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Article: Blastic Plasmacytoid Dendritic Cell Neoplasm in Long-Term Complete Remission After Venetoclax Monotherapy.

Sasaki, Yohei / Murai, So / Shiozawa, Eisuke / Yamochi, Toshiko / Hattori, Norimichi

2024 Volume 16, Issue 1, Page(s) e52446

Abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematological malignancy associated with a poor prognosis and limited treatment options. Although allogeneic hematopoietic stem cell transplantation or intensive chemotherapy ... ...

Abstract	Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematological malignancy associated with a poor prognosis and limited treatment options. Although allogeneic hematopoietic stem cell transplantation or intensive chemotherapy prolongs overall survival in patients with BPDCN, intensive chemotherapy is inappropriate for older or unfit patients. Venetoclax (VEN), an oral BCL2 inhibitor, is approved for use in patients with acute myeloid leukemia (AML). BPDCN cells require BCL2 protein and are uniformly sensitive to VEN in vivo. Moreover, patients with AML who have achieved complete remission after induction therapy are reportedly considered to receive VEN monotherapy as maintenance therapy, especially older patients. However, the efficacy of VEN monotherapy as a maintenance therapy for patients with BPDCN remains controversial. Recently, BPDCN has been classified into MYC+ and MYC- subtypes, which show clinical differences. Hence, BPDCN treatment strategies based on the MYC classification may be necessary. Here, we report a case of MYC- BPDCN in an older patient in long-term complete remission after VEN monotherapy following VEN and azacitidine induction chemotherapy.
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52446
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ephedrine Alkaloid-Independent High-Affinity Immunoglobulin-E Receptor (FcεRI) Internalization Results in CCL2 Production without Inducing Mast Cell Degranulation.

Nagata, Yuka / Sasaki, Yohei / Suzuki, Ryo

Biological & pharmaceutical bulletin

2023 Volume 46, Issue 6, Page(s) 811–816

Abstract: Mast cells (MCs) play an important role in allergies, leading to the development of MC-targeted therapies. Ephedra herb (Mao) has potent anti-allergic activity, but contains ephedrine alkaloids (EAs); therefore, its hazardous effects are taken into ... ...

Abstract	Mast cells (MCs) play an important role in allergies, leading to the development of MC-targeted therapies. Ephedra herb (Mao) has potent anti-allergic activity, but contains ephedrine alkaloids (EAs); therefore, its hazardous effects are taken into consideration during its clinical use. We previously reported that Mao attenuates robust MC degranulation by an allergen through high-affinity immunoglobulin E (IgE) receptor (FcεRI) internalization, in which an EA-independent mechanism was suggested to be at play. This study aimed to deepen our understanding of the potential of Mao against FcεRI internalization using two strains with different EA contents. Mao extracts were administered to bone marrow-derived MCs (BMMCs), and their cellular responses, including FcεRI internalization, were analyzed. In addition, physiological events were evaluated using a passive cutaneous anaphylactic (PCA) reaction mouse model. BMMCs mediate the production of diverse inflammatory mediators. Among these, the potent chemokine CCL2 is thought to be differentially regulated from other pro-inflammatory mediators. We found that Mao significantly induces CCL2 expression in BMMCs despite suppressing robust degranulation through FcεRI internalization. Importantly, this was a distinctly EAs-independent response. In the PCA reaction, local MC activation following allergen challenge was suppressed by Mao treatment, which strengthened the view that Mao sufficiently decreased the rapid activation of MCs and promoted CCL2 secretion. Collectively, these observations provide additional insights into the mechanism of Mao-induced silent FcεRI internalization in MCs and the complex and heterogeneous secretory responses operating in MCs.
MeSH term(s)	Mice ; Animals ; Receptors, IgE/metabolism ; Ephedrine/metabolism ; Cell Degranulation ; Mast Cells/metabolism ; Antineoplastic Agents/pharmacology ; Alkaloids/pharmacology ; Allergens/metabolism ; Inflammation Mediators/metabolism ; Immunoglobulins ; Monoamine Oxidase/metabolism ; Monoamine Oxidase/pharmacology
Chemical Substances	Receptors, IgE ; Ephedrine (GN83C131XS) ; Antineoplastic Agents ; Alkaloids ; Allergens ; Inflammation Mediators ; Immunoglobulins ; Monoamine Oxidase (EC 1.4.3.4)
Language	English
Publishing date	2023-05-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b23-00006
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Article ; Online: Correction to: Quality evaluation of Angelicae acutilobae radix: individual differences and localization of (Z)-ligustilide in Angelica acutiloba root.

