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Article: Synthesis and Liquid Crystalline Properties of Low Molecular Weight Bis- Chalcone Compounds.

Sasidharan, Anju K / Mathew, Jomon / Achalkumar, Ammathnadu S / Mathews, Manoj

Current organic synthesis

2022 Volume 19, Issue 3, Page(s) 463–475

Abstract: Aims: In this paper, we report on the synthesis and liquid crystalline properties of some low molecular weight bis-chalcone compounds derived from acetone, cyclopentanone and cyclohexanone mesogenic cores.: Background: Structurally bis-chalcones ... ...

Abstract	Aims: In this paper, we report on the synthesis and liquid crystalline properties of some low molecular weight bis-chalcone compounds derived from acetone, cyclopentanone and cyclohexanone mesogenic cores. Background: Structurally bis-chalcones belong to a broader family of chalcone compounds. Chalcone is a compound that consists of two aromatic rings linked by an unsaturated α, β-ketone. Objective: Liquid crystalline chalcones are prepared by aliphatic chain substituents on two aromatic rings. Chalcones are well studied for their mesomorphic properties. Compared to a large number of chalcone based LCs reported, only a few articles have been published on the mesomorphic properties of bis-chalcone compounds. The target compounds of the present study varied not only in their central core but also in number and position of terminal aliphatic chain substitution-a key structural unit in deciding the liquid crystalline properties of a compound. Methods: All target compounds were synthesized in good yield by base catalyzed Claisen-Schmidt condensation reaction. Molecular structures were confirmed by FT-IR, Results: Although none of the acetone based compounds exhibited mesomorphism, cyclopentanone and cyclohexanone based compounds with octyloxy chain at para position on either side of the dibenzylidine ring stabilized liquid crystalline smectic (SmA and SmC) and nematic (N) phases. The observed structure-liquid crystalline property relationship was explained by structural analysis of molecules using DFT calculations. Considering the inherent photoluminescence nature of the chalcone moiety, a preliminary study was carried out on a selected compound to reveal its fluorescence property. Conclusion: Our study brings about an important structure-liquid crystalline property relationship in a relatively unexplored class of bis-chalcone liquid crystals.
MeSH term(s)	Acetone ; Chalcone/chemistry ; Chalcones ; Cyclohexanones ; Molecular Weight ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Chalcones ; Cyclohexanones ; Acetone (1364PS73AF) ; Chalcone (5S5A2Q39HX)
Language	English
Publishing date	2022-10-05
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1570-1794
ISSN	1570-1794
DOI	10.2174/1570179418666211006144308
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Article ; Online: SATB2 Immunopositivity in Spindle Cell (Sarcomatoid) Squamous Cell Carcinoma: A Potential Pitfall in Diagnosis.

Sasidharan, Anju / Kakkar, Aanchal / Thakar, Alok / Deo, Suryanarayan V S

Applied immunohistochemistry & molecular morphology : AIMM

2022 Volume 30, Issue 3, Page(s) 184–189

Abstract: Spindle cell squamous cell carcinomas (SpSCC) are aggressive neoplasms constituting 1% of oral cavity tumors. A proportion of SpSCC do not stain with epithelial markers, and frequently express mesenchymal markers, viz. Vimentin, smooth muscle actin, ... ...

