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Article ; Online: Invited commentary.

Sarkar, Rajabrata

2017 Volume 66, Issue 2, Page(s) 593

Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2017.02.029
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Zs.A 1933: Show issues

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Article ; Online: Awareness and Early Diagnosis of Popliteal Artery Entrapment Syndrome Is Needed.

Mustapha, Jihad A / Sarkar, Rajabrata / Rastogi, Ujjwal

JACC. Case reports

2022 Volume 4, Issue 7, Page(s) 429–432

Language	English
Publishing date	2022-04-06
Publishing country	Netherlands
Document type	Editorial
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2022.02.002
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Article ; Online: Time-dependent ultrastructural changes during venous thrombogenesis and thrombus resolution.

Chernysh, Irina N / Mukhopadhyay, Subhradip / Johnson, Tierra A / Brooks, Jacob A / Sarkar, Rajabrata / Weisel, John W / Antalis, Toni M

Journal of thrombosis and haemostasis : JTH

2024

Abstract: Background: Deep vein thrombosis is a common vascular event that can result in debilitating morbidity and even death due to pulmonary embolism. Clinically, patients with faster resolution of a venous thrombus have improved prognosis, but the detailed ... ...

Abstract	Background: Deep vein thrombosis is a common vascular event that can result in debilitating morbidity and even death due to pulmonary embolism. Clinically, patients with faster resolution of a venous thrombus have improved prognosis, but the detailed structural information regarding changes that occur in a resolving thrombus over time is lacking. Objectives: To define the spatial-morphologic characteristics of venous thrombus formation, propagation, and resolution at the submicron level over time. Methods: Using a murine model of stasis-induced deep vein thrombosis along with scanning electron microscopy and immunohistology, we determine the specific structural, compositional, and morphologic characteristics of venous thrombi formed after 4 days and identify the changes that take place during resolution by day 7. Comparison is made with the structure and composition of venous thrombi formed in mice genetically deficient in plasminogen activator inhibitor type 1. Results: As venous thrombus resolution progresses, fibrin exists in different structural forms, and there are dynamic cellular changes in the compositions of leukocytes, platelet aggregates, and red blood cells. Intrathrombus microvesicles are present that are not evident by histology, and red blood cells in the form of polyhedrocytes are an indicator of clot contraction. Structural evidence of fibrinolysis is observed early during thrombogenesis and is accelerated by plasminogen activator inhibitor type 1 deficiency. Conclusion: The results reveal unique, detailed ultrastructural and compositional insights along with documentation of the dynamic changes that occur during accelerated resolution that are not evident by standard pathologic procedures and can be applied to inform diagnosis and effectiveness of thrombolytic treatments to improve patient outcomes.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2024.02.020
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Utilizing an office based laboratory (OBL) during the COVID-19 pandemic for vascular surgical patients.

Fitzpatrick, Suzanna / Dunlap, Eleanor / Hawkins, Shannon / Nagarsheth, Khanjan / Sarkar, Rajabrata

Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing

2022 Volume 41, Issue 1, Page(s) 19–21

Abstract: COVID-19 pandemic brought new challenges in healthcare including the need to create tiered class recommendations about which types patients to treat urgently and which surgical cases to defer. This is a report of a single center's Office Based Laboratory ...

Abstract	COVID-19 pandemic brought new challenges in healthcare including the need to create tiered class recommendations about which types patients to treat urgently and which surgical cases to defer. This is a report of a single center's Office Based Laboratory (OBL) system to prioritize vascular patients and preserve acute care resources and personnel. In reviewing three months of data, it appears that by continuing to provide the urgent care needed for this chronically ill population, the insurmountable backup of surgical procedures is prevented in the operating room once elective surgeries resumed. The OBL was able to continue providing care at the same pre-pandemic rate to a large intercity population.
MeSH term(s)	Humans ; COVID-19 ; Pandemics/prevention & control ; Vascular Surgical Procedures ; Ambulatory Care
Language	English
Publishing date	2022-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1083367-5
ISSN	1532-6578 ; 1062-0303
ISSN (online)	1532-6578
ISSN	1062-0303
DOI	10.1016/j.jvn.2022.12.003
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Zs.A 3297: Show issues

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Article ; Online: Diameter and depth of femoral vessels by duplex ultrasound.

