LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Satoh, Ryosuke"
  2. AU="Geeviman, Khamushavalli"
  3. AU="Cuenca-Estrella, Manuel"
  4. AU="Liljeström, Simon"
  5. AU="de Beltrán, Paula"
  6. AU="Bhatti, Asim"
  7. AU="Giménez Pardo, Consuelo"
  8. AU=Pollock Jennifer S AU=Pollock Jennifer S
  9. AU=Yakar Halil Ibrahim
  10. AU="O'Hara, Montana"
  11. AU="Connor, Jean A"
  12. AU="Wozniak, Kinga A"
  13. AU="Manjila, Sunil"
  14. AU="Gaviria-Cantin, Tania"
  15. AU="Pickett, Brett E"
  16. AU="Lee, Seung Yeol"
  17. AU="Waters, Aubri M"
  18. AU="Tremblay, Cyntia"
  19. AU="Sharafeldin, Tamer A"
  20. AU="Alladio, Francesca"
  21. AU="Cheng, Zhiluo"
  22. AU="Silva, Dândara Santos"
  23. AU="Timmann, Dagmar"
  24. AU="Jingping, Lin"
  25. AU="Yoon, Sangwook"
  26. AU="Sedor, John R."
  27. AU="Legrand, Julien"
  28. AU="Mintz, Kevin Todd"
  29. AU="Kösters, Markus"
  30. AU="Castano-Duque, Lina"
  31. AU="Lowry, Gregory V"
  32. AU="Gao, Xiaojuan"
  33. AU="Daniłowicz-Szymanowicz, Ludmiła"
  34. AU="Weber, Jesse N"
  35. AU="Fages-Masmiquel, Ester"
  36. AU="Macias Gil, Raul"
  37. AU="Planchat, Arnaud"
  38. AU="McElrath, Erin E"
  39. AU="Koji Ueda"
  40. AU="Pillas, Diana J"
  41. AU="Thomson, Jason J"
  42. AU="Mitra, Kalyan"
  43. AU="Sanjay Desai"
  44. AU=Cox David J AU=Cox David J
  45. AU="Grebenok, Robert J."
  46. AU="Blackburne, Brittney"
  47. AU="Bortoleti, Bruna Taciane da Silva"
  48. AU="Ehrbar, Martin"
  49. AU="Lepre, Davide"
  50. AU="Olszewska, Zuzanna"
  51. AU="Vojta, Leslie"
  52. AU=Wickstrom Eric AU=Wickstrom Eric
  53. AU="Gangavarapu, Sridevi"
  54. AU="Hussein, Hazem Abdelwaheb"
  55. AU=Cai Yixin AU=Cai Yixin
  56. AU="Hüls, Anke"
  57. AU="Poondru, Srinivasu"
  58. AU="Coca, Daniel"
  59. AU="Lebeau, Paul"
  60. AU="Dehghani, Sedigheh"
  61. AU="Ishibashi, Kenji"
  62. AU="Xu, Yanhua"
  63. AU="Matera, Katarzyna"
  64. AU="Ait-Ouarab, Slimane"
  65. AU="Nicola, Coppede"
  66. AU="Dewitt, John M"
  67. AU="Sorin M. Dudea"
  68. AU="Tanusha D. Ramdin"
  69. AU="Hao, Zehui"
  70. AU="Chauhan, Aman"

Suchergebnis

Treffer 1 - 10 von insgesamt 53

Suchoptionen

  1. Buch ; Online: RuLa

    Satoh, Ryosuke

    A Programming Language for RuleSet-based Quantum Repeaters

    2023  

    Abstract: Quantum Repeaters are one critical technology for scalable quantum networking. One of the key challenges regarding quantum repeaters is their management of how they provide quantum entanglement for distant quantum computers. We focus on the RuleSet ... ...

