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  1. AU="Sather, D Noah"
  2. AU="Yuan-Qiang Lu"
  3. AU="Almeida, Isabela"
  4. AU="Feng, Yan-Yan"
  5. AU=Thyagarajan Baskaran
  6. AU="Olness, F"
  7. AU="Roberts, Jessica A"
  8. AU=Arutyunov G P
  9. AU="Strautmanis, Jurgis"
  10. AU="Klein, Friederike"
  11. AU=Richards JoAnne S.
  12. AU="Nair, Venugopalan D"
  13. AU="Anne Fåne"
  14. AU=Liang John W
  15. AU="Segura-Martínez, Patricia"
  16. AU="Cao, Xi-Ming"
  17. AU="Labaronne, Emmanuel"
  18. AU="Shimpukade, Bharat"
  19. AU="Claude, Pierre-Abel"
  20. AU="Rocha Vogel, Angus"
  21. AU="Larkin, J"
  22. AU="Gilbert, A."
  23. AU="Jérémie Bruno"
  24. AU="Barg, Alexej"
  25. AU="Niranjan, M"
  26. AU="Solomon, Hilla"
  27. AU="de Aguiar Junior, Francisco Carlos Amanajás"
  28. AU=Carley David W
  29. AU="Solvig Ekblad"
  30. AU=Gibertoni Dino
  31. AU="Sein, Maung Kyaw"
  32. AU="Yun-Fei Xia"

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  1. Artikel ; Online: Freshly remodeled and ready to fight malaria.

    Sather, D Noah

    Immunity

    2022  Band 55, Heft 9, Seite(n) 1588–1590

    Abstract: Poor biochemical characteristics have severely hampered the development of the promising malaria transmission-blocking vaccine candidate Pfs48/45. In this issue of Immunity, McLeod et al. applied structure-guided vaccine design to transform this protein ... ...

    Abstract Poor biochemical characteristics have severely hampered the development of the promising malaria transmission-blocking vaccine candidate Pfs48/45. In this issue of Immunity, McLeod et al. applied structure-guided vaccine design to transform this protein into a stable, high-producing antigen that elicits exceptional blocking antibodies, renewing its promise as a tool to fight malaria.
    Mesh-Begriff(e) Antibodies, Protozoan ; Humans ; Malaria/prevention & control ; Malaria Vaccines ; Membrane Glycoproteins ; Protozoan Proteins
    Chemische Substanzen Antibodies, Protozoan ; Malaria Vaccines ; Membrane Glycoproteins ; Protozoan Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-09-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.08.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Deep mutational scanning of the RNase III-like domain in

    McDermott, Suzanne M / Pham, Vy / Oliver, Brian / Carnes, Jason / Sather, D Noah / Stuart, Kenneth D

    Frontiers in cellular and infection microbiology

    2024  Band 14, Seite(n) 1381155

    Abstract: Kinetoplastid pathogens ... ...

    Abstract Kinetoplastid pathogens including
    Mesh-Begriff(e) Amino Acid Substitution ; DNA Mutational Analysis ; High-Throughput Nucleotide Sequencing ; Mutation ; Protein Domains/genetics ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Ribonuclease III/genetics ; Ribonuclease III/metabolism ; RNA Editing ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/metabolism ; Trypanosoma brucei brucei/growth & development
    Chemische Substanzen Protozoan Proteins ; Ribonuclease III (EC 3.1.26.3) ; KREPA4 protein, Trypanosoma brucei
    Sprache Englisch
    Erscheinungsdatum 2024-04-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1381155
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria.

    Watson, Felicia N / Shears, Melanie J / Kalata, Anya C / Duncombe, Caroline J / Seilie, A Mariko / Chavtur, Chris / Conrad, Ethan / Cruz Talavera, Irene / Raappana, Andrew / Sather, D Noah / Chakravarty, Sumana / Sim, B Kim Lee / Hoffman, Stephen L / Tsuji, Moriya / Murphy, Sean C

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 2881

    Abstract: Radiation-attenuated sporozoite (RAS) vaccines can completely prevent blood stage Plasmodium infection by inducing liver-resident memory ... ...

    Abstract Radiation-attenuated sporozoite (RAS) vaccines can completely prevent blood stage Plasmodium infection by inducing liver-resident memory CD8
    Mesh-Begriff(e) Mice ; Animals ; Sporozoites ; Malaria Vaccines ; CD8-Positive T-Lymphocytes ; Glycolipids ; Malaria/parasitology ; Adjuvants, Immunologic/pharmacology ; Adjuvants, Pharmaceutic ; Mice, Inbred BALB C
    Chemische Substanzen Malaria Vaccines ; Glycolipids ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic
    Sprache Englisch
    Erscheinungsdatum 2024-02-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53118-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Coimmunization with Preerythrocytic Antigens alongside Circumsporozoite Protein Can Enhance Sterile Protection against

    Vigdorovich, Vladimir / Patel, Hardik / Watson, Alexander / Raappana, Andrew / Reynolds, Laura / Selman, William / Beeman, Suzannah / Edlefsen, Paul T / Kappe, Stefan H I / Sather, D Noah

    Microbiology spectrum

    2023  , Seite(n) e0379122

    Abstract: ... Malaria- ... ...

    Abstract Malaria-causing
    Sprache Englisch
    Erscheinungsdatum 2023-02-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03791-22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection.

    Sack, Brandon / Kappe, Stefan H I / Sather, D Noah

    Expert review of vaccines

    2017  Band 16, Heft 5, Seite(n) 403–414

    Abstract: Introduction: An effective malaria vaccine would be considered a milestone of modern medicine, yet has so far eluded research and development efforts. This can be attributed to the extreme complexity of the malaria parasites, presenting with a multi- ... ...

    Abstract Introduction: An effective malaria vaccine would be considered a milestone of modern medicine, yet has so far eluded research and development efforts. This can be attributed to the extreme complexity of the malaria parasites, presenting with a multi-stage life cycle, high genome complexity and the parasite's sophisticated immune evasion measures, particularly antigenic variation during pathogenic blood stage infection. However, the pre-erythrocytic (PE) early infection forms of the parasite exhibit relatively invariant proteomes, and are attractive vaccine targets as they offer multiple points of immune system attack. Areas covered: We cover the current state of and roadblocks to the development of an effective, antibody-based PE vaccine, including current vaccine candidates, limited biological knowledge, genetic heterogeneity, parasite complexity, and suboptimal preclinical models as well as the power of early stage clinical models. Expert commentary: PE vaccines will need to elicit broad and durable immunity to prevent infection. This could be achievable if recent innovations in studying the parasites' infection biology, rational vaccine selection and design as well as adjuvant formulation are combined in a synergistic and multipronged approach. Improved preclinical assays as well as the iterative testing of vaccine candidates in controlled human malaria infection trials will further accelerate this effort.
    Mesh-Begriff(e) Animals ; Disease Models, Animal ; Drug Discovery/trends ; Humans ; Malaria/prevention & control ; Malaria Vaccines/immunology ; Malaria Vaccines/isolation & purification
    Chemische Substanzen Malaria Vaccines
    Sprache Englisch
    Erscheinungsdatum 2017-05
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2017.1295853
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Evaluation of repRNA vaccine for induction and in utero transfer of maternal antibodies in a pregnant rabbit model.

    Khandhar, Amit P / Landon, Chelsea D / Archer, Jacob / Krieger, Kyle / Warner, Nikole L / Randall, Samantha / Berube, Bryan J / Erasmus, Jesse H / Sather, D Noah / Staats, Herman F

    Molecular therapy : the journal of the American Society of Gene Therapy

    2023  Band 31, Heft 4, Seite(n) 1046–1058

    Abstract: Mother-to-child transmission is a major route for infections in newborns. Vaccination in mothers to leverage the maternal immune system is a promising approach to vertically transfer protective immunity. During infectious disease outbreaks, such as the ... ...

    Abstract Mother-to-child transmission is a major route for infections in newborns. Vaccination in mothers to leverage the maternal immune system is a promising approach to vertically transfer protective immunity. During infectious disease outbreaks, such as the 2016 Zika virus (ZIKV) outbreak, rapid availability of vaccines can prove critical in reducing widespread disease burden. The recent successes of mRNA vaccines support their evaluation in pregnant animal models to justify their use in neonatal settings. Here we evaluated immunogenicity of self-amplifying replicon (repRNA) vaccines, delivered with our clinical-stage LION nanoparticle formulation, in pregnant rabbits using ZIKV and HIV-1 as model disease targets. We showed that LION/repRNA vaccines induced robust antigen-specific antibody responses in adult pregnant rabbits that passively transferred to newborn kits in utero. Using a matrixed study design, we further elucidate the effect of vaccination in kits on the presence of pre-existing maternal antibodies. Our findings showed that timing of maternal vaccination is critical in maximizing in utero antibody transfer, and subsequent vaccination in newborns maintained elevated antibody levels compared with no vaccination. Overall, our results support further development of the LION/repRNA vaccine platform for maternal and neonatal settings.
    Mesh-Begriff(e) Pregnancy ; Animals ; Female ; Rabbits ; Zika Virus ; Zika Virus Infection ; Infectious Disease Transmission, Vertical/prevention & control ; Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing
    Chemische Substanzen Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing
    Sprache Englisch
    Erscheinungsdatum 2023-03-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2023.02.022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: A repurposed drug screen identifies compounds that inhibit the binding of the COVID-19 spike protein to ACE2.

    Tsegay, Kaleb B / Adeyemi, Christiana M / Gniffke, Edward P / Sather, D Noah / Walker, John K / Smith, Stephen E P

    bioRxiv : the preprint server for biology

    2021  

    Abstract: Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2701 compounds from a commercial library of drugs approved ... ...

