utilize and process lime crops into Home Industry products, so they do not suffer losses when the lime price drops. Activities are carried out through learning using interactive lecture methods and training through product manufacturing demos. The successful indicator was carried out by evaluating the participants' level of understanding before and after the activity. The training activities significantly increased the participants' knowledge and experience. In addition, this activity also obtained data on the needs of lime farmers. It is hoped that this data can be used for the continuation of the next activity or can also be used by the local government, which wants to help advance agriculture and product diversification in the village of Bolo.
Keywords	Lime ; Farmers ; Gresik ; Home industry ; SDGS ; Social Sciences ; H
Subject code	910
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Universitas Nahdlatul Ulama Surabaya, Lembaga Penelitian dan Pengabdian kepada Masyarakat
Document type	Article ; Online
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Article ; Online: The stability and irritability study of the chitosan-

Retnowati, Dini / Sari, Retno / Hendradi, Esti / Septiani, Septiani

Journal of basic and clinical physiology and pharmacology

2021 Volume 32, Issue 4, Page(s) 651–656

Abstract: Objectives: Chitosan is a natural polysaccharide widely used in various clinical applications including regeneration of skin tissue. : Methods: The spray gel stability test was conducted using thermal cycling and centrifugation methods. The ... ...

Abstract	Objectives: Chitosan is a natural polysaccharide widely used in various clinical applications including regeneration of skin tissue. Methods: The spray gel stability test was conducted using thermal cycling and centrifugation methods. The organoleptic, viscosity, and pH of the spray were evaluated. The irritation test was performed by Draize Rabbit Test method. Results: Chitosan (0.5%)- Conclusions: The spray gel of chitosan (0.5%)-
MeSH term(s)	Aloe ; Animals ; Chitosan ; Plant Leaves ; Rabbits ; Skin ; Wound Healing
Chemical Substances	Chitosan (9012-76-4)
Language	English
Publishing date	2021-06-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2020-0407
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Article: Nanoparticles use for Delivering Ursolic Acid in Cancer Therapy: A Scoping Review.

Miatmoko, Andang / Mianing, Ester Adelia / Sari, Retno / Hendradi, Esti

Frontiers in pharmacology

2021 Volume 12, Page(s) 787226

Abstract: Ursolic acid is a natural pentacyclic triterpenoid that exerts a potent anticancer effect. Furthermore, it is classified as a BCS class IV compound possessing low permeability and water solubility, consequently demonstrating limited bioavailability in ... ...

Abstract	Ursolic acid is a natural pentacyclic triterpenoid that exerts a potent anticancer effect. Furthermore, it is classified as a BCS class IV compound possessing low permeability and water solubility, consequently demonstrating limited bioavailability in addition to low therapeutic effectiveness. Nanoparticles are developed to modify the physical characteristics of drug and can often be produced in the range of 30-200 nm, providing highly effective cancer therapy due to the Enhanced Permeation and Retention (EPR) Effect. This study aims to provide a review of the efficacy and safety of various types of Ursolic Acid-loading nanoparticles within the setting of preclinical and clinical anticancer studies. This literature study used scoping review method, where the extracted data must comply with the journal inclusion criteria of within years of 2010-2020. The identification stage produced 237 suitable articles. Duplicate screening was then conducted followed by the initial selection of 18 articles that had been reviewed and extracted for data analysis. Based on this review, the use of nanoparticles can be seen to increase the anticancer efficacy of Ursolic Acid in terms of several parameters including pharmacokinetic data, survival rates and inhibition rates, as well as the absence of serious toxicity in preclinical and clinical trials in terms of several parameters including body weight, blood clinical chemistry, and organ histipathology. Based on this review, the use of nanoparticles has been able to increase the anticancer efficacy of Ursolic Acid, as well as show the absence of serious toxicity in preclinical and clinical trials. Evenmore, the liposome carrier provides development data that has reached the clinical trial phase I. The use of nanoparticle provides high potential for Ursolic Acid delivery in cancer therapy.
Language	English
Publishing date	2021-12-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.787226
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Article ; Online: The effect of chitosan type and drug-chitosan ratio on physical characteristics and release profile of ketoprofen microparticles prepared by spray drying.

