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  1. AU="Sarigül-Yildirim, Figen"
  2. AU=Chang Yu-Ting
  3. AU="Xu, Ivana"
  4. AU="Linde, Lauren"
  5. AU="Brewer, Katlyn K"
  6. AU="Prow, Natalie A"
  7. AU=Venkatesan Arun
  8. AU="Russcher, H."
  9. AU="Chambino, Beatriz"
  10. AU="L'Abbé, Ericka N."
  11. AU=Moore Stephen M.
  12. AU="Gabriel, Berteșteanu Șerban Vifor" AU="Gabriel, Berteșteanu Șerban Vifor"
  13. AU="Gallo, Eduado"
  14. AU="Yurchenko, Maria"
  15. AU="Fabiana Giber"
  16. AU="Rajakumar, Gopal Suseela" AU="Rajakumar, Gopal Suseela"
  17. AU="Gutierrez, M. N"
  18. AU=Zhuo Jia L.
  19. AU=Miller Mark A
  20. AU="Dąbrowski, Leszek"
  21. AU="Röltgen, Katharina"
  22. AU="Tumanov, Alexey"
  23. AU="Berns, Lauren"
  24. AU="Elena A. Deshevaya"
  25. AU=Zhang Ruijuan
  26. AU="Mueller, Luke"
  27. AU=Barzon Luisa
  28. AU="Karunakaran, Denuja"
  29. AU="Figueroa-Rivera, Ivonne M"
  30. AU="Blackburn, Fran"
  31. AU="Lee, Hee-Kyung"
  32. AU=Kinoshita J H
  33. AU="Hernesniemi, Juha"
  34. AU="Evans, Matthew L"
  35. AU=Payne Thomas
  36. AU="Brown, Dexter"

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  1. Artikel: Real-Life Experience With Bictegravir/Emtricitabine/Tenofovir Alafenamide in Turkey.

    Balcı, Umay / Üser, Ülkü / Tahmaz, Alper / Sarigul Yildirim, Figen

    Cureus

    2023  Band 15, Heft 10, Seite(n) e47253

    Abstract: Introduction: Single-tablet regimens (STRs) can increase treatment success and even improve the quality of life of human immunodeficiency virus (HIV) patients. In this study, we aim to analyze the real-life efficacy and tolerability data of people ... ...

    Abstract Introduction: Single-tablet regimens (STRs) can increase treatment success and even improve the quality of life of human immunodeficiency virus (HIV) patients. In this study, we aim to analyze the real-life efficacy and tolerability data of people living with HIV (PLWH) initiated on or switched to bictegravir/emtricitabine/tenofovir alafenamide fumarate (BIC/FTC/TAF) as first-line treatment.
    Materials and methods: This retrospective analysis was performed in HIV-1-positive patients who were initiated BIC/FTC/TAF in the HIV clinic between June 2020 and June 2022. Patients who received BIC/FTC/TAF for at least 12 months were included in this study. Virological suppression, laboratory parameters, side effects, and immunological response were analyzed at one, three, six, nine, and 12 months.
    Results: A total of 116 patients, 66 (56.9%) treatment-experienced and 50 (43.1%) naive, were evaluated within the scope of the study. In the naive patient group, baseline HIV-RNA, CD4+ and CD8+ T cell counts, CD4/CD8 ratio, and estimated glomerular filtration rate (eGFR) values were significantly different in different follow-up months. The number of patients with HIV-1 RNA levels below 50 copies/mL was 55.9% in the first month, 73.7% in the third month, 90.2% in the sixth month, and 100% in the ninth and 12th months.
    Conclusion: In our real-life observational study, BIC/FTC/TAF treatment achieved rapid viral suppression, maintained viral suppression in virally suppressed patients, and was effective for immunological recovery in both treatment-experienced and naive HIV patients. No serious side effects were observed. Our study has proved the potential of BIC/FTC/TAF as an important option in the treatment of HIV patients.
    Sprache Englisch
    Erscheinungsdatum 2023-10-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.47253
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Assessment of Microcirculation in HIV-Positive Patients with a Noninvasive Method: Nailfold Videocapillaroscopy.

    Sarigul Yildirim, Figen / Balkarli, Ayse

    AIDS research and human retroviruses

    2019  Band 36, Heft 1, Seite(n) 8–12

    Abstract: Chronic inflammation that contributes to the deterioration of the mechanical form of both the vascular wall and the function of endothelial has been shown to cause vascular dysfunction in patients with human immunodeficiency virus (HIV). Nailfold ... ...

