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  1. Article: Effects of

    Luthfiana, Fina / Sari, Riza Ambar / Sholikhah, Irawati / Matsunami, Katsuyoshi / Sukardiman / Widyowati, Retno

    Journal of public health in Africa

    2023  Volume 14, Issue Suppl 1, Page(s) 2507

    Abstract: Background: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb ... ...

    Abstract Background: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb extract has been shown to affect bone because of its content, which can help osteoblast differentiation and inhibit osteoclast differentiation.
    Objective: This study aimed to assess the effects of 70% ethanol extract of
    Methods: Six groups of 30 female Wistar rats were created. There were no test materials offered to the healthy group; the negative group received 0.5% CMC; the positive group received alendronate 0.9 mg/kg BW; and the dose group received 30, 60, and 120 mg/kg BW. Glucocorticoid (Dexamethasone) 0.1015 mg/kg BW/day induction was given to all groups except the healthy group to create osteoporosis rats for approximately four weeks. Then they were given oral therapy for approximately 28 days. Followed by the determination of blood calcium levels, the number of osteoblast cells, and bone density of the rat femur trabecular.
    Results: The result showed that
    Conclusions: The findings indicate that
    Language English
    Publishing date 2023-03-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2574977-8
    ISSN 2038-9930 ; 2038-9922
    ISSN (online) 2038-9930
    ISSN 2038-9922
    DOI 10.4081/jphia.2023.2507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antiosteoarthritis activities of 70% ethanol extract of

    Sari, Riza Ambar / Luthfiana, Fina / Sholihah, Irawati / Matsunami, Katsuyoshi / Sukardiman / Widyowati, Retno

    Journal of public health in Africa

    2023  Volume 14, Issue Suppl 1, Page(s) 2506

    Abstract: Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, : Objective: In this research, we employed an : Methods: A singular intraarticular injection of Monosodium ... ...

    Abstract Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally,
    Objective: In this research, we employed an
    Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1. level, joint swelling, and hyperalgesia.
    Results: Induction was successful, indicated by a significant difference (P<0.05) in decreasing latency time, increasing joint swelling, and IL-1. level. EBE 24 mg/200 g BW treatment has significantly (P<0.05) reduced IL-1. levels, joint swelling, and response to hyperalgesia.
    Conclusion: The 70% ethanol extract of
    Language English
    Publishing date 2023-03-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2574977-8
    ISSN 2038-9930 ; 2038-9922
    ISSN (online) 2038-9930
    ISSN 2038-9922
    DOI 10.4081/jphia.2023.2506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Activity and Toxicity of Eleutherine palmifolia (L.) Merr. Extract on BALB/c Mice Colitis-Associated Colon Cancer Model.

    Mutiah, Roihatul / Sari, Riza Ambar / Firsyaradha, Wahyi Yucha / Listiyana, Anik / Indrawijaya, Yen Yen Ari / Wafi, Abdul / Suryadinata, Arief / Susilowati, Retno / Rahmawati, Ana

    Asian Pacific journal of cancer prevention : APJCP

    2020  Volume 21, Issue 12, Page(s) 3579–3586

    Abstract: Objective: Eleutherine palmifolia (L.) Merr. extract (EPE) containing isoliquiritigenin and oxyresveratrol is believed to be an anticancer agent. This study evaluates colon histopathology, TNF-α, TGF-β, and hepatotoxicity on BALB/c mice colitis- ... ...

    Abstract Objective: Eleutherine palmifolia (L.) Merr. extract (EPE) containing isoliquiritigenin and oxyresveratrol is believed to be an anticancer agent. This study evaluates colon histopathology, TNF-α, TGF-β, and hepatotoxicity on BALB/c mice colitis-associated colon cancer (CAC) model treated with EPE.
    Methods: In vivo study was performed on BALB/c mice CAC model induced by 10 mg/kgBW AOM on the first day followed by administration that each cycle consisted of 5% DSS in water for seven days and regular water for seven days. The indicators of the formation of CAC were observed by a fecal occult blood test (FOBT) and serum amyloid α (SAA) test. The treatment was conducted once a week started from the seventh week up to the twentieth week with six treatment groups: I was administrated by regular water only (negative control), II was administrated by AOM and DSS only (positive control), III was administrated by doxorubicin,  IV-VI were treated by EPE (0.25 mg/kg BW, 0.50 mg/kg BW, and 1.00 mg/kg BW) respectively. The colon and liver's histopathology was observed using hematoxylin-eosin (HE) staining, TNF-α with immunohistochemistry (IHC), and level measurement of TGF-β colon with ELISA reader. The data were used one-way ANOVA followed by post hoc as statistical analysis.
    Results: The administration of EPE increased the expression of TNF-α, the total of goblet cells of the colon, and decreased the level of TGF-β. Administration of EPE 0.50 mg/20g BW decreased a liver histopathological score but induced a histopathological alteration of the liver at a dose of 1.00 mg/20g BW.
    Conclusion: This study indicate that EPE could be recommended as a colon anticancer through increase the goblet cells, induce apoptosis through increase TNF-α, and decrease TGF-β.
    MeSH term(s) Animals ; Colitis/chemically induced ; Colitis/complications ; Colitis-Associated Neoplasms/drug therapy ; Colitis-Associated Neoplasms/etiology ; Colitis-Associated Neoplasms/pathology ; Dextran Sulfate/toxicity ; Female ; Goblet Cells/drug effects ; Iridaceae/chemistry ; Mice ; Mice, Inbred BALB C ; Plant Extracts/pharmacology ; Toxicity Tests ; Transforming Growth Factor beta/drug effects ; Transforming Growth Factor beta/metabolism ; Tumor Necrosis Factor-alpha/drug effects ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Plant Extracts ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2020-12-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2020.21.12.3579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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