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  1. Book ; Conference proceedings: 3ème Journée d'Actualité en Diabétologie

    Sauvanet, J. P.

    Paris, 17 octobre 2003

    (Annales d'endocrinologie ; 65,1, Suppl.)

    2004  

    Event/congress Journée d'Actualité en Diabétologie (3, 2003, Paris)
    Author's details coord.: J.-P. Sauvanet
    Series title Annales d'endocrinologie ; 65,1, Suppl.
    Collection
    Language French
    Size 1S73 S. : Ill., graph. Darst.
    Publisher Masson
    Publishing place Paris
    Publishing country France
    Document type Book ; Conference proceedings
    HBZ-ID HT014039942
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 132 -65,1,Suppl.- verfügbar in Königswinter Königswinter

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  2. Book ; Conference proceedings: 2ème Journée d'Actualité en Diabétologie

    Sauvanet, J. P.

    Paris, 18 octobre 2002

    (Annales d'endocrinologie ; 64,3, Suppl.)

    2003  

    Institution GlaxoSmithKline
    Event/congress Journée d'Actualité en Diabétologie (2, 2002, Paris)
    Author's details GlaxoSmithKline. Coord.: J.-P. Sauvanet
    Series title Annales d'endocrinologie ; 64,3, Suppl.
    Collection
    Language French
    Size 1S50 S. : graph. Darst.
    Publisher Masson
    Publishing place Paris
    Publishing country France
    Document type Book ; Conference proceedings
    HBZ-ID HT013796175
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Uh III Zs 132 -64,3,Suppl.- verfügbar in Königswinter Königswinter

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  3. Book ; Conference proceedings: 1ère Journée d'Actualité en Diabétologie

    Sauvanet, J. P.

    Paris, 30 novembre 2001

    (Annales d'endocrinologie ; 63,2, Cah. 2)

    2002  

    Institution GlaxoSmithKline
    Event/congress Journée d'Actualité en Diabétologie (1, 2001, Paris)
    Author's details GlaxoSmithKline. Coord.: J.-P. Sauvanet
    Series title Annales d'endocrinologie ; 63,2, Cah. 2
    Collection
    Language French
    Size 1S557 S. : Ill.
    Publisher Masson
    Publishing place Paris
    Publishing country France
    Document type Book ; Conference proceedings
    HBZ-ID HT013369594
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 132 -63,2,Cah.2- verfügbar in Königswinter Königswinter

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  4. Book ; Conference proceedings: Imidazopyridines in sleep disorders

    Sauvanet, J. P.

    a novel experimental and therapeut. approach ; [proceed. of a Symposium on Zolpidem, held Oct. 22 - 24, 1986, in Paris]

    (L.E.R.S. monograph series ; 6)

    1988  

    Institution Symposium on Zolpidem
    Author's details ed. J. P. Sauvanet
    Series title L.E.R.S. monograph series ; 6
    LERS monograph series
    Collection LERS monograph series
    Keywords Hypnotics and Sedatives / therapeutic use / congresses ; Pyridines / therapeutic use / congresses ; Sleep Disorders / drug therapy / congresses ; Schlafstörung ; Imidazopyridine
    Subject Agrypnie ; Asomnie ; Insomnie ; Schlaflosigkeit
    Size XXV, 400 S. : graph. Darst.
    Edition 1. [Dr.]
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003094570
    ISBN 0-88167-377-3 ; 978-0-88167-377-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1988 A 1786 order for loan Magazin

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  5. Article: Simplifier l'autosurveillance glycémique des patients diabétiques.

    Sauvanet, J P

    Soins. Pediatrie, puericulture

    2008  , Issue 242, Page(s) 14

    Title translation Simplifying blood glucose self monitoring for diabetic patients.
    MeSH term(s) Blood Glucose Self-Monitoring/methods ; Diabetes Mellitus/blood ; Humans ; Patient Education as Topic
    Language French
    Publishing date 2008-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 1234484-9
    ISSN 2214-9325 ; 1259-4792
    ISSN (online) 2214-9325
    ISSN 1259-4792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2788: Show issues Location:
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  6. Article: Diabète de type 2: nouvelles insulines et nouvelle stratégies thérapeutiques.

    Sauvanet, J-P

    Diabetes & metabolism

    2004  Volume 30, Issue 5, Page(s) 478–480

    Title translation Type 2 diabetes: new insulins and new therapeutic strategies.
    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/analogs & derivatives ; Insulin/therapeutic use ; Insulin Glargine ; Insulin, Long-Acting
    Chemical Substances Hypoglycemic Agents ; Insulin ; Insulin, Long-Acting ; Insulin Glargine (2ZM8CX04RZ)
    Language French
    Publishing date 2004-11
    Publishing country France
    Document type News
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1267: Show issues Location:
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  7. Article ; Online: Efficacy of saxagliptin as an add-on to oral monotherapy in the phase 3 clinical development program: predictive factors of the treatment response in type 2 diabetes.

    Gautier, J-F / Sauvanet, J-P

    Annales d'endocrinologie

    2011  Volume 72, Issue 4, Page(s) 287–295

    Abstract: Saxagliptin, a dipeptidyl peptidase-4 inhibitor, has been the focus of a large clinical development programme, including Phase 3 randomized vs placebo-controlled clinical trials as add-on therapy in patients with type 2 diabetes (T2D) with inadequate ... ...

