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  1. Article ; Online: Letermovir and new horizons in prevention of post-transplant CMV.

    Siegrist, Emily A / Sassine, Joseph

    Expert review of clinical pharmacology

    2023  Volume 16, Issue 10, Page(s) 887–889

    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Editorial
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2023.2259308
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  2. Article ; Online: Shorter might not always be better: the case for longer antibiotic therapy for Pseudomonas aeruginosa pneumonia.

    Siegrist, Emily A / Sassine, Joseph

    Intensive care medicine

    2022  Volume 48, Issue 7, Page(s) 963–964

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Humans ; Pneumonia/drug therapy ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06754-6
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    Zs.A 1089: Show issues Location:
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  3. Article ; Online: Antivirals With Activity Against Mpox: A Clinically Oriented Review.

    Siegrist, Emily A / Sassine, Joseph

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 76, Issue 1, Page(s) 155–164

    Abstract: Mpox virus is an emergent human pathogen. While it is less lethal than smallpox, it can still cause significant morbidity and mortality. In this review, we explore 3 antiviral agents with activity against mpox and other orthopoxviruses: cidofovir, ... ...

    Abstract Mpox virus is an emergent human pathogen. While it is less lethal than smallpox, it can still cause significant morbidity and mortality. In this review, we explore 3 antiviral agents with activity against mpox and other orthopoxviruses: cidofovir, brincidofovir, and tecovirimat. Cidofovir, and its prodrug brincidofovir, are inhibitors of DNA replication with a broad spectrum of activity against multiple families of double-stranded DNA viruses. Tecovirimat has more specific activity against orthopoxviruses and inhibits the formation of the extracellular enveloped virus necessary for cell-to-cell transmission. For each agent, we review basic pharmacology, data from animal models, and reported experience in human patients.
    MeSH term(s) Animals ; Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cidofovir ; Cytosine/pharmacology ; Organophosphonates/pharmacology ; Mpox (monkeypox)/drug therapy ; Monkeypox virus/drug effects
    Chemical Substances Antiviral Agents ; brincidofovir (6794O900AX) ; Cidofovir (JIL713Q00N) ; Cytosine (8J337D1HZY) ; Organophosphonates
    Language English
    Publishing date 2022-07-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac622
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    Zs.A 1505: Show issues Location:
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  4. Article ; Online: Clinical trials for treatment of respiratory viral infections in recipients of haematopoietic cell transplantation and cellular therapies: are we on the right path to the finish line?

    Sassine, Joseph / Hirsch, Hans H / Chemaly, Roy F

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 30, Issue 3, Page(s) 270–275

    MeSH term(s) Humans ; Hematopoietic Stem Cell Transplantation/adverse effects ; Immunocompromised Host ; Respiratory Tract Infections/therapy ; Virus Diseases/prevention & control ; Virus Diseases/drug therapy ; Clinical Trials as Topic
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.09.013
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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  5. Article ; Online: A 77-Year-Old Man with Multiple Myeloma and a Lytic Bone Lesion.

    Sassine, Joseph / Kontoyiannis, Dimitrios P

    The American journal of medicine

    2021  Volume 134, Issue 7, Page(s) 860–862

    MeSH term(s) Aged ; Angiogenesis Inhibitors/adverse effects ; Angiogenesis Inhibitors/therapeutic use ; Cryptococcosis/complications ; Humans ; Lenalidomide/adverse effects ; Lenalidomide/therapeutic use ; Male ; Multiple Myeloma/diagnosis ; Multiple Myeloma/diagnostic imaging ; Multiple Myeloma/etiology
    Chemical Substances Angiogenesis Inhibitors ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2021-02-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2021.01.032
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  6. Article ; Online: Disseminated histoplasmosis after alemtuzumab.

    Siegrist, Emily A / Thomas, Cody / Khawandanah, Mohamad / Sassine, Joseph

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 6, Page(s) e14089

    MeSH term(s) Humans ; Histoplasmosis/drug therapy ; Alemtuzumab/adverse effects ; Histoplasma ; Antifungal Agents/therapeutic use
    Chemical Substances Alemtuzumab (3A189DH42V) ; Antifungal Agents
    Language English
    Publishing date 2023-06-15
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14089
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    Zs.A 5100: Show issues Location:
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  7. Article ; Online: CNS Aspergillosis and Cryptococcosis with Cytomegalovirus Pneumonia in a Patient with Chronic Lymphocytic Leukemia Treated with Acalabrutinib.

    Fallin, Taylor / Thacker, Erica / Sahra, Syeda / Siegrist, Emily A / White, Bryan P / Summers, Katherine / Shibib, Dena / Sassine, Joseph

    Journal of pharmacy practice

    2024  , Page(s) 8971900241247660

    Abstract: Bruton's tyrosine kinase inhibitors (BTKis) are the preferred treatment for chronic lymphocytic leukemia (CLL). Despite their therapeutic benefits, these targeted agents have been associated with an increased risk of invasive infections. We describe a 68- ...

    Abstract Bruton's tyrosine kinase inhibitors (BTKis) are the preferred treatment for chronic lymphocytic leukemia (CLL). Despite their therapeutic benefits, these targeted agents have been associated with an increased risk of invasive infections. We describe a 68-year-old male who developed multiple bacterial, fungal and viral infections while on treatment with acalabrutinib. To our knowledge, this is the first reported case of concomitant CNS infections with
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/08971900241247660
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    Zs.A 2893: Show issues Location:
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  8. Article ; Online: The diagnostic dilemma for atypical presentation of progressive human Mpox.

