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  1. AU="Sattin, Tommaso"
  2. AU="Embke, Holly S"
  3. AU="Marie‐Alix Derieppe"
  4. AU="Dindar, Kemal" AU="Dindar, Kemal"
  5. AU="Dupéré-Richer, Daphne"
  6. AU="Talia Gutman"
  7. AU="Coroyer, Lucas"
  8. AU="Norred, Carol L"
  9. AU="Pejić, Tomislav"
  10. AU=Popovitchenko Tatiana AU=Popovitchenko Tatiana
  11. AU=Lee Jiun
  12. AU="Ricklund, Niklas"
  13. AU="Doyle, Taylor"
  14. AU="McLaughlin, Katie A" AU="McLaughlin, Katie A"
  15. AU="Konrad Grützmann"
  16. AU=Pulido Amada
  17. AU="Malawski, Maciej"
  18. AU="Luquain-Costaz, Céline"
  19. AU=Channin David S
  20. AU="Chiba, Takahito"
  21. AU="Jeffcoat, A. Robert"
  22. AU=Scappatura Giuseppe
  23. AU=Sakaguchi Atsumi
  24. AU="Rodriguez-Cabello, Jose C"
  25. AU=Merter Ayse Arducoglu
  26. AU="Ewers, U."
  27. AU="Reichling, Jürgen"
  28. AU="Eichner, Timo"
  29. AU="Seunghee Kim-Schulze"
  30. AU=Ozaki Shoichi
  31. AU="Clerici, Giovanna" AU="Clerici, Giovanna"
  32. AU="Firoz Ahmed"
  33. AU="Dżugan, Małgorzata"
  34. AU="Rolf Bjerkvig"
  35. AU=Khosravi-Far Roya
  36. AU="Udeochu, Joe C"
  37. AU="Osoba, Osonde A." AU="Osoba, Osonde A."
  38. AU="Palani, Sowmiya"
  39. AU="Manfred Frick"
  40. AU="Jensen, Leonard"
  41. AU="Pakhomov, Evgeny A."
  42. AU="Subramanyam, Chithirala Bala"
  43. AU=Petrek J A
  44. AU="Thomson-Baker, B"
  45. AU=Shahidi Shahrzad
  46. AU="Taylor, Holly A"
  47. AU="Yeong Jeong Jeon"
  48. AU="Bueno-Cavanillas, Aurora"
  49. AU="Kavčič, Tina"
  50. AU="Arias-Jiménez, José Luís"
  51. AU="Tünçok, Ekin"
  52. AU="Roberto Toro"
  53. AU="Bharti Sahu"
  54. AU="Soo-Yeon Choi"
  55. AU="Nono, Sandra"
  56. AU="Diepens, Robin J W"
  57. AU="Baselga-Garriga, Clara"

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  1. Artikel ; Online: Novel SCN5A gene mutation in a patient affected by multifocal ectopic premature Purkinje-related contractions syndrome.

    Ventrella, Nicoletta / Bianchini, Lorenzo / Riva, Stefania / Pizzamiglio, Francesca / Dessanai, Maria Antonietta / Tundo, Fabrizio / Sattin, Tommaso / De Lio, Francesca / Cellucci, Selene / Tondo, Claudio

    ESC heart failure

    2024  

    Abstract: We report the case of a 36-year-old woman who presented to the emergency department complaining of palpitations and asthenia. Investigations showed frequent ventricular ectopy and severe left ventricular ejection fraction impairment. She was diagnosed ... ...

    Abstract We report the case of a 36-year-old woman who presented to the emergency department complaining of palpitations and asthenia. Investigations showed frequent ventricular ectopy and severe left ventricular ejection fraction impairment. She was diagnosed with a peculiar condition defined multifocal ectopic premature Purkinje-related contractions syndrome, which in some cases can be associated with a dilated cardiomyopathy phenotype. Genetic testing showed a novel mutation in the SCN5A gene (c.673C > G). In the context of acute left ventricular dysfunction in a young patient, we discuss the clinical presentation of this rare condition and its clinical management, as well as its genetic substrate.
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14677
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Omics Analyses of Stromal Cells from ACM Patients Reveal Alterations in Chromatin Organization and Mitochondrial Homeostasis.

    Lippi, Melania / Maione, Angela Serena / Chiesa, Mattia / Perrucci, Gianluca Lorenzo / Iengo, Lara / Sattin, Tommaso / Cencioni, Chiara / Savoia, Matteo / Zeiher, Andreas M / Tundo, Fabrizio / Tondo, Claudio / Pompilio, Giulio / Sommariva, Elena

    International journal of molecular sciences

    2023  Band 24, Heft 12

    Abstract: Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder characterized by ventricular arrhythmias, contractile dysfunctions and fibro-adipose replacement of myocardium. Cardiac mesenchymal stromal cells (CMSCs) participate in disease pathogenesis by ... ...

    Abstract Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder characterized by ventricular arrhythmias, contractile dysfunctions and fibro-adipose replacement of myocardium. Cardiac mesenchymal stromal cells (CMSCs) participate in disease pathogenesis by differentiating towards adipocytes and myofibroblasts. Some altered pathways in ACM are known, but many are yet to be discovered. We aimed to enrich the understanding of ACM pathogenesis by comparing epigenetic and gene expression profiles of ACM-CMSCs with healthy control (HC)-CMSCs. Methylome analysis identified 74 differentially methylated nucleotides, most of them located on the mitochondrial genome. Transcriptome analysis revealed 327 genes that were more expressed and 202 genes that were less expressed in ACM- vs. HC-CMSCs. Among these, genes implicated in mitochondrial respiration and in epithelial-to-mesenchymal transition were more expressed, and cell cycle genes were less expressed in ACM- vs. HC-CMSCs. Through enrichment and gene network analyses, we identified differentially regulated pathways, some of which never associated with ACM, including mitochondrial functioning and chromatin organization, both in line with methylome results. Functional validations confirmed that ACM-CMSCs exhibited higher amounts of active mitochondria and ROS production, a lower proliferation rate and a more pronounced epicardial-to-mesenchymal transition compared to the controls. In conclusion, ACM-CMSC-omics revealed some additional altered molecular pathways, relevant in disease pathogenesis, which may constitute novel targets for specific therapies.
    Mesh-Begriff(e) Humans ; Myocardium ; Mesenchymal Stem Cells/metabolism ; Adipocytes ; Homeostasis ; Chromatin/genetics ; Chromatin/metabolism
    Chemische Substanzen Chromatin
    Sprache Englisch
    Erscheinungsdatum 2023-06-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Live integration of comprehensive cardiac CT with electroanatomical mapping in patients with refractory ventricular tachycardia.

    Conte, Edoardo / Carbucicchio, Corrado / Catto, Valentina / Kochi, Adriano Nunes / Mushtaq, Saima / De Iuliis, Pasquale Giovanni / Guglielmo, Marco / Baggiano, Andrea / Sattin, Tommaso / Pontone, Gianluca / Pepi, Mauro / Tondo, Claudio / Andreini, Daniele

    Journal of cardiovascular computed tomography

    2021  Band 16, Heft 3, Seite(n) 262–265

    Abstract: Background: Aim of the present study was to verify the feasibility and accuracy of live integration of myocardial fibrosis evaluated at CCT with EAM (electro-anatomical mapping).: Methods: We prospectively enrolled a consecutive cohort of patients ... ...