Zambetti, Benjamin R / Kankaria, Aman / Fang, Francia / Kim, Nahye / Nagarsheth, Khanjan / Sarkar, Rajabrata

The journal of vascular access

2023 , Page(s) 11297298231200036

Abstract: Background: The anatomy of the femoral artery and vein plays an integral role in vascular access. Both technical feasibility and complication rates are associated with femoral vessel diameter and depth. The goal of this study is to establish normative ... ...

Abstract	Background: The anatomy of the femoral artery and vein plays an integral role in vascular access. Both technical feasibility and complication rates are associated with femoral vessel diameter and depth. The goal of this study is to establish normative values for common femoral artery (CFA) and vein (CFV) depth and diameter using a large, diverse patient population. Methods: A retrospective review of all patients undergoing lower extremity venous duplex imaging over a 1 year period were reviewed. Patients with inadequate imaging or with evidence of deep vein thrombosis were excluded. The index image of all studies was a non-compressed view of the common femoral vein at the saphenous-femoral junction. All measurements were taken from this still. Vessel diameters were measured from intima to intima. Depth was measured from skin to intima. BMI and BSA were calculated using standard formulas. Chi square was used for univariate analysis. Linear regression was used to establish correlation. Results: Over the 1 year period, 983 patients met criteria for inclusion. The majority were male (53%) with a mean age of 55. The patients were 47% white and 44% black. The majority had hypertension (53%). The mean BMI and BSA were 29 and 2, respectively. Mean CFA depth was 1.7 cm, while mean CFV depth was 1.8 cm. The mean CFA and CFV diameters were 0.9 and 1.1 cm, respectively. Amongst height, weight, BMI, and BSA, weight correlated best with CFA ( Conclusions: This study establishes mean diameters and depths for the common femoral artery and vein using a large, diverse patient group. BSA was most closely associated with vessel diameter, while weight was correlated with depth. This study provides normative diameter and depth values for the common femoral vasculature, which may assist in vascular access planning for providers.
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2252820-9
ISSN	1724-6032 ; 1129-7298
ISSN (online)	1724-6032
ISSN	1129-7298
DOI	10.1177/11297298231200036
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Zs.A 6414: Show issues

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Article ; Online: Reply.

Hao, Scarlett / Sarkar, Rajabrata

Journal of vascular surgery. Venous and lymphatic disorders

2018 Volume 6, Issue 3, Page(s) 420–421

Language	English
Publishing date	2018
Publishing country	United States
Document type	Letter ; Comment
ISSN	2213-3348
ISSN (online)	2213-3348
DOI	10.1016/j.jvsv.2017.12.010
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Article ; Online: Reply.

Hao, Scarlett / Sarkar, Rajabrata

Journal of vascular surgery. Venous and lymphatic disorders

2018 Volume 6, Issue 6, Page(s) 806

Language	English
Publishing date	2018-10-18
Publishing country	United States
Document type	Letter ; Comment
ISSN	2213-3348
ISSN (online)	2213-3348
DOI	10.1016/j.jvsv.2018.08.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Directly Cooling Gut Prevents Mortality in the Rat Model of Reboa Management of Lethal Hemorrhage.

Liu, Chunli / Yuan, Dong / Crawford, Robert / Sarkar, Rajabrata / Hu, Bingren

Shock (Augusta, Ga.)

2021 Volume 56, Issue 5, Page(s) 813–823

Abstract: Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a lifesaving technique for the management of lethal torso hemorrhage. Its benefit, however, must be weighed against the lethal distal organ ischemia-reperfusion injury (IRI) ...

