LIVIVO - Search results -

Search results

Result 1 - 10 of total 210

Search options

Article ; Online: Occlusion and catheter ablation using a large-size cryoballoon for various pulmonary veins: a case series.

Yoshizawa, Reisuke / Sasaki, Hiroki / Urushikubo, Takashi / Sawa, Yohei / Owada, Shingen

European heart journal. Case reports

2023 Volume 7, Issue 12, Page(s) ytad593

Abstract: Background: It is established that pulmonary vein isolation using the POLARx™ (Boston Scientific, Marlborough, MA, USA) cryoballoon is a rapid, safe, and effective approach. The new POLARx™ FIT (Boston Scientific), which is expandable from 28 to 31 mm ... ...

Abstract	Background: It is established that pulmonary vein isolation using the POLARx™ (Boston Scientific, Marlborough, MA, USA) cryoballoon is a rapid, safe, and effective approach. The new POLARx™ FIT (Boston Scientific), which is expandable from 28 to 31 mm in diameter, is currently available. However, there is limited evidence available regarding the treatment of atrial fibrillation in this setting. In this article, we report a case series of cryoballoon ablation in patients with atrial fibrillation using POLARx™ FIT. Case summary: This case series describes a comparison of obstruction in three patients with pulmonary veins of different shapes and diameters undergoing cryoballoon ablation and pulmonary vein isolation with a 31 mm diameter balloon. Discussion: Cryoballoon ablation using the 31 mm mode of POLARx™ FIT has the potential to provide safe and stable pulmonary vein isolation with good occlusion for a variety of pulmonary vein geometries. In this case series, the 31 mm mode of the POLARx™ FIT resulted in better pulmonary vein occlusion than the 28 mm mode in patients with large left atria and large pulmonary veins, including the left common pulmonary vein. This approach may be considered a first-line therapy option of cryoballoon ablation in patients with atrial fibrillation.
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad593
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Conference proceedings ; Online: Do Japanese Citizens Move to Rural Areas Seeking a Slower Life? Differences between Rural and Urban Areas in Subjective Well-Being

Sasaki, Hiroki

2016

Abstract: For some time, individuals in multiple contexts have been moving from rural to urban areas for economic reasons. In recent years, however, young people in Japan have been increasingly turning to rural areas to embrace a slower, less-hectic lifestyle. ... ...

Abstract	For some time, individuals in multiple contexts have been moving from rural to urban areas for economic reasons. In recent years, however, young people in Japan have been increasingly turning to rural areas to embrace a slower, less-hectic lifestyle. Despite this interesting development, researchers have thus far failed to identify determinants of residents’ well-being in rural and urban areas in Japan. Moreover, recent empirical work has shown that stated happiness or subjective well-being (SWB) can serve as an empirical proxy for perceived utility. To expand upon this line of research, in this paper, I use SWB to gauge disparities between the Japanese rural and urban environments. In addition, I determine how natural capital and social capital affect SWB for both rural and urban residents. Results show that on average, rural residents report higher SWB than urban residents despite low average income. I also identify multiple factors other than household income that affect SWB; these relationships are particularly pronounced for rural residents. Finally, results demonstrate that residents that migrate from urban to rural areas reported high levels of SWB. Taken together, the results of this study provide new insight into rural values and the attractiveness of rural residency.
Keywords	happiness ; subjective well-being ; Natural Capital ; Social Capital ; Community/Rural/Urban Development ; I31 ; D63 ; Q15
Subject code	910
Language	English
Publishing country	us
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Relation of Nodal expression to the specification of the dorsal-ventral axis and tissue patterning in the starfish Patiria pectinifera.

Sasaki, Hiroki / Kominami, Tetsuya

Development, growth & differentiation

2017 Volume 59, Issue 9, Page(s) 724–740

Abstract: In this study, we attempted to reveal fundamental aspects of starfish embryogenesis, particularly embryonic axis specification or determination, in Patiria pectinifera. We first cloned PpNodal, which is known to play an important role in the ... ...

Abstract	In this study, we attempted to reveal fundamental aspects of starfish embryogenesis, particularly embryonic axis specification or determination, in Patiria pectinifera. We first cloned PpNodal, which is known to play an important role in the specification of the embryonic axis in a wide range of animals, and studied its expression profile. PpNodal expression was first detected at the mid-blastula stage and showed a single peak around the onset of gastrulation. These features of Nodal expression were shifted to later stages by several hours, compared with those of sea urchin embryos. After the gastrulation started, the expression level became gradually lowered up to the early bipinnaria stage, while the expression level became drastically lowered in sea urchin embryos during gastrulation. The localized Nodal expression in the presumptive oral region was not observed in starfish embryos, unlike in sea urchin embryos. Furthermore, SB431542, an inhibitor of Nodal receptor, did not affect the formation of the DV axis, although it caused the loss of left-right asymmetry. In contrast to this, SB525334, a specific inhibitor of TGF-beta receptor, caused the complete loss of the DV axis. Thus, the usage of signaling molecules during early embryogenesis likely varies among echinoderm classes.
MeSH term(s)	Animals ; Benzamides/pharmacology ; Body Patterning/genetics ; Body Patterning/physiology ; Dioxoles/pharmacology ; Gene Expression Regulation, Developmental/genetics ; Gene Expression Regulation, Developmental/physiology ; Nodal Protein/genetics ; Nodal Protein/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Signal Transduction/physiology ; Starfish/embryology ; Starfish/metabolism
Chemical Substances	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide ; Benzamides ; Dioxoles ; Nodal Protein
Language	English
Publishing date	2017-11-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	280433-5
ISSN	1440-169X ; 0012-1592
ISSN (online)	1440-169X
ISSN	0012-1592
DOI	10.1111/dgd.12409
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 194: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Body weight loss is a simple and useful indicator of prognosis and predictive tolerability in the first year of nintedanib therapy in patients with interstitial lung disease.

Yamakawa, Hideaki / Sato, Shintaro / Ohta, Hiroki / Kusano, Kenji / Kawabe, Rie / Oba, Tomohiro / Uzuka, Chisa / Sasaki, Hiroki / Akasaka, Keiichi / Amano, Masako / Takemura, Tamiko / Araya, Jun / Matsushima, Hidekazu

Respiratory investigation

2024 Volume 62, Issue 4, Page(s) 551–557

Abstract: Background: Nintedanib is generally safe and well tolerated and can improve prognosis in patients with various interstitial lung diseases (ILDs). Appropriate management of adverse events of nintedanib is important to ensure its long-term persistent use. ...

Abstract	Background: Nintedanib is generally safe and well tolerated and can improve prognosis in patients with various interstitial lung diseases (ILDs). Appropriate management of adverse events of nintedanib is important to ensure its long-term persistent use. Weight loss is a routinely assessed adverse event in clinical practice. This study aimed to elucidate whether body weight change in the first year of nintedanib therapy can indicate prognosis and predict tolerability in patients with ILD. Methods: We analysed 245 consecutive ILD patients treated with nintedanib. We calculated the slope of body weight change using baseline weight and that recorded closest after the first year and then categorized percent change in body weight at this time. Significant weight loss was defined as that ≥5%. Results: Subjects included 67 patients with idiopathic pulmonary fibrosis (IPF) and 76 with non-IPF progressive fibrosing-ILD including fibrotic hypersensitivity pneumonitis (n = 16), unclassifiable (n = 35), connective tissue disease-ILD (n = 21), and nonspecific interstitial pneumonia (n = 4). Older age, low body weight at initial examination, significant weight loss, and lower %FVC were significant predictors of discontinuation of nintedanib. Patients with weight loss ≥5% over the first year showed worse survival than those with weight loss <5% regardless of whether IPF existed or BMI indicated obesity. Conclusions: Careful monitoring of body weight change might suggest useful information for predicting long-term use of nintedanib and mortality risk in ILD patients treated with nintedanib. Appropriate body weight management is needed to prevent adverse events of nintedanib itself.
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2024.04.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Aurora kinase blockade drives de novo addiction of cervical squamous cell carcinoma to druggable EGFR signalling.

Komatsu, Masayuki / Nakamura, Kanako / Takeda, Takashi / Chiwaki, Fumiko / Banno, Kouji / Aoki, Daisuke / Takeshita, Fumitaka / Sasaki, Hiroki

Oncogene

2022 Volume 41, Issue 16, Page(s) 2326–2339

Abstract: Oncogenic signalling confers tumour-progression advantages; thus, its pharmacological blockade is the best strategy for cancer chemotherapy. However, drug resistance and heterogeneous dependency of tumour hamper their therapeutic potential, suggesting ... ...

Abstract	Oncogenic signalling confers tumour-progression advantages; thus, its pharmacological blockade is the best strategy for cancer chemotherapy. However, drug resistance and heterogeneous dependency of tumour hamper their therapeutic potential, suggesting the necessity for a new ubiquitous modality based on evading drug resistance. Here, we proposed a de novo addiction to oncogenic signalling (Dead-On) concept, wherein specific blockade of target molecules forces cancer cells to develop dependency on an oncogenic signalling. In cervical squamous cell carcinoma cells, Aurora A/B dual blockade elicited rapid addiction to EGFR-Erk signalling, and its pharmacological/genetic inhibition synergistically enhanced anti-cancer activities in vitro, in vivo, and in a patient-derived organoid model. The signal activation was independent of EGFR genetic status, it was triggered by receptor accumulation on the plasma membrane via Rab11-mediated endocytic recycling machinery. These findings support our novel Dead-On concept which may lead to drug discovery as well as expand the adaptation of approved targeted drugs.
MeSH term(s)	Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/genetics ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/metabolism ; Female ; Humans ; Oncogenes ; Signal Transduction ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/genetics
Chemical Substances	EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-022-02256-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2218: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Conference proceedings: Yūgen-gun-no-kohomorojī-ron-to-sono-shūhen