Kudo, Yoshitomi / Ando, Hirokazu / Sasaki, Yohei

Journal of natural medicines

2022 Volume 76, Issue 3, Page(s) 718

Language	English
Publishing date	2022-03-15
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-022-01618-1
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Article ; Online: Development of Highly Sensitive Method for Sugar Determination in Herbal Medicine; Application of Monosaccharides and Oligosaccharides in Japanese Angelica Root and Rehmannia Root.

Han, Xu / Ando, Hirokazu / Kudo, Yoshitomi / Sasaki, Yohei

Chemical & pharmaceutical bulletin

2022 Volume 70, Issue 11, Page(s) 796–804

Abstract: We have developed a simple and accurate method for quantifying sugars in herbal medicines, which have hitherto been difficult to quantify. Using ultra performance liquid chromatography-quadrupole-time-of-flight (UPLC-Q-TOF)-MS and two types of columns ... ...

Abstract	We have developed a simple and accurate method for quantifying sugars in herbal medicines, which have hitherto been difficult to quantify. Using ultra performance liquid chromatography-quadrupole-time-of-flight (UPLC-Q-TOF)-MS and two types of columns with different chemical properties, we determined the optimum conditions for separating nine sugars (fructose, galactose, glucose, mannitol, sucrose, melibiose, raffinose, manninotriose, and stachyose) commonly found in herbal medicines. Separation was completed within 10 min when an apHera NH
MeSH term(s)	Angelica/chemistry ; Carbohydrates/analysis ; Chromatography, High Pressure Liquid/methods ; Herbal Medicine ; Monosaccharides/analysis ; Oligosaccharides/analysis ; Plants, Medicinal/chemistry ; Rehmannia/chemistry ; Sugars/analysis ; Plant Roots/chemistry
Chemical Substances	Carbohydrates ; Monosaccharides ; Oligosaccharides ; rehmannia root (1BEM3U6LQQ) ; Sugars
Language	English
Publishing date	2022-11-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	213307-6
ISSN	1347-5223 ; 0009-2363
ISSN (online)	1347-5223
ISSN	0009-2363
DOI	10.1248/cpb.c22-00402
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Zs.A 770: Show issues

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Article ; Online: Ephedra Herb, Mao, Inhibits Antigen-Induced Mast Cell Degranulation by Induction of the Affinity Receptor for IgE Internalization.

Nagata, Yuka / Ando, Hirokazu / Sasaki, Yohei / Suzuki, Ryo

Pharmaceutical research

2021 Volume 38, Issue 4, Page(s) 569–581

Abstract: Purpose: Ephedra herb (Mao) exerts potent anti-allergic effects. This study aimed to examine the underlying mechanisms of Mao on allergic inflammation using in vitro cultured mast cells (MCs) and an in vivo model of MC-dependent anaphylaxis.: Methods!# ...

Abstract	Purpose: Ephedra herb (Mao) exerts potent anti-allergic effects. This study aimed to examine the underlying mechanisms of Mao on allergic inflammation using in vitro cultured mast cells (MCs) and an in vivo model of MC-dependent anaphylaxis. Methods: Bone marrow-derived MCs (BMMCs) were presensitized with anti-2,4-dinitrophenol (DNP) immunoglobulin E (IgE) and challenged with antigens (Ag; DNP-human serum albumin). Degranulation responses and cell surface high-affinity receptor for IgE (FcεRI) expression were assessed with/without Mao treatment. Passive systemic anaphylaxis (PSA)-treated mice were administered Mao and the pathophysiological responses were evaluated. Results: Mao inhibited Ag-induced BMMC degranulation, but not polyclonal activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, indicating that Mao inhibits IgE-dependent activation of BMMCs. Mao-treated BMMCs exhibited significant reductions in expression of surface IgE and its receptor FcεRI. Analysis of subcellular localization revealed that Mao induces FcεRI internalization in BMMCs without degranulation. In the PSA mouse model, Mao administration prevented antigen-induced hypothermia. Mao administration significantly reduced cell surface expression of IgE-bound FcεRI on peritoneal MCs. Conclusions: Mao induced FcεRI internalization in MCs, thereby inhibiting Ag-induced IgE-dependent degranulation. The inhibitory effects of Mao on MC degranulation may offer a novel therapeutic approach for allergic diseases.
MeSH term(s)	Anaphylaxis/drug therapy ; Anaphylaxis/immunology ; Animals ; Anti-Allergic Agents/pharmacology ; Anti-Allergic Agents/therapeutic use ; Cell Degranulation/drug effects ; Cell Degranulation/immunology ; Cells, Cultured ; Disease Models, Animal ; Ephedra/chemistry ; Female ; Humans ; Immunoglobulin E/metabolism ; Ionomycin/immunology ; Mast Cells/drug effects ; Mast Cells/immunology ; Medicine, Kampo/methods ; Mice ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Stems/chemistry ; Primary Cell Culture ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Tetradecanoylphorbol Acetate/immunology
Chemical Substances	Anti-Allergic Agents ; Plant Extracts ; Immunoglobulin E (37341-29-0) ; Ionomycin (56092-81-0) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
Language	English
Publishing date	2021-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	843063-9
ISSN	1573-904X ; 0724-8741 ; 0739-0742
ISSN (online)	1573-904X
ISSN	0724-8741 ; 0739-0742
DOI	10.1007/s11095-021-03020-0
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Zs.A 1937: Show issues