    Abstract Saxagliptin, a dipeptidyl peptidase-4 inhibitor, has been the focus of a large clinical development programme, including Phase 3 randomized vs placebo-controlled clinical trials as add-on therapy in patients with type 2 diabetes (T2D) with inadequate glycemic control using initial monotherapy (metformin, glibenclamide, thiazolidinedione). This clinical programme has shown saxagliptin to be effective in the control of fasting and postprandial glycemic parameters, in addition to a good overall safety profile. The present paper aims at reviewing the overall short-term and long-term efficacy of saxagliptin in its Phase 3 development program and tries to pinpoint some factors that may be more predictive of treatment response in clinical practice. In individual and pooled analyses of the three pivotal add-on to monotherapy trials, saxagliptin (5mg once daily) led to significant reductions in HbA(1c) from baseline to 24 weeks. Additional analyses showed that reductions in HbA(1c) were maintained in the long-term, notably for 102 weeks, in combination with metformin. Data have also shown that the absolute reduction in HbA(1c) seen with saxagliptine from baseline to Week 24 was numerically greater with an elevated baseline HbA(1c). In these recently published pooled analyses, clinically pertinent reductions in HbA(1c) were also obtained with saxagliptin across a wide range of subgroups of T2D patients when examined either by specific baseline demographic characteristics or by β-cell function indices such as the HOMA-β.
    MeSH term(s) Adamantane/administration & dosage ; Adamantane/analogs & derivatives ; Adamantane/therapeutic use ; Blood Glucose/analysis ; Clinical Trials, Phase III as Topic ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptides/administration & dosage ; Dipeptides/therapeutic use ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Drug Therapy, Combination ; Fasting ; Food ; Glycated Hemoglobin A/analysis ; Humans ; Hypoglycemic Agents/administration & dosage ; Randomized Controlled Trials as Topic
    Chemical Substances Blood Glucose ; Dipeptides ; Dipeptidyl-Peptidase IV Inhibitors ; Glycated Hemoglobin A ; Hypoglycemic Agents ; saxagliptin (9GB927LAJW) ; Adamantane (PJY633525U)
    Language English
    Publishing date 2011-09
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2011.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Prise en charge du diabète de type 2: de la théorie à la pratique.

    Sauvanet, J-P

    Diabetes & metabolism

    2003  Volume 29, Issue 5, Page(s) 556–557

    Title translation Treating type 2 diabetes: theory and practice.
    MeSH term(s) Diabetes Mellitus, Type 2/therapy ; Humans ; Reproducibility of Results
    Language French
    Publishing date 2003-11
    Publishing country France
    Document type News
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
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    Zs.A 1267: Show issues Location:
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  9. Article: De nouveaux progrès dans la prise en charge du diabète!

    Sauvanet, J-P

    Diabetes & metabolism

    2003  Volume 29, Issue 5, Page(s) 557–558

    Title translation New therapies in the treatment of diabetes!.
    MeSH term(s) Clinical Trials as Topic/trends ; Diabetes Mellitus/therapy ; Humans
    Language French
    Publishing date 2003-11
    Publishing country France
    Document type News
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1267: Show issues Location:
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  10. Article: Subcutaneous insulin: pharmacokinetic variability and glycemic variability.

    Guerci, B / Sauvanet, J P

    Diabetes & metabolism

    2005  Volume 31, Issue 4 Pt 2, Page(s) 4S7–4S24

    Abstract: The therapeutic goal in insulin-treated diabetic patients is to maintain on the long-term a tight glucose control (HbA1, < 6.5-7% or less) through an insulin regimen which "mimic" the physiological insulin profile: a basal insulin secretion to maintain ... ...

    Abstract The therapeutic goal in insulin-treated diabetic patients is to maintain on the long-term a tight glucose control (HbA1, < 6.5-7% or less) through an insulin regimen which "mimic" the physiological insulin profile: a basal insulin secretion to maintain glucose homeostasis and an acute post-prandial secretion in response to meal intake. Such goal represents a challenge for the clinician as conventional human insulins have major drawbacks: slow absorption and too late peak with regular insulins, delayed peak and often occuring at an unwanted time with intermediate and long-acting insulins. Furthermore, these insulins are characterised by a large within- and between-subjects variability, which complicate patients' task to self-adapt their daily doses, even for those well educated and compliants. These limitations and unpredictable variations in insulin action are responsible for an increased risk of hypoglycemic events, between meals as well as during the night period. As a consequence, glucose control is frequently insufficient in type 1 diabetic patients, and these limitations may contribute also to the delayed initiation of insulin therapy in type 2 diabetics when oral antidiabetic agents fail. This variability and the non-reproducibility of the conventional insulin pharmacodynamics are explained by several exogenous and endogenous factors describe in this review. Availability of new short-acting (lispro, aspart and glulisine) and long-acting analogs (glargine, detemir) of human insulin, with improved pharmacokinetic characteristics, and a lesser variability and better reproducibility, should facilitate a tight glucose control in insulin-treated patients. The main pharmacokinetic and pharmacodynamic characteristics of these new insulin analogs are presented and discussed in the light of there intra- and inter-individual variability. Their reduced variability should permit to reinforce near "physiological" insulin regimen such as "basal-bolus" technique and to consider new approaches and therapeutic strategies in type 1 and type 2 diabetic patients.
    MeSH term(s) Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacokinetics ; Insulin/administration & dosage ; Insulin/analogs & derivatives ; Insulin/pharmacokinetics
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Insulin
    Language English
    Publishing date 2005-09
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1315751-6
    ISSN 1262-3636 ; 0338-1684
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/s1262-3636(05)88263-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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