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  1. Article ; Online: Study of the effect of higher-order dispersions on photoionisation induced by ultrafast laser pulses applying a classical theoretical method.

    Márton, István / Sarkadi, László

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 13841

    Abstract: We investigated the effect of higher order dispersion on ultrafast photoionisation with Classical Trajectory Monte Carlo (CTMC) method for hydrogen and krypton atoms. In our calculations we used linearly polarised ultrashort 7 fs laser pulses, [Formula: ... ...

    Abstract We investigated the effect of higher order dispersion on ultrafast photoionisation with Classical Trajectory Monte Carlo (CTMC) method for hydrogen and krypton atoms. In our calculations we used linearly polarised ultrashort 7 fs laser pulses, [Formula: see text] intensity, and a central wavelength of 800 nm. Our results show that electrons with the highest kinetic energies are obtained with transform limited (TL) pulses. The shaping of the pulses with negative second- third- or fourth- order dispersion results in higher ionisation yield and electron energies compared to pulses shaped with positive dispersion values. We have also investigated how the Carrier Envelope Phase (CEP) dependence of the ionisation is infuenced by dispersion. We calculated the left-right asymmetry as a function of energy and CEP for sodium atoms employing pulses of 4.5 fs, 800 nm central wavelength, and [Formula: see text] intensity. We found that the left-right asymmetry is more pronounced for pulses shaped with positive Group Delay Dispersion (GDD). It was also found that shaping a pulse with increasing amounts of GDD in absolute value blurs the CEP dependence, which is attributed to the increasing number of optical cycles.
    Language English
    Publishing date 2022-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-18034-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: Fast ion-atom collisions

    Sarkadi, László

    proceedings of the Eighth Workshop on Fast Ion-Atom Collisions, Debrecen, Hungary, 1 - 3 September 2004

    (Nuclear instruments & methods in physics research : Section B, Beam interactions with materials and atoms ; 233.2005)

    2005  

    Institution Workshop on Fast Ion - Atom Collisions
    Event/congress Workshop on Fast Ion-Atom Collisions (8, 2004.09.01-03, Debrecen)
    Author's details ed.: L. Sarkadi
    Series title Nuclear instruments & methods in physics research : Section B, Beam interactions with materials and atoms ; 233.2005
    Language English
    Size XII, 338 S, graph. Darst
    Publisher North-Holland
    Publishing place Amsterdam u.a.
    Document type Book ; Conference proceedings
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article: Triple coincidence experiment to explore the two-electron continuum states of the projectile resulting from mutual ionization in 100-keV He0 + He collisions.

    Sarkadi, László / Orbán, Andrea

    Physical review letters

    2008  Volume 100, Issue 13, Page(s) 133201

    Abstract: The existence of the two-electron cusp in atomic collisions, i.e., the enhanced emission of two electrons in the forward direction with velocities equal to that of the projectile, has been investigated experimentally. Using a time-of-flight technique, ... ...

    Abstract The existence of the two-electron cusp in atomic collisions, i.e., the enhanced emission of two electrons in the forward direction with velocities equal to that of the projectile, has been investigated experimentally. Using a time-of-flight technique, the energies of the two electrons resulting from the simultaneous target and projectile ionization in 100-keV He(0)+He collisions have been measured by detecting triple coincidence between the electrons and the outgoing He(+) ion. The coincidence yield clearly shows a peak as a function of the electron energies at the expected cusp position. Furthermore, a strong correlation was found between the energies of the two electrons, which is traced back to an angular correlation of 180 degrees in the projectile-centered reference system.
    Language English
    Publishing date 2008-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.100.133201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: Role of core needle biopsy in the treatment of radial scar.

    Tóth, Dezső / Sebő, Éva / Sarkadi, László / Kovács, Ilona / Kiss, Csongor / Damjanovich, László

    Breast (Edinburgh, Scotland)

    2012  Volume 21, Issue 6, Page(s) 761–763

    Abstract: Invasive tumor or ductal carcinoma in situ occur in radial sclerosing lesions in one third of the cases therefore, surgical excision is mandatory. Forty-five patients with radial scar morphology were examined. Ultrasound guided fine-needle aspiration ... ...

