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  1. Article ; Online: Editorial Comment.

    Sas, David J

    The Journal of urology

    2021  Volume 205, Issue 4, Page(s) 1187

    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001411.01
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  2. Article ; Online: Dietary risk factors for urinary stones in children.

    Sas, David J

    Current opinion in pediatrics

    2020  Volume 32, Issue 2, Page(s) 284–287

    Abstract: Purpose of review: As the incidence of urinary stone disease in children is increasing, identifying dietary risk factors becomes vitally important, especially in the context of targeting interventions to reduce risk for stone formation. Indiscriminant ... ...

    Abstract Purpose of review: As the incidence of urinary stone disease in children is increasing, identifying dietary risk factors becomes vitally important, especially in the context of targeting interventions to reduce risk for stone formation. Indiscriminant dietary restrictions are not appropriate for paediatric patients.
    Recent findings: Although large, prospective studies are still needed to better quantify dietary risk factors for paediatric stone formers, a number of smaller studies provide data to identify common risk factors to help prevent stone formation, while minimizing inappropriate dietary restrictions.
    Summary: Interpretation of 24-h urine samples to identify individualized dietary risk factors is crucial for implementing a strategy for prevention of further urinary stone formation in children. Clinicians should avoid generalized dietary restrictions in stone-forming children uninformed by laboratory data.
    MeSH term(s) Child ; Diet/adverse effects ; Humans ; Kidney Calculi/etiology ; Kidney Calculi/metabolism ; Kidney Calculi/urine ; Metabolic Diseases/complications ; Metabolic Diseases/diagnosis ; Metabolic Diseases/urine ; Risk Factors ; Socioeconomic Factors ; Urinary Calculi/etiology ; Urinary Calculi/metabolism ; Urinary Calculi/urine
    Language English
    Publishing date 2020-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000000886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3049: Show issues Location:
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  3. Article ; Online: New Insights Regarding Organ Transplantation in Primary Hyperoxaluria Type 1.

    Sas, David J / Lieske, John C

    Kidney international reports

    2021  Volume 7, Issue 2, Page(s) 146–148

    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Editorial
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.12.032
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  4. Article ; Online: Successful Treatment of Primary Hyperoxaluria Type 2 with a Combined Liver and Kidney Transplant.

    Genena, Kareem M / Sas, David J / Milliner, Dawn S / Lieske, John C

    Kidney international reports

    2023  Volume 8, Issue 7, Page(s) 1469–1472

    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.03.013
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  5. Article ; Online: An unusual case of necrotizing pneumonia presenting with acute kidney injury.

    Balkanci, Ugur B / Sas, David J / Demirel, Nadir

    Pediatric pulmonology

    2020  Volume 56, Issue 5, Page(s) 1257–1258

    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25177
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    Zs.A 2143: Show issues Location:
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  6. Article ; Online: 24-Hydroxylase Deficiency Due to

    Azer, Sarah M / Vaughan, Lisa E / Tebben, Peter J / Sas, David J

    Journal of the Endocrine Society

    2021  Volume 5, Issue 9, Page(s) bvab119

    Abstract: Context: CYP24A1 encodes 24-hydroxylase, which converts 25(OH)D3 and 1,25(OH): Objective: To identify features that differentiate 24HD from other vitamin D-mediated hypercalcemia disorders.: Methods: Patients seen at the Mayo Clinic (Rochester, MN) ...

    Abstract Context: CYP24A1 encodes 24-hydroxylase, which converts 25(OH)D3 and 1,25(OH)
    Objective: To identify features that differentiate 24HD from other vitamin D-mediated hypercalcemia disorders.
    Methods: Patients seen at the Mayo Clinic (Rochester, MN) from January 1, 2008, to 31 December, 2016, with the following criteria were retrospectively identified: serum calcium ≥9.6 mg/dL, parathyroid hormone <30 pg/mL, and 1,25(OH)
    Results: We identified 9 patients with 24HD and 28 with other vitamin D-mediated disorders. Patients with 24HD were younger at symptom onset (median 14 vs 63 years; P = .001) and had positive family history (88.9% vs 20.8%; P < .001), nephrocalcinosis (88.9% vs 6.3%; P < .001), lower lumbar spine Z-scores (median -0.50 vs 1.20; P = .01), higher peak serum phosphorus (% of peak reference range, median 107 vs 84;
    Conclusion: Patients with 24HD had clinical and laboratory findings that differed from other vitamin D-mediated hypercalcemia disorders. 24HD should be suspected in patients with hypercalcemia who present at younger age, have positive family history, and have nephrocalcinosis.
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvab119
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  7. Article ; Online: The genetics of kidney stone disease and nephrocalcinosis.