Sasaki, Hiroki

kenkyū-shūkai-hōkokushū

(Sūri-Kaiseki-Kenkyūsho-kōkyūroku ; 1466)

2006

Title variant	Cohomology theory of finite groups and related topics
Event/congress	Kongress (2005.08.29-09.02, Kyōto)
Author's details	Hiroki Sasaki
Series title	Sūri-Kaiseki-Kenkyūsho-kōkyūroku ; 1466
Language	Japanese ; English
Size	2, 118 S, graph. Darst
Publisher	Kyoto University, Research Institute for Mathematical Sciences
Publishing place	Kyōto
Document type	Book ; Conference proceedings
Note	Text japan., teilw. engl ; Literaturangaben
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Clinical significance of para-carinal air cysts in patients with pleuroparenchymal fibroelastosis: The relationship with pneumomediastinum and pneumothorax.

Yamakawa, Hideaki / Sato, Shintaro / Ohta, Hiroki / Takatsuka, Makiko / Kusano, Kenji / Kawabe, Rie / Oba, Tomohiro / Akasaka, Keiichi / Amano, Masako / Araya, Jun / Sasaki, Hiroki / Matsushima, Hidekazu

The clinical respiratory journal

2023 Volume 17, Issue 8, Page(s) 805–810

Abstract: Background: Para-tracheal or para-carinal air cysts (PACs) are often asymptomatic and usually detected incidentally by methods such as computed tomography. Their clinical significance is unclear in patients with pleuroparenchymal fibroelastosis (PPFE).!# ...

Abstract	Background: Para-tracheal or para-carinal air cysts (PACs) are often asymptomatic and usually detected incidentally by methods such as computed tomography. Their clinical significance is unclear in patients with pleuroparenchymal fibroelastosis (PPFE). Methods: We evaluated the clinical significance of PACs in PPFE and their relationship with pneumomediastinum or pneumothorax. Results: In total, 50 patients had PPFE and 34 (68%) had PACs. Most PACs were para-carinal (n = 30). A para-tracheal air cyst was detected in only nine patients, which included five patients having both para-carinal and para-tracheal air cysts. Overall median survival was 24.7 months. Survival was not significantly different between the patients with [PACs(+)] and without PACs (P = 0.268). A high frequency (64%) of the complication of pneumomediastinum or pneumothorax occurred in the overall population during follow-up. Pneumomediastinum/pneumothorax occurred significantly more frequently in patients with PACs(+) than in those without (76.5% vs. 37.5%; P = 0.012). PACs(+) was the only significant risk factor for pneumomediastinum/pneumothorax. Conclusions: Our data showed that PACs commonly occur in patients with PPFE, and most PACs were para-carinal air cysts. Additionally, PACs(+) was a significant risk factor for pneumomediastinum/pneumothorax; therefore, clinicians should be more aware of these complications during follow-up examination, particular in PACs(+) patients with PPFE.
MeSH term(s)	Humans ; Pneumothorax/diagnostic imaging ; Pneumothorax/epidemiology ; Pneumothorax/etiology ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/complications ; Clinical Relevance ; Tomography, X-Ray Computed ; Cysts/complications ; Cysts/diagnostic imaging
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13671
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: DNA methylation is a key factor in understanding differentiation phenotype in esophageal squamous cell carcinoma.

Komatsu, Masayuki / Sasaki, Hiroki

Epigenomics

2014 Volume 6, Issue 6, Page(s) 567–569

MeSH term(s)	Basic Helix-Loop-Helix Transcription Factors/genetics ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; DNA Methylation ; Epigenesis, Genetic ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics ; Humans ; Prognosis
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Homeodomain Proteins ; SIM2 protein, human ; SIX1 protein, human
Language	English
Publishing date	2014-12-19
Publishing country	England
Document type	Editorial
ISSN	1750-192X
ISSN (online)	1750-192X
DOI	10.2217/epi.14.56
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Molecular Networks of Platinum Drugs and Their Interaction with microRNAs in Cancer.

Tanabe, Shihori / Boonstra, Eger / Hong, Taehun / Quader, Sabina / Ono, Ryuichi / Cabral, Horacio / Aoyagi, Kazuhiko / Yokozaki, Hiroshi / Perkins, Edward J / Sasaki, Hiroki

Genes

2023 Volume 14, Issue 11

Abstract: The precise mechanism of resistance to anti-cancer drugs such as platinum drugs is not fully revealed. To reveal the mechanism of drug resistance, the molecular networks of anti-cancer drugs such as cisplatin, carboplatin, oxaliplatin, and arsenic ... ...