    Abstract Chronic inflammation that contributes to the deterioration of the mechanical form of both the vascular wall and the function of endothelial has been shown to cause vascular dysfunction in patients with human immunodeficiency virus (HIV). Nailfold videocapillaroscopy (NVC) is a noninvasive and simple technique used to analyze dermal microvasculature. The aims of our study were to detect the morphological and functional properties of microcirculation in HIV-positive patients utilizing NVC and to compare the results with those obtained from healthy individuals and investigate whether these changes had supported any correlation with HIV. In this prospective study, 51 male HIV-positive patients were the subjects and 59 male healthy individuals made up the control group. Capillaroscopic findings, obtained from both groups by NVC, were evaluated. Tortuosity, a capillaroscopic finding, was significantly higher in the group with HIV (
    Mesh-Begriff(e) Adult ; Aged ; Capillaries/diagnostic imaging ; Capillaries/physiopathology ; Female ; HIV Infections/diagnosis ; HIV Infections/physiopathology ; Humans ; Male ; Microcirculation ; Microscopic Angioscopy ; Middle Aged ; Prospective Studies ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2019-10-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/aid.2019.0107
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1928: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel ; Online: Bibliometric Analysis of HIV and Exercise Literature based on Scientific Studies from 1990-2020.

    Köse, Elif / Seyman, Derya / Sarigül-Yildirim, Figen / Yerlisu-Lapa, Tennur / Tercan-Kaas, Evren

    Iranian journal of public health

    2022  Band 50, Heft 12, Seite(n) 2397–2410

    Abstract: Background: Exercise is believed to play an important role in maintaining functionality in patients with HIV and it is thought that researchers are increasingly interested in this field. We aimed to shed light on the historical development of research ... ...

    Abstract Background: Exercise is believed to play an important role in maintaining functionality in patients with HIV and it is thought that researchers are increasingly interested in this field. We aimed to shed light on the historical development of research on HIV and exercise by utilizing visual mapping method.
    Methods: Overall, 1051 articles retrieved from Web of Science (WoS) core database were analyzed according to the publication year and language, number of issues, citation, country collaborations, co-citation networks and concept-topic trends by using CiteSpace software.
    Results: The United States played a key role in country collaborations, and had the highest citation burst. The most cited studies were meta-analysis studies. The studies gathered mainly around the clusters named "physical activity" and "metabolic abnormalities" meanwhile, the recent topics of research were heart failure, metabolism, comorbidity, Ethiopia, muscle, cardiovascular event and drug user.
    Conclusion: The reason why USA was found to be one of the key actors in the network is supposed to be the financial resources it can allocate for the studies conducted. It appears that the majority of the studies in the field dwell upon the impact of exercise on the physical parameters in HIV patients, whereas there are only a limited number of studies focusing on the impact of exercise on HIV-induced psychological and cognitive problems. Recent studies on neurocognitive impairment, on the other hand, are predictive of possible future popularity of such topics among researchers.
    Sprache Englisch
    Erscheinungsdatum 2022-10-22
    Erscheinungsland Iran
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2240935-X
    ISSN 2251-6093 ; 2251-6093
    ISSN (online) 2251-6093
    ISSN 2251-6093
    DOI 10.18502/ijph.v50i12.7923
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Türkiye’deki Bir Hastanede Dokuzuncu Ayda Uzamış Koronavirüs Hastalığı Belirtilerinin Değerlendirilmesi.

    Tahmaz, Alper / Çetin, Eda / Balcı, Umay / Sarıgül Yıldırım, Figen / Seyman, Derya / Gürgen, Atila

    Mikrobiyoloji bulteni

    2022  Band 56, Heft 4, Seite(n) 657–666

    Abstract: Long COVID is defined as symptoms related to various organs following COVID-19. There is currently very little information available about the prevalence of these symptoms and their long-term recovery time. The aim of this study was to describe the ... ...