    Abstract Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2701 compounds from a commercial library of drugs approved by international regulatory agencies for their ability to inhibit the binding of recombinant, trimeric SARS-CoV-2 spike protein to recombinant human ACE2. We identified 56 compounds that inhibited binding by <90%, measured the EC
    Sprache Englisch
    Erscheinungsdatum 2021-04-08
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2021.04.08.439071
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  8. Artikel: A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2.

    Tsegay, Kaleb B / Adeyemi, Christiana M / Gniffke, Edward P / Sather, D Noah / Walker, John K / Smith, Stephen E P

    Frontiers in pharmacology

    2021  Band 12, Seite(n) 685308

    Abstract: Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2,701 compounds from a commercial library of drugs approved ... ...

    Abstract Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2,701 compounds from a commercial library of drugs approved by international regulatory agencies for their ability to inhibit the binding of recombinant, trimeric SARS-CoV-2 spike protein to recombinant human ACE2. We identified 56 compounds that inhibited binding in a concentration-dependent manner, measured the IC
    Sprache Englisch
    Erscheinungsdatum 2021-06-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.685308
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  9. Artikel: Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria.

    Watson, Felicia N / Shears, Melanie J / Kalata, Anya C / Duncombe, Caroline J / Seilie, A Mariko / Chavtur, Chris / Conrad, Ethan / Talavera, Irene Cruz / Raappana, Andrew / Sather, D Noah / Chakravarty, Sumana / Sim, B Kim Lee / Hoffman, Stephen L / Tsuji, Moriya / Murphy, Sean C

    Research square

    2023  

    Abstract: Malaria is caused ... ...

    Abstract Malaria is caused by
    Sprache Englisch
    Erscheinungsdatum 2023-08-11
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-3243319/v1
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  10. Artikel ; Online: Germinal center activity and B cell maturation are associated with protective antibody responses against Plasmodium pre-erythrocytic infection.

    Visweswaran, Ganesh Ram R / Vijayan, Kamalakannan / Chandrasekaran, Ramyavardhanee / Trakhimets, Olesya / Brown, Samantha L / Vigdorovich, Vladimir / Yang, Ashton / Raappana, Andrew / Watson, Alex / Selman, William / Zuck, Meghan / Dambrauskas, Nicholas / Kaushansky, Alexis / Sather, D Noah

    PLoS pathogens

    2022  Band 18, Heft 7, Seite(n) e1010671

    Abstract: Blocking Plasmodium, the causative agent of malaria, at the asymptomatic pre-erythrocytic stage would abrogate disease pathology and prevent transmission. However, the lack of well-defined features within vaccine-elicited antibody responses that ... ...

    Abstract Blocking Plasmodium, the causative agent of malaria, at the asymptomatic pre-erythrocytic stage would abrogate disease pathology and prevent transmission. However, the lack of well-defined features within vaccine-elicited antibody responses that correlate with protection represents a major roadblock to improving on current generation vaccines. We vaccinated mice (BALB/cJ and C57BL/6J) with Py circumsporozoite protein (CSP), the major surface antigen on the sporozoite, and evaluated vaccine-elicited humoral immunity and identified immunological factors associated with protection after mosquito bite challenge. Vaccination achieved 60% sterile protection and otherwise delayed blood stage patency in BALB/cJ mice. In contrast, all C57BL/6J mice were infected similar to controls. Protection was mediated by antibodies and could be passively transferred from immunized BALB/cJ mice into naïve C57BL/6J. Dissection of the underlying immunological features of protection revealed early deficits in antibody titers and polyclonal avidity in C57BL/6J mice. Additionally, PyCSP-vaccination in BALB/cJ induced a significantly higher proportion of antigen-specific B-cells and class-switched memory B-cell (MBCs) populations than in C57BL/6J mice. Strikingly, C57BL/6J mice also had markedly fewer CSP-specific germinal center experienced B cells and class-switched MBCs compared to BALB/cJ mice. Analysis of the IgG γ chain repertoires by next generation sequencing in PyCSP-specific memory B-cell repertoires also revealed higher somatic hypermutation rates in BALB/cJ mice than in C57BL/6J mice. These findings indicate that the development of protective antibody responses in BALB/cJ mice in response to vaccination with PyCSP was associated with increased germinal center activity and somatic mutation compared to C57BL/6J mice, highlighting the key role B cell maturation may have in the development of vaccine-elicited protective antibodies against CSP.
    Mesh-Begriff(e) Animals ; Antibodies, Protozoan ; Antibody Formation ; Germinal Center ; Malaria ; Malaria Vaccines ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Protozoan Proteins/genetics
    Chemische Substanzen Antibodies, Protozoan ; Malaria Vaccines ; Protozoan Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-07-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010671
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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