Rijal, Muhammad A S / Masitah, Hanah / Purvitasari, Fanny / Sari, Retno

Journal of basic and clinical physiology and pharmacology

2021 Volume 32, Issue 4, Page(s) 669–673

Abstract: Objectives: In order to minimize gastrointestinal irritation and to extend the absorption of ketoprofen, microparticles prepared with chitosan have been developed. In this study, chitosan type and drug-chitosan ratio were investigated to prepare ... ...

Abstract	Objectives: In order to minimize gastrointestinal irritation and to extend the absorption of ketoprofen, microparticles prepared with chitosan have been developed. In this study, chitosan type and drug-chitosan ratio were investigated to prepare microparticles of ketoprofen and evaluated for physical characteristics and drug release profiles. Methods: Microparticles were prepared by using ionic gelation methods with chitosan, which has two different viscosities i.e., 19 and 50 cPs, cross-linked with tripolyphosphate, and dried by spray drying method. The microparticles were made with a drug-chitosan ratio of 5:15 and 6:15. Results: The results showed that the microparticles had spherical shapes. Increasing the amount of ketoprofen improved the drug content and entrapment efficiency. Evaluation of drug release in simulated intestinal fluid (pH 6.8) showed that the microparticles prepared with chitosan 19 cPs had the slowest release rate than those of chitosan 50 cPs, while that of the microparticles prepared with chitosan 50 cPs with the ratio of drug/polymer 6:15 was the fastest, as shown by its slope value. The release rate of microparticles with chitosan 19 cPs was slower than those microparticles with chitosan 50 cPs. Conclusions: It could be suggested that by increasing the amount of ketoprofen, it improved the entrapment efficiency and the release rate of microparticles.
MeSH term(s)	Chitosan ; Ketoprofen ; Particle Size ; Pharmaceutical Preparations ; Spray Drying
Chemical Substances	Pharmaceutical Preparations ; Chitosan (9012-76-4) ; Ketoprofen (90Y4QC304K)
Language	English
Publishing date	2021-06-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2020-0487
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Article ; Online: Improving solubility and dissolution of meloxicam by solid dispersion using hydroxypropyl methylcellulose 2910 3 cps and nicotinamide.

Fathanah, Ana / Setyawan, Dwi / Sari, Retno

Journal of basic and clinical physiology and pharmacology

2019 Volume 30, Issue 6

Abstract: Background Solid dispersion (SD) represents a good method for enhancing the solubility of poorly water-soluble drugs. Meloxicam (MLX), a nonsteroidal anti-inflammatory drug has poor solubility in water. Hydroxypropyl methylcellulose (HPMC) 2910 3 cps, a ... ...

Abstract	Background Solid dispersion (SD) represents a good method for enhancing the solubility of poorly water-soluble drugs. Meloxicam (MLX), a nonsteroidal anti-inflammatory drug has poor solubility in water. Hydroxypropyl methylcellulose (HPMC) 2910 3 cps, a hydrophilic carrier and nicotinamide (NC), a hydrotropic agent can be used as matrix of SD. The aim of this study is to investigate the effect of HPMC 2910 3 cps and NC as SD matrix on the solubility and dissolution rate of MLX. Methods The SD of MLX was prepared by solvent evaporation method using methanol as solvent. The SD formulations composed of HPMC and NC in different ratios (1:1:1, 1:1:2, 1:2:1, 1:2:2). The physical state of MLX SD were characterized by Differential Thermal Analyzer (DTA), Fourier Transform Infrared Spectroscopy, powder X-ray diffractometer (PXRD), Scanning Electron Microscopy (SEM). The solubility and dissolution of the MLX SD were also evaluated. Results The results of differential thermal analysis (DTA) showed that the melting point of MLX SD was lower than MLX further the X-ray diffractogram showed a decrease of the crystallinity of MLX in SD. Those indicated that MLX was dispersed molecularly in SD. The SD showed a widening transmission peak at 3000-3500 cm-1 which resembled the peak of pure MLX transmission. It indicated that intermolecular hydrogen bonds were formed between MLX, HPMC, and NC. The solubility and the dissolution efficiency (ED60) of SD with MLX-HPMC 2910 3 cps-NC = 1:2:1 increased 3.59 times and 1.50 times higher then MLX substance. Conclusions MLX-HPMC-NC SD system increased the solubility and dissolution of MLX. The SD with MLX-HPMC 2910 3 cps-NC ratio of 1:2:1 had the highest solubility and ED60 compared to the other SD formulas.
MeSH term(s)	Drug Compounding/methods ; Hypromellose Derivatives/chemistry ; Meloxicam/chemistry ; Niacinamide/chemistry ; Solubility
Chemical Substances	Niacinamide (25X51I8RD4) ; Hypromellose Derivatives (3NXW29V3WO) ; Meloxicam (VG2QF83CGL)
Language	English
Publishing date	2019-12-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2019-0249
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Article ; Online: The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes.

