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Article ; Online: Outbreak investigation in cargo ship in times of COVID-19 crisis, Port of Santos, Brazil.

Fernandes, Eder Gatti / Santos, Janice da Silva / Sato, Helena Keico

2020 Volume 54, Page(s) 34

Abstract: In February 2020, a Chinese cargo ship docked at the Port of Santos with reports of crew members with a feverish and respiratory condition. A team was gathered to verify the existence of suspected cases of COVID-19 inside the vessel and define its ... ...

Abstract	In February 2020, a Chinese cargo ship docked at the Port of Santos with reports of crew members with a feverish and respiratory condition. A team was gathered to verify the existence of suspected cases of COVID-19 inside the vessel and define its clearance. All 25 crew members were interviewed, and no suspected cases were found. The vessel was then cleared for port activities. The investigation resulted from the implementation of the contingency plan to face a public health emergency of international importance and several surveillance entities cooperated.
MeSH term(s)	Adult ; Brazil ; COVID-19 ; China/ethnology ; Communicable Disease Control/methods ; Coronavirus Infections/prevention & control ; Disease Outbreaks/prevention & control ; Humans ; Indonesia/ethnology ; Male ; Middle Aged ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Ships ; Young Adult
Keywords	covid19
Language	Portuguese
Publishing date	2020-03-30
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	732179-x
ISSN	1518-8787 ; 0034-8910
ISSN (online)	1518-8787
ISSN	0034-8910
DOI	10.11606/s1518-8787.2020054002461
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Book ; Online: Outbreak investigation in cargo ship in times of COVID-19 crisis, Port of Santos, Brazil

Fernandes, Eder Gatti / Santos, Janice da Silva / Sato, Helena Keico

Revista de Saúde Pública v.54 2020

2020

Abstract: ABSTRACT In February 2020, a Chinese cargo ship docked at the Port of Santos with reports of crew members with a feverish and respiratory condition. A team was gathered to verify the existence of suspected cases of COVID-19 inside the vessel and define ... ...

Abstract	ABSTRACT In February 2020, a Chinese cargo ship docked at the Port of Santos with reports of crew members with a feverish and respiratory condition. A team was gathered to verify the existence of suspected cases of COVID-19 inside the vessel and define its clearance. All 25 crew members were interviewed, and no suspected cases were found. The vessel was then cleared for port activities. The investigation resulted from the implementation of the contingency plan to face a public health emergency of international importance and several surveillance entities cooperated.
Keywords	Coronavirus Infections ; epidemiology ; prevention & ; control ; Ships ; International Health Regulations ; covid19
Language	English
Publishing date	2020-01-01
Publisher	Faculdade de Saúde Pública da Universidade de São Paulo
Publishing country	br
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vaccines for post-exposure prophylaxis against varicella (chickenpox) in children and adults.

Sato, Helena Keico

Sao Paulo medical journal = Revista paulista de medicina

2012 Volume 130, Issue 2, Page(s) 133

Language	English
Publishing date	2012-03-08
Publishing country	Brazil
Document type	Comment ; Journal Article
ZDB-ID	1203171-9
ISSN	1806-9460 ; 1516-3180 ; 0035-0362
ISSN (online)	1806-9460
ISSN	1516-3180 ; 0035-0362
DOI	10.1590/s1516-31802012000200014
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Article: Outbreak investigation in cargo ship in times of COVID-19 crisis, Port of Santos, Brazil

Fernandes, Eder Gatti / Santos, Janice da Silva / Sato, Helena Keico

Rev Saude Publica

Abstract	In February 2020, a Chinese cargo ship docked at the Port of Santos with reports of crew members with a feverish and respiratory condition. A team was gathered to verify the existence of suspected cases of COVID-19 inside the vessel and define its clearance. All 25 crew members were interviewed, and no suspected cases were found. The vessel was then cleared for port activities. The investigation resulted from the implementation of the contingency plan to face a public health emergency of international importance and several surveillance entities cooperated.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #34154
Database	COVID19

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Article ; Online: Investigação de surto em navio de carga em tempo de COVID-19, Porto de Santos, Brasil ; Outbreak investigation in cargo ship in times of COVID-19 crisis, Port of Santos, Brazil

Fernandes, Eder Gatti / Santos, Janice da Silva / Sato, Helena Keico

Revista de Saúde Pública; v.; 34 ; Revista de Saúde Pública; Vol 54 (2020); 34 ; Revista de Saúde Pública; Vol. 54 (2020); 34 ; 1518-8787 ; 0034-8910

2020 Volume 54

Abstract: Em fevereiro de 2020, um navio de carga vindo da China atracou no Porto de Santos com relato de tripulantes com quadro febril e respiratório. Uma equipe foi mobilizada para verificar a existência de casos suspeitos de COVID-19 dentro da embarcação e ... ...

