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Article: Acute toxicity study of onion peel-derived gold nano-bioconjugate.

Phukan, Kabyashree / Sarma, Himangshu / Devi, Rajlakshmi / Chowdhury, Devasish

2023 Volume 13, Issue 6, Page(s) 172

Abstract: The acute anti-inflammatory activity of onion peel-derived gold nano-bioconjugate was already established earlier. The current study was aimed to investigate the acute oral toxicity of onion peel-derived gold nano-bioconjugate (GNBC) for safe therapeutic ...

Abstract	The acute anti-inflammatory activity of onion peel-derived gold nano-bioconjugate was already established earlier. The current study was aimed to investigate the acute oral toxicity of onion peel-derived gold nano-bioconjugate (GNBC) for safe therapeutic utilization in vivo. The acute toxicity study was carried out in female mice for 15 days and showed no mortality and any abnormal complications. The lethal dose (LD
Language	English
Publishing date	2023-05-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-023-03592-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ultrasound-Assisted Extraction of Verbascoside from

Khound, Puspanjali / Sarma, Himangshu / Sarma, Partha Pratim / Jana, Uttam Kumar / Devi, Rajlakshmi

ACS omega

2023 Volume 8, Issue 23, Page(s) 20360–20369

Abstract: Verbascoside (VER) is a phenylethanoid glycoside compound found ... ...

Abstract	Verbascoside (VER) is a phenylethanoid glycoside compound found in
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c00173
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Article ; Online: Complementary and alternative approaches for diabetic foot ulcer treatment: A systematic review

Suman Kumar / Bharali, Alakesh / Sarma, Himangshu / Kushari, Susankar / Gam, Sameeran / Hazarika, Iswar / Prasad, Satyendra K. / Laloo, Damiki

Journal of Ayurveda and Integrative Medicine. 2023, p.100745-

2023 , Page(s) 100745–

Abstract: Diabetic Foot Ulcers (DFUs) are a devastating micro-vascular complication of diabetes with an increased prevalence and incidence and high rate of morbidity and mortality. Since antibiotics are frequently used to treat DFU, managing the condition has ... ...

Abstract	Diabetic Foot Ulcers (DFUs) are a devastating micro-vascular complication of diabetes with an increased prevalence and incidence and high rate of morbidity and mortality. Since antibiotics are frequently used to treat DFU, managing the condition has proven to be extremely challenging and may eventually lead to the development of antibiotic resistance. Scientists from around the world are working to develop an alternative solution to the problem of drug resistance by exploring complementary and alternative medicines that may be obtained from natural sources. Hence, the review aims to comprehensively report the information on the natural treatments and therapy used to manage DFU. All of the information described in the current study was gathered from electronic scientific resources, including Google Scholar, PubMed, Scopus, Science Direct, and Springer Link. Findings from the current review revealed the pre-clinical and clinical utility of 18 medicinal plants, 1 isolated compound, 7 polyherbal formulations including herbal creams, a few micronutrients including vitamins and minerals, insect products such as propolis, honey and, Maggot debridement therapy for the treatment and management of DFU. Natural therapies possess better efficacy, low cost, and shorter duration of treatment when compared with the conventional treatments; hence, all information made available about them is crucial to alter the direction of treatment. Furthermore, the data presented in this review are up to date on the potential efficacy of natural complementary medicines for alleviating DFU problems in in vitro and in vivo tests, as well as clinical studies.
Keywords	Ayurvedic medicine ; antibiotic resistance ; debridement ; diabetic foot ; honey ; insect larvae ; insects ; morbidity ; mortality ; propolis ; systematic review ; Diabetic foot ulcer ; natural therapy ; medicinal plant extracts ; polyherbal formulation ; clinical aspect ; molecular mechanism
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ISSN	0975-9476
DOI	10.1016/j.jaim.2023.100745
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Chemical composite of indigenous whole grain scented joha rice varietal prevents type 2 diabetes in rats through ameliorating insulin sensitization by the IRS-1/AKT/PI3K signalling cascade.