    Titelübersetzung The Evaluation of Long Coronavirus Disease Symptoms at Ninth Month from a Hospital in Türkiye.
    Abstract Long COVID is defined as symptoms related to various organs following COVID-19. There is currently very little information available about the prevalence of these symptoms and their long-term recovery time. The aim of this study was to describe the symptoms that persisted nine months after COVID-19. This cross-sectional study was conducted in Antalya, Türkiye, between November 1 and 30, 2020 on COVID-19 patients. Patients were contacted approximately nine months later by two infectious diseases physicians, and the questionnaire which included 27 symptoms was completed. Of the 390 patients who met the criteria, 329 agreed to participate in the study. Patients' average age was 48.9 ± 14.4 years, and 51.7% were male. 79.3% of the people still had at least one symptom at the end of the ninth month. The most common symptoms were weakness-fatigue (54.7%), forgetfulness (45.3%), effort loss (35.0%), sleep disturbance (34.3%), joint pain (27.4%), and hair loss (23.4%). According to analysis performed in terms of sex; hair loss, diarrhea, nausea, dizziness, sore throat, loss of taste and smell were more common in women than in men (p= 0.042, p= 0.047, p= 0.050, p= 0.026, p= 0.016, p= 0.036, p= 0.027, respectively). Individuals aged 65 years and over had a significantly lower number of symptoms (p= 0.029) than all other age groups. Furthermore, the number of symptoms was higher in patients who used steroids (p= 0.049). This study is an important source of information on the long-term symptoms of COVID-19. Our results have shown that the symptoms associated with COVID-19 do not completely resolve even after nine months, which explains why long COVID requires continuous monitoring.
    Mesh-Begriff(e) Humans ; Female ; Male ; Adult ; Middle Aged ; Coronavirus ; COVID-19 ; Cross-Sectional Studies ; Coronavirus Infections ; Hospitals ; Alopecia
    Sprache Türkisch
    Erscheinungsdatum 2022-05-31
    Erscheinungsland Turkey
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 985146-x
    ISSN 0374-9096
    ISSN 0374-9096
    DOI 10.5578/mb.20229604
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3943: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Artikel ; Online: Capacity Evaluation of Diagnostic Tests For COVID-19 Using Multicriteria Decision-Making Techniques.

    Sayan, Murat / Sarigul Yildirim, Figen / Sanlidag, Tamer / Uzun, Berna / Uzun Ozsahin, Dilber / Ozsahin, Ilker

    Computational and mathematical methods in medicine

    2020  Band 2020, Seite(n) 1560250

    Abstract: In December 2019, cases of pneumonia were detected in Wuhan, China, which were caused by the highly contagious coronavirus. This study is aimed at comparing the confusion regarding the selection of effective diagnostic methods to make a mutual comparison ...

    Abstract In December 2019, cases of pneumonia were detected in Wuhan, China, which were caused by the highly contagious coronavirus. This study is aimed at comparing the confusion regarding the selection of effective diagnostic methods to make a mutual comparison among existing SARS-CoV-2 diagnostic tests and at determining the most effective one. Based on available published evidence and clinical practice, diagnostic tests of coronavirus disease (COVID-19) were evaluated by multi-criteria decision-making (MCDM) methods, namely, fuzzy preference ranking organization method for enrichment evaluation (fuzzy PROMETHEE) and fuzzy technique for order of preference by similarity to ideal solution (fuzzy TOPSIS). Computerized tomography of chest (chest CT), the detection of viral nucleic acid by polymerase chain reaction, cell culture, CoV-19 antigen detection, CoV-19 antibody IgM, CoV-19 antibody IgG, and chest X-ray were evaluated by linguistic fuzzy scale to compare among the diagnostic tests. This scale consists of selected parameters that possessed different weights which were determined by the experts' opinions of the field. The results of our study with both proposed MCDM methods indicated that the most effective diagnosis method of COVID-19 was chest CT. It is interesting to note that the methods that are consistently used in the diagnosis of viral diseases were ranked in second place for the diagnosis of COVID-19. However, each country should use appropriate diagnostic solutions according to its own resources. Our findings also show which diagnostic systems can be used in combination.
    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Decision Making ; Fuzzy Logic ; Humans ; Immunoglobulin G ; Models, Statistical ; Pandemics ; Pneumonia, Viral/diagnosis ; Program Evaluation ; Reproducibility of Results ; SARS-CoV-2 ; Sensitivity and Specificity ; Tomography, X-Ray Computed
    Chemische Substanzen Immunoglobulin G
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2252430-7
    ISSN 1748-6718 ; 1748-670X ; 1027-3662
    ISSN (online) 1748-6718
    ISSN 1748-670X ; 1027-3662
    DOI 10.1155/2020/1560250
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Comparison of Immunological and Virological Recovery with Rapid, Early, and Late Start of Antiretroviral Treatment in Naive Plwh: Real-World Data.

    Sarıgül Yıldırım, Figen / Candevir, Aslıhan / Akhan, Sıla / Kaya, Selçuk / Çabalak, Mehmet / Ersöz, Gülden / İnan, Dilara / Ceren, Nurgül / Karaoğlan, İlkay / Damar Çakırca, Tuba / Özer Balin, Şafak / Alkan, Sevil / Kandemir, Özlem / Üser, Ülkü / Karabay, Oğuz / Çelen, Mustafa Kemal

    International journal of general medicine

    2023  Band 16, Seite(n) 1867–1877

    Abstract: Background: Rapid initiation of antiretroviral therapy (ART) reduces the transmission of HIV infection in the community. This study aimed to determine whether rapid ART initiation is effective compared to standard ART treatment in our country.: ... ...

    Abstract Background: Rapid initiation of antiretroviral therapy (ART) reduces the transmission of HIV infection in the community. This study aimed to determine whether rapid ART initiation is effective compared to standard ART treatment in our country.
    Methods: Patients were grouped based on time to treatment initiation. HIV RNA levels, CD+4 T cell count, CD4/CD8 ratio, and ART regimens were recorded at baseline and follow-up visits for 12 months.
    Results: There were 368-ART naive adults (treatment initiated at the time of HIV diagnosis; 143 on the first day, 48 on the second-seventh day, and 177 after the seventh day). Although virological suppression rates at 12
    Conclusion: Our findings support the broader application of recommendations for rapid ART initiation in HIV patients.
    Sprache Englisch
    Erscheinungsdatum 2023-05-17
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S393370
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Abnormal Dispersion of Ventricular Repolarization as a Risk Factor in Patients with Human Immunodeficiency Virus: Tp-e Interval, Tp-e/QTc Ratio.

    Unal Evren, Emine / Cekirdekci, Elif Ijlal / Evren, Hakan / Suer, Kaya / Sarigul Yildirim, Figen / Asan, Ali / Bugan, Baris

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2020  Band 29, Heft 6, Seite(n) 544–550

    Abstract: Objective: In recent years, there has been worldwide recognition of the problems associated with Human Immunodeficiency Virus (HIV) infection and Acquired Immune Deficiency Syndrome (AIDS). The prevalence of cardiovascular disease in the HIV-infected ... ...

    Abstract Objective: In recent years, there has been worldwide recognition of the problems associated with Human Immunodeficiency Virus (HIV) infection and Acquired Immune Deficiency Syndrome (AIDS). The prevalence of cardiovascular disease in the HIV-infected population is increasing. Repolarization abnormalities, the significant contributor to life-threatening arrhythmias and mortality, are the most frequent electrocardiographic changes in this population. This study aimed to evaluate the changes in Tp-e interval, Tp-e/QT and Tp-e/corrected QT (QTc) ratios, and traditional electrocardiographic features of electrical dispersion in adults infected with HIV.
    Subjects and methods: A total of 235 participants were selected in the current study. The HIV group consisted of 85 subjects (median age 36 years [25-48], and the control group included 150 individuals (median age 39 years [27-51]). Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were measured by the 12-lead electrocardiogram.
    Results: Tp-e interval, cTp-e interval, and Tp-e/QT and Tp-e/QTc ratios were significantly higher in HIV patients compared to the control group (p = 0.006, p = 0.004, p = 0.003, and p = 0.002, respectively). In correlation analysis, there was inverse correlation between the mean cTp-e interval and CD4 count and Tp-e/QTc ratios and CD4 count (r = - 0.407, p < 0.001, r = - 0.416, p < 0.001, respectively). Besides, there was correlation between the mean cTp-e interval and high-sensitivity C-reactive protein (hsCRP) and Tp-e/QTc ratios and hsCRP (r = 0.403, p = 0.001, r = 0.406, p = 0.001, respectively).
    Conclusion: Our study revealed that the cTp-e interval, Tp-e/QT and cTp-e/QT ratios were prolonged and correlated to the severity of the disease in HIV-infected patients. Our findings may shed light on the cTp-e interval and Tp-e/QTc ratio and lead to further studies showing a relationship with ventricular arrhythmias and mortality in HIV-infected individuals.
    Mesh-Begriff(e) Adult ; Age Factors ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/pathology ; Electrocardiography ; Female ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Sex Factors
    Sprache Englisch
    Erscheinungsdatum 2020-05-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000508725
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2486: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Artikel: Capacity Evaluation of Diagnostic Tests For COVID-19 Using Multicriteria Decision-Making Techniques

    Sayan, Murat / Sarigul Yildirim, Figen / Sanlidag, Tamer / Uzun, Berna / Uzun Ozsahin, Dilber / Ozsahin, Ilker

    Comput Math Methods Med

    Abstract: In December 2019, cases of pneumonia were detected in Wuhan, China, which were caused by the highly contagious coronavirus. This study is aimed at comparing the confusion regarding the selection of effective diagnostic methods to make a mutual comparison ...