    Singh, Prince / Harris, Peter C / Sas, David J / Lieske, John C

    Nature reviews. Nephrology

    2021  Volume 18, Issue 4, Page(s) 224–240

    Abstract: Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent, affecting approximately 10% of adults worldwide, and the incidence of stone disease is increasing. Kidney stone formation results from an imbalance of inhibitors and ... ...

    Abstract Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent, affecting approximately 10% of adults worldwide, and the incidence of stone disease is increasing. Kidney stone formation results from an imbalance of inhibitors and promoters of crystallization, and calcium-containing calculi account for over 80% of stones. In most patients, the underlying aetiology is thought to be multifactorial, with environmental, dietary, hormonal and genetic components. The advent of high-throughput sequencing techniques has enabled a monogenic cause of kidney stones to be identified in up to 30% of children and 10% of adults who form stones, with ~35 different genes implicated. In addition, genome-wide association studies have implicated a series of genes involved in renal tubular handling of lithogenic substrates and of inhibitors of crystallization in stone disease in the general population. Such findings will likely lead to the identification of additional treatment targets involving underlying enzymatic or protein defects, including but not limited to those that alter urinary biochemistry.
    MeSH term(s) Adult ; Child ; Female ; Genome-Wide Association Study ; Humans ; Incidence ; Kidney Calculi/chemistry ; Kidney Calculi/genetics ; Kidney Tubules ; Male ; Nephrocalcinosis/complications ; Nephrocalcinosis/genetics
    Language English
    Publishing date 2021-12-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00513-4
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    Zs.A 6334: Show issues Location:
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    Zs.MG 107: Show issues

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  8. Article ; Online: An investigation of metabolic disturbances, including urinary stone disease, hypothyroidism, and osteoporosis in basal cell nevus syndrome.

    Schlaht, Karl M / Sas, David J / Davis, Dawn Marie R / Hand, Jennifer L

    Pediatric dermatology

    2022  Volume 39, Issue 5, Page(s) 713–717

    Abstract: Background/objectives: Basal cell nevus syndrome (BCNS) is an autosomal dominant skin cancer predisposition syndrome associated with abnormal mineral metabolism, a risk factor for urinary stone disease (USD). However, no research investigating the ... ...

    Abstract Background/objectives: Basal cell nevus syndrome (BCNS) is an autosomal dominant skin cancer predisposition syndrome associated with abnormal mineral metabolism, a risk factor for urinary stone disease (USD). However, no research investigating the association between BCNS and USD or other manifestations of abnormal mineral metabolism has been conducted. The objective of this study is to investigate the association between BCNS and conditions associated with disordered mineral metabolism including USD, hypothyroidism, and osteoporosis and compare them to prevalence in the general population to elucidate potential unknown manifestations of the condition.
    Methods: This retrospective study examined medical records of adult and pediatric patients with confirmed BCNS from the Mayo Clinic database from 1 January 1995 to 12 January 2020. Records were surveyed for evidence of USD and other comorbidities potentially related to BCNS. The studied cohort included 100 adult patients and 5 pediatric patients.
    Results: A total of 105 patients were included in this analysis, 10 of whom experienced confirmed USD, representing a prevalence of 10%. Six adult patients were identified with a diagnosis of osteoporosis, representing a prevalence of 6%. Thirteen adult patients were identified with a diagnosis of hypothyroidism, representing a prevalence of 13%.
    Conclusions: This study identified a prevalence of USD in BCNS patients comparable to estimates of national prevalence, indicating that known abnormalities in mineral metabolism likely do not increase the incidence of USD in BCNS patients. Additional findings included increased prevalence of hypothyroidism and decreased prevalence of osteoporosis in the BCNS cohort compared to national averages.
    MeSH term(s) Adult ; Basal Cell Nevus Syndrome/complications ; Child ; Humans ; Hypothyroidism/complications ; Hypothyroidism/epidemiology ; Osteoporosis/complications ; Osteoporosis/epidemiology ; Retrospective Studies ; Skin Neoplasms/diagnosis ; Urinary Calculi/complications ; Urologic Diseases
    Language English
    Publishing date 2022-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15022
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    Zs.A 1882: Show issues Location:
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  9. Article ; Online: Examination of nutritional factors associated with urolithiasis risk in plant based meat alternatives marketed to children and infants.

    Ungerer, Garrett N / Liaw, Christine W / Potretzke, Aaron M / Sas, David J / Gargollo, Patricio C / Granberg, Candace F / Koo, Kevin

    Journal of pediatric urology

    2023  Volume 19, Issue 5, Page(s) 513.e1–513.e7

    Abstract: Introduction: The global prevalence of pediatric nephrolithiasis continues to rise amidst increased sodium and animal protein intake. Plant-based meat alternatives (PBMAs) have recently gained popularity due to health benefits, environmental ... ...

    Abstract Introduction: The global prevalence of pediatric nephrolithiasis continues to rise amidst increased sodium and animal protein intake. Plant-based meat alternatives (PBMAs) have recently gained popularity due to health benefits, environmental sustainability, and increased retail availability. PBMAs have the potential to reduce the adverse metabolic impact of animal protein on kidney stone formation. We analyzed PBMAs targeted to children to characterize potential lithogenic risk vs animal protein.
    Methods: We performed a dietary assessment using a sample of PBMAs marketed to or commonly consumed by children and commercially available at national retailers. Nutrient profiles for PBMAs were compiled from US Department of Agriculture databases and compared to animal protein sources using standardized serving sizes. We also analyzed nutrient profiles for plant-based infant formulas against typical dairy protein-based formulas. Primary protein sources were identified using verified ingredient lists. Oxalate content was extrapolated from dietary data sources.
    Results: A total of 41 PBMAs were analyzed: chicken (N = 18), hot dogs (N = 3), meatballs (N = 5), fish (N = 10), and infant formula (N = 5). Most products (76%) contained a high-oxalate ingredient as the primary protein source (soy, wheat, or almond). Average oxalate content per serving was substantially higher in these products (soy 11.6 mg, wheat 3.8 mg, almond 10.2 mg) vs animal protein (negligible oxalate). PBMAs containing pea protein (24%) had lower average oxalate (0.11 mg). Most PBMAs averaged up to six times more calcium and three times more sodium per serving compared to their respective animal proteins. Protein content was similar for most categories.
    Conclusions: Three-quarters of the examined plant-based meat products for children and infants contain high-oxalate protein sources. Coupled with higher per-serving sodium and calcium amounts, our findings raise questions about possible lithogenic risk in some PBMAs, and further studies are needed to assess the relationship between PBMAs and nephrolithiasis.
    MeSH term(s) Animals ; Humans ; Child ; Infant ; Calcium ; Risk Factors ; Kidney Calculi/epidemiology ; Calcium, Dietary ; Meat/adverse effects ; Oxalates ; Sodium
    Chemical Substances Calcium (SY7Q814VUP) ; Calcium, Dietary ; Oxalates ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2023.04.017
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  10. Article ; Online: Correction to: Recent advances in the identification and management of inherited hyperoxalurias.

    Sas, David J / Harris, Peter C / Milliner, Dawn S

    Urolithiasis

    2019  Volume 48, Issue 1, Page(s) 93

    Abstract: The original version of this article unfortunately contained a mistake. On page 84, the dose for oral potassium citrate is incorrectly written as "0.1 mg/kg/day divided BID-QID for children, 30-60 mg per day divided BID-QID for adults". ...

    Abstract The original version of this article unfortunately contained a mistake. On page 84, the dose for oral potassium citrate is incorrectly written as "0.1 mg/kg/day divided BID-QID for children, 30-60 mg per day divided BID-QID for adults".
    Language English
    Publishing date 2019-10-09
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-019-01166-6
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