    Sahra, Syeda / Villalobos, Raul Orozco / Scott, Brian M / Bowman, Deidra J / Sassine, Joseph / Salvaggio, Michelle / Drevets, Douglas A / Higuita, Nelson Iván Agudelo

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 850

    Abstract: Background: Human mpox has increasingly been reported worldwide since May 2022, with higher incidence in men who have sex with men (MSM) and persons living with HIV (PLHIV) with presentation typical for generalized macules and papules.: Case ... ...

    Abstract Background: Human mpox has increasingly been reported worldwide since May 2022, with higher incidence in men who have sex with men (MSM) and persons living with HIV (PLHIV) with presentation typical for generalized macules and papules.
    Case presentation: We are describing a case of human mpox, which presented as widespread, atypical round verrucous lesions that went undiagnosed in the community for six months and was treated with antibacterials and antifungals given the similarity to skin manifestations associated with endemic mycoses.
    Conclusions: Suspicion for human mpox should be high in young MSM and PLHIV who present with rash and mpox should be ruled out earlier.
    MeSH term(s) Male ; Humans ; Homosexuality, Male ; Mpox (monkeypox) ; Sexual and Gender Minorities ; Anti-Bacterial Agents/therapeutic use ; Antifungal Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Antifungal Agents
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08852-2
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  9. Article ; Online: Mortality in recipients of allogeneic haematopoietic cell transplantation in the era of cytomegalovirus primary prophylaxis: a single-centre retrospective experience.

    Febres-Aldana, Anthony / Khawaja, Fareed / Morado-Aramburo, Oscar / Shigle, Terri Lynn / Rondon, Gabriela / Sassine, Joseph / Spallone, Amy / Srinivasan, Krithika / Ramdial, Jeremy / Alousi, Amin / Champlin, Richard / Chen, George / Daher, May / Rezvani, Katayoun / Ariza-Heredia, Ella J / Shpall, Elizabeth J / Chemaly, Roy F

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  

    Abstract: Objectives: Allogeneic haematopoietic cell transplant (allo-HCT) recipients who are cytomegalovirus (CMV)-seronegative have better post-transplant outcomes than CMV-seropositive recipients. Letermovir (LTV) is approved for CMV primary prophylaxis in ... ...

    Abstract Objectives: Allogeneic haematopoietic cell transplant (allo-HCT) recipients who are cytomegalovirus (CMV)-seronegative have better post-transplant outcomes than CMV-seropositive recipients. Letermovir (LTV) is approved for CMV primary prophylaxis in adults who are CMV-seropositive after allo-HCT, and its use is associated with improved long-term post-transplant outcomes. We analysed whether LTV has affected the relationship between CMV serostatus and post-transplant outcomes.
    Methods: We conducted a retrospective single-centre cohort study of allo-HCT recipients, stratified according to donor (D) and recipient (R). CMV serostatus and the use of LTV: D
    Results: The analysis included 1071 consecutive allo-HCT recipients: 131 D
    Discussion: CMV primary prophylaxis with LTV abrogated the mortality gap based on CMV serostatus, a protective effect that persisted after discontinuation of primary prophylaxis.
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2024.03.001
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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  10. Article ; Online: Population Pharmacokinetics of Intraperitoneal Gentamicin and the Impact of Varying Dwell Times on Pharmacodynamic Target Attainment in Patients with Acute Peritonitis Undergoing Peritoneal Dialysis.

    Farkas, Andras / Oikonomou, Katerina / Ghanbar, Mohammad / Villasurda, Phillip / Varghese, Julie / Lipman, Jeffrey / Sassine, Joseph / Ranganathan, Dwarakanathan / Roberts, Jason A

    Antimicrobial agents and chemotherapy

    2021  Volume 66, Issue 2, Page(s) e0167921

    Abstract: While the use of intraperitoneal (i.p.) gentamicin is common in the treatment of peritoneal dialysis (PD)-related infections, the ability of these regimens to attain pharmacodynamic target indices of interest in blood and dialysate has not been widely ... ...

    Abstract While the use of intraperitoneal (i.p.) gentamicin is common in the treatment of peritoneal dialysis (PD)-related infections, the ability of these regimens to attain pharmacodynamic target indices of interest in blood and dialysate has not been widely reported. Pharmacokinetic (PK) data were obtained and analyzed from a multiple-dose PK study of i.p. gentamicin with 24 patients who received the drug at 0.6 mg/kg dose of body weight. The probability of target attainment (PTA) for indices of treatment success (i.p. peak/MIC ratio > 10) and toxicity (plasma area under the concentration-time curve [AUC] < 120 mg·h/L) was determined for 0.3- to 1.2-mg/kg i.p. regimens every 24 h for dwell times of 2 to 6 h and for the duration of a 2-week course. In the peritoneum, successful PTA was achieved by all of the simulated regimens up to an MIC of 1 mg/L and by doses equal to or greater than 0.6 mg/kg up to the MIC of 2 mg/L. At the susceptibility breakpoint of 4 mg/L, only the highest dose of 1.2 mg/kg is likely to provide adequate PTA. The probability of achieving exposure below the threshold of 120 mg·h/L in the daily AUC in plasma seems acceptable for all regimens at or below 0.6 mg/kg. Based on the model we developed, a gentamicin dose of 0.6 mg/kg is sufficient to treat organisms with an MIC of ≤2 mg/L without the risk of significant systemic exposure. The 1.2-mg/kg dose necessary to reach the pharmacodynamic target for efficacy at the clinical breakpoint of 4 mg/L is likely to produce early toxic levels of exposure that are expected to be detrimental to the renal system.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Gentamicins/pharmacokinetics ; Gentamicins/therapeutic use ; Humans ; Peritoneal Dialysis/adverse effects ; Peritonitis/drug therapy ; Prospective Studies
    Chemical Substances Anti-Bacterial Agents ; Gentamicins
    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01679-21
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