Abstract	Spindle cell squamous cell carcinomas (SpSCC) are aggressive neoplasms constituting 1% of oral cavity tumors. A proportion of SpSCC do not stain with epithelial markers, and frequently express mesenchymal markers, viz. Vimentin, smooth muscle actin, muscle specific actin, S100 and desmin, confounding the diagnosis. Immunoexpression of SATB2, a transcription factor indicating osteoblastic lineage, has not been evaluated in SpSCC previously. We therefore performed SATB2 immunohistochemistry in 15 cases of SpSCCs and scored them with respect to intensity and percentage of tumor cells stained. SATB2 immunopositivity was identified in 9/15 (60%) SpSCCs, with varying intensity and distribution. Eight cases (53.3%) showed nonfocal staining of moderate to strong intensity, and 1 case (6.7%) showed focal weak staining. Of these, 3 cases (3/9; 33.33%) did not stain with epithelial/squamous markers. Thus, a subset of SpSCC demonstrate SATB2 immunopositivity. In oral tumors with bone involvement, SATB2 positivity may lead away from the diagnosis of SpSCC. Knowledge of this aberrant immunostaining is, therefore, extremely relevant to guard against misdiagnosis as osteosarcoma, particularly on biopsies which lack adjacent dysplastic epithelium, in cases which are monophasic spindle cell, and in those that do not show immunopositivity for epithelial/ squamous markers. Our results emphasize that an appropriate panel and not a single immunomarker is required to distinguish SpSCC from mesenchymal tumors including osteosarcoma.
MeSH term(s)	Actins ; Biomarkers, Tumor ; Bone Neoplasms/diagnosis ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Humans ; Matrix Attachment Region Binding Proteins ; Mouth Neoplasms ; Osteosarcoma ; Sarcoma/pathology ; Soft Tissue Neoplasms ; Transcription Factors
Chemical Substances	Actins ; Biomarkers, Tumor ; Matrix Attachment Region Binding Proteins ; SATB2 protein, human ; Transcription Factors
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0000000000000986
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Article ; Online: Efficacy and Safety of Olanzapine for the Prevention of Chemotherapy-induced Nausea and Vomiting in Children: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Meena, Jagdish Prasad / Gupta, Aditya Kumar / Jat, Kana Ram / Anandani, Garima / Sasidharan, Anju / Tanwar, Pranay

Journal of pediatric hematology/oncology

2023 Volume 45, Issue 7, Page(s) 361–369

Abstract: Chemotherapy-induced nausea and vomiting (CINV) remain the most distressing event in patients receiving highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC). This meta-analysis was conducted to evaluate the efficacy and ... ...

Abstract	Chemotherapy-induced nausea and vomiting (CINV) remain the most distressing event in patients receiving highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC). This meta-analysis was conducted to evaluate the efficacy and safety of olanzapine containing regimen in preventing CINV in children on HEC and MEC. We searched PubMed, Embase, and Cochrane central register of controlled trials electronic databases to identify randomized clinical trials that compared 2 groups who either got olanzapine (olanzapine group) or placebo/no olanzapine (control group) for the prevention of CINV in children. The primary outcome was to determine the efficacy of olanzapine (complete response). The secondary outcomes were nausea control, the need for rescue medications, and adverse events of olanzapine. Three randomized clinical trials (n=394 patients) were included in this meta-analysis (olanzapine group, n=194, and placebo/control group, n=200). The pooled analysis of this meta-analysis found that olanzapine had a higher complete response in all phases of emesis in the HEC group and only in the acute phase in HEC/MEC groups compared with the control group. Olanzapine had higher nausea control in all phases of HEC but no nausea control in HEC/MEC. Olanzapine also reduced the need for rescue medications. A significant number of patients in the olanzapine group experienced somnolence (grades 1 and 2), but none of the participants discontinued the study due to side effects. In conclusion, this meta-analysis showed that olanzapine significantly prevented CINV in HEC. There was also a lesser need for rescue medications in the olanzapine group. Somnolence was higher in the olanzapine group, but it was clinically insignificant.
MeSH term(s)	Humans ; Child ; Olanzapine/adverse effects ; Antiemetics/therapeutic use ; Sleepiness ; Randomized Controlled Trials as Topic ; Nausea/chemically induced ; Nausea/prevention & control ; Vomiting/chemically induced ; Vomiting/prevention & control ; Antineoplastic Agents/adverse effects ; Neoplasms/drug therapy
Chemical Substances	Olanzapine (N7U69T4SZR) ; Antiemetics ; Antineoplastic Agents
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002737
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Article ; Online: IgG4-Related Disease in Intradural Extramedullary Location- Detailed Case Illustration and Literature Review with Special Emphasis on Role of Surgery in its Management.

Sharma, Rajeev / Kaur, Kavneet / Sasidharan, Anju / Gupta, Ranjan / Laythalling, Rajinder Kumar

Neurology India

2021 Volume 69, Issue 5, Page(s) 1176–1183

Abstract: Background: IgG4-related disease (IgG4RD) is a multisystemic progressive fibroinflammatory and lymphoproliferative autoimmune disorder of unknown etiopathogenesis; and its occurrence in intradural extramedullary (IDEM) location is extremely rare.: Aim ...