Miatmoko, Andang / Hariawan, Berlian S / Cahyani, Devy M / Sari, Retno / Dinaryanti, Aristika / Hendrianto, Eryk

Anais da Academia Brasileira de Ciencias

2021 Volume 93, Issue 3, Page(s) e20201850

Abstract: This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. ... ...

Abstract	This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher cytotoxicity in HeLa cells than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, chitosan layers improved the cellular uptake, which clathrin-mediated endocytosis may determine the cellular transport of UA niosomes. In conclusion, the addition of chitosan improved cellular uptake and cytotoxicity of UA niosomes in the HeLa cells.
MeSH term(s)	Chitosan/toxicity ; HeLa Cells ; Humans ; Liposomes ; Triterpenes/pharmacology ; Ursolic Acid
Chemical Substances	Liposomes ; Triterpenes ; Chitosan (9012-76-4)
Language	English
Publishing date	2021-07-19
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2046885-4
ISSN	1678-2690 ; 0001-3765
ISSN (online)	1678-2690
ISSN	0001-3765
DOI	10.1590/0001-3765202120201850
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Article ; Online: N-nitrosodiethylamine induces inflammation of liver in mice.

Cahyani, Devy Maulidya / Miatmoko, Andang / Hariawan, Berlian Sarasitha / Purwantari, Kusuma Eko / Sari, Retno

Journal of basic and clinical physiology and pharmacology

2021 Volume 32, Issue 4, Page(s) 505–510

Abstract: Objectives: For designing early treatment for liver cancer, it is important to prepare an animal model to evaluate cancer prevention treatment by using inflammation disease. The hepatocarcinogenic N-Nitrosodiethylamine (NDEA) has been reportedly able to ...

Abstract	Objectives: For designing early treatment for liver cancer, it is important to prepare an animal model to evaluate cancer prevention treatment by using inflammation disease. The hepatocarcinogenic N-Nitrosodiethylamine (NDEA) has been reportedly able to produce free radicals that cause liver inflammation leading to liver carcinoma. This study aimed to evaluate the inflammation disease model of mice induced with hepatocarcinogenic NDEA for five weeks induction. Methods: The BALB-c mice were induced with NDEA 25 mg/kg of body weight once a week for five weeks intraperitonially and it was then evaluated for the body weight during study periods. The mice were then sacrificed and excised for evaluating their organs including physical and morphological appearances and histopathology evaluations. Results: The results showed a significant decrease of body weight of mice after five times induction of 25 mg NDEA/kgBW per week intraperitonially. Different morphological appearances and weight of mice organs specifically for liver and spleen had also been observed. The histopathology examination showed that there were hepatic lipidosis and steatohepatitis observed in liver and spleen, respectively that might indicate the hepatocellular injury. Conclusions: It can be concluded that inducing mice with NDEA intraperitonially resulted in fatty liver disease leading to progress of cancer disease.
MeSH term(s)	Animals ; Body Weight ; Diethylnitrosamine/toxicity ; Inflammation/chemically induced ; Liver ; Liver Neoplasms, Experimental/chemically induced ; Mice ; Mice, Inbred BALB C
Chemical Substances	Diethylnitrosamine (3IQ78TTX1A)
Language	English
Publishing date	2021-06-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2020-0475
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Article ; Online: Cocrystal formation of loratadine-succinic acid and its improved solubility.

Setyawan, Dwi / Adyaksa, Firdaus Rendra / Sari, Hanny Lystia / Paramita, Diajeng Putri / Sari, Retno

Journal of basic and clinical physiology and pharmacology

2021 Volume 32, Issue 4, Page(s) 623–630

Abstract: Objectives: Loratadine belongs to Class II compound of biopharmaceutics classification system (BCS) due its low solubility and high membrane permeability. Cocrystal is a system of multicomponent crystalline that mostly employed to improve solubility. ... ...

