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  1. Article: Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease.

    Bigio, Eileen H / Reisch, Joan S / White, Charles L / Satumtira, Sivapong / Sontag, Estelle / Bonte, Frederick J

    Dementia and geriatric cognitive disorders

    2003  Volume 15, Issue 2, Page(s) 72–78

    Abstract: In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 ... ...

    Abstract In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results. Synapse loss was evaluated in postmortem brain samples using an enzyme-linked immunosorbant assay (ELISA) that measures synaptophysin, with results expressed as picomoles synaptophysin/10 mg brain. Synaptophysin was expressed either as concentration (QS method) or as the ratio of the concentration to the combined results in frontal, temporal and parietal lobe (RS method). There was no correlation between synapse loss and rCBF using the QS method and only borderline significance between right SPECT and right temporal synaptophysin using the RS method. The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD.
    MeSH term(s) Aged ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Brain/blood supply ; Brain/pathology ; Brain/ultrastructure ; Case-Control Studies ; Cerebrovascular Circulation ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Synapses/pathology ; Synaptophysin/analysis ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Synaptophysin
    Language English
    Publishing date 2003
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1026007-9
    ISSN 1420-8008 ; 1013-7424
    ISSN 1420-8008 ; 1013-7424
    DOI 10.1159/000067970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Synapse Loss May Be a Minor Contributor to Decreased Regional Cerebral Blood Flow in Alzheimer Disease

    Bigio, Eileen H. / Reisch, Joan S. / White 3rd, Charles L. / Satumtira, Sivapong / Sontag, Estelle / Bonte, Frederick J.

    Dementia and Geriatric Cognitive Disorders

    2003  Volume 15, Issue 2, Page(s) 72–78

    Abstract: In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 ... ...

    Institution Department of Pathology, Northwestern University Medical School, Chicago, Ill., and Departments of Academic Computing Family Practice Pathology and Radiology, University of Texas Southwestern Medical School, Dallas, Tex., USA
    Abstract In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results. Synapse loss was evaluated in postmortem brain samples using an enzyme-linked immunosorbant assay (ELISA) that measures synaptophysin, with results expressed as picomoles synaptophysin/10 mg brain. Synaptophysin was expressed either as concentration (QS method) or as the ratio of the concentration to the combined results in frontal, temporal and parietal lobe (RS method). There was no correlation between synapse loss and rCBF using the QS method and only borderline significance between right SPECT and right temporal synaptophysin using the RS method. The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD.
    Keywords Synaptophysin ; Cerebral blood flow, regional ; SPECT ; Alzheimer disease ; Synapse
    Language English
    Publishing date 2003-01-20
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Research Article
    ZDB-ID 1026007-9
    ISSN 1421-9824 ; 1420-8008 ; 1013-7424
    ISSN (online) 1421-9824
    ISSN 1420-8008 ; 1013-7424
    DOI 10.1159/000067970
    Database Karger publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2866: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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