    Abstract Background: Aim of the present study was to verify the feasibility and accuracy of live integration of myocardial fibrosis evaluated at CCT with EAM (electro-anatomical mapping).
    Methods: We prospectively enrolled a consecutive cohort of patients with clinical indication to EAM before radiofrequency catheter ablation (RFCA) of refractory ventricular tachycardia (VT) and an absolute contraindication to cardiac magnetic resonance. All patients underwent per protocol CCT for myocardial fibrosis and coronary anatomy evaluation. Diagnostic performance was assessed for myocardial fibrosis evaluation with CCT vs EAM. Live integration feasibility of CCT vs EAM was evaluated for every patients.
    Results: A total of 19 patients were included in the present study with 323 myocardial segments analyzed for myocardial fibrosis at CCT. In all patients CCT data were successfully integrated with EAM during RFCA procedure. All patients had myocardial fibrosis correctly identified at CCT vs EAM on a per-patients basis. A diagnostic accuracy on a per-segment basis of 94.1% for detection of any type of myocardial fibrosis at CCT vs EAM was recorded.
    Conclusions: CCT identification of myocardial fibrosis is feasible and accurate vs EAM in a very selected high risk patients with clinical indication to RFCA of VT and contraindication to CMR.
    Mesh-Begriff(e) Cardiomyopathies ; Catheter Ablation/adverse effects ; Fibrosis ; Humans ; Predictive Value of Tests ; Tachycardia, Ventricular/diagnostic imaging ; Tachycardia, Ventricular/surgery ; Tomography, X-Ray Computed
    Sprache Englisch
    Erscheinungsdatum 2021-12-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2021.12.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The role of indocyanine green videoangiography with FLOW 800 analysis for the surgical management of central nervous system tumors: an update.

    Acerbi, Francesco / Vetrano, Ignazio G / Sattin, Tommaso / de Laurentis, Camilla / Bosio, Lorenzo / Rossini, Zefferino / Broggi, Morgan / Schiariti, Marco / Ferroli, Paolo

    Neurosurgical focus

    2018  Band 44, Heft 6, Seite(n) E6

    Abstract: OBJECTIVE Indocyanine green videoangiography (ICG-VA) is an intraoperative technique used to highlight vessels in neurovascular surgery. Its application in the study of the vascular pathophysiology in CNS tumors and its role in their surgical management ... ...

    Abstract OBJECTIVE Indocyanine green videoangiography (ICG-VA) is an intraoperative technique used to highlight vessels in neurovascular surgery. Its application in the study of the vascular pathophysiology in CNS tumors and its role in their surgical management are still rather limited. A recent innovation of ICG-VA (i.e., the FLOW 800 algorithm integrated in the surgical microscope) allows a semiquantitative evaluation of cerebral blood flow. The aim of this study was to evaluate for the first time the systematic application of ICG-VA and FLOW 800 analysis during surgical removal of CNS tumors. METHODS Between May 2011 and December 2017, all cases in which ICG-VA and FLOW 800 analysis were used at least one time before, during, or after the tumor resection, and in which surgical videos were available, were retrospectively reviewed. Results of the histological analysis were analyzed together with the intraoperative ICG-VA with FLOW 800 in order to investigate the tumor-related videoangiographic features. RESULTS Seventy-one patients who underwent surgery for cerebral and spinal tumors were intraoperatively analyzed using ICG-VA with FLOW 800, either before or after tumor resection, for a total of 93 videoangiographic studies. The histological diagnosis was meningioma in 25 cases, glioma in 14, metastasis in 7, pineal region tumor in 5, hemangioblastoma in 4, chordoma in 3, and other histological types in 13 cases. The authors identified 4 possible applications of ICG-VA and FLOW 800 in CNS tumor surgery: extradural surveys allowed exploration of sinus patency and the course of veins before dural opening; preresection surveys helped in identifying pathological vascularization (arteriovenous fistulas and neo-angiogenesis) and regional venous outflow, and in performing temporary venous clipping tests, when necessary; postresection surveys were conducted to evaluate arterial and venous patency and parenchymal perfusion after tumor removal; and a premyelotomy survey was conducted in intramedullary tumors to highlight the posterior median sulcus. CONCLUSIONS The authors found ICG-VA with FLOW 800 to be a useful method to monitor blood flow in the exposed vessels and parenchyma during microsurgical removal of CNS tumors in selected cases. In particular, a preresection survey provides useful information about pathophysiological changes of brain vasculature related to the tumor and aids in the individuation of helpful landmarks for the surgical approach, and the postresection survey helps to prevent potential complications associated with the resection (such as local hypoperfusion or venous infarction).
    Mesh-Begriff(e) Central Nervous System Neoplasms/diagnostic imaging ; Central Nervous System Neoplasms/surgery ; Cerebral Angiography/methods ; Coloring Agents ; Databases, Factual ; Disease Management ; Humans ; Indocyanine Green ; Intraoperative Neurophysiological Monitoring/methods
    Chemische Substanzen Coloring Agents ; Indocyanine Green (IX6J1063HV)
    Sprache Englisch
    Erscheinungsdatum 2018-05-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2018.3.FOCUS1862
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Use of ICG videoangiography and FLOW 800 analysis to identify the patient-specific venous circulation and predict the effect of venous sacrifice: a retrospective study of 172 patients.

    Acerbi, Francesco / Vetrano, Ignazio G / Sattin, Tommaso / Falco, Jacopo / de Laurentis, Camilla / Zattra, Costanza M / Bosio, Lorenzo / Rossini, Zefferino / Broggi, Morgan / Schiariti, Marco / Ferroli, Paolo

    Neurosurgical focus

    2018  Band 45, Heft 1, Seite(n) E7

    Abstract: OBJECTIVE The best management of veins encountered during the neurosurgical approach is still a matter of debate. Even if venous sacrifice were to lead to devastating consequences, under certain circumstances, it might prove to be desirable, enlarging ... ...

    Abstract OBJECTIVE The best management of veins encountered during the neurosurgical approach is still a matter of debate. Even if venous sacrifice were to lead to devastating consequences, under certain circumstances, it might prove to be desirable, enlarging the surgical field or increasing the extent of resection in tumor surgery. In this study, the authors present a large series of patients with vascular or oncological entities, in which they used indocyanine green videoangiography (ICG-VA) with FLOW 800 analysis to study the patient-specific venous flow characteristics and the management workflow in cases in which a venous sacrifice was necessary. METHODS Between May 2011 and December 2017, 1972 patients were admitted to the authors' division for tumor and/or neurovascular surgery. They retrospectively reviewed all cases in which ICG-VA and FLOW 800 were used intraoperatively with a specific target in the venous angiographic phase or for the management of venous sacrifice, and whose surgical videos and FLOW 800 analysis were available. RESULTS A total of 296 ICG-VA and FLOW 800 studies were performed intraoperatively. In all cases, the venous structures were clearly identifiable and were described according to the flow direction and speed. The authors therefore defined different patterns of presentation: arterialized veins, thrombosed veins, fast-draining veins with anterograde flow, slow-draining veins with anterograde flow, and slow-draining veins with retrograde flow. In 16 cases we also performed a temporary clipping test to predict the effect of the venous sacrifice by the identification of potential collateral circulation. CONCLUSIONS ICG-VA and FLOW 800 analysis can provide complete and real-time intraoperative information regarding patient-specific venous drainage pattern and can guide the decision-making process regarding venous sacrifice, with a possible impact on reduction of surgical complications.
    Mesh-Begriff(e) Cerebral Angiography/methods ; Cerebral Veins/diagnostic imaging ; Cerebral Veins/surgery ; Cerebrovascular Circulation/physiology ; Collateral Circulation/physiology ; Coloring Agents ; Humans ; Indocyanine Green ; Monitoring, Intraoperative/methods ; Neurosurgical Procedures/methods ; Predictive Value of Tests ; Retrospective Studies
    Chemische Substanzen Coloring Agents ; Indocyanine Green (IX6J1063HV)
    Sprache Englisch
    Erscheinungsdatum 2018-06-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2018.4.FOCUS18120
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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