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  1. AU="Sarkar, Bidhan Chandra"
  2. AU="Glenn, Christensen"
  3. AU="Korobov, A. A."
  4. AU="Farzaneh Ashrafi"
  5. AU="Mitamura, Yasuhito"
  6. AU="Mayfield, Margaret M"
  7. AU="Rebsomen, L"
  8. AU="Abtie Abebaw"
  9. AU="Treitz, Christian"
  10. AU=Abd-Elsayed Alaa
  11. AU="Vesajoki, Marja" AU="Vesajoki, Marja"
  12. AU=Lewiecki E Michael
  13. AU=von Bubnoff Nikolas
  14. AU="Tang, Walfred W C"
  15. AU=Hashitani Hikaru
  16. AU="Löw, Martina"
  17. AU="Robertson, Leon S"
  18. AU="Wright, Aaron T"
  19. AU="Jones, T. B."
  20. AU=Shirtliff Mark E.
  21. AU="Riis, Kamilla R"
  22. AU="Xu, Leyao"
  23. AU="Udayakumar, Karthikrajan Parasuraman"
  24. AU="Fry, Brian"

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  1. Artikel ; Online: Unveiling the potential anti-cancer activity of calycosin against multivarious cancers with molecular insights: A promising frontier in cancer research.

    Sohel, Md / Zahra Shova, Fatema Tuj / Shuvo, Shahporan / Mahjabin, Taiyara / Mojnu Mia, Md / Halder, Dibyendu / Islam, Hafizul / Roman Mogal, Md / Biswas, Partha / Saha, Hasi Rani / Sarkar, Bidhan Chandra / Mamun, Abdullah Al

    Cancer medicine

    2024  Band 13, Heft 3, Seite(n) e6924

    Abstract: Background: Calycosin may be a potential candidate regarding chemotherapeutic agent, because already some studies against multivarious cancer have been made with this natural compound.: Aim: This review elucidated a brief overview of previous studies ...

    Abstract Background: Calycosin may be a potential candidate regarding chemotherapeutic agent, because already some studies against multivarious cancer have been made with this natural compound.
    Aim: This review elucidated a brief overview of previous studies on calycosin potential effects on various cancers and its potential mechanism of action.
    Methodology: Data retrieved by systematic searches of Google Scholar, PubMed, Science Direct, Web of Science, and Scopus by using keywords including calycosin, cancer types, anti-cancer mechanism, synergistic, and pharmacokinetic and commonly used tools are BioRender, ChemDraw Professional 16.0, and ADMETlab 2.0.
    Results: Based on our review, calycosin is available in nature and effective against around 15 different types of cancer. Generally, the anti-cancer mechanism of this compound is mediated through a variety of processes, including regulation of apoptotic pathways, cell cycle, angiogenesis and metastasis, oncogenes, enzymatic pathways, and signal transduction process. These study conducted in various study models, including in silico, in vitro, preclinical and clinical models. The molecular framework behind the anti-cancer effect is targeting some oncogenic and therapeutic proteins and multiple signaling cascades. Therapies based on nano-formulated calycosin may make excellent nanocarriers for the delivery of this compound to targeted tissue as well as particular organ. This natural compound becomes very effective when combined with other natural compounds and some standard drugs. Moreover, proper use of this compound can reverse resistance to existing anti-cancer drugs through a variety of strategies. Calycosin showed better pharmacokinetic properties with less toxicity in human bodies.
    Conclusion: Calycosin exhibits excellent potential as a therapeutic drug against several cancer types and should be consumed until standard chemotherapeutics are available in pharma markets.
    Mesh-Begriff(e) Humans ; Neoplasms/drug therapy ; Oncogenes ; Research ; Isoflavones/pharmacology ; Isoflavones/therapeutic use
    Chemische Substanzen 7,3'-dihydroxy-4'-methoxyisoflavone (09N3E8P7TA) ; Isoflavones
    Sprache Englisch
    Erscheinungsdatum 2024-01-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6924
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Esculetin unveiled: Decoding its anti-tumor potential through molecular mechanisms-A comprehensive review.

    Rezoan Hossain, Md / Zahra Shova, Fatema Tuj / Akter, Munni / Shuvo, Shahporan / Ahmed, Nasim / Akter, Afroza / Haque, Munira / Salma, Umme / Roman Mogal, Md / Saha, Hasi Rani / Sarkar, Bidhan Chandra / Sohel, Md

    Cancer reports (Hoboken, N.J.)