Abstract	The precise mechanism of resistance to anti-cancer drugs such as platinum drugs is not fully revealed. To reveal the mechanism of drug resistance, the molecular networks of anti-cancer drugs such as cisplatin, carboplatin, oxaliplatin, and arsenic trioxide were analyzed in several types of cancers. Since diffuse-type stomach adenocarcinoma, which has epithelial-mesenchymal transition (EMT)-like characteristics, is more malignant than intestinal-type stomach adenocarcinoma, the gene expression and molecular networks in diffuse- and intestinal-type stomach adenocarcinomas were analyzed. Analysis of carboplatin revealed the causal network in diffuse large B-cell lymphoma. The upstream regulators of the molecular networks of cisplatin-treated lung adenocarcinoma included the anti-cancer drug trichostatin A (TSA), a histone deacetylase inhibitor. The upstream regulator analysis of cisplatin revealed an increase in FAS, BTG2, SESN1, and CDKN1A, and the involvement of the tumor microenvironment pathway. The molecular networks were predicted to interact with several microRNAs, which may contribute to the identification of new drug targets for drug-resistant cancer. Analysis of oxaliplatin, a platinum drug, revealed that the SPINK1 pancreatic cancer pathway is inactivated in ischemic cardiomyopathy. The study showed the importance of the molecular networks of anti-cancer drugs and tumor microenvironment in the treatment of cancer resistant to anti-cancer drugs.
MeSH term(s)	Humans ; Cisplatin ; Carboplatin/pharmacology ; Platinum/pharmacology ; Platinum/therapeutic use ; Oxaliplatin/therapeutic use ; MicroRNAs/genetics ; MicroRNAs/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Adenocarcinoma ; Tumor Microenvironment ; Trypsin Inhibitor, Kazal Pancreatic ; Immediate-Early Proteins ; Tumor Suppressor Proteins
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Carboplatin (BG3F62OND5) ; Platinum (49DFR088MY) ; Oxaliplatin (04ZR38536J) ; MicroRNAs ; Antineoplastic Agents ; SPINK1 protein, human ; Trypsin Inhibitor, Kazal Pancreatic (50936-63-5) ; BTG2 protein, human (141490-22-4) ; Immediate-Early Proteins ; Tumor Suppressor Proteins
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14112073
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Conference proceedings ; Online: Relationships between Agricultural policies and Environmental Effects in Japan

Sasaki, Hiroki

An Environmental-Economic Integrated Model Approach

2010

Abstract: This study investigates the optimal agricultural land use allocation and nitrogen application to a representative Japanese farm. The site-specific nature of numerous agri-environmental issues necessitates analysis at a disaggregated level in order to ... ...

Abstract	This study investigates the optimal agricultural land use allocation and nitrogen application to a representative Japanese farm. The site-specific nature of numerous agri-environmental issues necessitates analysis at a disaggregated level in order to capture the underlying heterogeneity of agricultural productivity and environmental sensitivity across different parcels of land. This study adopts an integrated approach—a decision-making economic model for representative farms is combined with a stylized site-specific biophysical model, which quantifies the impact of different policy instruments on agricultural production practices and on multiple environmental effects. This model estimates the government budget outlays and social welfare, which require monetary valuation of environmental effects as well as of crop production. In addition to several agri-environmental policy scenarios, this study investigates the impact of the rice production adjustment policy, wherein a rice production quota is allocated to each region on the basis of the sales records for the previous two years. According to the simulation results, there is greater increase in social welfare when farmers are paid in order to reduce chemical fertilizer applications rather than by levying a nitrogen tax. Regarding carbon sequestration, the modelling exercise indicates that an agrienvironmental payment depending on the level of application of organic fertilizer (manure) is preferable; however, the social welfare derived by payments on the basis of the application of a minimum organic matter, which may avoid increasing the fiscal budget burden (on account of the increased application of organic matter on paddy fields), is higher than that derived by unit payments depending on the level of application of organic matter. The relaxation of the rice production quota results in an increase in social welfare. This integrated model approach is subject to limitations with respect to the data, model parameters, as well as economic and biophysical relationships. However, this approach is a valuable tool for enabling policy makers to design and implement effective and efficient policies.
Keywords	integrate model ; agri-environmental policy ; paddy field ; production quota ; Agricultural and Food Policy ; Crop Production/Industries ; Environmental Economics and Policy ; Farm Management ; Land Economics/Use ; Production Economics ; Productivity Analysis
Subject code	338
Language	English
Publishing country	us
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED