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  1. Article: Universal health coverage in the context of population ageing: catastrophic health expenditure and unmet need for healthcare.

    Okamoto, Shohei / Sata, Mizuki / Rosenberg, Megumi / Nakagoshi, Natsuko / Kamimura, Kazuki / Komamura, Kohei / Kobayashi, Erika / Sano, Junko / Hirazawa, Yuzuki / Okamura, Tomonori / Iso, Hiroyasu

    Health economics review

    2024  Volume 14, Issue 1, Page(s) 8

    Abstract: Background: Universal health coverage means that all people can access essential health services without incurring financial hardship. Even in countries with good service coverage and financial protection, the progress towards universal health coverage ... ...

    Abstract Background: Universal health coverage means that all people can access essential health services without incurring financial hardship. Even in countries with good service coverage and financial protection, the progress towards universal health coverage may decelerate or be limited with respect to the growing older population. This study investigates the incidence/prevalence, determinants, and consequences of catastrophic health expenditure (CHE) and unmet need for healthcare and assesses the potential heterogeneity between younger (≤ 64 years) and older people (65 years≤).
    Methods: Utilising an annual nationally representative survey of Japanese aged 20 years and over, we estimated the incidence of CHE and unmet need for healthcare using disaggregated estimates by household members' age (i.e. ≤64 years vs. 65 years≤) between 2004 and 2020. Using a fixed-effects model, we assessed the determinants of CHE and unmet need along with the consequences of CHE. We also assessed the heterogeneity by age.
    Results: Households with older members were more likely to have their healthcare needs met but experienced CHE more so than households without older members. The financial consequences of CHE were heterogeneous by age, suggesting that households with older members responded to CHE by reducing food and social expenditures more so than households without older members reducing expenditure on education. Households without older members experienced an income decline in the year following the occurrence of CHE, while this was not found among households with older members. A U-shaped relationship was observed between age and the probability of experiencing unmet healthcare need.
    Conclusions: Households with older members are more likely to experience CHE with different financial consequences compared to those with younger members. Unmet need for healthcare is more common among younger and older members than among their middle-aged counterparts. Different types and levels of health and financial support need to be incorporated into national health systems and social protection policies to meet the unique needs of individuals and households.
    Language English
    Publishing date 2024-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2634483-X
    ISSN 2191-1991
    ISSN 2191-1991
    DOI 10.1186/s13561-023-00475-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Correction: Universal health coverage in the context of population ageing: catastrophic health expenditure and unmet need for healthcare.

    Okamoto, Shohei / Sata, Mizuki / Rosenberg, Megumi / Nakagoshi, Natsuko / Kamimura, Kazuki / Komamura, Kohei / Kobayashi, Erika / Sano, Junko / Hirazawa, Yuzuki / Okamura, Tomonori / Iso, Hiroyasu

    Health economics review

    2024  Volume 14, Issue 1, Page(s) 20

    Language English
    Publishing date 2024-03-11
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2634483-X
    ISSN 2191-1991
    ISSN 2191-1991
    DOI 10.1186/s13561-024-00495-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mortality from major causes and lifestyles by proportions of public assistance recipients among 47 prefectures in Japan: Ecological panel data analysis from 1999 to 2016.

    Nishi, Nobuo / Kitaoka, Kaori / Tran Ngoc Hoang, Phap / Okami, Yukiko / Kondo, Keiko / Sata, Mizuki / Kadota, Aya / Nakamura, Mieko / Yoshita, Katsushi / Okamura, Tomonori / Ojima, Toshiyuki / Miura, Katsuyuki

    Preventive medicine reports

    2024  Volume 39, Page(s) 102635

    Abstract: Objective: Comprehensive investigations of correlations between subnational socioeconomic factors and trends in mortality and lifestyle are important for addressing public health problems.: Methods: Forty-seven prefectures in Japan were divided into ... ...

    Abstract Objective: Comprehensive investigations of correlations between subnational socioeconomic factors and trends in mortality and lifestyle are important for addressing public health problems.
    Methods: Forty-seven prefectures in Japan were divided into quartiles based on the proportion of public assistance recipients (PPAR). Age-standardized mortality from all causes, cancer, heart disease, and stroke in each prefecture were averaged for these quartiles in 2000, 2005, 2010, and 2015. Data from the National Health and Nutrition Survey were obtained for the following periods: 1999-2001, 2003-2005, 2007-2009, 2012, and 2016. Body mass index (BMI), intake of total energy, vegetable and salt, step count, and prevalence of current smoking and drinking for individuals aged 40-69 years age range were standardized for each prefecture and averaged by quartile. A two-way analysis of variance was used to assess differences in mortality and lifestyle across different years or periods, and quartiles.
    Results: Mortality rates decreased, with the first (lowest) quartile showing the lowest rates, across all causes, cancer and heart diseases in both sexes. BMI exhibited an increase in men, whereas, BMI in women and other lifestyle factors in both sexes, excluding smoking and drinking in women, exhibited a decrease. BMI, vegetable and salt intake, total energy intake in men, and smoking in women varied across quartiles. Lower quartiles exhibited lower BMI and smoking prevalence but higher energy, vegetables, and salt intake.
    Conclusions: PPAR exhibited favorable trends and significant differences in mortality related to all causes, cancer and heart disease across both sexes, along with BMI among women.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2024.102635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Trends in Prevalence, Treatment, and Control of Hypertension According to 40-Year-Old Life Expectancy at Prefectures in Japan from the National Health and Nutrition Surveys

    Sata, Mizuki / Okamura, Tomonori / Nishi, Nobuo / Kadota, Aya / Nakamura, Mieko / Kondo, Keiko / Okami, Yukiko / Kitaoka, Kaori / Ojima, Toshiyuki / Yoshita, Katsushi / Miura, Katsuyuki

    Nutrients. 2022 Mar. 14, v. 14, no. 6

    2022  

    Abstract: The prevalence of hypertension has been decreasing in Japan due to improved medical treatment and a decrease in dietary salt intake. However, disparities in the prevalence, treatment, and control of hypertension are expected to occur in different regions. ...

    Abstract The prevalence of hypertension has been decreasing in Japan due to improved medical treatment and a decrease in dietary salt intake. However, disparities in the prevalence, treatment, and control of hypertension are expected to occur in different regions. This study aimed to investigate the trends in the prevalence, treatment, and control of hypertension at the prefectural level of life expectancy among Japanese population. We used data from the National Health and Nutrition Survey and analysed the individual survey information of individuals aged 40–69 years by dividing it into six terms, i.e., 1995–1997, 1999–2001, 2003–2005, 2007–2009, 2012, and 2016. Prefectures were classified into four groups according to their 40-year-old life expectancy in 2000. Outcome values were standardised to the population by 10-year age groups in 2010, and they were tested by two-way analysis of variance according to six terms and life expectancies. The prevalence of hypertension tended to decrease, especially among women, whereas the treatment and control tended to improve from the first to the sixth period in both men and women. The prevalence and treatment of hypertension in men with longer life expectancy tended to be lower than that in other groups, and there was no obvious difference in the control. In women, there were no obvious differences in the prevalence, treatment, or control. Reducing the prevalence of hypertension by improving lifestyle factors, such as high salt intake in each prefecture with a relatively short life expectancy, may be important to resolve the disparity in life expectancy among prefectures.
    Keywords Japan ; analysis of variance ; hypertension ; lifestyle ; longevity ; medical treatment ; nutrition ; nutrition surveys ; table salt
    Language English
    Dates of publication 2022-0314
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14061219
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: A population-based urinary and plasma metabolomics study of environmental exposure to cadmium.

    Ishibashi, Yoshiki / Harada, Sei / Eitaki, Yoko / Kurihara, Ayako / Kato, Suzuka / Kuwabara, Kazuyo / Iida, Miho / Hirata, Aya / Sata, Mizuki / Matsumoto, Minako / Shibuki, Takuma / Okamura, Tomonori / Sugiyama, Daisuke / Sato, Asako / Amano, Kaori / Hirayama, Akiyoshi / Sugimoto, Masahiro / Soga, Tomoyoshi / Tomita, Masaru /
    Takebayashi, Toru

    Environmental health and preventive medicine

    2024  Volume 29, Page(s) 22

    Abstract: Background: The application of metabolomics-based profiles in environmental epidemiological studies is a promising approach to refine the process of health risk assessment. We aimed to identify potential metabolomics-based profiles in urine and plasma ... ...

    Abstract Background: The application of metabolomics-based profiles in environmental epidemiological studies is a promising approach to refine the process of health risk assessment. We aimed to identify potential metabolomics-based profiles in urine and plasma for the detection of relatively low-level cadmium (Cd) exposure in large population-based studies.
    Method: We analyzed 123 urinary metabolites and 94 plasma metabolites detected in fasting urine and plasma samples collected from 1,412 men and 2,022 women involved in the Tsuruoka Metabolomics Cohort Study. Regression analysis was performed for urinary N-acetyl-beta-D-glucosaminidase (NAG), plasma, and urinary metabolites as dependent variables, and urinary Cd (U-Cd, quartile) as an independent variable. The multivariable regression model included age, gender, systolic blood pressure, smoking, rice intake, BMI, glycated hemoglobin, low-density lipoprotein cholesterol, alcohol consumption, physical activity, educational history, dietary energy intake, urinary Na/K ratio, and uric acid. Pathway-network analysis was carried out to visualize the metabolite networks linked to Cd exposure.
    Result: Urinary NAG was positively associated with U-Cd, but not at lower concentrations (Q2). Among urinary metabolites in the total population, 45 metabolites showed associations with U-Cd in the unadjusted and adjusted models after adjusting for the multiplicity of comparison with FDR. There were 12 urinary metabolites which showed consistent associations between Cd exposure from Q2 to Q4. Among plasma metabolites, six cations and one anion were positively associated with U-Cd, whereas alanine, creatinine, and isoleucine were negatively associated with U-Cd. Our results were robust by statistical adjustment of various confounders. Pathway-network analysis revealed metabolites and upstream regulator changes associated with mitochondria (ACACB, UCP2, and metabolites related to the TCA cycle).
    Conclusion: These results suggested that U-Cd was associated with metabolites related to upstream mitochondrial dysfunction in a dose-dependent manner. Our data will help develop environmental Cd exposure profiles for human populations.
    MeSH term(s) Male ; Humans ; Female ; Cadmium/urine ; Cohort Studies ; Environmental Exposure/analysis ; Kidney ; Regression Analysis ; Biomarkers/urine
    Chemical Substances Cadmium (00BH33GNGH) ; Biomarkers
    Language English
    Publishing date 2024-03-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2018758-0
    ISSN 1347-4715 ; 1342-078X
    ISSN (online) 1347-4715
    ISSN 1342-078X
    DOI 10.1265/ehpm.23-00218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers.

    Hirata, Aya / Harada, Sei / Iida, Miho / Kurihara, Ayako / Fukai, Kota / Kuwabara, Kazuyo / Kato, Suzuka / Matsumoto, Minako / Sata, Mizuki / Miyagawa, Naoko / Toki, Ryota / Edagawa, Shun / Sugiyama, Daisuke / Sato, Asako / Hirayama, Akiyoshi / Sugimoto, Masahiro / Soga, Tomoyoshi / Tomita, Masaru / Okamura, Tomonori /
    Takebayashi, Toru

    Journal of atherosclerosis and thrombosis

    2024  

    Abstract: Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads to atherosclerosis. The study aimed to confirm the association between NAFLD and ... ...

    Abstract Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads to atherosclerosis. The study aimed to confirm the association between NAFLD and the cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, and explore metabolites involved in both by assessing 94 plasma polar metabolites.
    Methods: A total of 928 Japanese community-dwellers (306 men and 622 women) were included in this study. The association between NAFLD and CAVI was examined using a multivariable regression model adjusted for confounders. Metabolites commonly associated with NAFLD and CAVI were investigated using linear mixed-effects models in which batch numbers of metabolite measurements were used as a random-effects variable, and false discovery rate-adjusted p-values were calculated. To determine the extent to which these metabolites mediated the association between NAFLD and CAVI, mediation analysis was conducted.
    Results: NAFLD was positively associated with CAVI (coefficients [95% Confidence intervals (CI)]=0.23 [0.09-0.37]; p=0.001). A total of 10 metabolites were involved in NAFLD and CAVI, namely, branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), aromatic amino acids (AAAs; tyrosine and tryptophan), alanine, proline, glutamic acid, glycerophosphorylcholine, and 4-methyl-2-oxopentanoate. Mediation analysis showed that BCAAs mediated more than 20% of the total effect in the association between NAFLD and CAVI.
    Conclusions: NAFLD was associated with a marker of atherosclerosis, and several metabolites related to insulin resistance, including BCAAs and AAAs, could be involved in the process by which NAFLD leads to atherosclerosis.
    Language English
    Publishing date 2024-02-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.64616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Trends in mortality from major causes and lifestyle factors by per capita prefectural income: Ecological panel data analysis from 1995 to 2016 in Japan.

    Nishi, Nobuo / Kitaoka, Kaori / Tran Ngoc Hoang, Phap / Okami, Yukiko / Kondo, Keiko / Sata, Mizuki / Kadota, Aya / Nakamura, Mieko / Yoshita, Katsushi / Okamura, Tomonori / Ojima, Toshiyuki / Miura, Katsuyuki

    Preventive medicine reports

    2023  Volume 35, Page(s) 102348

    Abstract: In Japan, trends in mortality and lifestyle have not been fully investigated according to subnational socioeconomic factors. Forty-seven prefectures (subnational units) were divided into quartiles by annual per capita prefectural income. Age-standardized ...

    Abstract In Japan, trends in mortality and lifestyle have not been fully investigated according to subnational socioeconomic factors. Forty-seven prefectures (subnational units) were divided into quartiles by annual per capita prefectural income. Age-standardized mortality from all causes, cancer, heart disease, and stroke was averaged by quartile in 1995, 2000, 2005, 2010, and 2015. Data from the National Health and Nutrition Survey were obtained for periods 1 (1995-1997), 2 (1999-2001), 3 (2003-2005), 4 (2007-2009), 5 (2012), and 6 (2016). Body mass index (BMI), the intake of vegetables and salt, the number of steps, and the prevalence of current smoking and drinking for the 40-69-year age range were standardized by 10-year age groups in the 2010 Japanese population and were averaged by quartile. Differences in mortality and lifestyle by year and period, and quartile were tested using a two-way analysis of variance. Mortality decreased in both sexes and mortality in men from all causes, cancer, and stroke differed by quartile, with mortality highest in the first (lowest) quartile. BMI in men and smoking prevalence in women increased, whereas remaining lifestyle factors except for the prevalence of drinking decreased in women. BMI and the number of steps in both sexes and current smoking prevalence in women differed by quartile, with lower quartiles showing a higher BMI and fewer step counts. In conclusion, favorable trends and significant differences in mortality from all causes, cancer, and stroke in men and BMI in women were observed by per capita prefectural income level.
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2023.102348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Determinants of salt taste threshold among urban residents: the KOBE study].

    Wakako, Minami / Sata, Mizuki / Kubota, Yoshimi / Nishida, Yoko / Kubo, Sachimi / Higashiyama, Aya / Hirata, Takumi / Kadota, Aya / Hirata, Aya / Miyazaki, Junji / Kawahara, Mizuki / Kuwabara, Kazuyo / Sugiyama, Daisuke / Miyamatsu, Naomi / Miyamoto, Yoshihiro / Okamura, Tomonori

    Nihon koshu eisei zasshi] Japanese journal of public health

    2023  Volume 70, Issue 5, Page(s) 300–310

    Abstract: Objectives Though having a high salt taste threshold has been associated with hypertension, its exact determinants remains unclear. This study aimed to identify the determinants of salt taste threshold in a community-based population and to determine the ...

    Abstract Objectives Though having a high salt taste threshold has been associated with hypertension, its exact determinants remains unclear. This study aimed to identify the determinants of salt taste threshold in a community-based population and to determine the relationship between salt taste thresholds and the simultaneous presence of multiple determinants.Methods Of the 1,117 participants of the baseline survey of the Kobe study, a cohort study of healthy urban residents, aged 40-74 years, with no history of cancer or cardiovascular diseases, nor undergoing treatment for hypertension, diabetes, or dyslipidemia, was conducted. Among them, 1,116 underwent the salt taste threshold test, and urine samples were collected to determine their estimated salt intake. The salt taste threshold test was carried out using SALSAVE
    MeSH term(s) Female ; Humans ; Cohort Studies ; Hypertension/epidemiology ; Sodium Chloride, Dietary/urine ; Taste Threshold ; Urban Population ; Male ; Middle Aged ; Aged
    Chemical Substances Sodium Chloride, Dietary
    Language Japanese
    Publishing date 2023-03-10
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 45044-3
    ISSN 0546-1766
    ISSN 0546-1766
    DOI 10.11236/jph.22-062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Determinants of double product: a cross-sectional study of urban residents in Japan.

    Nakagoshi, Natsuko / Kubo, Sachimi / Nishida, Yoko / Kuwabara, Kazuyo / Hirata, Aya / Sata, Mizuki / Higashiyama, Aya / Kubota, Yoshimi / Hirata, Takumi / Tatsumi, Yukako / Kawamura, Kuniko / Miyazaki, Junji / Miyamatsu, Naomi / Sugiyama, Daisuke / Miyamoto, Yoshihiro / Okamura, Tomonori

    Environmental health and preventive medicine

    2023  Volume 28, Page(s) 37

    Abstract: Background: The current study aimed to investigate the determinants of high double product (DP) by evaluating the association between resting DP, which is calculated as systolic blood pressure (SBP) multiplied by heart rate (HR), and blood test results ... ...