    Abstract In December 2019, cases of pneumonia were detected in Wuhan, China, which were caused by the highly contagious coronavirus. This study is aimed at comparing the confusion regarding the selection of effective diagnostic methods to make a mutual comparison among existing SARS-CoV-2 diagnostic tests and at determining the most effective one. Based on available published evidence and clinical practice, diagnostic tests of coronavirus disease (COVID-19) were evaluated by multi-criteria decision-making (MCDM) methods, namely, fuzzy preference ranking organization method for enrichment evaluation (fuzzy PROMETHEE) and fuzzy technique for order of preference by similarity to ideal solution (fuzzy TOPSIS). Computerized tomography of chest (chest CT), the detection of viral nucleic acid by polymerase chain reaction, cell culture, CoV-19 antigen detection, CoV-19 antibody IgM, CoV-19 antibody IgG, and chest X-ray were evaluated by linguistic fuzzy scale to compare among the diagnostic tests. This scale consists of selected parameters that possessed different weights which were determined by the experts' opinions of the field. The results of our study with both proposed MCDM methods indicated that the most effective diagnosis method of COVID-19 was chest CT. It is interesting to note that the methods that are consistently used in the diagnosis of viral diseases were ranked in second place for the diagnosis of COVID-19. However, each country should use appropriate diagnostic solutions according to its own resources. Our findings also show which diagnostic systems can be used in combination.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #721219
    Datenquelle COVID19

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  9. Artikel ; Online: Capacity Evaluation of Diagnostic Tests For COVID-19 Using Multicriteria Decision-Making Techniques

    Sayan, Murat / Sarigul Yildirim, Figen / Sanlidag, Tamer / Uzun, Berna / Uzun Ozsahin, Dilber / Ozsahin, Ilker

    Computational and mathematical methods in medicine, 2020:1560250

    2020  

    Abstract: In December 2019, cases of pneumonia were detected in Wuhan, China, which were caused by the highly contagious coronavirus. This study is aimed at comparing the confusion regarding the selection of effective diagnostic methods to make a mutual comparison ...

    Abstract In December 2019, cases of pneumonia were detected in Wuhan, China, which were caused by the highly contagious coronavirus. This study is aimed at comparing the confusion regarding the selection of effective diagnostic methods to make a mutual comparison among existing SARS-CoV-2 diagnostic tests and at determining the most effective one. Based on available published evidence and clinical practice, diagnostic tests of coronavirus disease (COVID-19) were evaluated by multi-criteria decision-making (MCDM) methods, namely, fuzzy preference ranking organization method for enrichment evaluation (fuzzy PROMETHEE) and fuzzy technique for order of preference by similarity to ideal solution (fuzzy TOPSIS). Computerized tomography of chest (chest CT), the detection of viral nucleic acid by polymerase chain reaction, cell culture, CoV-19 antigen detection, CoV-19 antibody IgM, CoV-19 antibody IgG, and chest X-ray were evaluated by linguistic fuzzy scale to compare among the diagnostic tests. This scale consists of selected parameters that possessed different weights which were determined by the experts’ opinions of the field. The results of our study with both proposed MCDM methods indicated that the most effective diagnosis method of COVID-19 was chest CT. It is interesting to note that the methods that are consistently used in the diagnosis of viral diseases were ranked in second place for the diagnosis of COVID-19. However, each country should use appropriate diagnostic solutions according to its own resources. Our findings also show which diagnostic systems can be used in combination.
    Schlagwörter COVID-19 ; covid19
    Sprache Englisch
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  10. Artikel: HIV-1 Enfekte Bireylerde İnsan Lökosit Antijeni (HLA)-B*57:01 Pozitifliği Prevalansının Dağılımı ve Tedavi Üzerine Etkileri: Türkiye Haritası-BUHASDER Çalışma Grubu.