Abstract	Em fevereiro de 2020, um navio de carga vindo da China atracou no Porto de Santos com relato de tripulantes com quadro febril e respiratório. Uma equipe foi mobilizada para verificar a existência de casos suspeitos de COVID-19 dentro da embarcação e definir a liberação da embarcação no porto. Todos os 25 tripulantes foram entrevistados e não foram encontrados casos suspeitos. Então a embarcação foi liberada para atividades no porto. A investigação resultou da aplicação do plano de contingência diante de uma emergência de saúde pública de importância internacional e houve a colaboração de diversas entidades de vigilância. In February 2020, a Chinese cargo ship docked at the Port of Santos with reports of crew members with a feverish and respiratory condition. A team was gathered to verify the existence of suspected cases of COVID-19 inside the vessel and define its clearance. All 25 crew members were interviewed, and no suspected cases were found. The vessel was then cleared for port activities. The investigation resulted from the implementation of the contingency plan to face a public health emergency of international importance and several surveillance entities cooperated.
Keywords	Coronavirus Infections ; epidemiology ; prevention & control ; Ships ; International Health Regulations ; Infecções por Coronavirus ; epidemiologia ; prevenção & controle ; Navios ; Regulamento Sanitário Internacional ; covid19
Language	English
Publishing date	2020-04-23
Publisher	Universidade de São Paulo. Faculdade de Saúde Pública
Publishing country	br
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The search for yellow fever virus vaccine in breast milk of inadvertently vaccinated women in Brazil.

Fernandes, Eder Gatti / Nogueira, Juliana Silva / Porto, Victor Bertollo Gomes / Sato, Helena Keico

Revista do Instituto de Medicina Tropical de Sao Paulo

2020 Volume 62, Page(s) e33

Abstract: Eleven lactating women were inadvertently vaccinated with 17DD yellow fever vaccine in a small city of Sao Paulo State, Brazil. Their infants were being exclusively breast-fed and the breastfeeding was interrupted for 10 days. Serum and breastmilk were ... ...

Abstract	Eleven lactating women were inadvertently vaccinated with 17DD yellow fever vaccine in a small city of Sao Paulo State, Brazil. Their infants were being exclusively breast-fed and the breastfeeding was interrupted for 10 days. Serum and breastmilk were collected from the vaccinated mothers and tested for the presence of genomic RNA of the vaccine strain 8, 10 and 15 days after vaccination. Viral RNA was not detected in any of the serum and human milk samples tested and the infants remained asymptomatic. Our result strengthens the effectineness of stopping breastfeeding for 10 days after the inadvertent yellow fever vaccination of lactating women.
MeSH term(s)	Antibodies, Viral/blood ; Antigens, Viral/blood ; Brazil ; Breast Feeding/adverse effects ; Female ; Humans ; Infant, Newborn ; Milk, Human/virology ; RNA, Viral/blood ; Yellow Fever/prevention & control ; Yellow Fever/transmission ; Yellow Fever Vaccine/administration & dosage ; Yellow Fever Vaccine/adverse effects ; Yellow fever virus/immunology
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; RNA, Viral ; Yellow Fever Vaccine
Language	English
Publishing date	2020-05-29
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/s1678-9946202062033
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Article ; Online: Yellow Fever Vaccine-Associated Viscerotropic Disease among Siblings, São Paulo State, Brazil.

Fernandes, Eder Gatti / Gomes Porto, Victor Bertollo / de Oliveira, Patrícia Mouta Nunes / Duarte-Neto, Amaro Nunes / de Sousa Maia, Maria de Lourdes / Lignani, Letícia Kegele / Nogueira, Juliana Silva / Teixeira, Gabriellen Vitiello / Iglezias, Silvia D'Andretta / Blanco, Roberta Morozetti / Sato, Helena Keico

Emerging infectious diseases

2023 Volume 29, Issue 3, Page(s) 493–500

Abstract: We describe 5 cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) in 2 familial clusters during the 2017-2018 yellow fever (YF) vaccination campaign in São Paulo state, Brazil. The first case was that of a 40-year-old white man who ... ...