    Abstract Background: The current study aimed to investigate the determinants of high double product (DP) by evaluating the association between resting DP, which is calculated as systolic blood pressure (SBP) multiplied by heart rate (HR), and blood test results and lifestyle factors.
    Methods: This research included 973 participants in the baseline survey of the KOBE study, which included a cohort of urban residents. The possible DP determinants were identified by examining the association between lifestyle factors and laboratory findings and DP by analyzing covariance adjusted for sex and age. Logistic regression analysis was performed with high DP (SBP × HR ≥ 9145 mmHg beats/min or quintile according to sex) as outcome and DP determinants as independent variables.
    Results: Age, hematocrit, and gamma-glutamyl transferase (log) level were positively associated with a high DP in both men and women. In addition, a high DP was positively associated with Homeostatic Model Assessment for Insulin Resistance score in women alone. Meanwhile, the amount of exercise was negatively associated with a high DP in men alone.
    Conclusions: High DP values at rest were associated with insulin resistance, gamma-glutamyl transferase, and the amount of exercise in participants without underlying disease.
    MeSH term(s) Male ; Humans ; Female ; Cross-Sectional Studies ; Insulin Resistance ; Japan ; Urban Population ; Blood Pressure/physiology ; Heart Rate/physiology ; Transferases
    Chemical Substances Transferases (EC 2.-)
    Language English
    Publishing date 2023-06-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2018758-0
    ISSN 1347-4715 ; 1342-078X
    ISSN (online) 1347-4715
    ISSN 1342-078X
    DOI 10.1265/ehpm.23-00002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Frequency of Seaweed Intake and Its Association with Cardiovascular Disease Mortality: The JACC Study.

    Kishida, Rie / Yamagishi, Kazumasa / Muraki, Isao / Sata, Mizuki / Tamakoshi, Akiko / Iso, Hiroyasu

    Journal of atherosclerosis and thrombosis

    2020  Volume 27, Issue 12, Page(s) 1340–1347

    Abstract: Aim: Seaweed is a popular traditional foodstuff in Asian countries. To our knowledge, few studies have examined the association of seaweed intake with mortality from cardiovascular disease. We examined the association of frequency of seaweed intake with ...

    Abstract Aim: Seaweed is a popular traditional foodstuff in Asian countries. To our knowledge, few studies have examined the association of seaweed intake with mortality from cardiovascular disease. We examined the association of frequency of seaweed intake with total and specific cardiovascular disease mortality.
    Methods: We examined the association of seaweed intake with mortality from cardiovascular disease among 40,234 men and 55,981 women who participated in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Sex-specific hazard ratios for mortality from cardiovascular disease (stroke, stroke subtypes, and coronary heart disease) according to the frequency of seaweed intake were calculated stratified by study area and adjusted for potential cardiovascular risk factors and dietary factors.
    Results: During the 1,580,996 person-year follow-up, 6,525 cardiovascular deaths occurred, of which 2,820 were due to stroke, and 1,378, to coronary heart disease. Among men, the multivariable analysis showed that participants who ate seaweed almost every day compared with those who never ate seaweed had hazard ratios (95% confidence interval; P for trend) of 0.79 (0.62-1.01; 0.72) for total cardiovascular disease, 0.70 (0.49-0.99; 0.47) for total stroke, 0.69 (0.41-1.16; 0.11) for cerebral infarction. Among women, the multivariable-adjusted hazard ratios were 0.72 (0.55-0.95; 0.001) for total cardiovascular disease, 0.70 (0.46-1.06; 0.01) for total stroke, and 0.49 (0.27-0.90; 0.22) for cerebral infarction. No associations were observed between seaweed intake and risk of intraparenchymal hemorrhage and coronary heart disease among either men or women.
    Conclusions: We found an inverse association between seaweed intake and cardiovascular mortality among Japanese men and women, especially that from cerebral infarction.
    MeSH term(s) Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/mortality ; Diet ; Female ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Protective Factors ; Seaweed/metabolism ; Stroke/etiology ; Stroke/metabolism ; Stroke/mortality
    Language English
    Publishing date 2020-03-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.53447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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