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  1. Article ; Online: Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin against COVID-19.

    Sathyamoorthy, NandhaKumar / Chintamaneni, Pavan Kumar / Chinni, Santhivardhan

    Medical hypotheses

    2020  Volume 144, Page(s) 110011

    MeSH term(s) Chlorpromazine/administration & dosage ; Drug Synergism ; Humans ; Hydrogen-Ion Concentration ; Inhibitory Concentration 50 ; Models, Theoretical ; Teicoplanin/administration & dosage ; COVID-19 Drug Treatment
    Chemical Substances Teicoplanin (61036-62-2) ; Chlorpromazine (U42B7VYA4P)
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Shielding Therapeutic Drug Carriers from the Mononuclear Phagocyte System: A Review.

    Sathyamoorthy, Nandhakumar / Dhanaraju, Magharla Dasaratha

    Critical reviews in therapeutic drug carrier systems

    2016  Volume 33, Issue 6, Page(s) 489–567

    Abstract: The mononuclear phagocyte system (MPS) defends the body against the invasion of microorganisms by phagocytosis. In the presence of opsonins, the invading matter is readily recognized by phagocytes because of the interaction between receptors on the ... ...

    Abstract The mononuclear phagocyte system (MPS) defends the body against the invasion of microorganisms by phagocytosis. In the presence of opsonins, the invading matter is readily recognized by phagocytes because of the interaction between receptors on the phagocytic cell surfaces and the modified conformation of opsonins. The particulate carriers, which are otherwise capable of optimizing drug delivery, are subjected to opsonization and phagocytosis by the MPS immediately following intravenous administration. These drug carriers should remain in the bloodstream in order to spatially locate the drug to the target site and temporally control the drug's release from there on; however, they are devastated by opsonization by serum proteins. Therefore, to restrict opsonization, which is critical for recognition of particulate carriers by the MPS, stealth devices have been developed by engineering the carriers' surface characteristics. Physicochemical properties that influence protein immunogenicity include particle size, surface charge, and surface hydrophobicity. Steric stabilization using polyethylene glycol (PEG) and polyethylene oxide (PEO) chains attached to the particle surface is principally effective in preventing the adsorption of serum opsonins. This article reviews the literature on the MPS and its development and functions, as well as approaches for designing long-circulating carrier particles. It also comprehensively reviews parameters affecting the steric characteristics of drug carriers, such as particle size, shape, surface charge, and surface affinity, including PEGylation of carriers.
    MeSH term(s) Drug Carriers/chemistry ; Humans ; Hydrophobic and Hydrophilic Interactions ; Opsonin Proteins/blood ; Opsonin Proteins/chemistry ; Opsonin Proteins/immunology ; Particle Size ; Phagocytes/immunology ; Phagocytosis ; Polyethylene Glycols/chemistry ; Static Electricity ; Surface Properties
    Chemical Substances Drug Carriers ; Opsonin Proteins ; Polyethylene Glycols (30IQX730WE)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2012632-3
    ISSN 2162-660X ; 0743-4863
    ISSN (online) 2162-660X
    ISSN 0743-4863
    DOI 10.1615/CritRevTherDrugCarrierSyst.2016012303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2124: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin against COVID-19

    Sathyamoorthy, NandhaKumar / Chintamaneni, Pavan Kumar / Chinni, Santhivardhan

    Med Hypotheses

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #608983
    Database COVID19

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  4. Article ; Online: Plausible role of combination of Chlorpromazine hydrochloride and Teicoplanin against COVID-19

    Sathyamoorthy, NandhaKumar / Chintamaneni, Pavan Kumar / Chinni, Santhivardhan

    Medical Hypotheses

    2020  Volume 144, Page(s) 110011

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110011
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Effect of Surface Modification on the

    Sathyamoorthy, Nandhakumar / Magharla, Dhanaraju Dasaratha / Vankayalu, Sundar Devendaran

    Journal of pharmacy & bioallied sciences

    2016  Volume 9, Issue 2, Page(s) 135–143

    Abstract: Context: Nanocarriers possessing long-circulating abilities could take advantage of the pathophysiology of tumor vasculature to achieve spatial placement. To attain such qualities, the drug carriers should possess suitable physicochemical properties ... ...

    Abstract Context: Nanocarriers possessing long-circulating abilities could take advantage of the pathophysiology of tumor vasculature to achieve spatial placement. To attain such qualities, the drug carriers should possess suitable physicochemical properties such as size and surface hydrophilicity.
    Aim: The aim of this study was to prepare poly(ε-caprolactone) nanoparticles (NPs) loaded with vinorelbine bitartrate (VB) and to modify its steric properties using polyethylene glycol and poloxamer. Furthermore, the influence of surface modification of NPs on their physicochemical and cell interactive properties was evaluated.
    Materials and methods: NPs were prepared by double emulsion solvent extraction-evaporation technique. The prepared NPs were evaluated for their physicochemical properties,
    Results and discussion: The NPs were <250 nm with an entrapment efficiency ranging between 40% and 52%. The zeta potential of the NPs varied from -7.52 mV to -1.27 mV depending on the surface modification. The
    Conclusion: The results emphasize that surface modification of nanocarriers is an essential and effective tool to dodge opsonization and phagocytosis in the physiological milieu.
    Language English
    Publishing date 2016-03-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.JPBS_258_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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