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Article ; Online: Correction: Evaluation of rooting characteristics of Ephedra cuttings by anatomy and promising strain selection based on rooting characteristics and alkaloid content.

Kudo, Yoshitomi / Ando, Hirokazu / Kaneda, Ai / Ito, Honoka / Umemoto, Kazuki / Ni, Si-Ran / Mikage, Masayuki / Sasaki, Yohei

Journal of natural medicines

2024

Language	English
Publishing date	2024-04-03
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-024-01807-0
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Article ; Online: Studies on cultivation of Angelica acutiloba using paper pot (Part 2): effect of difference in taproot base diameter of seedlings on growth after planting and quality of toki produced from paper pot seedlings.

Kudo, Yoshitomi / Ando, Hirokazu / Sasaki, Yohei

Journal of natural medicines

2021 Volume 75, Issue 3, Page(s) 565–576

Abstract: By using Angelica acutiloba seedlings produced by short-period raising in paper pot (PP), we investigated the effect of taproot base diameter on the growth after planting and evaluated the quality of toki (, Angelicae Acutilobae Radix) produced from PP- ... ...

Abstract	By using Angelica acutiloba seedlings produced by short-period raising in paper pot (PP), we investigated the effect of taproot base diameter on the growth after planting and evaluated the quality of toki (, Angelicae Acutilobae Radix) produced from PP-grown seedlings (PT). In this study, PP-grown seedlings of seven classes which are sorted difference taproot base diameter (P1-P7) were transplanted. As a result, the survival rates were not less than 90% for P6 (taproot base diameter: 10.0-12.7 cm) and P7 (taproot base diameter: 12.8-17.3 cm), and the bolting rates were 20.5% and 24.1% for P6 and P7, respectively. The traditionally grown seedling (TS) showed the highest available harvest rate of 82.3%, followed by P6 (71.8%) and P7 (69.0%). P7 showed the highest fresh weight and dry weight per 1a (100 m
MeSH term(s)	Angelica/growth & development ; Drugs, Chinese Herbal/analysis ; Plant Roots ; Seedlings/growth & development
Chemical Substances	Drugs, Chinese Herbal ; angelicae sinensis extract
Language	English
Publishing date	2021-03-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-021-01497-y
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Zs.A 2692: Show issues

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Article: The association between emotion malleability beliefs and severe psychological distress stratified by sex, age, and presence of any psychiatric disorders.

Sasaki, Yohei / Okubo, Ryo / Takeda, Kazuyoshi / Ikezawa, Satoru / Tabuchi, Takahiro / Shirotsuki, Kentaro

Frontiers in psychology

2023 Volume 14, Page(s) 1251945

Abstract: Background: Recent studies have shown an association between psychological distress and emotion malleability beliefs, meaning mindsets about whether one's emotions are fixed or changeable. However, most studies have not examined the association between ... ...

Abstract	Background: Recent studies have shown an association between psychological distress and emotion malleability beliefs, meaning mindsets about whether one's emotions are fixed or changeable. However, most studies have not examined the association between these beliefs and sociodemographic factors. Methods: A nationwide cross-sectional Internet survey of residents of Japan aged 15-79 years was conducted using sampling weights for national estimates to investigate the association between emotion malleability beliefs and sociodemographic factors and between fixed beliefs and severe psychological distress (SPD). SPD was defined as a Kessler 6 Scale score of ≥13. Adjusted odds ratios for SPD were calculated considering potential confounders. Further analyses were stratified by sex, age and presence of any psychiatric disorder. Results: The analysis included 23,142 participants (female, 48.64%). Fixed beliefs were associated with female sex, age < 45 years, and presence of psychiatric disorders. These beliefs were associated with SPD, and additional analysis showed stronger associations with SPD among female respondents, respondents aged 45-59 years, and those aged ≥60 years. Conclusion: Results indicate that female sex, age < 45 years, and current mental disorders were associated with fixed emotion malleability beliefs. Associations between fixed emotion malleability beliefs and SPD were particularly strong among female respondents and people aged ≥45 years compared with the general population. Our study extends the association between emotion malleability beliefs and psychological health to the general population. Future studies should explore mechanisms underlying individual differences in emotion beliefs.
Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1251945
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Article: Studies on cultivation of Angelica acutiloba using paper pot (Part 2): effect of difference in taproot base diameter of seedlings on growth after planting and quality of toki produced from paper pot seedlings

Kudo, Yoshitomi / Ando, Hirokazu / Sasaki, Yohei

Natural medicines. 2021 June, v. 75, no. 3

2021

Abstract: By using Angelica acutiloba seedlings produced by short-period raising in paper pot (PP), we investigated the effect of taproot base diameter on the growth after planting and evaluated the quality of toki (当帰, Angelicae Acutilobae Radix) produced from PP- ...