Abstract	Objectives: Loratadine belongs to Class II compound of biopharmaceutics classification system (BCS) due its low solubility and high membrane permeability. Cocrystal is a system of multicomponent crystalline that mostly employed to improve solubility. Succinic acid is one of common coformer in cocrystal modification. This research aims to investigate cocrystal formation between loratadine and succinic acid and its effect on solubility property of loratadine. Methods: Cocrystal of loratadine-succinic acid was prepared by solution method using methanol as the solvent. Cocrystal formation was identified under observation of polarization microscope and analysis of the binary phase diagram. The cocrystal phase was characterized by differential thermal analysis (DTA), powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM). Solubility study was conducted in phosphate-citrate buffer pH 7.0 ± 0.5 at 30 ± 0.5 °C. Results: Loratadine is known to form cocrystal with succinic acid in 1:1 M ratio. Cocrystal phase has lower melting point at 110.9 °C. Powder diffractograms exhibited new diffraction peaks at 2 Conclusions: Cocrystal of loratadine and succinic acid is formed by stoichiometry of 1:1 via C=O and H-O interaction. Cocrystal phase shows different physicochemical properties and responding to those properties, it shows improved loratadine solubility as well.
MeSH term(s)	Crystallization ; Loratadine/chemistry ; Powders ; Solubility ; Succinic Acid/chemistry ; X-Ray Diffraction
Chemical Substances	Powders ; Loratadine (7AJO3BO7QN) ; Succinic Acid (AB6MNQ6J6L)
Language	English
Publishing date	2021-06-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2020-0456
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Article ; Online: Pemanfaatan IPTEK Dalam Kegiatan Belajar Mengajar Untuk Masyarakat Pela Mampang Di Masa Pandemi

Saryoko, Andi / Sari, Retno / Rianto, Verry / Rosyida, Susy

ABDIMAS: Jurnal Pengabdian Masyarakat; Vol. 3 No.; 304-310 ; 2614-8544 ; 10.35568/abdimas.v3i2

2020 Volume 2, Issue : ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat

Abstract: Di masa pandemi covid-19 saat ini, masyarakat terutama anak-anak yang bersekolah maupun orang tua dipaksa untuk bisa menggunakan teknologi untuk melakukan kegiatan belajar mengajar secara daring. Kegiatan belajar daring ini membuat sebagian anak-anak ... ...

Abstract	Di masa pandemi covid-19 saat ini, masyarakat terutama anak-anak yang bersekolah maupun orang tua dipaksa untuk bisa menggunakan teknologi untuk melakukan kegiatan belajar mengajar secara daring. Kegiatan belajar daring ini membuat sebagian anak-anak atau orang tua mempelajari teknologi yang digunakan secara otodidak. Kami selaku Dosen dan PPPM (Pusat Penelitian dan Pengabdian Masyarakat) Sekolah Tinggi Manajemen Informatika dan Komputer Nusa Mandiri ingin melakukan pengabdian masyarakat dengan memberikan pelatihan kepada warga RT 008/010 Pela Mampang dengan tema pemanfaatan IPTEK dalam kegiatan belajar mengajar untuk masyarakat pela mampang di masa pandemi. Bentuk dari kegiatan pengabdian masyarakat yang akan dilaksanakan adalah berupa webinar memberikan pengetahuan dan keterampilan dasar belajar menggunakan aplikasi pembelajaran daring yaitu Google Classroom untuk menunjang kegiatan belajar secara daring selama pandemi covid-19 kepada warga RT 008/010 Pela Mampang, Melakukan penyampaian materi berkenaan dengan pengenalan Google Classroom, Menjelaskan bagaimana langkah-langkah memulai Google Classroom dan apa saja yang dapat dilakukan dengan Google Classroom, Memberikan latihan mengakses Google Classroom dan memulai kegiatan belajar. Hasil dari kegiatan pelatihan ini adalah Peningkatan keterampilan peserta terhadap pengenalan penggunaan Google Classroom yang memudahkan sebagai tambahan ilmu yang bisa diterapkan pada kegiatan belajar, Para peserta dapat mengoperasikan Google Classroom untuk mendukung proses belajar secara daring selama pandemi, Para peserta dapat mengajari teman-temannya yang lain, yang belum bisa mengoperasikan Google Classroom untuk kegiatan belajar di sekolah.
Keywords	IPTEK ; Warga Pela Mampang ; Pandemi Covid-19 ; covid19
Language	English
Publishing date	2020-10-30
Publisher	LPPM Universitas Muhammadiyah Tasikmalaya
Publishing country	id
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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