    Büyüktuna, Seyit Ali / Öksüz, Caner / Tahmaz, Alper / Sarıgül Yıldırım, Figen / Türken, Melda / Günal, Özgür / Topal, Şeyma / Baran, Ali İrfan / Sarıkaya, Burak / Çelik Ekinci, Semiha / Kaya, Selçuk / Alkan Çeviker, Sevil / Aypak, Adalet / Yürük Atasoy, Pınar / İnan, Dilara / Köse, Adem / Koç İnce, Nevind / Şenbayrak, Seniha / Kaya, Şafak /
    Özgüler, Müge / Dindar Demiray, Emine Kübra / Köse, Şükran

    Mikrobiyoloji bulteni

    2023  Band 58, Heft 1, Seite(n) 29–38

    Abstract: Human immunodeficiency virus (HIV)/acquired immundeficiency syndrome (AIDS) is a critical global public health problem that significantly affects both life expectancy and the overall quality of life of individuals in all age groups. The landscape of HIV ... ...

    Titelübersetzung Distribution of the Prevalence of Human Leukocyte Antigen (HLA)-B*57:01 Positivity in HIV-1 Infected Individuals and Its Effects on Treatment: Türkiye Map-Buhasder Working Group.
    Abstract Human immunodeficiency virus (HIV)/acquired immundeficiency syndrome (AIDS) is a critical global public health problem that significantly affects both life expectancy and the overall quality of life of individuals in all age groups. The landscape of HIV infection has changed significantly in recent years due to the introduction of effective combination antiretroviral therapies (ART). A key component of first-line ART regimens for HIV treatment is abacavir, a nucleoside HIV reverse transcriptase inhibitor. Although abacavir is effective in suppressing viral replication and managing disease, its clinical utility is overshadowed by the potential for life-threatening hypersensitivity reactions in HLA-B*57:01-positive patients. In our country, local data obtained from various centers regarding the prevalence of HLA-B*57:01 in HIV-1-infected patients are available. In this study, it was aimed to determine the prevalence of the HLA-B*57:01 genotype in HIV-infected patients who were followed up and treated in many regions of our country. This retrospective study consists of the data of the patients aged 18 years and over diagnosed with HIV-1 infection between 01.01.2019 and 31.07.2022. Age, gender, place of birth, mode of transmission of the disease, death status, CD4+ T cell count and HIV RNA levels at the first clinical presentation, HLA-B*57:01 positivity, and the method used, clinical stage of the disease, virological response time with the treatment they received were recorded from the patient files. Data were collected from 16 centers and each center used different methods to detect HLA-B*57:01. These methods were sequence-specific oligonucleotide probe hybridization (SSOP), DNA sequence-based typing (SBT), single-specific primer-polymerase chain reaction (SSP-PCR), allele-specific PCR (AS-PCR) and quantitative PCR (Q-PCR). A total of 608 HIV-infected individuals, 523 males (86%) and 85 females (14%), were included in the study. The mean age of the patients was 36.9 ± 11.9 (18-73) years. The prevalence of HLA-B*57:01 allele was found to be 3.6% (22 patients). The number of CD4+ T lymphocytes in HLA-B*57:01 allele-positive patients was > 500/ mm3 in 10 patients (45.5%), while the number of CD4+ T lymphocytes in HLA-B*57:01 negative patients was > 500/mm3 in 216 patients (36.9%) (p> 0.05). Viral load at the time of diagnosis was found to be lower in patients with positive HLA-B*57:01 allele but it was not statistically significant (p> 0.05). Although different treatment algorithms were used in the centers following the patients, it was observed that the duration of virological response was shorter in HLA-B*57:01 positive patients (p= 0.006). Although the presence of the HLA-B*57:01 allele has a negative impact due to its association with hypersensitivity, it is likely to continue to attract interest due to its association with slower progression of HIV infection and reduced risk of developing AIDS. In addition, although the answer to the question of whether it is cost-effective to screen patients for HLA-B*57:01 before starting an abacavir-containing ART regimen for the treatment of HIV infection is being sought, it seems that HIV treatment guidelines will continue to recommend screening to identify patients at risk in this regard.
    Mesh-Begriff(e) Female ; Male ; Humans ; Adolescent ; Adult ; Middle Aged ; HIV-1 ; Prevalence ; HIV Infections ; Acquired Immunodeficiency Syndrome ; Quality of Life ; Retrospective Studies ; Turkey ; HLA Antigens ; Cyclopropanes ; Dideoxyadenosine/analogs & derivatives
    Chemische Substanzen abacavir (WR2TIP26VS) ; HLA Antigens ; Cyclopropanes ; Dideoxyadenosine (4Q86AH641A)
    Sprache Türkisch
    Erscheinungsdatum 2023-03-05
    Erscheinungsland Turkey
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 985146-x
    ISSN 0374-9096
    ISSN 0374-9096
    DOI 10.5578/mb.20249903
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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