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  1. Book: Cut-and-Paste Genetics

    Sarkar, Sahotra

    A CRISPR Revolution

    2021  

    Author's details Sahotra Sarkar is a Professor in the Departments of Philosophy and Integrative Biology at the University of Texas, Austin. He came to Texas after teaching at Boston and McGill Universities and holding fellowships at MIT and the Max Planck Institute. A specialist in the history and philosophy of science, he has particular interests in both philosophy of biology and physics
    Keywords bioethics ; biology ; biotechnology ; CRISPR ; designer babies ; Disability ; eugenics ; gene-editing ; genetic disease ; genetic enhancement ; genetics ; genome editing ; history of science ; Human Genome Project; bioethics; Biology; biotechnology
    Language English
    Size 224 p.
    Publisher Rowman & Littlefield
    Document type Book
    Note PDA Manuell_25
    Format 157 x 235 x 17
    ISBN 9781786614377 ; 1786614375
    Database PDA

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  2. Article ; Online: A desirable advancement but not without concern for black blood sequences: vessel wall imaging may not be blindly done.

    Sarkar, Subhendra

    European radiology

    2024  

    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-024-10608-8
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  3. Article ; Online: How patriarchy and conservatism fuel deadly hesitancy among women with breast cancer.

    Sarkar, Sonia

    BMJ (Clinical research ed.)

    2024  Volume 384, Page(s) 2563

    MeSH term(s) Humans ; Female ; Breast Neoplasms ; Family Structure ; Family Characteristics
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p2563
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  4. Article ; Online: WHO Southeast Asia regional flagships - building beyond global frameworks.

    Sarkar, Swarup

    The Lancet regional health. Southeast Asia

    2023  Volume 18, Page(s) 100314

    Language English
    Publishing date 2023-10-29
    Publishing country England
    Document type Journal Article
    ISSN 2772-3682
    ISSN (online) 2772-3682
    DOI 10.1016/j.lansea.2023.100314
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  5. Article: Managing ecological thresholds of a risky commons.

    Sarkar, Sukanta

    Royal Society open science

    2023  Volume 10, Issue 10, Page(s) 230969

    Abstract: Common resources are often overexploited and appear subject to critical transitions from one stable state to another antagonistic state. Many times resulting in tragedy of the commons (TOC)-exploitation of shared resources for personal gain/payoffs, ... ...

    Abstract Common resources are often overexploited and appear subject to critical transitions from one stable state to another antagonistic state. Many times resulting in tragedy of the commons (TOC)-exploitation of shared resources for personal gain/payoffs, leading to worse outcomes or extinction. An adequate response would be strategic interaction, such as inspection and punishment by institutions to avoid TOC. This strategic interaction is often coupled with dynamically changing common resources. However, effect of strategic interaction in complex, coupled socio-ecological systems is less studied. Here, we develop replicator equations using evolving games in which strategy and common resources co-evolve. We consider the shared commons as fish dynamics governed by the intrinsic growth rate, predation and harvesting. The joint dynamics exhibit an oscillatory TOC, revealing that institutions need to pay special attention to intrinsic growth rate and nonlinear interaction. Our research shows that the co-evolving system exhibits a broader range of dynamics when predation is present compared to the disengaged fishery system. We conclude that the usefulness, chances and challenges of modelling co-evolutionary games to create sustainable systems merit further research.
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.230969
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  6. Article ; Online: GWASs and polygenic scores inherit all the old problems of heritability estimates.

    Sarkar, Sahotra

    The Behavioral and brain sciences

    2023  Volume 46, Page(s) e227

    Abstract: Polygenic score (PGS) computations assume an additive model of gene action because associations between phenotypes and alleles at different loci are compounded, ignoring interactions between alleles or loci let alone between genotype and environment. ... ...

    Abstract Polygenic score (PGS) computations assume an additive model of gene action because associations between phenotypes and alleles at different loci are compounded, ignoring interactions between alleles or loci let alone between genotype and environment. Consequently, PGSs are subject to the same objections that invalidated traditional heritability analyses in the 1970s. Thus, PGSs should not be used in the social sciences.
    MeSH term(s) Humans ; Dandy-Walker Syndrome ; Mental Retardation, X-Linked ; Social Sciences
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X22002321
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  7. Article ; Online: "Past the point of sanity"-South East Asia faces critical shortage of healthcare workers.

    Sarkar, Sonia

    BMJ (Clinical research ed.)

    2023  Volume 382, Page(s) 1655

    MeSH term(s) Humans ; Asia, Southeastern ; Health Personnel ; Asia, Eastern
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p1655
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  8. Article ; Online: Despite historic bans, south Asia still struggles with pesticide suicides.

    Sarkar, Sonia

    BMJ (Clinical research ed.)

    2023  Volume 381, Page(s) 678

    MeSH term(s) Humans ; Pesticides ; Suicide ; Asia, Southern ; Suicide Prevention ; Agriculture
    Chemical Substances Pesticides
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p678
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  9. Article ; Online: Brain arteriovenous malformations: the long way ahead in physics, chemistry, and MR angiography practice before fully replacing digital subtraction angiography.

    Sarkar, Subhendra

    European radiology

    2023  Volume 33, Issue 10, Page(s) 7136–7138

    MeSH term(s) Humans ; Angiography, Digital Subtraction ; Follow-Up Studies ; Arteriovenous Malformations ; Brain/diagnostic imaging ; Physics
    Language English
    Publishing date 2023-08-15
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10063-x
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  10. Article ; Online: Fighting in Sudan threatens its already fragile healthcare system.

    Sarkar, Sonia

    BMJ (Clinical research ed.)

    2023  Volume 381, Page(s) 1009

    MeSH term(s) Humans ; Sudan/epidemiology ; Delivery of Health Care
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p1009
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