Abstract	We describe 5 cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) in 2 familial clusters during the 2017-2018 yellow fever (YF) vaccination campaign in São Paulo state, Brazil. The first case was that of a 40-year-old white man who died of icterohemorrhagic syndrome, which was confirmed to be YEL-AVD by using real-time reverse transcription PCR to detect 17DD YF vaccine in the liver. Ten years previously, his brother died of a clinically similar disease without a confirmed diagnosis 9 days after YF vaccination. The second cluster included 3 of 9 siblings in whom hepatitis developed in the first week after receiving fractionated doses of YF vaccine. Two of them died of hemorrhagic diathesis and renal and respiratory failure, and 17DD-YF vaccine was detected in serum samples from all patients and in the liver in 1 case. Genetic factors might play a substantial role in the incidence of YEL-AVD.
MeSH term(s)	Male ; Humans ; Adult ; Yellow Fever Vaccine ; Siblings ; Brazil ; Yellow Fever/epidemiology ; Vaccination ; Antigens, Viral
Chemical Substances	Yellow Fever Vaccine ; Antigens, Viral
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2903.220989
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Article ; Online: Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil.

Silva, Patricia Vieira da / Oliveira, Silvano Barbosa de / Escalante, Juan José Cortez / Almiron, Maria / Tsuha, Daniel Henrique / Sato, Helena Keico / Menezes, Paulo Rossi / Paula, Regiane Cardoso de / D'Agostini, Tatiana Lang / Croda, Julio

The American journal of tropical medicine and hygiene

2021 Volume 105, Issue 1, Page(s) 88–92

Abstract: São Paulo is a state in Brazil with one of the highest numbers of confirmed and severe cases of coronavirus disease (COVID-19), with an incidence of 294 hospitalizations per 100,000 inhabitants. We report the clinical characteristics and outcomes of 120, ... ...

Abstract	São Paulo is a state in Brazil with one of the highest numbers of confirmed and severe cases of coronavirus disease (COVID-19), with an incidence of 294 hospitalizations per 100,000 inhabitants. We report the clinical characteristics and outcomes of 120,804 hospitalized patients with confirmed COVID-19 from February 26 to October 10, 2020, in São Paulo. Characteristics of patients who died and survived were compared using a survival analysis. The median age was 60 years (interquartile range [IQR], 47-72), 67,821 (56.1%) were men, and 61,659 (51.0%) were white. Most hospitalized patients (79,812; 66.1%) reported one or more comorbidities, 41,708 (34.5%) hospitalized patients were admitted to intensive care units, and 33,079 (27.4%) died. Men (hazard ratio [HR], 1.22; 95% confidence interval [CI], 1.18-1.25), elderly individuals (HR, 3.85; 95% CI, 3.68-4.02), and patients with chronic cardiovascular disease including hypertension (HR, 1.05; 95% CI, 1.02-1.08), chronic lung disease (HR, 1.38; 95% CI, 1.31-1.45), diabetes mellitus (HR, 1.14; 95% CI, 1.11-1.18), and chronic neurological disease (HR, 1.48; 95% CI, 1.41-1.55) were at higher risk for death from COVID-19.
MeSH term(s)	Adult ; Aged ; Brazil/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/mortality ; Cardiovascular Diseases/complications ; Central Nervous System Diseases/complications ; Diabetes Mellitus ; Female ; Humans ; Inpatients ; Lung Diseases/complications ; Male ; Middle Aged ; Risk Factors ; SARS-CoV-2
Language	English
Publishing date	2021-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-1598
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Article ; Online: Adverse events following Quadrivalent HPV vaccination reported in Sao Paulo State, Brazil, in the first three years after introducing the vaccine for routine immunization (March 2014 to December 2016).

Mauro, Alexandre Blikstad / Fernandes, Eder Gatti / Miyaji, Karina Takesaki / Arantes, Benedito Antônio / Valente, Maria Gomes / Sato, Helena Keico / Sartori, Ana Marli C

Revista do Instituto de Medicina Tropical de Sao Paulo

2019 Volume 61, Page(s) e43

Abstract: In March 2014, the Quadrivalent human papilloma virus vaccine (4vHPV) was introduced in the female adolescents vaccination schedule of the National Immunization Program (PNI). A school-based vaccination program was implemented. We conducted a ... ...

Abstract	In March 2014, the Quadrivalent human papilloma virus vaccine (4vHPV) was introduced in the female adolescents vaccination schedule of the National Immunization Program (PNI). A school-based vaccination program was implemented. We conducted a retrospective, descriptive study of the adverse events that took place after HPV vaccination, reported to the Adverse Events Following Immunization (AEFI) Information System in Sao Paulo State, from March 2014 to December 2016. All reports that fit the definitions of the 2014 National Manual on AEFI surveillance were included. AEFI risk was estimated by dividing the number of reports by the number of vaccine doses administered in the period. In the three-year period, 3,390,376 HPV vaccine doses were administered and 465 AEFI reports were registered, with 1,378 signs and symptoms. The reporting rate was 13.72 per 100,000 vaccine doses administered. The reports peaked in the first year of the program. The most frequent AEFI was syncope, with 5.7 reports per 100,000 doses administered, followed by dizziness, malaise, headache and nausea. Overall, 39 AEFI cases (8.4%) were classified as severe , with a reporting rate of 1.15 per 100,000 vaccine doses administered. Most cases were classified as severe because of hospitalization. Among them, there were cases of Guillain-Barré Syndrome, deep vein thrombosis, seizures and miscarriage. All young women recovered without sequelae. We identified five clusters of AEFI reports in four cities; the larger AEFI cluster occurred in the city of Bertioga, in September 2014, involving 13 female adolescents. Our data are in accordance with those from other countries and corroborate the safety of HPV vaccines.
MeSH term(s)	Adolescent ; Adult ; Adverse Drug Reaction Reporting Systems ; Brazil/epidemiology ; Child ; Female ; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18/administration & dosage ; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18/adverse effects ; Humans ; Immunization Schedule ; Papillomavirus Infections/prevention & control ; Population Surveillance ; Retrospective Studies ; Young Adult
Chemical Substances	Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
Language	English
Publishing date	2019-09-12
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/S1678-9946201961043
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Article ; Online: Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in inadvertently vaccinated healthy children.

Fernandes, Eder Gatti / López-Lopes, Giselle Ibette Silva / Silva, Valeria Oliveira / Yamashiro, Rosemeire / Madureira, Karen Cristina Rolim / Gallo, Juliana Failde / Lindoso, José Angelo / Sato, Helena Keico / de Araujo, Núbia Virginia D'Avila Limeira / Nerger, Maria Ligia Bacciotte Ramos / Brigido, Luis Fernando Macedo

Revista do Instituto de Medicina Tropical de Sao Paulo

2021 Volume 63, Page(s) e83

Abstract: Twenty-seven children aged seven months to 5 years were inadvertently vaccinated with a COVID-19 vaccine, the CoronaVac (Sinovac, China), an inactivated SARS-CoV-2 vaccine, in two different cities of Sao Paulo State, Brazil. After the event, these ... ...

Abstract	Twenty-seven children aged seven months to 5 years were inadvertently vaccinated with a COVID-19 vaccine, the CoronaVac (Sinovac, China), an inactivated SARS-CoV-2 vaccine, in two different cities of Sao Paulo State, Brazil. After the event, these children were monitored by local pediatricians and serum samples were collected at the first visit and 30 days after vaccination and tested for SARS-CoV-2 S1 serology with Ortho total IgG anti-S1 protein and Cpass, an ACE2 receptor binding domain inhibition assay. Only one child had a mild symptom after vaccination, with no other adverse events documented up to the 30 days follow-up. Of 27 children tested 3-9 days after vaccination, 5 (19%) had positive serology suggesting a previous natural SARS-CoV-2 infection, with all 19 tested on day 30 after vaccination and presenting with positive tests, with an increment of antibody titers in those initially positive. A low Cpass binding inhibition was observed in the first collection in 11 seronegative cases, with high titers among those anti-S1 positive. All children showed an important increase in antibody titers on day 30. The event allowed the documentation of a robust serological response to one dose of CoronaVac in this small population of young children, with no major adverse effects. Although it was an unfortunate accident, this event may contribute with future vaccine strategies in this age group. The data suggest that CoronaVac is safe and immunogenic for children.
MeSH term(s)	Antibodies, Viral ; Brazil ; COVID-19 ; COVID-19 Vaccines ; Child ; Child, Preschool ; Humans ; SARS-CoV-2
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	English
Publishing date	2021-12-06
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/S1678-9946202163083
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