Abstract	Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a lifesaving technique for the management of lethal torso hemorrhage. Its benefit, however, must be weighed against the lethal distal organ ischemia-reperfusion injury (IRI). This study uses a novel direct gut cooling technique to manage the distal organ IRI. Methods: A rat lethal hemorrhage model was established by bleeding of 50% of the estimated total blood volume via inferior vena cava. A novel TransRectal Intra-Colon (TRIC) temperature management device was positioned in the descending colon either to maintain intra-colon temperature at 37°C or 12°C. The upper body temperature was maintained at as close to 37°C as possible in both groups. A 2F Fogarty balloon catheter was inserted via the femoral artery into the descending thoracic aorta for the implementation of REBOA. After REBOA, the balloon was deflated, and the shed blood was returned. The temperature managements were continued for additional 180 to 270 min during the post-REBOA period. Results: All rats subjected to REBOA management of lethal hemorrhage at 37°C had severe histopathological gut and abdominal organ IRI, severe functional deficits, and died within 24 h with 100% mortality. By contrast, directly cooling the colon to 10°C to 12°C with the novel TRIC device abolished mortality, and dramatically improved ABG parameters, prevented the abdominal organ injury, and reduced the functional deficits during the 7-day post-REBOA period. Conclusions: Direct trans-rectal colon cooling during REBOA management of lethal hemorrhage offers extraordinary functional improvement and amazing tissue protection, and abolishes mortality.
MeSH term(s)	Animals ; Balloon Occlusion ; Cold Temperature ; Disease Models, Animal ; Gastrointestinal Transit ; Hemorrhage/complications ; Hemorrhage/mortality ; Hemorrhage/therapy ; Male ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/etiology ; Reperfusion Injury/prevention & control ; Resuscitation
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000001744
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Zs.A 3985: Show issues

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Article: Intravascular ultrasound imaging for diagnosis and characterization of the popliteal compression syndrome.

Hall, Michael R / Vyas, Yamini / Kang, Jeanwan / Nagarsheth, Khanjan / Sarkar, Rajabrata

Journal of vascular surgery cases and innovative techniques

2022 Volume 9, Issue 1, Page(s) 101076

Abstract: Objective: Functional popliteal artery entrapment syndrome (fPAES) is a rare form of nonatherosclerotic claudication most often seen in young athletic patients. Diagnosis remains challenging, with various imaging modalities showing equivocal or subtle ... ...

Abstract	Objective: Functional popliteal artery entrapment syndrome (fPAES) is a rare form of nonatherosclerotic claudication most often seen in young athletic patients. Diagnosis remains challenging, with various imaging modalities showing equivocal or subtle findings that may be missed. We sought to critically examine and quantitate the utility of intravascular ultrasound (IVUS) imaging, a common diagnostic tool for vascular compression syndromes, in diagnosis and characterization of fPAES. Methods: Patients presenting to a single tertiary care center between 2019 and 2022 with symptoms of PAES but without an anatomic etiology or equivocal workup were selected. Angiogram and IVUS with maneuvers were performed on affected extremities at rest, active plantarflexion/dorsiflexion, and plantarflexion/dorsiflexion against resistance. IVUS examination was recorded using a pull-back technique from the tibial vessels to the superficial femoral artery. The degree, length, and anatomic location of compression using the two imaging modalities were compared. Results: Angiogram and IVUS with maneuvers were performed on 17 lower extremities (9 left, 8 right) in 15 patients (88% female; mean age, 21.2 years). Evidence of arterial compression on angiography was noted in 88.2% (n = 15) of limbs (66.7% complete contrast cessation and 20% popliteal artery tapering); 13.3% (n = 2) only demonstrated sluggish flow as possible evidence of compression. Arterial compression was seen on IVUS imaging in 15 of 17 limbs, and all completely compressed around the IVUS catheter. The IVUS-measured mean length of compression was 10.5 cm ± 4.2 (median, 11 cm; range, 4-23 cm). Compression involved only the popliteal vessels in 86.7% (n = 13); one patient had both popliteal and tibioperoneal trunk compression, whereas another had tibioperoneal trunk and peroneal artery compression. Popliteal vein compression was 100%. The contrast cessation point on angiography and the proximal point of compression on IVUS imaging differed in 80% of cases ( Conclusions: IVUS imaging is a more sensitive diagnostic and descriptive imaging modality compared with angiogram in patients with possible fPAES. IVUS and angiogram findings are greatly discordant; moreover, IVUS imaging can provide detailed information such as the precise extent and anatomic location of the arterial compression, which may be useful in aiding surgical planning. IVUS imaging should be considered the gold standard for diagnosing and characterizing fPAES before intervention planning.
Language	English
Publishing date	2022-12-12
Publishing country	United States
Document type	Journal Article
ISSN	2468-4287
ISSN	2468-4287
DOI	10.1016/j.jvscit.2022.11.013
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Article ; Online: Evaluating the Safety of Transcarotid Artery Revascularization under Local Anesthesia Prior to Coronary Artery Bypass Grafting Surgery.