    Abstract Invasive tumor or ductal carcinoma in situ occur in radial sclerosing lesions in one third of the cases therefore, surgical excision is mandatory. Forty-five patients with radial scar morphology were examined. Ultrasound guided fine-needle aspiration biopsy (FNAB) and core biopsy (CB) were performed in all cases. The postoperative pathological findings were compared to the results of preoperative biopsies. Sensitivity of preoperative percutaneous biopsies (FNAB and CB) was 17.6% and 70.6%, false-negative rate was 82.4% with FNAB and 29.4% with CB. The negative predictive value was 48.1% and 84.8% respectively. Had we done preoperative cytology only, we would have had to perform a two-step procedure (sentinel lymph node biopsy) in 7 patients (15.6%), while with preoperative core biopsy it has decreased to 2 patients (4.4%). Preoperative CB in small radial stellate lesions is recommended to achieve accurate diagnosis in order to avoid a two-step surgical procedures.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Biopsy, Large-Core Needle ; Breast/pathology ; Breast/surgery ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/diagnostic imaging ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/surgery ; Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Diagnosis, Differential ; Female ; Humans ; Mammography ; Middle Aged ; Precancerous Conditions/diagnostic imaging ; Precancerous Conditions/pathology ; Precancerous Conditions/surgery ; Predictive Value of Tests ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy
    Language English
    Publishing date 2012-12
    Publishing country Netherlands
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1143210-x
    ISSN 1532-3080 ; 0960-9776
    ISSN (online) 1532-3080
    ISSN 0960-9776
    DOI 10.1016/j.breast.2012.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3620: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 588: Show issues

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  5. Article: TASK-3 immunoreactivity shows differential distribution in the human gastrointestinal tract.

    Kovács, Ilona / Pocsai, Krisztina / Czifra, Gabriella / Sarkadi, László / Szucs, Géza / Nemes, Zoltán / Rusznák, Zoltán

    Virchows Archiv : an international journal of pathology

    2005  Volume 446, Issue 4, Page(s) 402–410

    Abstract: The presence and distribution of TASK-3 immunopositivity (a channel with potential oncogenic significance) was investigated in the human gastrointestinal system. The immunohistochemical reactions were performed with two commercially available polyclonal ... ...

    Abstract The presence and distribution of TASK-3 immunopositivity (a channel with potential oncogenic significance) was investigated in the human gastrointestinal system. The immunohistochemical reactions were performed with two commercially available polyclonal antibodies, targeting different epitopes of the channel protein. Experiments conducted on frozen and formalin-fixed samples indicated that the application of a suitable antigen retrieval (AR) technique was essential to produce consistent, strong and reproducible TASK-3-specific immunolabelling of the formalin-fixed tissue. The lack of or inappropriate selection of the AR resulted in false-negative reactions. As for the distribution of the TASK-3 channels, strong immunolabelling was observed in the gastric and large intestinal mucosa, with particularly prominent immunoreactivity of the epithelial cells. In contrast, the smooth-muscle layers demonstrated weak TASK-3 positivity. Intense TASK-3 expression was noted in both the exocrine and endocrine pancreas, but the islets of Langerhans exhibited more powerful reactions. The ductal apparatus of the submandibular gland and lymphocytes situated in pericolonic lymph nodes were also TASK-3 positive. Strong TASK-3 positivity could also be observed in malignant gastrointestinal tumours, with intense nuclear-perinuclear labelling of some of the tumour cells. The present findings suggest that TASK-3 channels may have roles in the gastrointestinal functions, including insular hormone secretion.
    MeSH term(s) Biomarkers/metabolism ; Gastrointestinal Tract/metabolism ; Humans ; Immunoenzyme Techniques/methods ; Potassium Channels, Tandem Pore Domain/immunology ; Potassium Channels, Tandem Pore Domain/metabolism
    Chemical Substances Biomarkers ; KCNK9 protein, human ; Potassium Channels, Tandem Pore Domain
    Language English
    Publishing date 2005-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-005-1205-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud III Zs.10: Show issues Location:
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  6. Article ; Online: Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women.

    Hrabovszky, Erik / Molnár, Csilla S / Sipos, Máté T / Vida, Barbara / Ciofi, Philippe / Borsay, Beáta A / Sarkadi, László / Herczeg, László / Bloom, Stephen R / Ghatei, Mohammad A / Dhillo, Waljit S / Kalló, Imre / Liposits, Zsolt

    Frontiers in endocrinology

    2011  Volume 2, Page(s) 80

    Abstract: The secretory output of gonadotropin-releasing hormone (GnRH) neurons is critically influenced by peptidergic neurons synthesizing kisspeptins (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus (Inf). These cells mediate negative ... ...