    2023  Band 7, Heft 1, Seite(n) e1948

    Abstract: Background: The growing complexity of cancer has made it a significant concern in the medical community. Although cancer research has advanced, it is still challenging to create new effective medications due to the limitations and side effects of ... ...

    Abstract Background: The growing complexity of cancer has made it a significant concern in the medical community. Although cancer research has advanced, it is still challenging to create new effective medications due to the limitations and side effects of existing treatment strategies. These are enforcing the development of some alternative drugs from natural compounds with fewer drawbacks and side effects.
    Aim: Therefore, this review aims to provide up-to-date, crucial, and all-encompassing data on esculetin's anticancer activity, including all relevant molecular and cellular processes based on in vivo and in vitro investigations.
    Results: According to the literature review, esculetin is available in nature and is effective against 16 different types of cancer. The general mechanism shown by esculetin is modulating signaling cascades and its related pathways, like cell proliferation, cell growth, autophagy, apoptosis, necrosis, inflammation, angiogenesis, metastasis, invasion, and DNA damage. Nanoformulation of esculetin improves this natural product's efficacy by improving water solubility. Esculetin's synergistic effects with both natural substances and conventional treatments have been shown, and this method aids in reversing resistance mechanisms by modulating resistance-related proteins. In addition, it has fewer side effects on humans than other phytochemicals and standard drugs with some good pharmacokinetic features.
    Conclusion: Therefore, until standard chemotherapeutics are available in pharmaceutical markets, esculetin should be used as a therapeutic drug against various cancer types.
    Mesh-Begriff(e) Humans ; Neoplasms/drug therapy ; Umbelliferones/pharmacology ; Apoptosis ; Signal Transduction
    Chemische Substanzen esculetin (SM2XD6V944) ; Umbelliferones
    Sprache Englisch
    Erscheinungsdatum 2023-12-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1948
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management.

    Singh, Sukhbir / Sharma, Neelam / Behl, Tapan / Sarkar, Bidhan Chandra / Saha, Hasi Rani / Garg, Kanika / Singh, Supriya Kamari / Arora, Sandeep / Amran, Md Shah / Abdellatif, Ahmed A H / Bilgrami, Anwar L / Ashraf, Ghulam Md / Rahman, Md Sohanur

    Pharmaceutics

    2021  Band 13, Heft 11

    Abstract: Psoriasis is a chronic inflammatory autoimmune disorder that moderately affects social and interpersonal relationships. Conventional treatments for psoriasis have certain problems, such as poor drug penetration through the skin, hyper-pigmentation, and a ...

    Abstract Psoriasis is a chronic inflammatory autoimmune disorder that moderately affects social and interpersonal relationships. Conventional treatments for psoriasis have certain problems, such as poor drug penetration through the skin, hyper-pigmentation, and a burning sensation on normal and diseased skin. Colloidal drug delivery systems overcome the pitfalls of conventional approaches for psoriasis therapeutics and have improved patient safety parameters, compliance, and superior effectiveness. They also entail reduced toxicity. This comprehensive review's topics include the pathogenesis of psoriasis, causes and types of psoriasis, conventional treatment alternatives for psoriasis, the need for colloidal drug delivery systems, and recent studies in colloidal drug delivery systems for the treatment of psoriasis. This review briefly describes colloidal drug delivery approaches, such as emulsion systems-i.e., multiple emulsion, microemulsion, and nano-emulsion; vesicular systems-i.e., liposomes, ethosomes, noisomes, and transferosomes; and particulate systems-i.e., solid lipid nanoparticles, solid lipid microparticles, nano-structured lipid carriers, dendrimers, nanocrystals, polymeric nanoparticles, and gold nanoparticles. The review was compiled through an extensive search of the literature through the PubMed, Google Scholar, and ScienceDirect databases. A survey of literature revealed seven formulations based upon emulsion systems, six vesicular drug delivery systems, and fourteen particulate systems reported for antipsoriatic drugs. Based on the literature studies of colloidal approaches for psoriasis management carried out in recent years, it has been concluded that colloidal pharmaceutical formulations could be investigated broadly and have a broad scope for effective management of many skin disorders in the coming decades.
    Sprache Englisch
    Erscheinungsdatum 2021-11-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13111978
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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