    Abstract Quantum Repeaters are one critical technology for scalable quantum networking. One of the key challenges regarding quantum repeaters is their management of how they provide quantum entanglement for distant quantum computers. We focus on the RuleSet architecture, which is a decentralized way to manage repeaters. The RuleSet concept is designed to scale up the management of quantum repeaters for future quantum repeaters, suitable because of its flexibility and asynchronous operation, however, it is still at the conceptual level of definition and it is very hard to define raw RuleSets. In this thesis, we introduce a new programming language, called "RuLa", to write the RuleSets in an intuitive and coherent way. The way RuLa defines RuleSet and Rule is very similar to how the Rule and RuleSets are executed so that the programmer can construct the RuleSets the way they want repeaters to execute them. We provide some examples of how the RuleSets are defined in RuLa and what is the output of the compilation. We also discussed future use cases and applications of this language.
    Schlagwörter Quantum Physics ; Computer Science - Programming Languages
    Thema/Rubrik (Code) 190
    Erscheinungsdatum 2023-05-16
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: [The Molecular Basis of Drug Discovery Targeting the Regulatory Mechanism of MAPK Signaling via the Spatial Regulation of RNA-binding Proteins].

    Satoh, Ryosuke

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2019  Band 139, Heft 1, Seite(n) 7–12

    Abstract: Mitogen-activated protein kinase (MAPK) is a highly conserved serine/threonine kinase that regulates multiple cellular processes such as cell proliferation, differentiation, apoptosis, and inflammation. Rnc1 has been identified as a regulator of Pmk1 ... ...

    Abstract Mitogen-activated protein kinase (MAPK) is a highly conserved serine/threonine kinase that regulates multiple cellular processes such as cell proliferation, differentiation, apoptosis, and inflammation. Rnc1 has been identified as a regulator of Pmk1 MAPK signaling, a homologue of extracellular signal-regulated kinase (ERK)-1 MAPK in mammals. Rnc1 encodes a K-homology (KH)-type RNA-binding protein (RBP). Previously, it was reported that Rnc1 acts as a negative regulator of Pmk1 MAPK signaling through the mRNA stabilization of Pmp1, the MAPK phosphatase for Pmk1 in our laboratory. We analyzed the spatial regulation of Rnc1 and discovered that Rnc1 is exported from the nucleus by the mRNA-export system. The nuclear export of Rnc1 is important for exerting its function to stabilize Pmp1 mRNA. Therefore, the spatial regulation of Rnc1 affects MAPK signaling activity. We also reported that Nrd1, an RRM-type RBP, plays a critical role in cytokinesis by binding to and stabilizing myosin mRNA. Notably, Rnc1 and Nrd1 localize to stress granules (SGs) in response to various environmental stresses. Moreover, SG formation is inhibited in the Nrd1 or Rnc1 deletion cells, whereas the overproduction of Nrd1 or Rnc1, as well as that of mammalian RBP TIA-1, induces granule formation. These data show that Nrd1 and Rnc1 regulate SG formation as a novel SG component. Alterations of SG formation are linked to neurodegenerative diseases and resistance to anti-cancer drugs, thus conferring remarkable clinical importance to SGs. This review discusses the spatial regulation of RBPs or SG formation as novel targets for drug discovery.
    Mesh-Begriff(e) Animals ; Cytoplasmic Granules/metabolism ; Drug Discovery ; Humans ; MAP Kinase Signaling System/physiology ; Metalloendopeptidases ; Mitogen-Activated Protein Kinases/physiology ; Molecular Targeted Therapy ; RNA-Binding Proteins/metabolism ; Schizosaccharomyces ; Schizosaccharomyces pombe Proteins
    Chemische Substanzen RNA-Binding Proteins ; Schizosaccharomyces pombe Proteins ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Pmk1 protein, S pombe (EC 2.7.11.24) ; Metalloendopeptidases (EC 3.4.24.-) ; NRDC protein, human (EC 3.4.24.61)
    Sprache Japanisch
    Erscheinungsdatum 2019-01-03
    Erscheinungsland Japan
    Dokumenttyp Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.18-00189
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 643: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: [Regulation of translation initiation via signal transduction].

    Satoh, Ryosuke

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2016  Band 147, Heft 6, Seite(n) 368–369

    Mesh-Begriff(e) Animals ; Eukaryotic Initiation Factor-2/metabolism ; Eukaryotic Initiation Factor-4F/metabolism ; Humans ; Mechanistic Target of Rapamycin Complex 1 ; Multiprotein Complexes/metabolism ; Phosphorylation ; Protein Binding ; Protein Biosynthesis ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Chemische Substanzen Eukaryotic Initiation Factor-2 ; Eukaryotic Initiation Factor-4F ; Multiprotein Complexes ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Sprache Japanisch
    Erscheinungsdatum 2016-06
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.147.368
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 439: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Rcn1, the fission yeast homolog of human DSCR1, regulates arsenite tolerance independently from calcineurin.

    Takasaki, Teruaki / Bamba, Asuka / Kukita, Yuka / Nishida, Aiko / Kanbayashi, Daiki / Hagihara, Kanako / Satoh, Ryosuke / Ishihara, Keiichi / Sugiura, Reiko

    Genes to cells : devoted to molecular & cellular mechanisms

    2024  

    Abstract: Calcineurin (CN) is a conserved ... ...

    Abstract Calcineurin (CN) is a conserved Ca
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/gtc.13122
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4539: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Atg1, a key regulator of autophagy, functions to promote MAPK activation and cell death upon calcium overload in fission yeast.

    Takasaki, Teruaki / Utsumi, Ryosuke / Shimada, Erika / Bamba, Asuka / Hagihara, Kanako / Satoh, Ryosuke / Sugiura, Reiko

    Microbial cell (Graz, Austria)

    2023  Band 10, Heft 6, Seite(n) 133–140

    Abstract: Autophagy promotes or inhibits cell death depending on the environment and cell type. Our previous findings suggested that Atg1 is genetically involved in the regulation of Pmk1 MAPK in fission yeast. Here, we showed that ... ...

    Abstract Autophagy promotes or inhibits cell death depending on the environment and cell type. Our previous findings suggested that Atg1 is genetically involved in the regulation of Pmk1 MAPK in fission yeast. Here, we showed that Δ
    Sprache Englisch
    Erscheinungsdatum 2023-05-10
    Erscheinungsland Austria
    Dokumenttyp Journal Article
    ZDB-ID 2814756-X
    ISSN 2311-2638
    ISSN 2311-2638
    DOI 10.15698/mic2023.06.798
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel ; Online: ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer.

    Sugiura, Reiko / Satoh, Ryosuke / Takasaki, Teruaki

    Cells

    2021  Band 10, Heft 10

    Abstract: The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally promotes cell proliferation, and its deregulated activity is a hallmark ... ...

    Abstract The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally promotes cell proliferation, and its deregulated activity is a hallmark of many cancers. Therefore, components and regulators of the ERK pathway are considered potential therapeutic targets for cancer, and inhibitors of this pathway, including some MEK and BRAF inhibitors, are already being used in the clinic. Notably, ERK1/2 kinases also have pro-apoptotic functions under certain conditions and enhanced ERK1/2 signaling can cause tumor cell death. Although the repertoire of the compounds which mediate ERK activation and apoptosis is expanding, and various anti-cancer compounds induce ERK activation while exerting their anti-proliferative effects, the mechanisms underlying ERK1/2-mediated cell death are still vague. Recent studies highlight the importance of dual-specificity phosphatases (DUSPs) in determining the pro- versus anti-apoptotic function of ERK in cancer. In this review, we will summarize the recent major findings in understanding the role of ERK in apoptosis, focusing on the major compounds mediating ERK-dependent apoptosis. Studies that further define the molecular targets of these compounds relevant to cell death will be essential to harnessing these compounds for developing effective cancer treatments.
    Mesh-Begriff(e) Apoptosis/drug effects ; Apoptosis/physiology ; Dual-Specificity Phosphatases/metabolism ; Humans ; MAP Kinase Signaling System/drug effects ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Protein Kinase Inhibitors/pharmacology ; Signal Transduction/drug effects
    Chemische Substanzen Protein Kinase Inhibitors ; Dual-Specificity Phosphatases (EC 3.1.3.48)
    Sprache Englisch
    Erscheinungsdatum 2021-09-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10102509
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Distinct spatiotemporal distribution of Hsp90 under high-heat and mild-heat stress conditions in fission yeast.

    Takasaki, Teruaki / Tomimoto, Naofumi / Ikehata, Takumi / Satoh, Ryosuke / Sugiura, Reiko

    microPublication biology

    2021  Band 2021

    Abstract: The molecular chaperone Hsp90 is highly conserved from bacteria to mammals. In fission yeast, Hsp90 is essential in many cellular processes and its expression is known to be increased by heat stress (HS). Here, we describe the distinct spatiotemporal ... ...