    Abstract The secretory output of gonadotropin-releasing hormone (GnRH) neurons is critically influenced by peptidergic neurons synthesizing kisspeptins (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus (Inf). These cells mediate negative feedback effects of sex steroids on the reproductive axis. While negative feedback is lost in postmenopausal women, it is partly preserved by the sustained testosterone secretion in aged men. We hypothesized that the different reproductive physiology of aged men and women is reflected in morphological differences of KP and NKB neurons. This sexual dimorphism was studied with immunohistochemistry in hypothalamic sections of aged human male (≥50 years) and female (>55 years) subjects. KP and NKB cell bodies of the Inf were larger in females. The number of KP cell bodies, the density of KP fibers, and the incidence of their contacts on GnRH neurons were much higher in aged women compared with men. The number of NKB cell bodies was only slightly higher in women and there was no sexual dimorphism in the regional density of NKB fibers and the incidence of their appositions onto GnRH cells. The incidences of NKB cell bodies, fibers, and appositions onto GnRH neurons exceeded several-fold those of KP-IR elements in men. More NKB than KP inputs to GnRH cells were also present in women. Immunofluorescent studies identified only partial overlap between KP and NKB axons. KP and NKB were colocalized in higher percentages of afferents to GnRH neurons in women compared with men. Most of these sex differences might be explained with the lack of estrogen negative feedback in aged women, whereas testosterone can continue to suppress KP, and to a lesser extent, NKB synthesis in men. Overall, sex differences in reproductive physiology of aged humans were reflected in the dramatic sexual dimorphism of the KP system, with significantly higher incidences of KP-IR neurons, fibers and inputs to GnRH neurons in aged females vs. males.
    Language English
    Publishing date 2011-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392 ; 1664-2392
    ISSN (online) 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2011.00080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Estrogen receptor negative and progesterone receptor positive breast carcinomas-how frequent are they?

    Cserni, Gábor / Francz, Monika / Kálmán, Endre / Kelemen, Gyöngyi / Komjáthy, Detre Csaba / Kovács, Ilona / Kulka, Janina / Sarkadi, László / Udvarhelyi, Nóra / Vass, László / Vörös, András

    Pathology oncology research : POR

    2011  Volume 17, Issue 3, Page(s) 663–668

    Abstract: Estrogen receptor (ER) testing has become an important part of breast cancer reporting as the ER status is a predictor of hormonal treatment efficacy. Progesteron receptors (PR) are often tested in parallel, and the best response to hormonal ... ...

    Abstract Estrogen receptor (ER) testing has become an important part of breast cancer reporting as the ER status is a predictor of hormonal treatment efficacy. Progesteron receptors (PR) are often tested in parallel, and the best response to hormonal manipulations can be expected in tumors positive for both receptors. The existence of breast cancers with an ER negative and PR positive phenotype is controversial. A series of cases with this phenotype were reevaluated to clarify the existence and the frequency of this entity. A total of 205/6587 (3.1%; range of the rate per department: 0.3-7.1%.) cases reported to have the ER-negative and PR-positive status by immunohistochemistry were collected from 9 Hungarian departments. After careful reevaluation of the tumor slides and control tissues with a 1% cut-off for positivity and restaining of the questionable cases, all but 1 of the reevaluable 182 cases changed their original phenotype. Most cases converted to dual positives (n = 124) or dual negatives (n = 31) or unassessable / questionable. ER-negative and PR-positive breast cancers are very rare if existing. Such a phenotype should prompt reassessment.
    MeSH term(s) Breast Neoplasms/classification ; Breast Neoplasms/metabolism ; Case-Control Studies ; Female ; Humans ; Immunoenzyme Techniques ; Prognosis ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism
    Chemical Substances Receptors, Estrogen ; Receptors, Progesterone
    Language English
    Publishing date 2011-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1375979-6
    ISSN 1532-2807 ; 1219-4956
    ISSN (online) 1532-2807
    ISSN 1219-4956
    DOI 10.1007/s12253-011-9366-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4936: Show issues Location:
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