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  1. Book ; Online ; E-Book: Endophytes for a growing world

    Hodkinson, Trevor R. / Doohan, Fiona M. / Saunders, Matthew J. / Murphy, Brian R.

    2019  

    Author's details edited by Trevor R. Hodkinson (Trinity College Dublin), Fiona M. Doohan (University College Dublin), Brian R. Murphy (Trinity College Dublin), Matthew J. Saunders (Trinity College Dublin)
    Keywords Endophytes ; Plants / Microbiology ; Endophyten ; Pflanzenbau ; Endophytische Pilze ; Symbiose ; Pflanzenparasit
    Subject Anbau ; Pflanzenkultur ; Kulturpflanzenbau ; Kulturpflanzenanbau ; Nutzpflanzenbau ; Nutzpflanzenanbau ; Phytoparasit ; Pflanzen ; Entophyten ; Endophyt
    Language English
    Size 1 Online-Ressource (xi, 420 Seiten)
    Publisher Cambridge University Press
    Publishing place Cambridge ; New York, NY ; Port Melbourne ; New Delhi ; Singapore
    Publishing country Great Britain ; United States ; Australia ; India ; Singapore
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020130339
    ISBN 978-1-108-67601-4 ; 978-1-108-60766-7 ; 9781108471763 ; 9781108458405 ; 1-108-67601-4 ; 1-108-60766-7 ; 1108471765 ; 1108458408
    DOI 10.1017/ 9781108607667
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Simplifying the detection and monitoring of protein glycosylation during in vitro glycoengineering.

    Saunders, Matthew J / Woods, Robert J / Yang, Loretta

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 567

    Abstract: The majority of mammalian proteins are glycosylated, with the glycans serving to modulate a wide range of biological activities. Variations in protein glycosylation can have dramatic effects on protein stability, immunogenicity, antibody effector ... ...

    Abstract The majority of mammalian proteins are glycosylated, with the glycans serving to modulate a wide range of biological activities. Variations in protein glycosylation can have dramatic effects on protein stability, immunogenicity, antibody effector function, pharmacological safety and potency, as well as serum half-life. The glycosylation of therapeutic biologicals is a critical quality attribute (CQA) that must be carefully monitored to ensure batch-to-batch consistency. Notably, many factors can affect the composition of the glycans during glycoprotein production, and variations in glycosylation are among the leading causes of pharmaceutical batch rejection. Currently, the characterization of protein glycosylation relies heavily on methods that employ chromatography and/or mass spectrometry, which require a high level of expertise, are time-consuming and costly and, because they are challenging to implement during in-process biologics production or during in vitro glycan modification, are generally performed only post-production. Here we report a simplified approach to assist in monitoring glycosylation features during glycoprotein engineering, that employs flow cytometry using fluorescent microspheres chemically coupled to high-specificity glycan binding reagents. In our GlycoSense method, a range of carbohydrate-sensing microspheres with distinct optical properties may be combined into a multiplex suspension array capable of detecting multiple orthogonal glycosylation features simultaneously, using commonplace instrumentation, without the need for glycan release. The GlycoSense method is not intended to replace more detailed post-production glycan profiling, but instead, to complement them by potentially providing a cost-effective, rapid, yet robust method for use at-line as a process analytic technology (PAT) in a biopharmaceutical workflow or at the research bench. The growing interest in using in vitro glycoengineering to generate glycoproteins with well-defined glycosylation, provides motivation to demonstrate the capabilities of the GlycoSense method, which we apply here to monitor changes in the protein glycosylation pattern (GlycoPrint) during the in vitro enzymatic modification of the glycans in model glycoproteins.
    MeSH term(s) Animals ; Glycosylation ; Glycoproteins/metabolism ; Antibodies/metabolism ; Mass Spectrometry ; Mammals/metabolism ; Polysaccharides/metabolism
    Chemical Substances Glycoproteins ; Antibodies ; Polysaccharides
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-27634-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19, tuberculosis and poverty: preventing a perfect storm.

    Saunders, Matthew J / Evans, Carlton A

    The European respiratory journal

    2020  Volume 56, Issue 1

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Poverty ; SARS-CoV-2 ; Tuberculosis
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01348-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  4. Article ; Online: Ending Tuberculosis through Prevention.

    Saunders, Matthew J / Evans, Carlton A

    The New England journal of medicine

    2019  Volume 380, Issue 11, Page(s) 1073–1074

    MeSH term(s) HIV ; Humans ; Isoniazid ; Rifampin/analogs & derivatives ; Tuberculosis/prevention & control
    Chemical Substances Isoniazid (V83O1VOZ8L) ; Rifampin (VJT6J7R4TR) ; rifapentine (XJM390A33U)
    Language English
    Publishing date 2019-03-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1901656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Contact Investigation: A Priority for Tuberculosis Control Programs.

    Saunders, Matthew J / Datta, Sumona

    American journal of respiratory and critical care medicine

    2016  Volume 194, Issue 9, Page(s) 1049–1051

    MeSH term(s) Contact Tracing ; Humans ; Tuberculosis/epidemiology
    Language English
    Publishing date 2016-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201605-1007ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: How Local SARS-CoV-2 Prevalence Shapes Pulmonary Function Testing Laboratory Protocols and Practices During the COVID-19 Pandemic.

    Saunders, Matthew J / Haynes, Jeffrey M / McCormack, Meredith C / Stanojevic, Sanja / Kaminsky, David A

    Chest

    2021  Volume 160, Issue 4, Page(s) 1241–1244

    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; Clinical Laboratory Techniques/standards ; Humans ; Laboratories/standards ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Surveys and Questionnaires ; United States/epidemiology
    Language English
    Publishing date 2021-05-15
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 349: Show issues

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  8. Article ; Online: Fighting poverty to prevent tuberculosis.

    Saunders, Matthew J / Evans, Carlton A

    The Lancet. Infectious diseases

    2015  Volume 16, Issue 4, Page(s) 395–396

    MeSH term(s) Developing Countries ; Humans ; Poverty ; Tuberculosis
    Language English
    Publishing date 2015-12-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(15)00434-X
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    Zs.A 5743: Show issues Location:
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  9. Article ; Online: Social and health factors associated with adverse treatment outcomes among people with multidrug-resistant tuberculosis in Sierra Leone: a national, retrospective cohort study.

    Kamara, Rashidatu Fouad / Saunders, Matthew J / Sahr, Foday / Losa-Garcia, Juan E / Foray, Lynda / Davies, Geraint / Wingfield, Tom

    The Lancet. Global health

    2022  Volume 10, Issue 4, Page(s) e543–e554

    Abstract: Background: Multidrug-resistant tuberculosis (MDR-TB) is a global health emergency. We aimed to evaluate treatment outcomes among people with MDR-TB in Sierra Leone and investigate social and health factors associated with adverse treatment outcomes.: ...

    Abstract Background: Multidrug-resistant tuberculosis (MDR-TB) is a global health emergency. We aimed to evaluate treatment outcomes among people with MDR-TB in Sierra Leone and investigate social and health factors associated with adverse treatment outcomes.
    Methods: This national, retrospective cohort study recruited all people notified with MDR-TB to the Sierra Leone National TB Programme, admitted to Lakka hospital (Lakka, Western Area Rural District, Freetown, Sierra Leone) between April, 2017, and September, 2019. Participants were followed up to May, 2021. People who were eligible but had no social or health data available, or were subsequently found to have been misdiagnosed, were excluded from participation. MDR-TB treatment was with the 2017 WHO-recommended short (9-11 month) or long (18-24 month) aminoglycoside-containing regimens. Multivariable logistic regression models examined associations of programmatic social and health data with WHO-defined adverse treatment outcomes (death, treatment failure, loss to follow-up).
    Findings: Of 370 notified MDR-TB cases, 365 (99%) were eligible for study participation (five participants were excluded due to lack of social or health data or misdiagnosis). Treatment was started by 341 (93%) of 365 participants (317 received the short regimen, 24 received the long regimen, and 24 received no treatment). Median age was 35 years (IQR 26-45), 263 (72%) of 365 were male and 102 (28%) were female, 71 (19%) were HIV-positive, and 127 (35%) were severely underweight (body-mass index <16·5 kg/m
    Interpretation: MDR-TB treatment success in Sierra Leone approached WHO targets and the short regimen was associated with higher success. The social and health factors associated with adverse outcomes in this study suggest a role for integrated tuberculosis, HIV, and non-communicable disease services alongside nutritional and socioeconomic support for people with MDR-TB and emphasise the urgent need to scale up coverage of all-oral aminoglycoside-sparing regimens.
    Funding: Wellcome Trust, Joint Global Health Trials.
    MeSH term(s) Adult ; Aminoglycosides ; Antitubercular Agents/therapeutic use ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sierra Leone/epidemiology ; Thinness ; Treatment Outcome ; Tuberculosis/drug therapy ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology
    Chemical Substances Aminoglycosides ; Antitubercular Agents
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(22)00004-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Interventions aiming to eliminate catastrophic costs due to tuberculosis: a protocol for a systematic review and meta-analysis.

    Carballo-Jimenez, Paula P / Datta, Sumona / Aguirre-Ipenza, Rubén / Saunders, Matthew J / Quevedo Cruz, Luz / Evans, Carlton A

    Wellcome open research

    2022  Volume 7, Page(s) 92

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.17521.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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