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Article ; Online: Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States.

Dubé, Karine / Ndukwe, Samuel O / Korolkova, Ana / Dee, Lynda / Sugarman, Jeremy / Sauceda, John A

HIV research & clinical practice

2024 Volume 25, Issue 1, Page(s) 2312318

Abstract: Background: There is limited systematic information available about the perspectives of participants enrolled in intensive combination HIV cure-related trials inclusive of an extended analytical treatment interruption (ATI).: Objective: To assess and ...

Abstract	Background: There is limited systematic information available about the perspectives of participants enrolled in intensive combination HIV cure-related trials inclusive of an extended analytical treatment interruption (ATI). Objective: To assess and understand experiences of people with HIV involved in a combination HIV cure-related trial with an extended ATI. Methods: The trial included five interventions and was followed by an ATI lasting up to 52 wk. From 2022 - 2023, we conducted in-depth interviews with study participants following their extended ATIs. Interviews were audio-recorded, transcribed, and analyzed Results: We interviewed seven participants. The majority were male, White, and non-Hispanic, with a median age of 37 years. Trust in the research team, scientific altruism and hope of becoming a post-intervention controller were key motivators for joining the trial. Interviewees reported being satisfied with their decision to participate in the trial and the extended ATI. Most recounted feelings of worry related to viral rebound during the ATI. Participants reported both defeat and relief with ART restart. Four faced challenges with protecting partners from HIV during their ATI, such as trying to find out if their partner(s) were using pre-exposure prophylaxis. Conclusions: Our findings demonstrate potential improvements for future ATI trial participant experiences, such as more robust resources for psychosocial support and partner protections. Dedicating greater effort to understanding participant ATI experiences can inform the design of future participant-centered HIV cure trial protocols.
MeSH term(s)	Humans ; Male ; United States ; Female ; Adult ; HIV Infections/drug therapy ; San Francisco ; Treatment Interruption ; Anxiety ; HIV-1
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ISSN	2578-7470
ISSN (online)	2578-7470
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Brief Report: The Influence of the COVID-19 Pandemic on the Physical, Social, and Mental Health of Black and Latinx Young People With HIV in the United States.

Sauceda, John A / Dubé, Karine / Harris, Orlando / Campbell, Chadwick K / Ndukwe, Samuel / Saberi, Parya

Journal of acquired immune deficiency syndromes (1999)

2023 Volume 93, Issue 3, Page(s) 187–190

Abstract: Background: Whereas national attention has been paid to the ongoing mental health crises among young people triggered by the COVID-19 pandemic, less is known about the social, physical and psychological impacts of COVID-19 on young people living with ... ...

Abstract	Background: Whereas national attention has been paid to the ongoing mental health crises among young people triggered by the COVID-19 pandemic, less is known about the social, physical and psychological impacts of COVID-19 on young people living with HIV, especially racial/ethnic minorities. Setting: Online survey of participants across the U.S. Method: A national cross-sectional survey of non-Latinx Black and Latinx young adults (18-29) living with HIV. Between April and August 2021, participants answered survey questions about several domains (eg, stress, anxiety, relationships, work, quality of life) that were worsened, improved, or unchanged during the pandemic. We ran a logistic regression estimating the self-reported impact of the pandemic on these domains between 2 age groups (ages 18-24 versus 25-29). Results: The sample size was 231 (186 non-Latinx Black, 45 Latinx) and mainly male (84.4%) and gay identified (62.2%). Nearly 20% of participants were 18-24 years old and 80% were ages 25-29. Participants who were 18-24 years old reported 2-3 times the odds for having worse sleep quality and mood and greater stress, anxiety, and weight gain compared with those 25-29 years old. Conclusion: Our data provide a nuanced picture of the negative impacts that COVID-19 had on non-Latinx Black and Latinx young adults living with HIV in the U.S. Given that these adults represent a priority population for HIV treatment outcomes, it is critical to better understand the ongoing toll that these dual pandemics have on their lives.
MeSH term(s)	Young Adult ; Humans ; Male ; Adolescent ; Adult ; Female ; COVID-19 ; Cross-Sectional Studies ; Mental Health ; Pandemics ; Quality of Life ; HIV Infections
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003188
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Article: Exploration of a Mobile Technology Vulnerability Scale's association with antiretroviral adherence among young adults living with HIV in the United States.

Saberi, Parya / Eskaf, Shadi / Campbell, Chadwick K / Neilands, Torsten B / Sauceda, John A / Dubé, Karine

mHealth

2022 Volume 8, Page(s) 23

Abstract: Background: Young adults living with HIV (YLWH) have suboptimal adherence to antiretroviral therapy (ART) and HIV care outcomes. Mobile health technologies are increasingly used to deliver interventions to address HIV health outcomes. However, not all ... ...

Abstract	Background: Young adults living with HIV (YLWH) have suboptimal adherence to antiretroviral therapy (ART) and HIV care outcomes. Mobile health technologies are increasingly used to deliver interventions to address HIV health outcomes. However, not all YLWH have equal and consistent access to mobile technologies. Methods: Using our novel Mobile Technology Vulnerability Scale (MTVS) to evaluate how vulnerable an individual feels with regard to their personal access to mobile technology in the past 6 months, we conducted a cross-sectional online survey with 271 YLWH (18-29 years) in the US to evaluate the relationships between MTVS and self-reported ART adherence. Results: Participants reported changes in phone numbers (25%), stolen (14%) or lost (22%) phones, and disconnections of phone service due to non-payment (39%) in the past 6 months. On a scale of 0 to 1 (0 having no mobile technology vulnerability and 1 having complete mobile technology vulnerability), participants had a mean MTVS of 0.33 (SD =0.26). Black and financially constrained participants had the highest MTVS, which was significantly higher that other racial/ethnic and financially non-constrained groups, respectively. Higher MTVS was significantly associated with ART non-adherence and non-persistence. Conclusions: Findings suggest the need to measure MTVS to recognize pitfalls when using mobile health interventions and identify populations whose inconsistent mobile technology access may be related to worse health outcomes.
Language	English
Publishing date	2022-07-20
Publishing country	China
Document type	Journal Article
ISSN	2306-9740
ISSN	2306-9740
DOI	10.21037/mhealth-21-54
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Article ; Online: Perceptions of Risks and Benefits of Participating in HIV Cure-Related Research Among Diverse Young Adults Living with HIV in the United States: Qualitative Research Findings.

Saberi, Parya / Campbell, Chadwick K / Sauceda, John A / Ndukwe, Samuel / Dubé, Karine

AIDS research and human retroviruses

2022 Volume 38, Issue 8, Page(s) 649–659

Abstract: In the United States, young adults have the highest rates of new HIV infections, and are less likely to be aware of their infection, be engaged in care, or achieve HIV viral suppression. As biomedical HIV research increasingly focuses on achieving long- ... ...

Abstract	In the United States, young adults have the highest rates of new HIV infections, and are less likely to be aware of their infection, be engaged in care, or achieve HIV viral suppression. As biomedical HIV research increasingly focuses on achieving long-term suppression without antiretroviral therapy (ART) and finding an HIV cure, little is known about perceptions of young adults living with HIV (YLWH) regarding HIV cure research. We recruited a diverse sample of 20 YLWH (18-29 years old) to participate in individual semistructured qualitative interviews to explore knowledge and perceptions of HIV cure research, and motivations and barriers to participation. Most participants had little knowledge of HIV cure research. Motivators of HIV cure research participation included altruism, stigma reduction, and the elimination of the clinical burdens of HIV. Barriers included potential physical side effects, psychological distress, the possibility of disclosure as a result of participating, and the amount of time required to participate. Most participants had concerns about analytic treatment interruptions (i.e., ART interruption to assess HIV remission), and indicated that they would want more frequent laboratory testing and protection for their sex partners during this time. Finally, participants suggested that, if other YLWH are considering participation in cure research, they should first learn as much as possible about the research, and then consider the potential personal benefits and the contribution that they could make to science and their communities. As HIV cure research advances, the participation of YLWH will be critical. Our study provides knowledge about how YLWH view HIV cure research. More sociobehavioral research is needed to ensure that those who are most likely to be the decision-makers and beneficiaries of an HIV cure are included at all levels of research.
MeSH term(s)	Adolescent ; Adult ; HIV Infections/prevention & control ; Humans ; Qualitative Research ; Risk Assessment ; Social Stigma ; United States ; Young Adult
Language	English
Publishing date	2022-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2021.0192
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Article ; Online: Overcoming Challenges of Online Research: Measures to Ensure Enrollment of Eligible Participants.

Campbell, Chadwick K / Ndukwe, Samuel / Dubé, Karine / Sauceda, John A / Saberi, Parya

Journal of acquired immune deficiency syndromes (1999)

2022 Volume 91, Issue 2, Page(s) 232–236

Abstract: Background: Internet-based surveys are increasingly used for health research because they offer several advantages including greater geographic reach, increased participant anonymity, and reduced financial/time burden. However, there is also a need to ... ...

Abstract	Background: Internet-based surveys are increasingly used for health research because they offer several advantages including greater geographic reach, increased participant anonymity, and reduced financial/time burden. However, there is also a need to address inherent challenges, such as the likelihood of fraudulent responses and greater difficulty in determining eligibility. Methods: We conducted an online nationwide survey of 18-29 year olds living with HIV in the United States, to assess willingness to participate in HIV cure research. To ensure that respondents met age and HIV serostatus inclusion criteria, we instituted screening procedures to identify ineligible respondents using tools that were built into the survey platform (eg, reCAPTCHA, geolocation) and required documentation of age and serostatus before providing access to the incentivized study survey. Results: Of 1308 eligibility surveys, 569 were incomplete or ineligible because of reported age or serostatus. Of the remaining 739 potentially eligible respondents, we determined that 413 were from fraudulent, bot, or ineligible respondents. We sent individual study survey links to 326 participants (25% of all eligibility survey respondents) whose eligibility was reviewed and confirmed by our study team. Conclusion: Our multicomponent strategy was effective for identifying ineligible and fraudulent responses to our eligibility survey, allowing us to send the study survey link only to those whose eligibility we were able to confirm. Our findings suggest that proactive fraud prevention can be built into the screening phase of the study to prevent wasted resources related to data cleaning and unretrievable study incentives and ultimately improve the quality of data.
MeSH term(s)	Eligibility Determination ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Humans ; Motivation ; Surveys and Questionnaires ; United States
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003035
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Article ; Online: Cash Transfer Apps are a Feasible, Acceptable, and More Equitable Method for Compensating Participants in HIV Research.

Campbell, Chadwick K / Dubé, Karine / Sauceda, John A / Sevelius, Jae M / Green-Ajufo, Barbara / Brown, Brandon / Ndukwe, Samuel / Saberi, Parya

Journal of acquired immune deficiency syndromes (1999)

2023 Volume 93, Issue 3, Page(s) e9–e11

MeSH term(s)	Humans ; HIV Infections ; Motivation
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003199
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Article ; Online: Accelerating Research Careers in Science Through Early Mentored Research Experiences for Undergraduates and Masters' Students at the University of California, San Francisco Center for AIDS Research.

Sauceda, John A / Watabe, Joseph / Sterling, Lauren / Fuchs, Jonathan / Parangan-Smith, Audrey / Uwaezuoke, Kelechi / Gandhi, Monica / Marquez, Carina

Journal of acquired immune deficiency syndromes (1999)

2023 Volume 94, Issue 2S, Page(s) S21–S27

Abstract: Background: Investments early in the academic pathway are essential to increasing the diversity of the HIV research workforce. Applied mentored research experiences can advance research skills, self-efficacy, and retention in science among scholars ... ...

Abstract	Background: Investments early in the academic pathway are essential to increasing the diversity of the HIV research workforce. Applied mentored research experiences can advance research skills, self-efficacy, and retention in science among scholars considered to be underrepresented minorities. Setting: The UCSF Center for AIDS Research Scholars Program is a 16-week program that pairs URM undergraduate and masters-level students from San Francisco State University with URM investigators from the UCSF. The program includes one-on-one mentorship on an independent research project, a core-curriculum on research methods and HIV-specific topics, and clinical shadowing. Methods: We evaluated program outcomes and areas for improvement with preprogram and postprogram survey and qualitative data from scholars and mentors from June to October 2022. Outcomes included interest in HIV research and growth on a 20-item measure of research skills, knowledge, and confidence. Results: Six URM scholars enrolled in the inaugural cohort and were paired with 6 mentors. Preprogram and postprogram evaluations showed gains in interest in HIV research, 0% preprogram and 100% of scholars postprogram reporting much or extensive interest in HIV research, and gains across all domains from self-confidence, skills, and clarification of a research career path. Qualitative findings noted the importance of peer support and interpersonal features of mentors, including treating them like equals. Areas for improvement included more opportunities for primary data collection and specific training around mentoring undergraduates for mentors. Conclusions: The UCSF Center for AIDS Research Scholars Program was successful in building foundational skills, knowledge, confidence, and interest in HIV research among URM undergraduates and masters-level students.
MeSH term(s)	Humans ; Mentors ; Acquired Immunodeficiency Syndrome ; San Francisco ; HIV Infections/prevention & control ; Students
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003259
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Article ; Online: The LAIs Are Coming! Implementation Science Considerations for Long-Acting Injectable Antiretroviral Therapy in the United States: A Scoping Review.

Kanazawa, John T / Saberi, Parya / Sauceda, John A / Dubé, Karine

AIDS research and human retroviruses

2020 Volume 37, Issue 2, Page(s) 75–88

Abstract: Long-acting injectable antiretroviral therapy (LAI-ART) is one of the latest advancements in HIV control with the potential to overcome oral ART barriers to adherence. The objective of this article is to anticipate and examine implementation ... ...

Abstract	Long-acting injectable antiretroviral therapy (LAI-ART) is one of the latest advancements in HIV control with the potential to overcome oral ART barriers to adherence. The objective of this article is to anticipate and examine implementation considerations for LAI-ART using components of the PRISM model, a
MeSH term(s)	Cost-Benefit Analysis ; HIV Infections/drug therapy ; Humans ; Implementation Science ; Injections ; United States
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2020.0126
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Article ; Online: Findings From a Probability-Based Survey of United States Households About Prevention Measures Based on Race, Ethnicity, and Age in Response to Severe Acute Respiratory Syndrome Coronavirus 2.

Sauceda, John A / Neilands, Torsten B / Lightfoot, Marguerita / Saberi, Parya

The Journal of infectious diseases

2020 Volume 222, Issue 10, Page(s) 1607–1611

Abstract: We investigated individual behaviors taken by white, African American, and Latino United States (US) households in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and likelihood of using digital tools for symptom surveillance/ ... ...

Abstract	We investigated individual behaviors taken by white, African American, and Latino United States (US) households in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and likelihood of using digital tools for symptom surveillance/reporting. We analyzed cross-sectional week 1 data (April 2020) of the coronavirus disease 2019 (COVID-19) Impact Survey in a large, nationally representative sample of US adults. In general, all groups engaged in the same prevention behaviors, but whites reported being more likely to use digital tools to report/act on symptoms and seek testing, compared with African Americans and Latinos. Individual behaviors may not explain COVID-19 case disparities, and digital tools for tracking should focus on uptake among race/ethnic minorities.
MeSH term(s)	Adolescent ; Adult ; African Americans/psychology ; Age Factors ; Attitude to Health/ethnology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/ethnology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Cross-Sectional Studies ; European Continental Ancestry Group/psychology ; Family Characteristics ; Female ; Health Status Disparities ; Hispanic Americans/psychology ; Humans ; Infection Control/methods ; Male ; Middle Aged ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/ethnology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Probability ; SARS-CoV-2 ; Surveys and Questionnaires ; United States/epidemiology ; United States/ethnology ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiaa554
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Article ; Online: Antiretroviral therapy experience, satisfaction, and preferences among a diverse sample of young adults living with HIV.

Campbell, Chadwick K / Dubé, Karine / Sauceda, John A / Ndukwe, Samuel / Saberi, Parya

AIDS care

2021 Volume 34, Issue 9, Page(s) 1212–1218

Abstract: Youth and young adults living with HIV (YLWH) have a high HIV infection rate and suboptimal oral medication adherence. Biomedical researchers hope that long-acting antiretroviral therapy (LAART) modalities can help those who struggle with daily oral ... ...

Abstract	Youth and young adults living with HIV (YLWH) have a high HIV infection rate and suboptimal oral medication adherence. Biomedical researchers hope that long-acting antiretroviral therapy (LAART) modalities can help those who struggle with daily oral adherence. While adults living with HIV have expressed interest in LAART, little research has explored perspectives of YLWH. This study explores ART experiences and perspectives on LAART through qualitative interviews with twenty diverse YLWH (18-29) in the United States. Data were analyzed using framework analysis. Most participants were satisfied with their current ART yet had experienced side effects or had struggled with daily adherence. Preferences for improving daily oral ART included making pills smaller and reformulating ART into flavored chewable gummies. Most expressed enthusiasm for LAART, although needle aversion and previous injection drug use were potential barriers for some. Approximately half were interested in an ART patch, though its visibility and fear of stigmatization was concerning. Few expressed interest in implantable ART, calling it unappealing. Although younger people are most likely to benefit from these advancements in HIV treatment, additional research is needed to identify gaps in uptake and to further explore perspectives of YLWH to improve the success of new treatment modalities.
MeSH term(s)	Adolescent ; HIV Infections/drug therapy ; Humans ; Medication Adherence ; Personal Satisfaction ; Surveys and Questionnaires ; United States ; Young Adult
Language	English
Publishing date	2021-11-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1012651-x
ISSN	1360-0451 ; 0954-0121
ISSN (online)	1360-0451
ISSN	0954-0121
DOI	10.1080/09540121.2021.2001783
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