Abstract	By using Angelica acutiloba seedlings produced by short-period raising in paper pot (PP), we investigated the effect of taproot base diameter on the growth after planting and evaluated the quality of toki (当帰, Angelicae Acutilobae Radix) produced from PP-grown seedlings (PT). In this study, PP-grown seedlings of seven classes which are sorted difference taproot base diameter (P1–P7) were transplanted. As a result, the survival rates were not less than 90% for P6 (taproot base diameter: 10.0–12.7 cm) and P7 (taproot base diameter: 12.8–17.3 cm), and the bolting rates were 20.5% and 24.1% for P6 and P7, respectively. The traditionally grown seedling (TS) showed the highest available harvest rate of 82.3%, followed by P6 (71.8%) and P7 (69.0%). P7 showed the highest fresh weight and dry weight per 1a (100 m²), followed by P6 and TS. However, PP-grown seedlings are prone to bolting, and it is expected the yield can be increased by preventing bolting. In addition, PT satisfied the regulations of JP17 in terms of, for example, dilute ethanol-soluble extract content, total ash content, and acid-insoluble ash content. It was also found that PT has a higher proportion of lateral roots with respect to the total weight than toki produced from traditionally grown seedlings (TT). The total (Z)-ligustilide contents were 0.07% in PT and 0.12% in TT. It was revealed that it is possible to produce toki that satisfies JP17 regulations; moreover, the period required for toki production was shortened by 6 months with PP-grown seedlings.
Keywords	Angelica acutiloba ; acid insoluble ash ; paper ; seedlings ; tap roots
Language	English
Dates of publication	2021-06
Size	p. 565-576.
Publishing place	Springer Singapore
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1201350-x
ISSN	1340-3443
ISSN	1340-3443
DOI	10.1007/s11418-021-01497-y
Database	NAL-Catalogue (AGRICOLA)

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Article: Quality evaluation of Angelicae acutilobae radix: individual differences and localization of (Z)-ligustilide in Angelica acutiloba root

Kudo, Yoshitomi / Ando, Hirokazu / Sasaki, Yohei

Natural medicines. 2021 Jan., v. 75, no. 1

2021

Abstract: It has been difficult to evaluate the quality of Angelicae acutilobae Radix (Toki) because of large differences in the contents of its chemical constituents. In this research, we revealed individual differences and localization of (Z)-ligustilide in Toki ...

Abstract	It has been difficult to evaluate the quality of Angelicae acutilobae Radix (Toki) because of large differences in the contents of its chemical constituents. In this research, we revealed individual differences and localization of (Z)-ligustilide in Toki cultivated and processed under the same conditions. Thirteen Toki samples (dry weight: 68.2 g–132.3 g) were divided and categorized into 13 parts and the (Z)-ligustilide content of each part was quantified. Total (Z)-ligustilide content ranged from 0.08% to 0.22% and the maximum difference between samples was approximately 2.8-fold. In addition, the localization of (Z)-ligustilide was examined. (Z)-Ligustilide content was the highest in lateral root at 0.19%, followed by main root at 0.13%, and the lowest in root head at 0.09%. Furthermore, the content tended to increase as the root became thinner. In particular, the difference in content between the inner side of upper root head (removed 5 mm from the epidermis 0.06%) and the 1.1–3.0 mm in diameter lateral root (0.24%) was largest at approximately 4.1-fold. We revealed that not only differences among individuals but also localization is a factor affecting the quality of Toki. In contrast, individuals with higher root part (main root + lateral root) weight ratio in whole root dry weight had higher (Z)-ligustilide content. The difference in (Z)-ligustilide content among individuals is due to the balance between root head part and root other than head part. It is possible to predict (Z)-ligustilide content from weight ratio of root part to whole root.
Keywords	Angelica acutiloba ; head ; lateral roots
Language	English
Dates of publication	2021-01
Size	p. 1-10.
Publishing place	Springer Singapore
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1201350-x
ISSN	1340-3443
ISSN	1340-3443
DOI	10.1007/s11418-020-01438-1
Database	NAL-Catalogue (AGRICOLA)

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