Abstract	Background: IgG4-related disease (IgG4RD) is a multisystemic progressive fibroinflammatory and lymphoproliferative autoimmune disorder of unknown etiopathogenesis; and its occurrence in intradural extramedullary (IDEM) location is extremely rare. Aim and objective: The aim of this study was to review all IDEM IgG4RD cases described in English literature and to signify the role of surgery in its management at this rare location along with the surgical technique and intraoperative findings. Methods: An Internet-based search (PubMed) for the published reports describing spinal cases of IgG4RD with IDEM involvement was done using the keyword: spinal IgG4-related disease. An illustration of a case of cranial IgG4-related disease in a young man who developed metachronous cervical involvement in intradural extramedullary (IDEM) location is also presented. Results: Amongst 45 spinal IgG4RD cases reported in English Literature, only 3 cases were IDEM IgG4RD. In the illustrated case, portion of the cervical lesion causing cervical cord encasement was intradural but extraarachnoidal- located between arachnoid and dura, without any pial involvement. All these 4 cases improved following surgery. Conclusion: Timely meticulous resection of mass lesion in situations of medical treatment failure or progressive neurological decline can lead to reversibility of mass effect-associated neurological manifestations of IgG4RD.
MeSH term(s)	Autoimmune Diseases ; Dura Mater ; Humans ; Immunoglobulin G4-Related Disease ; Male
Language	English
Publishing date	2021-11-08
Publishing country	India
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.329549
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Article: Mango ginger (Curcuma amada Roxb.) rhizome essential oils as source of environmental friendly biocides: Comparison of the chemical composition, antibacterial, insecticidal and larvicidal properties of essential oils extracted by different methods

Narayanankutty, Arunaksharan / Sasidharan, Anju / Job, Joice Tom / Rajagopal, Rajakrishnan / Alfarhan, Ahmed / Kim, Young Ock / Kim, Hak-Jae

Environmental research. 2021 Nov., v. 202

2021

Abstract: The essential oil isolated from plants is widely utilized as eco-friendly biocides and antibacterial agents. Curcuma amada, commonly known as mango ginger, is well-known for its applications in the food and aromatics industry for its significant mango- ... ...

Abstract	The essential oil isolated from plants is widely utilized as eco-friendly biocides and antibacterial agents. Curcuma amada, commonly known as mango ginger, is well-known for its applications in the food and aromatics industry for its significant mango-like aroma. The present study compared the different C. amada essential oils prepared by hydrodistillation (CHD), steam distillation (CSD), microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE), for their chemical composition, antibacterial, larvicidal and insecticidal properties. GC/MS analysis indicated the presence of compounds including α-pinene, β-myrcene, p-cymene, (Z)-β-ocimene, Camphor, linalyl acetate, safrole, ar-curcumene, and β-curcumene in the different C. amada essential oils. The antibacterial activity was observed against different strains of microbes, with a higher efficacy in the essential oils prepared by UAE and MAE methods. Apart from these, the MAE, UAE, CSD, and CHD were also shown to have significantly higher larvicidal activity against Aedes, Culex, and Armigeres species; however, no toxic effect was observed in non-targeted species like fishes and Allium cepa model of genotoxicity. Further, these essential oils were also found to have significant contact and fumigant toxicity as well as repellency against pests of stored grains (Sitophilus and Tribolium). Considering these results, the present study assumes that Curcuma amada essential oils may be a source of ecofriendly insecticides and antibacterial agents.
Keywords	Aedes ; Allium cepa ; Armigeres ; Culex ; Curcuma amada ; Sitophilus ; acetates ; antibacterial properties ; biocides ; camphor ; chemical composition ; essential oils ; fumigants ; genotoxicity ; hydrodistillation ; industry ; larvicides ; microwave treatment ; models ; odors ; p-cymene ; research ; rhizomes ; safrole ; steam distillation ; ultrasonic treatment
Language	English
Dates of publication	2021-11
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111718
Database	NAL-Catalogue (AGRICOLA)

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Article: Chemical Composition and Biological Activities of the Leaf Essential Oils of

Albaqami, Jawaher J / Hamdi, Hamida / Narayanankutty, Arunaksharan / Visakh, Naduvilthara U / Sasidharan, Anju / Kuttithodi, Aswathi Moothakoottil / Famurewa, Ademola C / Pathrose, Berin

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: ... ...

Abstract	Curcuma
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11111547
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Article ; Online: Chemical Composition, Antioxidant, Anti-Bacterial, and Anti-Cancer Activities of Essential Oils Extracted from

Narayanankutty, Arunaksharan / Visakh, Naduvilthara U / Sasidharan, Anju / Pathrose, Berin / Olatunji, Opeyemi Joshua / Al-Ansari, Abdullah / Alfarhan, Ahmed / Ramesh, Varsha

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 23

Abstract: Citrus plants are widely utilized for edible purposes and medicinal utility throughout the world. However, because of the higher abundance of the antimicrobial compound D-Limonene, the peel waste cannot be disposed of by biogas production. Therefore, ... ...

Abstract	Citrus plants are widely utilized for edible purposes and medicinal utility throughout the world. However, because of the higher abundance of the antimicrobial compound D-Limonene, the peel waste cannot be disposed of by biogas production. Therefore, after the extraction of D-Limonene from the peel wastes, it can be easily disposed of. The D-Limonene rich essential oil from the
Language	English
Publishing date	2022-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27238329
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Article ; Online: Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of

Albaqami, Jawaher J / Benny, Tancia P / Hamdi, Hamida / Altemimi, Ammar B / Kuttithodi, Aswathi Moothakoottil / Job, Joice Tom / Sasidharan, Anju / Narayanankutty, Arunaksharan

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 20

Abstract: Plants have been employed in therapeutic applications against various infectious and chronic diseases from ancient times. Various traditional medicines and folk systems have utilized numerous plants and plant products, which act as sources of drug ... ...

Abstract	Plants have been employed in therapeutic applications against various infectious and chronic diseases from ancient times. Various traditional medicines and folk systems have utilized numerous plants and plant products, which act as sources of drug candidates for modern medicine. Artemisia is a genus of the Asteraceae family with more than 500 species; however, many of these species are less explored for their biological efficacy, and several others are lacking scientific explanations for their uses. Artemisia nilagirica is a plant that is widely found in the Western Ghats, Kerala, India and is a prominent member of the genus. In the current study, the phytochemical composition and the antioxidant, enzyme-inhibitory, anti-inflammatory, and anticancer activities were examined. The results indicated that the ethanol extract of A. nilagirica indicated in vitro DPPH scavenging (23.12 ± 1.28 µg/mL), ABTS scavenging (27.44 ± 1.88 µg/mL), H2O2 scavenging (12.92 ± 1.05 µg/mL), and FRAP (5.42 ± 0.19 µg/mL). The anti-inflammatory effect was also noticed in the Raw 264.7 macrophages, where pretreatment with the extract reduced the LPS-stimulated production of cytokines (p < 0.05). A. nilagirica was also efficient in inhibiting the activities of α-amylase (38.42 ± 2.71 µg/mL), α-glucosidase (55.31 ± 2.16 µg/mL), aldose reductase (17.42 ± 0.87 µg/mL), and sorbitol dehydrogenase (29.57 ± 1.46 µg/mL). It also induced significant inhibition of proliferation in breast (MCF7 IC50 = 41.79 ± 1.07, MDAMB231 IC50 = 55.37 ± 2.11µg/mL) and colon (49.57 ± 1.46 µg/mL) cancer cells. The results of the phytochemical screening indicated a higher level of polyphenols and flavonoids in the extract and the LCMS analysis revealed the presence of various bioactive constituents including artemisinin.
MeSH term(s)	Aldehyde Reductase ; alpha-Amylases ; alpha-Glucosidases ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Artemisia/chemistry ; Artemisinins ; Cytokines ; Ethanol ; Flavonoids ; Hydrogen Peroxide ; L-Iditol 2-Dehydrogenase ; Lipopolysaccharides ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
Chemical Substances	Aldehyde Reductase (EC 1.1.1.21) ; alpha-Amylases (EC 3.2.1.1) ; alpha-Glucosidases (EC 3.2.1.20) ; Anti-Inflammatory Agents ; Antioxidants ; Artemisinins ; Cytokines ; Ethanol (3K9958V90M) ; Flavonoids ; Hydrogen Peroxide (BBX060AN9V) ; L-Iditol 2-Dehydrogenase (EC 1.1.1.14) ; Lipopolysaccharides ; Phytochemicals ; Plant Extracts
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27207119
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Article ; Online: Mango ginger (Curcuma amada Roxb.) rhizome essential oils as source of environmental friendly biocides: Comparison of the chemical composition, antibacterial, insecticidal and larvicidal properties of essential oils extracted by different methods.

Narayanankutty, Arunaksharan / Sasidharan, Anju / Job, Joice Tom / Rajagopal, Rajakrishnan / Alfarhan, Ahmed / Kim, Young Ock / Kim, Hak-Jae

Environmental research

2021 Volume 202, Page(s) 111718

Abstract	The essential oil isolated from plants is widely utilized as eco-friendly biocides and antibacterial agents. Curcuma amada, commonly known as mango ginger, is well-known for its applications in the food and aromatics industry for its significant mango-like aroma. The present study compared the different C. amada essential oils prepared by hydrodistillation (CHD), steam distillation (CSD), microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE), for their chemical composition, antibacterial, larvicidal and insecticidal properties. GC/MS analysis indicated the presence of compounds including α-pinene, β-myrcene, p-cymene, (Z)-β-ocimene, Camphor, linalyl acetate, safrole, ar-curcumene, and β-curcumene in the different C. amada essential oils. The antibacterial activity was observed against different strains of microbes, with a higher efficacy in the essential oils prepared by UAE and MAE methods. Apart from these, the MAE, UAE, CSD, and CHD were also shown to have significantly higher larvicidal activity against Aedes, Culex, and Armigeres species; however, no toxic effect was observed in non-targeted species like fishes and Allium cepa model of genotoxicity. Further, these essential oils were also found to have significant contact and fumigant toxicity as well as repellency against pests of stored grains (Sitophilus and Tribolium). Considering these results, the present study assumes that Curcuma amada essential oils may be a source of ecofriendly insecticides and antibacterial agents.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Curcuma ; Disinfectants ; Zingiber officinale ; Insecticides ; Mangifera ; Oils, Volatile/pharmacology ; Rhizome
Chemical Substances	Anti-Bacterial Agents ; Disinfectants ; Insecticides ; Oils, Volatile
Language	English
Publishing date	2021-07-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111718
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Article ; Online: Antifungal activity of violacein purified from a novel strain of Chromobacterium sp. NIIST (MTCC 5522).

Sasidharan, Anju / Sasidharan, Nishanth Kumar / Amma, Dileepkumar Bhaskaran Nair Saraswathy / Vasu, Radhakrishnan Kokkuvayil / Nataraja, Anupama Vijaya / Bhaskaran, Krishnakumar

Journal of microbiology (Seoul, Korea)

2015 Volume 53, Issue 10, Page(s) 694–701

Abstract: A novel strain of Chromobacterium sp. NIIST (MTCC 5522) producing high level of purple blue bioactive compound violacein was isolated from clay mine acidic sediment. During 24 h aerobic incubation in modified Luria Bertani medium, around 0.6 g crude ... ...

Abstract	A novel strain of Chromobacterium sp. NIIST (MTCC 5522) producing high level of purple blue bioactive compound violacein was isolated from clay mine acidic sediment. During 24 h aerobic incubation in modified Luria Bertani medium, around 0.6 g crude violacein was produced per gram of dry weight biomass. An inexpensive method for preparing crystalline, pure violacein from crude pigment was developed (12.8 mg violacein/L) and the pure compound was characterized by different spectrometric methods. The violacein prepared was found effective against a number of plant and human pathogenic fungi and yeast species such as Cryptococcus gastricus, Trichophyton rubrum, Fusarium oxysporum, Rhizoctonia solani, Aspergillus flavus, Penicillium expansum, and Candida albicans. The best activity was recorded against Trichophyton rubrum (2 -g/ml), a human pathogen responsible for causing athlete-s foot infection. This is the first report of antifungal activity of purified violacein against pathogenic fungi and yeast.
MeSH term(s)	Aluminum Silicates ; Antifungal Agents/chemistry ; Antifungal Agents/isolation & purification ; Antifungal Agents/metabolism ; Antifungal Agents/pharmacology ; Chromobacterium/chemistry ; Chromobacterium/isolation & purification ; Chromobacterium/physiology ; Fungi/drug effects ; Indoles/chemistry ; Indoles/isolation & purification ; Indoles/metabolism ; Indoles/pharmacology ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Phylogeny ; Soil Microbiology
Chemical Substances	Aluminum Silicates ; Antifungal Agents ; Indoles ; clay (1302-87-0) ; violacein (QJH0DSQ3SG)
Language	English
Publishing date	2015-10
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2012399-1
ISSN	1976-3794 ; 1225-8873
ISSN (online)	1976-3794
ISSN	1225-8873
DOI	10.1007/s12275-015-5173-6
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