Vyas, Yamini / Workneh, Eyerusalem / Leibowitz, Joshua L / Sarkar, Rajabrata / Ghoreishi, Mehrdad / Toursavadkohi, Shahab

Annals of vascular surgery

2022 Volume 91, Page(s) 176–181

Abstract: Background: Controversy exists regarding the timing of intervention for patients with critical coronary artery disease (CAD) awaiting coronary artery bypass and severe carotid artery stenosis (CAS). Transcarotid artery revascularization (TCAR) is a ... ...

Abstract	Background: Controversy exists regarding the timing of intervention for patients with critical coronary artery disease (CAD) awaiting coronary artery bypass and severe carotid artery stenosis (CAS). Transcarotid artery revascularization (TCAR) is a minimally invasive revascularization alternative through direct transcervical carotid access that minimizes the chance of arch manipulation and consequent antegrade embolic stroke rate. While the TCAR procedure can be performed under local anesthesia (monitored anesthesia care [MAC]) versus general anesthesia, the hemodynamic benefits of local anesthesia in patients with severe CAD are significant. Patients receiving staged TCAR-coronary artery bypass grafting (CABG) have high-risk cardiovascular disease and require accurate perioperative neurological and hemodynamic evaluation that can be safely provided with local anesthesia. Methods: In this retrospective single-center study, 14 patients were systematically identified to have undergone staged TCAR prior to CABG surgery from December 2018 to October 2021. All patients underwent TCAR with local anesthesia and minimal sedation. Relevant patient demographics, medical and surgical history, preoperative covariates, and type of anesthesia administered were obtained from patients' charts. CAD was confirmed by either carotid duplex imaging or computed tomography angiography (CTA) of the head/neck. Results: Staged TCAR-CABG interventions were performed on 14 patients (64% male; mean age 65.0 years). No major adverse cardiac events were reported including transient ischemic attack (TIA), stroke, myocardial infarction (MI), or TCAR-related death in the interval between their TCAR and CABG as well as in a 12-month follow-up period. One patient required to return to the operating room (OR) for evacuation of a neck hematoma. Conclusions: This study demonstrated high success rate of TCAR under local anesthesia prior to CABG (100%) with no incidence of perioperative stroke, MI, or death at 1-month, 6-month, and 12-month follow-up intervals. The authors support the use of staged TCAR-CABG with local anesthesia as a safe and promising treatment option for patients with high-grade cardiac disease, high risk of stroke, or multiple comorbidities that preclude a carotid endarterectomy (CEA).
MeSH term(s)	Humans ; Male ; Aged ; Female ; Anesthesia, Local/adverse effects ; Retrospective Studies ; Risk Factors ; Endovascular Procedures/adverse effects ; Time Factors ; Treatment Outcome ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/surgery ; Stroke/etiology ; Coronary Artery Bypass/adverse effects ; Myocardial Infarction/etiology ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Coronary Artery Disease/complications ; Carotid Arteries ; Stents/adverse effects
Language	English
Publishing date	2022-12-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2022.11.018
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