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  1. Article ; Online: Rat mandibular condyle and fossa grew separately then unified as a single joint at 20 days old, which was the weaning age.

    Satoh, Keitaro / Satoh, Kaori / Imaizumi-Ohashi, Yoshie / Yokoi-Hayakawa, Mika / Fukada, Toshiyuki / Seo, Yoshiteru

    Journal of oral science

    2020  Volume 62, Issue 2, Page(s) 197–201

    Abstract: Magnetic resonance imaging (MRI) was used to observe growth of the mandibular condyle, mandibular fossa, and articular disc as a single unit. Changes in each component's relative position and size were observed using 7-tesla MRI. Mandibular condyle ... ...

    Abstract Magnetic resonance imaging (MRI) was used to observe growth of the mandibular condyle, mandibular fossa, and articular disc as a single unit. Changes in each component's relative position and size were observed using 7-tesla MRI. Mandibular condyle chondrocytes' growth was evaluated with immunohistochemistry, using the expression of zinc transporter ZIP13. Three-dimensional T
    MeSH term(s) Animals ; Magnetic Resonance Imaging ; Mandibular Condyle ; Rats ; Rats, Sprague-Dawley ; Temporomandibular Joint ; Weaning
    Language English
    Publishing date 2020-01-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1434462-2
    ISSN 1880-4926 ; 1343-4934
    ISSN (online) 1880-4926
    ISSN 1343-4934
    DOI 10.2334/josnusd.19-0202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epidemiological and molecular characterization of invasive Streptococcus pneumoniae isolated following introduction of 7-valent conjugate vaccine in Kinki region, Japan, 2008-2013.

    Toda, Hirofumi / Tanaka, Yuji / Satoh, Kaori / Komatsu, Masaru / Wada, Yasunao / Tobe, Toru / Kamisako, Toshinori

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2019  Volume 26, Issue 5, Page(s) 451–458

    Abstract: Streptococcus pneumoniae is one of the most common bacteria causing community-acquired pneumonia and meningitis. The use of 7-valent pneumococcal conjugate vaccine (PCV7) has reduced the incidence of pneumococcal disease while changing pneumococcal ... ...

    Abstract Streptococcus pneumoniae is one of the most common bacteria causing community-acquired pneumonia and meningitis. The use of 7-valent pneumococcal conjugate vaccine (PCV7) has reduced the incidence of pneumococcal disease while changing pneumococcal population through herd immunity and non-vaccine pneumococci replacement. This study investigated molecular epidemiologic characteristics of pneumococcal strains in the Kinki region of Japan from 2008 to 2013. A total of 159 invasive pneumococcal isolates were characterized by serotyping, antibiotic susceptibility testing, PCR analysis of penicillin-binding protein genes, multilocus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE). In adult populations, pediatric PCV7 introduction decreased isolates expressing PCV7 serotypes via herd immunity and increased isolates expressing non-PCV7 serotypes. The rate of penicillin resistance and isolates with alterations in all three pbp genes was higher in PCV7 type isolates than in non-PCV7 type isolates. In MLST analysis, all of serotype 19F isolates were of the same sequence type, ST236, which is the antimicrobial-resistant clone Taiwan
    MeSH term(s) Adolescent ; Adult ; Child ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/genetics ; Community-Acquired Infections/microbiology ; Community-Acquired Infections/prevention & control ; Electrophoresis, Gel, Pulsed-Field ; Heptavalent Pneumococcal Conjugate Vaccine/therapeutic use ; Humans ; Immunologic Factors/therapeutic use ; Japan/epidemiology ; Microbial Sensitivity Tests ; Molecular Epidemiology ; Multilocus Sequence Typing ; Penicillin Resistance ; Penicillin-Binding Proteins/genetics ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/genetics ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/prevention & control ; Serogroup ; Serotyping ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/isolation & purification ; Vaccines, Conjugate/therapeutic use
    Chemical Substances Heptavalent Pneumococcal Conjugate Vaccine ; Immunologic Factors ; Penicillin-Binding Proteins ; Vaccines, Conjugate
    Language English
    Publishing date 2019-12-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2019.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Structure and Size-selective Permeability of the Synovial Membrane of the Temporomandibular Joint of the Mouse Measured by MR Imaging at 7T.

    Yamazaki, Fumie / Satoh, Kaori / Seo, Yoshiteru

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

    2015  Volume 14, Issue 2, Page(s) 115–122

    Abstract: Purpose: We analyzed the anatomical structure of the temporomandibular joint (TMJ) and molecular weight dependency of synovial membrane permeability in mice using 7-tesla magnetic resonance (MR) imaging.: Methods: We obtained 3-dimensional (3D) T1- ... ...

    Abstract Purpose: We analyzed the anatomical structure of the temporomandibular joint (TMJ) and molecular weight dependency of synovial membrane permeability in mice using 7-tesla magnetic resonance (MR) imaging.
    Methods: We obtained 3-dimensional (3D) T1-weighted gradient echo (3D-T1W) and 3D T2-weighted rapid acquisition with relaxation enhancement (3D-T2W RARE) MR images of the TMJ of male C57BL6 mice with voxel resolution of 65 µm. Two-dimensional (2D) T1w images were measured every 45 s before and after bolus intravenous (IV) injection of contrast reagents: gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA; 0.5 kDa); oligomer-based contrast agent (CH3-DTPA-Gd; 2.1 kDa); gadolinium-labeled polylysine (Gd-polylysine; 10 kDa); and gadolinium-labeled albumin (Gd-albumin; 74 kDa).
    Results: T1W images depicted the temporal bone and mandibular condyle as regions with lower signal intensity and the disc as a region of intermediate intensity. In the Gd-DTPA-enhanced T1W and T2W images, the articular disc could be identified as a region with lower signal intensity than that of the upper and lower joint cavities. After IV injection of Gd-DTPA or CH3-DTPA-Gd, the signal intensity of the joint cavities increased within 10 min, but this increase was not shown with Gd-polylysine and Gd-albumin.
    Conclusion: The structural findings obtained by MR imaging agreed with those obtained by hematoxylin-eosin staining under light microscopy. Contrast-enhanced MR imaging suggested that smaller (<2.1 kDa) but not larger (>10 kDa) molecules can permeate the synovial membrane. Our results suggest the utility of MR imaging for analyzing the structure of the TMJ as well as permeability of the synovial membrane.
    MeSH term(s) Albumins/administration & dosage ; Albumins/pharmacokinetics ; Animals ; Contrast Media/administration & dosage ; Contrast Media/pharmacokinetics ; Gadolinium DTPA/administration & dosage ; Gadolinium DTPA/pharmacokinetics ; Imaging, Three-Dimensional/methods ; Injections, Intravenous ; Magnetic Resonance Imaging/methods ; Male ; Mandibular Condyle/anatomy & histology ; Mandibular Condyle/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Weight ; Permeability ; Polylysine/administration & dosage ; Polylysine/analogs & derivatives ; Polylysine/pharmacokinetics ; Synovial Membrane/anatomy & histology ; Synovial Membrane/metabolism ; Temporal Bone/anatomy & histology ; Temporal Bone/metabolism ; Temporomandibular Joint/anatomy & histology ; Temporomandibular Joint/metabolism ; Temporomandibular Joint Disc/anatomy & histology ; Temporomandibular Joint Disc/metabolism
    Chemical Substances Albumins ; Contrast Media ; albumin-(gadolinium-DTPA) ; polylysine-(Gd-DTPA) ; Polylysine (25104-18-1) ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2015
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2217833-8
    ISSN 1880-2206 ; 1347-3182
    ISSN (online) 1880-2206
    ISSN 1347-3182
    DOI 10.2463/mrms.2014-0058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical effectiveness of direct resin composite restorations bonded using one-step or two-step self-etch adhesive systems: A three-year multicenter study.

    Hosaka, Keiichi / Kubo, Shisei / Tichy, Antonin / Ikeda, Masaomi / Shinkai, Koichi / Maseki, Toshio / Rikuta, Akitomo / Sasazaki, Hiromi / Satoh, Kaori / Fujitani, Morioki / Hanabusa, Masao / Yamamoto, Takatsugu / Yoshikawa, Kazushi / Morigami, Makoto / Uno, Shigeru / Sugizaki, Junpei / Yatani, Hirofumi / Nikaido, Toru

    Dental materials journal

    2021  Volume 40, Issue 5, Page(s) 1151–1159

    Abstract: The purpose of this multicenter clinical study was to compare the mid-term clinical effectiveness of direct resin composite restorations using one-step or two-step self-etch adhesives (1-SEAs or 2-SEAs). In total, 352 restorations of class I-V cavities ... ...

    Abstract The purpose of this multicenter clinical study was to compare the mid-term clinical effectiveness of direct resin composite restorations using one-step or two-step self-etch adhesives (1-SEAs or 2-SEAs). In total, 352 restorations of class I-V cavities and non-carious cervical lesions in vital teeth (1-SEAs; 52 cases, 2-SEAs; 300 cases) were placed at nine university hospitals and evaluated according to the modified USPHS criteria at baseline, and after 1, 2, and 3 years. The recall rates were 86.6% (1 year), 80.1% (2 years), and 62.2% (3 years). Two restorations failed due to fracture during the follow-up, and there was no significant difference in survival rates between 1-SEAs (97.6%) and 2-SEAs (99.4%). However, 2-SEAs exhibited significantly lower occurrences of discoloration, marginal discoloration, fracture, and plaque retention. Moreover, the subjects reported a significantly lower postoperative hypersensitivity and higher overall satisfaction at all evaluation periods if 2-SEAs were used.
    MeSH term(s) Composite Resins ; Dental Cements ; Dental Marginal Adaptation ; Dental Restoration, Permanent ; Dentin-Bonding Agents ; Humans ; Resin Cements ; Tooth Cervix ; Treatment Outcome
    Chemical Substances Composite Resins ; Dental Cements ; Dentin-Bonding Agents ; Resin Cements
    Language English
    Publishing date 2021-05-21
    Publishing country Japan
    Document type Journal Article ; Multicenter Study
    ZDB-ID 605650-7
    ISSN 1881-1361 ; 0287-4547
    ISSN (online) 1881-1361
    ISSN 0287-4547
    DOI 10.4012/dmj.2020-428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of Scoliosis on Laparoscopic Nissen Fundoplication.

    Ishimaru, Tetsuya / Sugiyama, Masahiko / Arai, Mari / Satoh, Kaori / Uotani, Chizue / Takahashi, Masataka / Takami, Shohei / Fujishiro, Jun / Iwanaka, Tadashi

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2016  Volume 26, Issue 11, Page(s) 930–933

    Abstract: Aim: Scoliosis, which is often associated with neurological impairment in children, sometimes makes it difficult to perform laparoscopic procedures. This study assessed the impact of scoliosis on performing laparoscopic Nissen fundoplication.: Methods! ...

    Abstract Aim: Scoliosis, which is often associated with neurological impairment in children, sometimes makes it difficult to perform laparoscopic procedures. This study assessed the impact of scoliosis on performing laparoscopic Nissen fundoplication.
    Methods: Medical records and radiographic examinations of patients who underwent laparoscopic Nissen fundoplication at a single institution from 2006 to 2015 were reviewed retrospectively. Patients' data on age at surgery, height, weight, duration of pneumoperitoneum, and amount of bleeding were collected. The Cobb angle was measured using X-rays, and the direction (right or left) of the scoliotic curve was recorded. The chest compression ratio was calculated using computed tomography axial images.
    Results: Eighty-five patients were included and analyzed in this study, of which 89% were neurologically impaired. Median age, height, and weight were 120 months, 110 cm, and 17 kg, respectively. A positive correlation between age and the Cobb angle (ρ = 0.64) and a negative correlation between age and the chest compression ratio (ρ = -0.56) were observed. The right-curved scoliotic group showed significantly more bleeding than the nonscoliotic (<10°) group (P = .01; nonscoliotic, 0 mL; right curved, 7.5 mL; left curved, 0 mL). The severe scoliotic group (≥45°) showed more bleeding than the nonscoliotic group (P = .02). Neither the direction of the scoliotic curve nor scoliotic severity showed a significant difference in the duration of pneumoperitoneum.
    Conclusions: The older the patient, the more severe their scoliosis and chest compression were. Right-curved or severe scoliosis could be risk factors for intraoperative bleeding in laparoscopic Nissen fundoplication.
    MeSH term(s) Adolescent ; Age Factors ; Body Weight ; Child ; Child, Preschool ; Female ; Fundoplication/methods ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/surgery ; Humans ; Laparoscopy/methods ; Male ; Operative Time ; Pneumoperitoneum, Artificial/statistics & numerical data ; Radiography ; Retrospective Studies ; Scoliosis/complications ; Scoliosis/diagnostic imaging ; Severity of Illness Index ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2608063-1
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2016.0173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [TDM management system for contribution to proper use of anti-mRSA drugs--establishment of cooperation support system between pharmacy and clinical laboratory in hospital].

    Yodoshi, Masahiro / Iwasaki, Naomi / Satoh, Kaori / Nomura, Morihiro / Morishima, Yoshiyuki / Nakae, Kenichi / Yamazoe, Yuzuru

    Rinsho byori. The Japanese journal of clinical pathology

    2013  Volume 61, Issue 2, Page(s) 127–134

    Abstract: In team medicine, highly specialized pharmacists have recently been in demand. As one of the specialties, there is therapeutic drug monitoring (TDM). It is important for the optimal dosing of a wide range of drugs. In our hospital, a TDM service was ... ...

    Abstract In team medicine, highly specialized pharmacists have recently been in demand. As one of the specialties, there is therapeutic drug monitoring (TDM). It is important for the optimal dosing of a wide range of drugs. In our hospital, a TDM service was started in 1987 at the clinical laboratory. A clinical laboratory technologist with the license of a pharmacist has performed administration plans for anti-methicillin-resistant Staphylococcus aureus (MRSA) drugs, vancomycin, teicoplanin, and arbekacin. In particular, the pharmacist in charge of TDM services, a TDM-specialized pharmacist, plays a central role in administration plans for anti MRSA drugs. Furthermore, we examined the active use of the TDM service to expand pharmaceutical care. Therefore, at first, we have worked in partnership with the clinical laboratory, as it is called the "Cooperation Support System", since September 2010. As a result, after the introduction of this system, from August 2011 to July 2012, the rate that the doctor referred to the administration plan was markedly improved by approximately 90%. We have been able to enhance TDM in practical training for pharmacology as an extension of this system. We thought that drug therapy can be performed more appropriately by increasing the number of executions of TDM in the future. For drug therapy to be done more appropriately, efforts made through cooperation with the clinical laboratory are essential for an effective TDM system. Naturally, an effective TDM process requires a collaborative, multidisciplinary approach with input from doctors, nurses, and clinical pharmacists.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Drug Monitoring ; Hospitals ; Humans ; Laboratories, Hospital ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Pharmaceutical Services ; Pharmacists
    Chemical Substances Anti-Bacterial Agents
    Language Japanese
    Publishing date 2013-02
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604196-6
    ISSN 0047-1860 ; 0485-1404
    ISSN 0047-1860 ; 0485-1404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Magnetic resonance imaging of the temporomandibular joint in the rat compared with low-powered light microscopy.

    Satoh, Kaori / Satoh, Keitaro / Imaizumi, Yoshie / Yokoi, Mika / Kondoh, Toshirou / Murakami, Masataka / Seo, Yoshiteru

    Archives of oral biology

    2011  Volume 56, Issue 11, Page(s) 1382–1389

    Abstract: Objective: High magnetic field magnetic resonance imaging (MRI) was applied to the temporomandibular joint (TMJ) in the rat. The purpose of this study was the depiction of the internal structure of the TMJ, including the articular disc, articular ... ...

    Abstract Objective: High magnetic field magnetic resonance imaging (MRI) was applied to the temporomandibular joint (TMJ) in the rat. The purpose of this study was the depiction of the internal structure of the TMJ, including the articular disc, articular cartilage, and the upper and lower joint cavities. We also proposed MRI settings and slices suitable for imaging the TMJ in the rat.
    Methods: Temporomandibular joints from one female and eight male Sprague Dawley rats (5-8 weeks old) and four male Wistar-Hamamatsu rats (7-8 weeks old) were used. Using scout images, the horizontal plane was defined as being parallel to the body of the basisphenoid bone underneath the base of the brain. The coronal plane was defined as a slice vertical to the horizontal plane and vertical to the longitudinal fissure of the cerebrum. The sagittal plane was defined as a slice vertical to the horizontal plane and parallel to the longitudinal fissure of the cerebrum.
    Results: T(1)-weighted MR images with a spatial resolution of 75 μm were obtained for 5 min. The temporal bone and mandibular condyle were depicted as lower signal intensity images and the articular disc was depicted as an intermediate signal intensity image. In accordance with Gd-DTPA-enhanced MR or T(2)-weighted MR images, the articular disc, articular cartilage, and the upper and lower joint cavities could be assigned clearly.
    Conclusion: These MRI findings closely agreed with those observed with haematoxylin-eosin staining under light microscopy, suggesting that MRI is a useful method for analyzing the complex structure of the TMJ in the rat.
    MeSH term(s) Animals ; Cartilage, Articular/anatomy & histology ; Contrast Media ; Female ; Gadolinium DTPA ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging/methods ; Male ; Mandibular Condyle/anatomy & histology ; Microscopy ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Temporal Bone/anatomy & histology ; Temporomandibular Joint/anatomy & histology ; Temporomandibular Joint Disc/anatomy & histology
    Chemical Substances Contrast Media ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2011-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2011.03.024
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  8. Article ; Online: Holding but not restriction.

    Kudoh, Hisashi / Satoh, Kaori / Bohra, Satoshi / Yamamoto, Taeko / Fujii, Masahiko / Sasaki, Hidetada

    Geriatrics & gerontology international

    2010  Volume 10, Issue 3, Page(s) 264–266

    MeSH term(s) Aged ; Aged, 80 and over ; Anxiety/etiology ; Anxiety/therapy ; Dementia/complications ; Female ; Humans ; Male ; Manikins ; Physical Therapy Modalities ; Relaxation Therapy/methods ; Restraint, Physical/instrumentation
    Language English
    Publishing date 2010-07
    Publishing country Japan
    Document type Letter ; Randomized Controlled Trial
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/j.1447-0594.2010.00615.x
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  9. Article ; Online: Nosocomial spread of Klebsiella pneumoniae isolates producing bla

    Yamasaki, Katsutoshi / Komatsu, Masaru / Ono, Tamotsu / Nishio, Hisaaki / Sueyoshi, Noriyuki / Kida, Kaneyuki / Satoh, Kaori / Toda, Hirofumi / Nishi, Isao / Akagi, Masahiro / Mizutani, Tetsu / Nakai, Isako / Kofuku, Tomomi / Orita, Tamaki / Zikimoto, Takuya / Nakamura, Tatsuya / Wada, Yasunao

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2017  Volume 23, Issue 1, Page(s) 40–44

    Abstract: Six Klebsiella pneumoniae clinical isolates resistant to various cephalosporins and cephamycins were identified in a Japanese general hospital, a tertiary care hospital, between November 2009 and April 2010. All K. pneumoniae isolates carried ... ...

    Abstract Six Klebsiella pneumoniae clinical isolates resistant to various cephalosporins and cephamycins were identified in a Japanese general hospital, a tertiary care hospital, between November 2009 and April 2010. All K. pneumoniae isolates carried bla
    MeSH term(s) Aged ; Aged, 80 and over ; Bacterial Proteins/metabolism ; Cephalosporins/metabolism ; Cross Infection/microbiology ; Electrophoresis, Gel, Pulsed-Field/methods ; Female ; Hospitals ; Humans ; Japan ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/isolation & purification ; Klebsiella pneumoniae/metabolism ; Male ; Middle Aged ; Plasmids/metabolism ; beta-Lactamases/metabolism
    Chemical Substances Bacterial Proteins ; Cephalosporins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2017-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2016.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Laboratory surveillance of antimicrobial resistance and multidrug resistance among Streptococcus pneumoniae isolated in the Kinki region of Japan, 2001-2015.

    Toda, Hirofumi / Satoh, Kaori / Komatsu, Masaru / Fukuda, Saori / Nakamura, Tatsuya / Jikimoto, Takumi / Nishio, Hisaaki / Yamasaki, Katsutoshi / Maede, Takuya / Orita, Tamaki / Sueyoshi, Noriyuki / Kita, Machiko / Toyokawa, Masahiro / Nishi, Isao / Akagi, Masahiro / Higuchi, Takefumi / Kofuku, Tomomi / Nakai, Isako / Ono, Tamotsu /
    Shimakawa, Koichi / Hikita, Yoshie / Moro, Kunihiko / Kida, Kaneyuki / Oohama, Masanobu / Wada, Yasunao / Tobe, Toru / Kamisako, Toshinori / Tanaka, Yuji

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2018  Volume 24, Issue 3, Page(s) 171–176

    Abstract: The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced among children in Japan in 2010. There are no long-term multicenter surveillance studies of antimicrobial resistance in S. pneumoniae before and after the introduction of PCV7. Therefore, ... ...

    Abstract The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced among children in Japan in 2010. There are no long-term multicenter surveillance studies of antimicrobial resistance in S. pneumoniae before and after the introduction of PCV7. Therefore, we examined chronological trends in antimicrobial resistance among 4534 strains of S. pneumoniae isolated from both children and adults in the Kinki region of Japan during 2001-2015. High-level penicillin and third-generation cephalosporin resistance in S. pneumoniae increased among both children and adults during the period before the introduction of PCV7 (2001-2010). Besides penicillin and cephalosporin, pneumococcal carbapenem and macrolide resistance increased among children. The rate of resistance to these antibiotics was higher among children than among adults. The introduction of PCV7 decreased the rate of non-susceptibility to β-lactam antibiotics and the rate of multidrug resistant S. pneumoniae among children, but not among adults.
    MeSH term(s) Adult ; Carbapenems/therapeutic use ; Cephalosporins/therapeutic use ; Child ; Drug Resistance, Multiple, Bacterial ; Epidemiological Monitoring ; Heptavalent Pneumococcal Conjugate Vaccine/administration & dosage ; Humans ; Japan/epidemiology ; Macrolides/therapeutic use ; Penicillins/therapeutic use ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/prevention & control ; Retrospective Studies ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/isolation & purification
    Chemical Substances Carbapenems ; Cephalosporins ; Heptavalent Pneumococcal Conjugate Vaccine ; Macrolides ; Penicillins
    Language English
    Publishing date 2018-02-01
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2017.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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