Choudhury, Paramita / Samanta, Suman Kumar / Bhattacharjee, Swarnali / Sarma, Himangshu / Devi, Rajlakshmi

Food & function

2022 Volume 13, Issue 22, Page(s) 11879–11895

Abstract: Preventive measures to lower the prevalence of type-2 diabetes development using dietary phytochemicals are most realistic. A phytochemical composite derived from whole grain scented joha rice (PCKJ), which is indigenous to the North-eastern Region, ... ...

Abstract	Preventive measures to lower the prevalence of type-2 diabetes development using dietary phytochemicals are most realistic. A phytochemical composite derived from whole grain scented joha rice (PCKJ), which is indigenous to the North-eastern Region, India, was investigated to understand its preventive efficacy in rats in which type 2 diabetes was induced using a high-fat high-fructose (HFHF) diet and a low dose of streptozotocin, and the findings were correlated with those in L6-myotubes. Studies on cultured L6 myotubes revealed that treatment with PCKJ facilitated glucose uptake and GLUT-4 translocation to the plasma membrane, as evidenced by confocal microscopy and/or cell fractionation studies. Furthermore, the FFA-induced L6 myotubes were identified as having elevated levels of PI3K, p-AKT (Ser473) and GLUT-4, which returned to the basal level upon exposure to PCKJ. The administration of PCKJ (100 mg per kg body weight, oral gavage, 24 weeks) to rats significantly reduced their blood glucose levels along with common lipid and liver biomarkers (LDL, triglycerides, cholesterol, ALT, and AST) compared to the control group. Moreover, immunoblotting analysis showed that upon PCKJ treatment, PI3K, p-AKT and GLUT-4 levels are upregulated in the skeletal tissue of HFHF-fed rats, similar to the
MeSH term(s)	Rats ; Animals ; Insulin/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Oryza/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Whole Grains ; Insulin Resistance ; Fructose
Chemical Substances	Insulin ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Fructose (30237-26-4)
Language	English
Publishing date	2022-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo02373c
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Article: An integrated computational approach towards the screening of active plant metabolites as potential inhibitors of SARS-CoV-2: an overview.

Kushari, Susankar / Hazarika, Iswar / Laloo, Damiki / Kumar, Suman / Kalita, Jun Moni / Sarma, Himangshu

Structural chemistry

2022 Volume 34, Issue 3, Page(s) 1073–1104

Abstract: COVID-19 and its causative organism SARS-CoV-2 paralyzed the world and was designated a pandemic by the World Health Organization in March 2020. The worldwide health system is trying to discover an effective therapeutic measure since no clinically ... ...

Abstract	COVID-19 and its causative organism SARS-CoV-2 paralyzed the world and was designated a pandemic by the World Health Organization in March 2020. The worldwide health system is trying to discover an effective therapeutic measure since no clinically authorized medications are present. Screening of plant-derived pharmaceuticals may be a viable technique to fight COVID-19 in this vital situation. This review discusses the potential application of in silico approaches in developing new therapeutic molecules related to preventing SARS-CoV-2 infection. Also, it describes the binding affinity of various phytoconstituents with distinct SARS-CoV-2 target sites. In this perspective, an extensive literature survey was carried out to find the potential phytoconstituents to develop new therapeutic entities to treat COVID-19 in different online academic databases and books. Data retrieved from databases were analyzed and interpreted to conclude that many phytochemicals will bind with the 3-chymotrypsin-like (3CLpro) and papain-like proteases (PL
Language	English
Publishing date	2022-10-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2018832-8
ISSN	1572-9001 ; 1040-0400
ISSN (online)	1572-9001
ISSN	1040-0400
DOI	10.1007/s11224-022-02066-z
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Article: Traditional complementary and alternative medicine (TCAM) for diabetic foot ulcer management: A systematic review.

Kumar, Suman / Bharali, Alakesh / Sarma, Himangshu / Kushari, Susankar / Gam, Sameeran / Hazarika, Iswar / Prasad, Satyendra K / Laloo, Damiki

Journal of Ayurveda and integrative medicine

2023 Volume 14, Issue 4, Page(s) 100745

Abstract	Diabetic Foot Ulcers (DFUs) are a devastating micro-vascular complication of diabetes with an increased prevalence and incidence and high rate of morbidity and mortality. Since antibiotics are frequently used to treat DFU, managing the condition has proven to be extremely challenging and may eventually lead to the development of antibiotic resistance. Scientists from around the world are working to develop an alternative solution to the problem of drug resistance by exploring complementary and alternative medicines that may be obtained from natural sources. Hence, the review aims to comprehensively report the information on the natural treatments and therapy used to manage DFU. All of the information described in the current study was gathered from electronic scientific resources, including Google Scholar, PubMed, Scopus, Science Direct, and Springer Link. Findings from the current review revealed the pre-clinical and clinical utility of 18 medicinal plants, 1 isolated compound, 7 polyherbal formulations including herbal creams, a few micronutrients including vitamins and minerals, insect products such as propolis, honey and, Maggot debridement therapy for the treatment and management of DFU. Natural therapies possess better efficacy, low cost, and shorter duration of treatment when compared with the conventional treatments; hence, all information made available about them is crucial to alter the direction of treatment. Furthermore, the data presented in this review are up to date on the potential efficacy of natural complementary medicines for alleviating DFU problems in in vitro and in vivo tests, as well as clinical studies.
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article ; Review
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2023.100745
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Article ; Online: Progress in Drug and Formulation Development for the Chemoprevention of Oral Squamous Cell Carcinoma: A Review.

Sarma, Himangshu / Jahan, Taslima / Sharma, Hemanta K

Recent patents on drug delivery & formulation

2019 Volume 13, Issue 1, Page(s) 16–36

Abstract: Background: Cancer is a life-threatening global problem with high incidence rates. Prioritizing the prevention of cancer, chemopreventive agents have drawn much attention from the researchers.: Objective: This review focuses on the discussion of the ... ...

Abstract	Background: Cancer is a life-threatening global problem with high incidence rates. Prioritizing the prevention of cancer, chemopreventive agents have drawn much attention from the researchers. Objective: This review focuses on the discussion of the progress in the development of chemopreventive agents and formulations related to the prevention of oral cancer. Methods: In this perspective, an extensive literature survey was carried out to understand the mechanism, control and chemoprevention of oral cancer. Different patented agents and formulations have also exhibited cancer preventive efficacy in experimental studies. This review summarizes the etiology of oral cancer and developments in prevention strategies. Results: The growth of oral cancer is a multistep activity necessitating the accumulation of genetic as well as epigenetic alterations in key regulatory genes. Many risk factors are associated with oral cancer. Genomic technique for sequencing all tumor specimens has been made available to help detect mutations. The recent development of molecular pathway and genetic tools has made the process of diagnosis easier, better forecast and efficient therapeutic management. Different chemical agents have been studied for their efficacy to prevent oral cancer and some of them have shown promising results. Conclusion: Use of chemopreventive agents, either synthetic or natural origin, to prevent carcinogenesis is a worthy concept in the management of cancers. Preventive measures are helpful in controlling the occurrence or severity of the disease. The demonstrated results of preventive agents have opened an arena for the development of promising chemopreventive agents in the management of oral squamous cell carcinoma.
MeSH term(s)	Anticarcinogenic Agents/administration & dosage ; Anticarcinogenic Agents/chemical synthesis ; Antioxidants/administration & dosage ; Antioxidants/chemical synthesis ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/prevention & control ; Chemoprevention/methods ; Chemoprevention/trends ; Drug Compounding ; Drug Delivery Systems/methods ; Drug Delivery Systems/trends ; Drug Development/methods ; Drug Development/trends ; Humans ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/prevention & control ; Papillomaviridae/drug effects ; Papillomaviridae/physiology
Chemical Substances	Anticarcinogenic Agents ; Antioxidants
Language	English
Publishing date	2019-02-25
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	2212-4039
ISSN (online)	2212-4039
DOI	10.2174/1872211313666190222182824
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Towards Generating Virtual Movement from Textual Instructions A Case Study in Quality Assessment

Sarma, Himangshu / Porzel, Robert / Smeddinck, Jan / Malaka, Rainer

2020

Abstract: Many application areas ranging from serious games for health to learning by demonstration in robotics, could benefit from large body movement datasets extracted from textual instructions accompanied by images. The interpretation of instructions for the ... ...

Abstract	Many application areas ranging from serious games for health to learning by demonstration in robotics, could benefit from large body movement datasets extracted from textual instructions accompanied by images. The interpretation of instructions for the automatic generation of the corresponding motions (e.g. exercises) and the validation of these movements are difficult tasks. In this article we describe a first step towards achieving automated extraction. We have recorded five different exercises in random order with the help of seven amateur performers using a Kinect. During the recording, we found that the same exercise was interpreted differently by each human performer even though they were given identical textual instructions. We performed a quality assessment study based on that data using a crowdsourcing approach and tested the inter-rater agreement for different types of visualizations, where the RGBbased visualization showed the best agreement among the annotators.
Keywords	Computer Science - Human-Computer Interaction
Publishing date	2020-06-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Nanotheranostics: application of nanosensors in diabetes management.

Pathak, Kalyani / Saikia, Riya / Sarma, Himangshu / Pathak, Manash Pratim / Das, Ratna Jyoti / Gogoi, Urvashee / Ahmad, Mohammad Zaki / Das, Aparoop / Wahab, Basel A Abdel

Journal of diabetes and metabolic disorders

2023 Volume 22, Issue 1, Page(s) 119–133

Abstract: Objectives: The objective of the present study is to discuss the use of nanomaterials like nanosensors for diagnosing Diabetes and highlight their applications in the treatment of Diabetes.: Methods: Diabetes mellitus (D.M.) is a group of metabolic ... ...

Abstract	Objectives: The objective of the present study is to discuss the use of nanomaterials like nanosensors for diagnosing Diabetes and highlight their applications in the treatment of Diabetes. Methods: Diabetes mellitus (D.M.) is a group of metabolic diseases characterized by hyperglycemia. Orally administered antidiabetic drugs like glibenclamide, glipalamide, and metformin can partially lower blood sugar levels, but long-term use causes kidney and liver damage. Recent breakthroughs in nanotheranostics have emerged as a powerful tool for diabetes treatment and diagnosis. Results: Nanotheranostics is a rapidly developing area that can revolutionize diabetes diagnosis and treatment by combining therapy and imaging in a single probe, allowing for pancreas-specific drug and insulin delivery. Nanotheranostic in Diabetes research has facilitated the development of improved glucose monitoring and insulin administration modalities, which promise to improve the quality of life for people with Diabetes drastically. Further, nanomaterials like nanocarriers and unique functional nanomaterials used as nano theranostics tools for treating Diabetes will also be highlighted. Conclusion: The nanosensors discussed in this review article will encourage researchers to develop innovative nanomaterials with novel functionalities and properties for diabetes detection and treatment.
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2680289-2
ISSN	2251-6581
ISSN	2251-6581
DOI	10.1007/s40200-023-01206-4
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Book ; Online: Data augmentation enhanced speaker enrollment for text-dependent speaker verification

Sarkar, Achintya Kumar / Sarma, Himangshu / Dwivedi, Priyanka / Tan, Zheng-Hua

2020

Abstract: Data augmentation is commonly used for generating additional data from the available training data to achieve a robust estimation of the parameters of complex models like the one for speaker verification (SV), especially for under-resourced applications. ...

Abstract	Data augmentation is commonly used for generating additional data from the available training data to achieve a robust estimation of the parameters of complex models like the one for speaker verification (SV), especially for under-resourced applications. SV involves training speaker-independent (SI) models and speaker-dependent models where speakers are represented by models derived from an SI model using the training data for the particular speaker during the enrollment phase. While data augmentation for training SI models is well studied, data augmentation for speaker enrollment is rarely explored. In this paper, we propose the use of data augmentation methods for generating extra data to empower speaker enrollment. Each data augmentation method generates a new data set. Two strategies of using the data sets are explored: the first one is to training separate systems and fuses them at the score level and the other is to conduct multi-conditional training. Furthermore, we study the effect of data augmentation under noisy conditions. Experiments are performed on RedDots challenge 2016 database, and the results validate the effectiveness of the proposed methods.
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Sound
Subject code	310
Publishing date	2020-07-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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