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  1. Article: COVID-19 Vaccines and Assisted Reproductive Techniques: A Systematic Review.

    Satorres-Pérez, Elena / Martínez-Varea, Alicia / Morales-Roselló, José

    Journal of personalized medicine

    2023  Volume 13, Issue 8

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13081232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The sFlt-1/PlGF Ratio at 12, 24, and 32 Weeks Gestation in Twin Pregnancies as a Predictor of Placental Dysfunction.

    Satorres-Pérez, Elena / Martínez-Varea, Alicia / Novillo-Del Álamo, Blanca / Morales-Roselló, José / Diago-Almela, Vicente

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cerebroplacental Ratio as a Predictive Factor of Emergency Cesarean Sections for Intrapartum Fetal Compromise: A Systematic Review.

    Novillo-Del Álamo, Blanca / Martínez-Varea, Alicia / Satorres-Pérez, Elena / Nieto-Tous, Mar / Bello-Martínez de Velasco, Silvia / García-Florenciano, María Victoria / Padilla-Prieto, Carmen / Modrego-Pardo, Fernando / Morales-Roselló, José

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of aging on the human myometrium at single-cell resolution.

    Punzon-Jimenez, Paula / Machado-Lopez, Alba / Perez-Moraga, Raul / Llera-Oyola, Jaime / Grases, Daniela / Galvez-Viedma, Marta / Sibai, Mustafa / Satorres-Perez, Elena / Lopez-Agullo, Susana / Badenes, Rafael / Ferrer-Gomez, Carolina / Porta-Pardo, Eduard / Roson, Beatriz / Simon, Carlos / Mas, Aymara

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 945

    Abstract: Age-associated myometrial dysfunction can prompt complications during pregnancy and labor, which is one of the factors contributing to the 7.8-fold increase in maternal mortality in women over 40. Using single-cell/single-nucleus RNA sequencing and ... ...

    Abstract Age-associated myometrial dysfunction can prompt complications during pregnancy and labor, which is one of the factors contributing to the 7.8-fold increase in maternal mortality in women over 40. Using single-cell/single-nucleus RNA sequencing and spatial transcriptomics, we have constructed a cellular atlas of the aging myometrium from 186,120 cells across twenty perimenopausal and postmenopausal women. We identify 23 myometrial cell subpopulations, including contractile and venous capillary cells as well as immune-modulated fibroblasts. Myometrial aging leads to fewer contractile capillary cells, a reduced level of ion channel expression in smooth muscle cells, and impaired gene expression in endothelial, smooth muscle, fibroblast, perivascular, and immune cells. We observe altered myometrial cell-to-cell communication as an aging hallmark, which associated with the loss of 25 signaling pathways, including those related to angiogenesis, tissue repair, contractility, immunity, and nervous system regulation. These insights may contribute to a better understanding of the complications faced by older individuals during pregnancy and labor.
    MeSH term(s) Pregnancy ; Humans ; Female ; Myometrium/metabolism ; Labor, Obstetric/genetics ; Labor, Obstetric/metabolism ; Muscle, Smooth ; Aging/genetics ; Muscle Contraction
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45143-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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