    Abstract The molecular chaperone Hsp90 is highly conserved from bacteria to mammals. In fission yeast, Hsp90 is essential in many cellular processes and its expression is known to be increased by heat stress (HS). Here, we describe the distinct spatiotemporal distribution of Hsp90 under high-heat stress (HHS: 45˚C) and mild-heat stress (MHS: 37˚C). Hsp90 is largely distributed in the cytoplasm under non-stressed conditions (27˚C). Under HHS, Hsp90 forms several cytoplasmic granules within 5 minutes, then the granules disappear within 60 minutes. Under MHS, Hsp90 forms fewer granules than under HHS within 5 minutes and strikingly the granules persist and grow in size. In addition, nuclear enrichment of Hsp90 was observed after 60 minutes under both HS conditions. Our data suggest that assembly/disassembly of Hsp90 granules is differentially regulated by temperatures.
    Sprache Englisch
    Erscheinungsdatum 2021-05-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000388
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: Autophagy-related genes genetically interact with Pmk1 MAPK signaling in fission yeast.

    Takasaki, Teruaki / Utsumi, Ryosuke / Shimada, Erika / Tomimoto, Naofumi / Satoh, Ryosuke / Sugiura, Reiko

    microPublication biology

    2022  Band 2022

    Abstract: Apart from the highly conserved role in the cellular degradation process, autophagy also appears to play a key role in cellular proliferation. Here, we describe the genetic interaction of autophagy-related genes and Pmk1 MAPK signaling in fission yeast. ...

    Abstract Apart from the highly conserved role in the cellular degradation process, autophagy also appears to play a key role in cellular proliferation. Here, we describe the genetic interaction of autophagy-related genes and Pmk1 MAPK signaling in fission yeast.
    Sprache Englisch
    Erscheinungsdatum 2022-08-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000618
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel ; Online: Fission Yeast PUF Proteins Puf3 and Puf4 Are Novel Regulators of PI4P5K Signaling.

    Satoh, Ryosuke / Tanaka, Taemi / Yoshida, Nobuyasu / Tanaka, Chiaki / Takasaki, Teruaki / Sugiura, Reiko

    Biological & pharmaceutical bulletin

    2022  Band 46, Heft 2, Seite(n) 163–169

    Abstract: Phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) is a highly conserved enzyme that generates phosphatidylinositol-4,5-bisphosphate (PI(4,5) ... ...

    Abstract Phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) is a highly conserved enzyme that generates phosphatidylinositol-4,5-bisphosphate (PI(4,5)P
    Mesh-Begriff(e) RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Schizosaccharomyces/enzymology ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism
    Chemische Substanzen 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) ; RNA, Messenger ; RNA-Binding Proteins ; Schizosaccharomyces pombe Proteins ; PUF3 protein, S cerevisiae ; PUF4 protein, S cerevisiae
    Sprache Englisch
    Erscheinungsdatum 2022-04-06
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b22-00569
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1474: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  10. Artikel ; Online: ACA-28, an anticancer compound, induces Pap1 nuclear accumulation via ROS-dependent and -independent mechanisms in fission yeast.

    Takasaki, Teruaki / Obana, Reo / Fujiwara, Daiki / Tomimoto, Naofumi / Khandakar, Golam Iftakhar / Satoh, Ryosuke / Sugiura, Reiko

    microPublication biology

    2023  Band 2023

    Abstract: The nucleocytoplasmic transport of proteins is an important mechanism to control cell fate. Pap1 is a fission yeast nucleocytoplasmic shuttling transcription factor of which localization is redox regulated. The nuclear export factor Crm1/exportin ... ...

    Abstract The nucleocytoplasmic transport of proteins is an important mechanism to control cell fate. Pap1 is a fission yeast nucleocytoplasmic shuttling transcription factor of which localization is redox regulated. The nuclear export factor Crm1/exportin negatively regulates Pap1 by exporting it from the nucleus to the cytoplasm. Here, we describe the effect of an anti-cancer compound ACA-28, an improved derivative of 1'-acetoxychavicol acetate (ACA), on the subcellular distribution of Pap1. ACA-28 induced nuclear accumulation of Pap1 more strongly than did ACA. ROS inhibitor N-acetyl-L-cysteine (NAC) partly antagonized the Pap1 nuclear accumulation induced by ACA-28. NAC almost abolished Pap1 nuclear localization upon H
    Sprache Englisch
    Erscheinungsdatum 2023-08-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000711
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang