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Article ; Online: P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis

Saurabh Chatterjee / Suvarthi Das

Oxidative Medicine and Cellular Longevity, Vol

2015 Volume 2015

Keywords	Cytology ; QH573-671 ; Biology (General) ; QH301-705.5 ; Science ; Q
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Public Transport System Ticketing system using RFID and ARM processor Perspective Mumbai bus facility B.E.S.T

Saurabh Chatterjee / Prof. Balram Timande

International Journal of Electronics and Computer Science Engineering, Vol 1, Iss 3, Pp 1619-

2012 Volume 1622

Abstract: This paper is based on ticketing and identification of the passenger in the public transport. In the metropolitan city like Mumbai, Kolkata we have a severe malfunction of public transport and various security problems. Firstly, there is a lot of ... ...

Abstract	This paper is based on ticketing and identification of the passenger in the public transport. In the metropolitan city like Mumbai, Kolkata we have a severe malfunction of public transport and various security problems. Firstly, there is a lot of confusion between the passengers regarding fares which lead to corruption, Secondly due to mismanagement of public transport the passengers faces the problem of traffic jam, thirdly nowadays we have severe security problems in public transport due anti social elements. This paper suggest a user friendly automated ticketing system which will automatically deduct the passenger’s fare according to the distance travelled as well as detect the passenger’s identification. This could be only possible by use of RFID tickets and GPS can be used to make the transaction and travelling very precise. This paper basically deals with the identification and ticketing of the passengers sitting in the bus.
Keywords	RFID ; ARM processor ; GPS ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Subject code	380
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	Buldanshahr : IJECSE
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: RFID based Traffic Control System using ARM processor perspective Kolkata and other densely populated cities

Saurabh Chatterjee, Prof. Balram Timande

International Journal of Advanced Research in Computer Science and Electronics Engineering, Vol 1, Iss 10, Pp 32-

2012 Volume 35

Abstract: This paper is based on traffic control system using RFID. In the metropolitan city like Mumbai, Kolkata we have a severe malfunction of traffic control and various security problems. Firstly, there are number of vehicles on road in such cities leading to ...

Abstract	This paper is based on traffic control system using RFID. In the metropolitan city like Mumbai, Kolkata we have a severe malfunction of traffic control and various security problems. Firstly, there are number of vehicles on road in such cities leading to mismanagement, Secondly breaking of traffic rules is quite obvious in such cities, thirdly nowadays we have severe security problems in traffic system due anti social elements. This paper suggest a user friendly automated traffic control system which will automatically detect a vehicle using the RFID active tag attached to the vehicle and as soon as the vehicle passes by a reader, this process would lead to identification of each vehicle reducing traffic malfunction and also reducing security problems. This could be only possible by use of RFID tickets and mesh network can be used to make the traffic control smooth and travelling very precise. This paper basically deals with the identification and positioning a vehicle for automated traffic control system.
Keywords	RFID ; ARM processor. ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Subject code	629
Language	English
Publishing date	2012-12-01T00:00:00Z
Publisher	Shri Pannalal Research Institute of Technolgy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

Dipro Bose / Somdatta Chatterjee / Ethan Older / Ratanesh Seth / Patricia Janulewicz / Punnag Saha / Ayan Mondal / Jeffrey M. Carlson / Alan W. Decho / Kimberly Sullivan / Nancy Klimas / Stephen Lasley / Jie Li / Saurabh Chatterjee

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 15

Abstract: Analysis of fecal samples from patients and mice, shows that chronic multisymptom illness which affects a subsection of elderly and war Veterans, is associated with alteration in genes related to antibiotic resistance. ...

Abstract	Analysis of fecal samples from patients and mice, shows that chronic multisymptom illness which affects a subsection of elderly and war Veterans, is associated with alteration in genes related to antibiotic resistance.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Time of the day dictates the variability of biomarkers of exposure to disinfection byproducts

Stephanie Gängler / Pantelis Charisiadis / Ratanesh Seth / Saurabh Chatterjee / Konstantinos C. Makris

Environment International, Vol 112, Iss , Pp 33-

2018 Volume 40

Abstract: Non-persistent environmental chemicals (NOPEC) are xenobiotics with short half-lives of elimination (<7h). Similar to chronopharmacokinetics, NOPEC metabolism may follow diurnal patterns of cytochrome P450 activity. The role of circadian liver clock in ... ...

Abstract	Non-persistent environmental chemicals (NOPEC) are xenobiotics with short half-lives of elimination (<7h). Similar to chronopharmacokinetics, NOPEC metabolism may follow diurnal patterns of cytochrome P450 activity. The role of circadian liver clock in shaping NOPEC metabolism and their concomitant measurements of biomarkers of exposure and effect remains poorly understood in real-life human settings. Metabolic activation (toxication) by CYP2E1 converts trihalomethanes (THM) to harmful metabolites. We investigated the diurnal variation of urinary THM exposures and their metabolism patterns as catalyzed by CYP2E1 redox activity, using the surrogate marker of 4-hydroxynonenal (4HNE). We implemented three time-series trials with adult volunteers conducting specific household cleaning activities at predefined times of a day. Circadia variation of 4HNE was assessed with a cosinor model and its mesor levels increased with THM exposure. The time of exposure within the day dictated the magnitude of urinary THM levels and their toxication effect; in all three trials and relative to urinary THM levels before the activity, lower and higher median THM were measured right after the activity in morning and afternoon/night, respectively. This is consistent with higher reported CYP2E1 redox activity in light/active phase. Population health studies should incorporate time-stamped biomarker data to improve the understanding of chronic disease processes. Keywords: Susceptibility, Circadian, Xenobiotics, Disinfection, Cosinor, Liver clock, Toxication, Metabolic activation
Keywords	Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Time of the day dictates the variability of biomarkers of exposure to disinfection byproducts

Gängler, Stephanie / Pantelis Charisiadis / Ratanesh Seth / Saurabh Chatterjee / Konstantinos C. Makris

Environment international. 2018 Mar., v. 112

2018

Abstract	Non-persistent environmental chemicals (NOPEC) are xenobiotics with short half-lives of elimination (<7h). Similar to chronopharmacokinetics, NOPEC metabolism may follow diurnal patterns of cytochrome P450 activity. The role of circadian liver clock in shaping NOPEC metabolism and their concomitant measurements of biomarkers of exposure and effect remains poorly understood in real-life human settings. Metabolic activation (toxication) by CYP2E1 converts trihalomethanes (THM) to harmful metabolites. We investigated the diurnal variation of urinary THM exposures and their metabolism patterns as catalyzed by CYP2E1 redox activity, using the surrogate marker of 4-hydroxynonenal (4HNE). We implemented three time-series trials with adult volunteers conducting specific household cleaning activities at predefined times of a day. Circadia variation of 4HNE was assessed with a cosinor model and its mesor levels increased with THM exposure. The time of exposure within the day dictated the magnitude of urinary THM levels and their toxication effect; in all three trials and relative to urinary THM levels before the activity, lower and higher median THM were measured right after the activity in morning and afternoon/night, respectively. This is consistent with higher reported CYP2E1 redox activity in light/active phase. Population health studies should incorporate time-stamped biomarker data to improve the understanding of chronic disease processes.
Keywords	adults ; biomarkers ; byproducts ; chronic diseases ; cytochrome P-450 ; disinfection ; diurnal variation ; half life ; household cleaning ; humans ; liver ; metabolism ; metabolites ; models ; time series analysis ; xenobiotics
Language	English
Dates of publication	2018-03
Size	p. 33-40.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2017.12.013
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis

Muthanna Sultan / Kiesha Wilson / Osama A. Abdulla / Philip Brandon Busbee / Alina Hall / Taylor Carter / Narendra Singh / Saurabh Chatterjee / Prakash Nagarkatti / Mitzi Nagarkatti

Cells, Vol 10, Iss 3305, p

2021 Volume 3305

Abstract: Acute respiratory distress syndrome (ARDS) is a serious lung condition characterized by severe hypoxemia leading to limitations of oxygen needed for lung function. In this study, we investigated the effect of anandamide (AEA), an endogenous cannabinoid, ... ...

Abstract	Acute respiratory distress syndrome (ARDS) is a serious lung condition characterized by severe hypoxemia leading to limitations of oxygen needed for lung function. In this study, we investigated the effect of anandamide (AEA), an endogenous cannabinoid, on Staphylococcal enterotoxin B (SEB)-mediated ARDS in female mice. Single-cell RNA sequencing data showed that the lung epithelial cells from AEA-treated mice showed increased levels of antimicrobial peptides (AMPs) and tight junction proteins. MiSeq sequencing data on 16S RNA and LEfSe analysis demonstrated that SEB caused significant alterations in the microbiota, with increases in pathogenic bacteria in both the lungs and the gut, while treatment with AEA reversed this effect and induced beneficial bacteria. AEA treatment suppressed inflammation both in the lungs as well as gut-associated mesenteric lymph nodes (MLNs). AEA triggered several bacterial species that produced increased levels of short-chain fatty acids (SCFAs), including butyrate. Furthermore, administration of butyrate alone could attenuate SEB-mediated ARDS. Taken together, our data indicate that AEA treatment attenuates SEB-mediated ARDS by suppressing inflammation and preventing dysbiosis, both in the lungs and the gut, through the induction of AMPs, tight junction proteins, and SCFAs that stabilize the gut-lung microbial axis driving immune homeostasis.
Keywords	acute respiratory distress syndrome (ARDS) ; Staphylococcus enterotoxin B (SEB) ; anandamide (AEA) ; COVID-19 ; microbiome ; MiSeq sequencing ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Health impacts of environmental contamination of micro- and nanoplastics

Baorong Jiang / Alexandra E Kauffman / Lei Li / Wayne McFee / Bo Cai / John Weinstein / Jamie R Lead / Saurabh Chatterjee / Geoffrey I Scott / Shuo Xiao

Environmental Health and Preventive Medicine, Vol 25, Iss 1, Pp 1-

a review

2020 Volume 15

Abstract: Abstract Plastics are extensively used in our daily life. However, a significant amount of plastic waste is discharged to the environment directly or via improper reuse or recycling. Degradation of plastic waste generates micro- or nano-sized plastic ... ...

Abstract	Abstract Plastics are extensively used in our daily life. However, a significant amount of plastic waste is discharged to the environment directly or via improper reuse or recycling. Degradation of plastic waste generates micro- or nano-sized plastic particles that are defined as micro- or nanoplastics (MNPs). Microplastics (MPs) are plastic particles with a diameter less than 5 mm, while nanoplastics (NPs) range in diameter from 1 to 100 or 1000 nm. In the current review, we first briefly summarized the environmental contamination of MNPs and then discussed their health impacts based on existing MNP research. Our review indicates that MNPs can be detected in both marine and terrestrial ecosystems worldwide and be ingested and accumulated by animals along the food chain. Evidence has suggested the harmful health impacts of MNPs on marine and freshwater animals. Recent studies found MPs in human stool samples, suggesting that humans are exposed to MPs through food and/or drinking water. However, the effect of MNPs on human health is scarcely researched. In addition to the MNPs themselves, these tiny plastic particles can release plastic additives and/or adsorb other environmental chemicals, many of which have been shown to exhibit endocrine disrupting and other toxic effects. In summary, we conclude that more studies are necessary to provide a comprehensive understanding of MNP pollution hazards and also provide a basis for the subsequent pollution management and control.
Keywords	Microplastics ; Nanoplastics ; Health impacts ; Additives ; Adsorbents ; Public aspects of medicine ; RA1-1270
Subject code	333
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Komiyama Printing Co. Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Trihalomethane exposure and biomonitoring for the liver injury indicator, alanine aminotransferase, in the United States population (NHANES 1999â2006)

Burch, James B / Todd M. Everson / Ratanesh K. Seth / Michael D. Wirth / Saurabh Chatterjee

Science of the total environment. 2015 July 15, v. 521-522

2015

Abstract: Exposure to trihalomethanes (or THMs: chloroform, bromoform, bromodichloromethane, and dibromochloromethane [DBCM]) formed via drinking water disinfection has been associated with adverse reproductive outcomes and cancers of the digestive or ... ...

Abstract	Exposure to trihalomethanes (or THMs: chloroform, bromoform, bromodichloromethane, and dibromochloromethane [DBCM]) formed via drinking water disinfection has been associated with adverse reproductive outcomes and cancers of the digestive or genitourinary organs. However, few studies have examined potential associations between THMs and liver injury in humans, even though experimental studies suggest that these agents exert hepatotoxic effects, particularly among obese individuals. This study examined participants in the National Health and Nutrition Examination Survey (1999â2006, N=2781) to test the hypothesis that THMs are associated with liver injury as assessed by alanine aminotransferase (ALT) activity in circulation. Effect modification by body mass index (BMI) or alcohol consumption also was examined. Associations between blood THM concentrations and ALT activity were assessed using unconditional multiple logistic regression to calculate prevalence odds ratios (ORs) with 95% confidence intervals (CIs) for exposure among cases with elevated ALT activity (men: >40IU/L, women: >30IU/L) relative to those with normal ALT, after adjustment for variables that may confound the relationship between ALT and THMs. Compared to controls, cases were 1.35 times more likely (95% CI: 1.02, 1.79) to have circulating DBCM concentrations exceeding median values in the study population. There was little evidence for effect modification by BMI, although the association varied by alcohol consumption. Among non-drinkers, cases were more likely than controls to be exposed to DBCM (OR: 3.30, 95% CI: 1.37, 7.90), bromoform (OR: 2.88, 95% CI: 1.21, 6.81), or brominated THMs (OR: 4.00, 95% CI: 1.31, 12.1), but no association was observed among participants with low, or moderate to heavy alcohol consumption. Total THM levels exceeding benchmark exposure limits continue to be reported both in the United States and globally. Results from this study suggest a need for further characterization of ALT activity and possibly other hepatic or metabolic diseases in populations with elevated drinking water THM concentrations.
Keywords	National Health and Nutrition Examination Survey ; alanine transaminase ; alcohol drinking ; blood ; body mass index ; chloroform ; confidence interval ; disinfection ; drinking water ; hepatotoxicity ; humans ; liver ; men ; metabolic diseases ; neoplasms ; odds ratio ; regression analysis ; women ; United States
Language	English
Dates of publication	2015-0715
Size	p. 226-234.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2015.03.050
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease

Sutapa Sarkar / Diana Kimono / Muayad Albadrani / Ratanesh K. Seth / Philip Busbee / Hasan Alghetaa / Dwayne E. Porter / Geoff I. Scott / Bryan Brooks / Mitzi Nagarkatti / Prakash Nagarkatti / Saurabh Chatterjee

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 22

Abstract: Abstract With increased climate change pressures likely to influence harmful algal blooms, exposure to microcystin, a known hepatotoxin and a byproduct of cyanobacterial blooms can be a risk factor for NAFLD associated comorbidities. Using both in vivo ... ...

Abstract	Abstract With increased climate change pressures likely to influence harmful algal blooms, exposure to microcystin, a known hepatotoxin and a byproduct of cyanobacterial blooms can be a risk factor for NAFLD associated comorbidities. Using both in vivo and in vitro experiments we show that microcystin exposure in NAFLD mice cause rapid alteration of gut microbiome, rise in bacterial genus known for mediating gut inflammation and lactate production. Changes in the microbiome were strongly associated with inflammatory pathology in the intestine, gut leaching, tight junction protein alterations and increased oxidative tyrosyl radicals. Increased lactate producing bacteria from the altered microbiome was associated with increased NOX-2, an NADPH oxidase isoform. Activationof NOX2 caused inflammasome activation as shown by NLRP3/ASCII and NLRP3/Casp-1 colocalizations in these cells while use of mice lacking a crucial NOX2 component attenuated inflammatory pathology and redox changes. Mechanistically, NOX2 mediated peroxynitrite species were primary to inflammasome activation and release of inflammatory mediators. Thus, in conclusion, microcystin exposure in NAFLD could significantly alter intestinal pathology especially by the effects on microbiome and resultant redox status thus advancing our understanding of the co-existence of NAFLD-linked inflammatory bowel disease phenotypes in the clinic.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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